CH507243A - Procedimento per la preparazione di 2,4-diamino-5-(-3,4,5-trimetossibenzil)-pirimidina - Google Patents

Procedimento per la preparazione di 2,4-diamino-5-(-3,4,5-trimetossibenzil)-pirimidina

Info

Publication number: CH507243A
Authority: CH; Switzerland
Prior art keywords: pyrimidine; give; diamino; cyano; gps
Prior art date: 1969-04-01

Application number

CH499069A

Other languages

English (en)

Inventor

Dompe Franco

Original Assignee

Dompe Farmaceutici Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1969-04-01

Filing date

1969-04-01

Publication date

1971-05-15

1969-04-01 Application filed by Dompe Farmaceutici Spa filed Critical Dompe Farmaceutici Spa

1969-04-01 Priority to CH499069A priority Critical patent/CH507243A/it

1971-05-15 Publication of CH507243A publication Critical patent/CH507243A/it

Links

IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 title 1
OPHQOIGEOHXOGX-UHFFFAOYSA-N 3,4,5-trimethoxybenzaldehyde Chemical compound COC1=CC(C=O)=CC(OC)=C1OC OPHQOIGEOHXOGX-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
OYUQCQCQLDTRHQ-UHFFFAOYSA-N 2,4-diaminopyrimidine-5-carbonitrile Chemical compound NC1=NC=C(C#N)C(N)=N1 OYUQCQCQLDTRHQ-UHFFFAOYSA-N 0.000 abstract 1
BUHYMJLFRZAFBF-UHFFFAOYSA-N 3,4,5-trimethoxybenzoyl chloride Chemical compound COC1=CC(C(Cl)=O)=CC(OC)=C1OC BUHYMJLFRZAFBF-UHFFFAOYSA-N 0.000 abstract 1
BCMKZSUDKHOYLA-UHFFFAOYSA-N N-[2-acetamido-5-(3,4,5-trimethoxybenzoyl)pyrimidin-4-yl]acetamide Chemical compound C(C)(=O)NC1=NC=C(C(=N1)NC(C)=O)C(C1=CC(=C(C(=C1)OC)OC)OC)=O BCMKZSUDKHOYLA-UHFFFAOYSA-N 0.000 abstract 1
238000005644 Wolff-Kishner reduction reaction Methods 0.000 abstract 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
230000021736 acetylation Effects 0.000 abstract 1
238000006640 acetylation reaction Methods 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
238000006114 decarboxylation reaction Methods 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
YAAWASYJIRZXSZ-UHFFFAOYSA-N pyrimidine-2,4-diamine Chemical compound NC1=CC=NC(N)=N1 YAAWASYJIRZXSZ-UHFFFAOYSA-N 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CH499069A 1969-04-01 1969-04-01 Procedimento per la preparazione di 2,4-diamino-5-(-3,4,5-trimetossibenzil)-pirimidina CH507243A (it)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CH499069A CH507243A (it)	1969-04-01	1969-04-01	Procedimento per la preparazione di 2,4-diamino-5-(-3,4,5-trimetossibenzil)-pirimidina

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH499069A CH507243A (it)	1969-04-01	1969-04-01	Procedimento per la preparazione di 2,4-diamino-5-(-3,4,5-trimetossibenzil)-pirimidina

Publications (1)

Publication Number	Publication Date
CH507243A true CH507243A (it)	1971-05-15

Family

ID=4286030

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH499069A CH507243A (it)	1969-04-01	1969-04-01	Procedimento per la preparazione di 2,4-diamino-5-(-3,4,5-trimetossibenzil)-pirimidina

Country Status (1)

Country	Link
CH (1)	CH507243A (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4189581A (en) *	1977-03-04	1980-02-19	Basf Aktiengesellschaft	2-Acylamino-4-amino-5-(3,4,5-trimethoxybenzyl)-pyrimidines

1969
- 1969-04-01 CH CH499069A patent/CH507243A/it not_active IP Right Cessation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4189581A (en) *	1977-03-04	1980-02-19	Basf Aktiengesellschaft	2-Acylamino-4-amino-5-(3,4,5-trimethoxybenzyl)-pyrimidines

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Legal Events

Date	Code	Title	Description
1974-11-15	PL	Patent ceased