CH514628A - Phosphocreatin salts - Google Patents
Phosphocreatin saltsInfo
- Publication number
- CH514628A CH514628A CH1582966A CH1582966A CH514628A CH 514628 A CH514628 A CH 514628A CH 1582966 A CH1582966 A CH 1582966A CH 1582966 A CH1582966 A CH 1582966A CH 514628 A CH514628 A CH 514628A
- Authority
- CH
- Switzerland
- Prior art keywords
- eluate
- vol
- resin
- salts
- dild
- Prior art date
Links
- CFPWPNDPUSLDPF-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]-2-phosphonoacetic acid Chemical class NC(=N)N(C)C(C(O)=O)P(O)(O)=O CFPWPNDPUSLDPF-UHFFFAOYSA-N 0.000 title 1
- 239000011347 resin Substances 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 abstract 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000001110 calcium chloride Substances 0.000 abstract 1
- 235000011148 calcium chloride Nutrition 0.000 abstract 1
- 229910001628 calcium chloride Inorganic materials 0.000 abstract 1
- QHFQAJHNDKBRBO-UHFFFAOYSA-L calcium chloride hexahydrate Chemical compound O.O.O.O.O.O.[Cl-].[Cl-].[Ca+2] QHFQAJHNDKBRBO-UHFFFAOYSA-L 0.000 abstract 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 235000011116 calcium hydroxide Nutrition 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 229960003624 creatine Drugs 0.000 abstract 1
- 239000006046 creatine Substances 0.000 abstract 1
- 229910001629 magnesium chloride Inorganic materials 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/222—Amides of phosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Method for prepn. of salts (II) (esp. Ca, K, Na, and Mg) of pure (I). "Therapeutic purposes". Creatine (4.600 kg.) was phosphorylated to give a suspension (220 l.) contng. crude II (1.55-1.6 kg.). This was centrifuged, washed, dild. to 260-300 l. (deionised H2O), adjusted to pH 8.5 (H+ resin) and 10% CaCl2.6H2O (60 l.) tog. with enough 4% Ca(OH)2 suspension to keep the pH 8-8.5 was added at 0 deg. to ppt. the phosphate, which was removed by centrifuging. This was adsorbed onto Cl- resin (20 to 50#, capacity 1.1 equiv./l.) contained in 2 cylindrical beds, 70 cm. high and 50 cm. diam. (Resin vol. 275 l), percolating at 3.5 ml./cm/min. (eluate), the eluate concn. being adjusted to 0.005N by diln. of the imput. The bed was then washed with 2 vol. deionised H2O, and eluted at 0-4 deg. with a soln. (0.2M CaCl2 + 0.5 m MgCl2) of pH 7.5, at 0.1 ml./cm2/min. The eluate was dild. with 3 vol. of an H2O miscible solvent, giving crude Ca-I (1.45-1.5 kg., 88-91% yield).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2466065 | 1965-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH514628A true CH514628A (en) | 1971-10-31 |
Family
ID=11214289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1582966A CH514628A (en) | 1965-11-02 | 1966-11-01 | Phosphocreatin salts |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE689132A (en) |
| CH (1) | CH514628A (en) |
| ES (1) | ES332955A1 (en) |
| NL (1) | NL6615468A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1191639B (en) * | 1985-11-11 | 1988-03-23 | Schiapparelli Farma | PHARMACEUTICAL COMPOSITION CONTAINING PHOSPHOCREATIN AND METHOD TO PREPARE IT |
| CN101812088B (en) * | 2010-03-19 | 2012-09-26 | 海南美大制药有限公司 | High-purity creatine phosphate sodium compound |
-
1966
- 1966-10-31 ES ES0332955A patent/ES332955A1/en not_active Expired
- 1966-10-31 BE BE689132D patent/BE689132A/xx unknown
- 1966-11-01 CH CH1582966A patent/CH514628A/en not_active IP Right Cessation
- 1966-11-02 NL NL6615468A patent/NL6615468A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES332955A1 (en) | 1967-10-01 |
| NL6615468A (en) | 1967-05-03 |
| BE689132A (en) | 1967-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1378133A (en) | Preparation of calcium sulphate | |
| CH514628A (en) | Phosphocreatin salts | |
| GB1202076A (en) | Phosphate pond water recovery | |
| GB1365405A (en) | Radionuclide generator and method for producing same | |
| GB1518759A (en) | Method of making steering wheels | |
| GB937327A (en) | Process for the preparation of codehydrogenase i (diphosphopyridine nucleotide) of high purity from yeast | |
| GB1184037A (en) | Separation of Molybdenum and Technetium | |
| US2626888A (en) | Vitamin b12-active substance elution from monmorillonite absorbents | |
| GB968324A (en) | Improvements in or relating to the recovery of cephalosporin c | |
| GB879551A (en) | Ion-exchange purification of nicotinamide | |
| GB1456218A (en) | Process for the production of high-purity metals from nickeli ferous mattes | |
| US3033849A (en) | Manufacture of vitamin b12 | |
| GB988065A (en) | Isolation of 6-aminopenicillanic acid | |
| FR2155889A1 (en) | Vincamine theophyllinepropanesulphonate - with cerebral vasodilatory activity | |
| GB1201823A (en) | Process for recovering glutamic acid | |
| GB697060A (en) | Process for recovering vitamin b and vitamin b-like substances from a montmorillonite adsorbent | |
| GB871221A (en) | Recovery of antibiotics by means of ion-exchange resins | |
| ES273852A1 (en) | Pharmaceutical purification process | |
| ES354704A1 (en) | Method of purification of trilaurylamine | |
| GB1315697A (en) | Process for the isolation of coenzyme b12 | |
| GB622982A (en) | Improvements in or relating to the recovery of streptomycin | |
| JPS6466127A (en) | Antitumor agent | |
| WIEDORN et al. | On Psychic Factors Conditioning Effects of Drugs in Psychiatry | |
| GB804639A (en) | Process for the manufacture of adrenocorticotropic hormone preparations | |
| BE791504A (en) | Technetium generator - using pertitanic acid as adsorbent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |