CH512244A - Mittel zur Erhaltung der Mundhygiene - Google Patents

Mittel zur Erhaltung der Mundhygiene

Info

Publication number: CH512244A
Authority: CH; Switzerland
Prior art keywords: dextranase; vehicle; units; teeth; enzyme
Prior art date: 1967-07-28

Application number

CH1109468A

Other languages

German (de)

English (en)

Inventor

Harold Boyd Woodruff

Thomas Henry Stoudt

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1967-07-28

Filing date

1968-07-24

Publication date

1971-09-15

1968-07-24 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1971-09-15 Publication of CH512244A publication Critical patent/CH512244A/de

Links

108010001682 Dextranase Proteins 0.000 title claims abstract description 29
238000002360 preparation method Methods 0.000 title abstract description 7
230000015572 biosynthetic process Effects 0.000 claims abstract description 10
239000000203 mixture Substances 0.000 claims abstract description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
229940112822 chewing gum Drugs 0.000 claims abstract description 6
235000015218 chewing gum Nutrition 0.000 claims abstract description 6
239000000606 toothpaste Substances 0.000 claims abstract description 6
229940034610 toothpaste Drugs 0.000 claims abstract description 6
239000000843 powder Substances 0.000 claims abstract description 5
239000002674 ointment Substances 0.000 claims abstract description 4
230000001055 chewing effect Effects 0.000 claims abstract description 3
238000000576 coating method Methods 0.000 claims description 15
239000011248 coating agent Substances 0.000 claims description 14
239000002324 mouth wash Substances 0.000 claims description 7
229940051866 mouthwash Drugs 0.000 claims description 7
239000007937 lozenge Substances 0.000 claims description 2
239000007910 chewable tablet Substances 0.000 claims 1
229940068682 chewable tablet Drugs 0.000 claims 1
229920002307 Dextran Polymers 0.000 abstract description 20
241001136494 Talaromyces funiculosus Species 0.000 abstract description 6
201000010099 disease Diseases 0.000 abstract description 6
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 abstract description 4
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract description 2
208000002064 Dental Plaque Diseases 0.000 abstract description 2
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract description 2
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract description 2
229910052921 ammonium sulfate Inorganic materials 0.000 abstract description 2
235000011130 ammonium sulphate Nutrition 0.000 abstract description 2
229960001230 asparagine Drugs 0.000 abstract description 2
235000009582 asparagine Nutrition 0.000 abstract description 2
235000013305 food Nutrition 0.000 abstract description 2
229910052943 magnesium sulfate Inorganic materials 0.000 abstract description 2
235000019341 magnesium sulphate Nutrition 0.000 abstract description 2
239000001963 growth medium Substances 0.000 abstract 2
239000000001 dental powder Substances 0.000 abstract 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 abstract 1
229910000396 dipotassium phosphate Inorganic materials 0.000 abstract 1
235000019797 dipotassium phosphate Nutrition 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 abstract 1
229910000359 iron(II) sulfate Inorganic materials 0.000 abstract 1
239000006210 lotion Substances 0.000 abstract 1
235000010603 pastilles Nutrition 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 description 24
102000004190 Enzymes Human genes 0.000 description 24
229940088598 enzyme Drugs 0.000 description 24
230000000694 effects Effects 0.000 description 13
208000002925 dental caries Diseases 0.000 description 12
239000003795 chemical substances by application Substances 0.000 description 11
238000000338 in vitro Methods 0.000 description 5
208000027418 Wounds and injury Diseases 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
239000000243 solution Substances 0.000 description 4
238000012360 testing method Methods 0.000 description 4
208000006558 Dental Calculus Diseases 0.000 description 3
241000282412 Homo Species 0.000 description 3
AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 description 3
-1 amylopsin Proteins 0.000 description 3
235000010633 broth Nutrition 0.000 description 3
230000001013 cariogenic effect Effects 0.000 description 3
230000006378 damage Effects 0.000 description 3
238000000855 fermentation Methods 0.000 description 3
230000004151 fermentation Effects 0.000 description 3
238000001727 in vivo Methods 0.000 description 3
208000014674 injury Diseases 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
239000002609 medium Substances 0.000 description 3
244000005700 microbiome Species 0.000 description 3
239000000758 substrate Substances 0.000 description 3
239000007640 basal medium Substances 0.000 description 2
210000004513 dentition Anatomy 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 description 2
229940011411 erythrosine Drugs 0.000 description 2
235000012732 erythrosine Nutrition 0.000 description 2
239000004174 erythrosine Substances 0.000 description 2
238000011534 incubation Methods 0.000 description 2
DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 2
238000012423 maintenance Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
238000000034 method Methods 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
239000007787 solid Substances 0.000 description 2
241000894007 species Species 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
230000036346 tooth eruption Effects 0.000 description 2
229920001817 Agar Polymers 0.000 description 1
241000228212 Aspergillus Species 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
241000699800 Cricetinae Species 0.000 description 1
206010061217 Infestation Diseases 0.000 description 1
241000364057 Peoria Species 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
241000733634 Prionosciadium lilacinum Species 0.000 description 1
208000014151 Stomatognathic disease Diseases 0.000 description 1
241000194017 Streptococcus Species 0.000 description 1
241000194022 Streptococcus sp. Species 0.000 description 1
241001516650 Talaromyces verruculosus Species 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
208000016599 Uterine disease Diseases 0.000 description 1
239000008351 acetate buffer Substances 0.000 description 1
230000009471 action Effects 0.000 description 1
239000008272 agar Substances 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000008859 change Effects 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
229940079919 digestives enzyme preparation Drugs 0.000 description 1
238000007598 dipping method Methods 0.000 description 1
230000029142 excretion Effects 0.000 description 1
238000011049 filling Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
150000004673 fluoride salts Chemical class 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
238000004362 fungal culture Methods 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000006872 improvement Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000002955 isolation Methods 0.000 description 1
238000011068 loading method Methods 0.000 description 1
238000005259 measurement Methods 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
239000012528 membrane Substances 0.000 description 1
238000009629 microbiological culture Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
230000003239 periodontal effect Effects 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
230000008569 process Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000007790 scraping Methods 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
108091016642 steapsin Proteins 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
230000000007 visual effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Oral & Maxillofacial Surgery (AREA)
Cosmetics (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CH1109468A 1967-07-28 1968-07-24 Mittel zur Erhaltung der Mundhygiene CH512244A (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65667167A	1967-07-28	1967-07-28
US70187568A	1968-01-31	1968-01-31

Publications (1)

Publication Number	Publication Date
CH512244A true CH512244A (de)	1971-09-15

Family

ID=27097233

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH1109468A CH512244A (de)	1967-07-28	1968-07-24	Mittel zur Erhaltung der Mundhygiene

Country Status (12)

Country	Link
JP (1)	JPS4834897B1 (fr)
AT (1)	AT303972B (fr)
BE (1)	BE718645A (fr)
CA (1)	CA945072A (fr)
CH (1)	CH512244A (fr)
DK (1)	DK120449B (fr)
FI (1)	FI46807C (fr)
FR (2)	FR1584054A (fr)
IL (1)	IL30362A0 (fr)
NL (1)	NL148236B (fr)
PH (1)	PH9638A (fr)
SE (1)	SE364182B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10237317B4 (de) *	2002-08-15	2010-04-08	3M Espe Ag	Enzymhaltige Zusammensetzung, Verfahren zu deren Herstellung und deren Verwendung
EP1600141B1 (fr)	2004-05-24	2013-04-17	3M Deutschland GmbH	Compositions contenant une enzyme active collagénolytique et son utilisation pour le traitement des carries dentaires

1968
- 1968-07-09 NL NL686809687A patent/NL148236B/xx unknown
- 1968-07-15 IL IL6830362A patent/IL30362A0/xx unknown
- 1968-07-17 FI FI682033A patent/FI46807C/fi active
- 1968-07-19 CA CA125,656A patent/CA945072A/en not_active Expired
- 1968-07-24 CH CH1109468A patent/CH512244A/de not_active IP Right Cessation
- 1968-07-25 SE SE10142/68A patent/SE364182B/xx unknown
- 1968-07-25 JP JP43052195A patent/JPS4834897B1/ja active Pending
- 1968-07-26 FR FR160833A patent/FR1584054A/fr not_active Expired
- 1968-07-26 DK DK362268AA patent/DK120449B/da not_active IP Right Cessation
- 1968-07-26 BE BE718645A patent/BE718645A/xx unknown
- 1968-07-26 AT AT730868A patent/AT303972B/de not_active IP Right Cessation
- 1968-07-26 FR FR160831A patent/FR7748M/fr not_active Expired
1971
- 1971-12-14 PH PH13104*UA patent/PH9638A/en unknown

Also Published As

Publication number	Publication date
SE364182B (fr)	1974-02-18
DK120449B (da)	1971-06-01
BE718645A (fr)	1969-01-27
FI46807C (fi)	1973-07-10
AT303972B (de)	1972-12-27
FR1584054A (fr)	1969-12-12
PH9638A (en)	1976-01-22
FR7748M (fr)	1970-03-16
NL6809687A (fr)	1969-01-30
JPS4834897B1 (fr)	1973-10-24
IL30362A0 (en)	1968-09-26
NL148236B (nl)	1976-01-15
CA945072A (en)	1974-04-09
FI46807B (fr)	1973-04-02

Legal Events

Date	Code	Title	Description
1985-03-29	PL	Patent ceased

Publication	Publication Date	Title
DE69211682T2 (de)	1997-01-16	Mittel gegen zahnbelag bestehend aus nichtantibakteriellem tetracyclin
DE19720437B4 (de)	2006-10-19	Mutanase enthaltende orale Zusammensetzungen
DE2152620C3 (de)	1979-12-06	Mutanase, Verfahren zu ihrer Herstellung und ihre Verwendung
Mombelli	1993	Microbiology of the dental implant
DE3539202C2 (fr)	1989-01-12
Van der Weijden et al.	1998	The effect of herbal extracts in an experimental mouthrinse on established plaque and gingivitis
DE3882775T2 (de)	1993-12-02	Zusammensetzung zur Behandlung von parodontaler Krankheit.
CN107281013B (zh)	2020-08-25	一种去除牙渍抑制牙菌斑牙膏
DE69804677T2 (de)	2002-11-21	Bleichende, zahnsteinverhindernde zahnpasta mit niedriger scheuerwirkung
DE69110125T2 (de)	1996-01-25	Zahnpasta gegen zahnbelag.
CN107595750B (zh)	2020-07-14	一种活性消炎牙膏
Kelstrup et al.	1978	Reduction of the formation of dental plaque and gingivitis in humans by crude mutanase
DE10394357T5 (de)	2007-03-08	Oro-dentale-Kräuterpflegezusammensetzung und Verfahren zur Herstellung derselben
DE2443646A1 (de)	1975-03-27	Zahnreinigungsmittel
Mitchell et al.	1956	The nature of the gingival plaque in the hamster—production, prevention, and removal
DE2329253A1 (de)	1973-12-13	Mundpraeparat
CN108175737A (zh)	2018-06-19	一种抗牙结石中药牙膏及其制备方法
DE2921697A1 (de)	1979-12-06	Anti-karies-praeparat
CH512244A (de)	1971-09-15	Mittel zur Erhaltung der Mundhygiene
DE2738652B2 (de)	1980-06-19	Lactobacillus-Präparat und seine Verwendung bei der Bekämpfung bakterieller Infektionen und Entzündungen
JP2723551B2 (ja)	1998-03-09	口腔用組成物
AU2016225938A1 (en)	2016-09-29	Compositions and methods for the prevention and treatment of oral diseases
CN110755297A (zh)	2020-02-07	一种高分子脱敏糊剂及其制备方法
DE2937964A1 (de)	1981-03-26	Mittel zur bekaempfung der karies
DE68909025T2 (de)	1994-01-05	Mittel zur Verhinderung von Zahnbelagbildung.