CH530207A - Verfahren zur Herstellung von Na(A1),Ne(B29)-Di-tert.-Butyloxycarbonyl-insulin - Google Patents

Verfahren zur Herstellung von Na(A1),Ne(B29)-Di-tert.-Butyloxycarbonyl-insulin

Info

Publication number: CH530207A
Authority: CH; Switzerland
Prior art keywords: butyloxycarbonyl; insulin; tert; preparation
Prior art date: 1968-09-28

Application number

CH1449569A

Other languages

English (en)

Inventor

Rolf Dr Geiger

Werner Dr Pfaff

Alfred Dr Baender

Hans-Hermann Dr Schoene

Adolf Dr Mager

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1968-09-28

Filing date

1969-09-25

Publication date

1972-11-15

1969-09-25 Application filed by Hoechst Ag filed Critical Hoechst Ag

1972-11-15 Publication of CH530207A publication Critical patent/CH530207A/de

Links

229940125396 insulin Drugs 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CH1449569A 1968-09-28 1969-09-25 Verfahren zur Herstellung von Na(A1),Ne(B29)-Di-tert.-Butyloxycarbonyl-insulin CH530207A (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE1793517A DE1793517C3 (de)	1968-09-28	1968-09-28	N(Al),N(B29>Bis-(tert.-butyloxycarbonyl)-insulin und Verfahren zu seiner Herstellung

Publications (1)

Publication Number	Publication Date
CH530207A true CH530207A (de)	1972-11-15

Family

ID=5707736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH1449569A CH530207A (de)	1968-09-28	1969-09-25	Verfahren zur Herstellung von Na(A1),Ne(B29)-Di-tert.-Butyloxycarbonyl-insulin

Country Status (10)

Country	Link
US (1)	US3684791A (de)
AT (1)	AT290032B (de)
BE (1)	BE739511A (de)
CH (1)	CH530207A (de)
DE (1)	DE1793517C3 (de)
DK (1)	DK123094B (de)
FR (1)	FR2019135A1 (de)
GB (1)	GB1223350A (de)
NL (1)	NL159089B (de)
SE (1)	SE362872B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3934008A (en) *	1968-08-23	1976-01-20	Ciba-Geigy Corporation	N-acyl and desamino human calcitonin and analogs thereof
GB1381274A (en) *	1971-01-28	1975-01-22	Nat Res Dev	Insulin derivatives
GB1381273A (en) *	1971-01-28	1975-01-22	Nat Res Dev	Insulin derivatives
US3864325A (en) *	1971-11-18	1975-02-04	Nat Res Dev	(N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives
JP2001521006A (ja)	1997-10-24	2001-11-06	イーライ・リリー・アンド・カンパニー	不溶性インシュリン組成物
US6531448B1 (en)	1997-12-23	2003-03-11	Eli Lilly And Company	Insoluble compositions for controlling blood glucose
US7040519B2 (en) *	2003-06-12	2006-05-09	Jere F. Irwin	Thermoformable web support apparatus and support device for a heated plastic sheet
BRPI1007457A2 (pt)	2009-01-28	2015-08-25	Smartcells Inc	Conjungado, formulação de liberação prolongada, e, sistema de distribuição de bomba.
WO2010088268A1 (en)	2009-01-28	2010-08-05	Smartcells, Inc.	Exogenously triggered controlled release materials and uses thereof
WO2010088300A1 (en)	2009-01-28	2010-08-05	Smartcells, Inc.	Crystalline insulin-conjugates
WO2010088286A1 (en)	2009-01-28	2010-08-05	Smartcells, Inc.	Synthetic conjugates and uses thereof
US8623345B2 (en)	2009-03-20	2014-01-07	Smartcells	Terminally-functionalized conjugates and uses thereof
WO2010107520A1 (en)	2009-03-20	2010-09-23	Smartcells, Inc.	Soluble non-depot insulin conjugates and uses thereof
EP2598522A4 (de)	2010-07-28	2014-11-12	Smartcells Inc	Rekombinante lektine, bindungsstellenmodifizierte lektine und anwendungen davon
JP2013535467A (ja)	2010-07-28	2013-09-12	スマートセルズ・インコーポレイテツド	組換えにより発現されたインスリンポリペプチドおよびその使用
AU2011282977A1 (en)	2010-07-28	2013-02-21	Smartcells, Inc.	Drug-ligand conjugates, synthesis thereof, and intermediates thereto
KR20160065930A (ko)	2013-10-04	2016-06-09	머크 샤프 앤드 돔 코포레이션	글루코스-반응성 인슐린 접합체
FR3120445B1 (fr)	2021-03-08	2023-02-10	Aryballe	Procédé de caractérisation d’un analyte présent dans un échantillon gazeux contenant au moins une espèce chimique parasite

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3528960A (en) *	1968-10-07	1970-09-15	Lilly Co Eli	N-carboxyaroyl insulins

1968
- 1968-09-28 DE DE1793517A patent/DE1793517C3/de not_active Expired
1969
- 1969-09-22 US US859688A patent/US3684791A/en not_active Expired - Lifetime
- 1969-09-23 NL NL6914400.A patent/NL159089B/xx not_active IP Right Cessation
- 1969-09-25 CH CH1449569A patent/CH530207A/de not_active IP Right Cessation
- 1969-09-25 DK DK511369AA patent/DK123094B/da not_active IP Right Cessation
- 1969-09-26 AT AT913469A patent/AT290032B/de not_active IP Right Cessation
- 1969-09-26 SE SE13247/69A patent/SE362872B/xx unknown
- 1969-09-29 FR FR6933086A patent/FR2019135A1/fr not_active Withdrawn
- 1969-09-29 BE BE739511D patent/BE739511A/xx not_active IP Right Cessation
- 1969-09-29 GB GB47799/69A patent/GB1223350A/en not_active Expired

Also Published As

Publication number	Publication date
BE739511A (de)	1970-03-31
AT290032B (de)	1971-05-10
NL159089B (nl)	1979-01-15
FR2019135A1 (de)	1970-06-26
DE1793517A1 (de)	1972-03-02
GB1223350A (en)	1971-02-24
SE362872B (de)	1973-12-27
DK123094B (da)	1972-05-15
US3684791A (en)	1972-08-15
DE1793517B2 (de)	1974-05-09
DE1793517C3 (de)	1974-12-05
NL6914400A (de)	1970-04-01

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Legal Events

Date	Code	Title	Description
1985-05-31	PL	Patent ceased