CH457464A - Verfahren zur Herstellung von Benzodiazepin-Derivaten - Google Patents

Verfahren zur Herstellung von Benzodiazepin-Derivaten

Info

Publication number: CH457464A
Authority: CH; Switzerland
Prior art keywords: voltage; coil; diodes; temperature compensation; volts
Prior art date: 1962-03-09

Application number

CH1765866A

Other languages

German (de)

English (en)

Inventor

Reeder Earl

Stempel Arthur

Henryk Sternbach Leo

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1962-03-09

Filing date

1963-02-21

Publication date

1968-06-15

1962-11-28 Priority claimed from US240750A external-priority patent/US3340253A/en

1963-02-21 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1968-06-15 Publication of CH457464A publication Critical patent/CH457464A/de

Links

238000000034 method Methods 0.000 title description 2
229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
239000004065 semiconductor Substances 0.000 claims description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 1
230000001419 dependent effect Effects 0.000 claims 1
230000005284 excitation Effects 0.000 description 17
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 4
229910052711 selenium Inorganic materials 0.000 description 4
239000011669 selenium Substances 0.000 description 4
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
230000033228 biological regulation Effects 0.000 description 3
238000013016 damping Methods 0.000 description 3
230000006698 induction Effects 0.000 description 3
229910052710 silicon Inorganic materials 0.000 description 3
239000010703 silicon Substances 0.000 description 3
230000000694 effects Effects 0.000 description 2
230000010355 oscillation Effects 0.000 description 2
230000006641 stabilisation Effects 0.000 description 2
238000011105 stabilization Methods 0.000 description 2
241001397173 Kali <angiosperm> Species 0.000 description 1
239000003990 capacitor Substances 0.000 description 1
229910052732 germanium Inorganic materials 0.000 description 1
GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
239000000463 material Substances 0.000 description 1
238000007740 vapor deposition Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
- C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Inductance-Capacitance Distribution Constants And Capacitance-Resistance Oscillators (AREA)

CH1765866A 1962-03-09 1963-02-21 Verfahren zur Herstellung von Benzodiazepin-Derivaten CH457464A (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17855162A	1962-03-09	1962-03-09
US240750A US3340253A (en)	1962-11-28	1962-11-28	Preparation of certain benzodiazepine compounds

Publications (1)

Publication Number	Publication Date
CH457464A true CH457464A (de)	1968-06-15

Family

ID=26874429

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CH1765866A CH457464A (de)	1962-03-09	1963-02-21	Verfahren zur Herstellung von Benzodiazepin-Derivaten
CH222063A CH442326A (de)	1962-03-09	1963-02-21	Verfahren zur Herstellung von Benzodiazepin-Derivaten

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CH222063A CH442326A (de)	1962-03-09	1963-02-21	Verfahren zur Herstellung von Benzodiazepin-Derivaten

Country Status (9)

Country	Link
BE (1)	BE629227A (fr)
CA (1)	CA976547A (fr)
CH (2)	CH457464A (fr)
DE (4)	DE1545955A1 (fr)
DK (1)	DK127507B (fr)
ES (1)	ES285854A1 (fr)
GB (2)	GB1013900A (fr)
NL (3)	NL7010712A (fr)
SE (2)	SE328583B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES405260A1 (es) *	1972-07-28	1975-07-01	Stabilimenti Chim Farmac Riuni	Procedimiento para la preparacion de 3-hidroxi-5-aril-7- sustituidos-1, 3-dihidro-2h-1, 4-benzodiacepin-2-onas.
NL173269C (nl) *	1974-04-30	1984-01-02	Ferrer Int	Werkwijze voor de bereiding van een geneesmiddel met als werkzaam bestanddeel een 1,4-benzodiazepinederivaat, alsmede werkwijze voor de bereiding van het 1,4-benzodiazepinederivaat.
DE3413592C2 (de) *	1984-04-11	1986-06-05	Dolorgiet GmbH & Co KG, 5205 St Augustin	Arzneimittel enthaltend 5-(2-Fluorphenyl)-1,3-dihydro-3-hydroxy-1-methyl-7-nitro-2H-1,4-benzodiazepin-2-on
DK287185A (da) *	1984-06-26	1986-02-24	Merck & Co Inc	Benzodiazepinderivat og farmaceutisk praeparat indeholdende et saadantderivat

0
- NL NL289735D patent/NL289735A/xx unknown
1963
- 1963-02-21 CH CH1765866A patent/CH457464A/de unknown
- 1963-02-21 CH CH222063A patent/CH442326A/de unknown
- 1963-02-23 DE DE19631545955 patent/DE1545955A1/de active Pending
- 1963-02-23 DE DE19631445873 patent/DE1445873A1/de active Pending
- 1963-02-23 DE DE19631545956 patent/DE1545956A1/de active Pending
- 1963-02-23 DE DE19631545957 patent/DE1545957A1/de active Pending
- 1963-02-27 CA CA869,700A patent/CA976547A/en not_active Expired
- 1963-03-06 BE BE629227A patent/BE629227A/fr unknown
- 1963-03-07 GB GB4791264A patent/GB1013900A/en not_active Expired
- 1963-03-07 GB GB909463A patent/GB1013229A/en not_active Expired
- 1963-03-08 SE SE02566/63A patent/SE328583B/xx unknown
- 1963-03-08 ES ES285854A patent/ES285854A1/es not_active Expired
1970
- 1970-07-20 NL NL7010712A patent/NL7010712A/xx unknown
- 1970-07-20 NL NL7010711A patent/NL7010711A/xx unknown
- 1970-09-11 SE SE12424/70A patent/SE361174B/xx unknown
1972
- 1972-01-18 DK DK25372A patent/DK127507B/da unknown

Also Published As

Publication number	Publication date
BE629227A (fr)	1963-10-21
DE1545956A1 (de)	1969-11-20
NL289735A (fr)
SE361174B (fr)	1973-10-22
DE1445873A1 (de)	1969-04-10
GB1013900A (en)	1965-12-22
DK127507B (da)	1973-11-19
NL7010711A (fr)	1970-10-26
GB1013229A (en)	1965-12-15
SE328583B (fr)	1970-09-21
CA976547A (en)	1975-10-21
DE1545957A1 (de)	1969-12-11
ES285854A1 (es)	1963-08-16
CH442326A (de)	1967-08-31
DE1545955A1 (de)	1969-11-20
NL7010712A (fr)	1970-10-26

Publication	Publication Date	Title
EP0010137B1 (fr)	1981-11-11	Circuit générateur pour tension de polarisation du substrat
DE3024936C2 (de)	1985-01-17	Wechselspannungsverstärker in Form einer integrierten Schaltung
DE2559096A1 (de)	1976-07-15	Stromquelle hoher gleichspannung mit stromstaerkeregelung
CH457464A (de)	1968-06-15	Verfahren zur Herstellung von Benzodiazepin-Derivaten
DE2745302C2 (de)	1982-03-18	Schaltungsanordnung zur Kontrolle der Versorgungsspannung für vorzugsweise integrierte Schaltkreise
CH497733A (de)	1970-11-30	Spannungs- und Temperaturkompensationsschaltung für elektronische Uhren
DE2238814A1 (de)	1973-02-22	Verfahren und schaltungsanordnung zur abstimmung des hohlraumresonators eines maser-oszillators
DE1209961B (de)	1966-01-27	Schaltungsanordnung fuer den elektrisch angetriebenen Schwinger eines zeithaltenden Geraetes
DE3009506A1 (de)	1980-09-18	Gleichspannungswandler
DE2147996A1 (de)	1972-04-13	Elektronischer Impulsgeber
DE2038435C3 (de)	1978-12-07	Oszillator
DE1904889A1 (de)	1969-09-11	Elektronisch-magnetisches Antriebssystem fuer Uhren
DE2221747C3 (de)	1977-03-03	Schaltung zur Aufrechterhaltung der Schwingungen eines mechanischen Antriebsorgans
DE1909543A1 (de)	1970-09-03	Schaltungsanordnung fuer den permanentmagnet-dynamischen Antrieb eines mechanischen Schwingers oder Rotors,insbesondere eines zeithaltenden Geraetes
DE1448342A1 (de)	1969-04-10	Elektronisches Antriebsprinzip fuer Uhren
DE2743099A1 (de)	1979-04-05	Schaltungsanordnung mit transistoren
DE1548004A1 (de)	1969-07-17	Schaltungsanordnung zur kontaktlosen elektrischen Unterhaltung von Drehschwingungen
DE2136329A1 (de)	1973-02-01	Elektronischer schaltkreis fuer elektrisch angetriebene uhren
CH71469A (fr)	1916-01-03	Projectile d'artillerie
DE2221747B2 (de)	1976-07-15	Schaltung zur aufrechterhaltung der schwingungen eines mechanischen antriebsorgans
DE260281C (fr)
AT212914B (de)	1961-01-10	Elektronisches Relais
DE656523C (de)	1938-02-12	Elektronenroehre
CH120964A (de)	1927-06-16	Namen- oder Nummernschild für Fahrzeuge.
CH447357A (de)	1967-11-30	Wechselrichter