CH609331A5 - Process for the preparation of 3-aryloxy-3-phenyl-propylamines - Google Patents
Process for the preparation of 3-aryloxy-3-phenyl-propylaminesInfo
- Publication number
- CH609331A5 CH609331A5 CH222878A CH222878A CH609331A5 CH 609331 A5 CH609331 A5 CH 609331A5 CH 222878 A CH222878 A CH 222878A CH 222878 A CH222878 A CH 222878A CH 609331 A5 CH609331 A5 CH 609331A5
- Authority
- CH
- Switzerland
- Prior art keywords
- formula
- denote
- compounds
- acid addition
- propylamines
- Prior art date
Links
- 239000002253 acid Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- HYTRGQCJEYUJKJ-UHFFFAOYSA-N (3-chloro-1-phenoxypropyl)benzene Chemical class C=1C=CC=CC=1C(CCCl)OC1=CC=CC=C1 HYTRGQCJEYUJKJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000004089 psychotropic agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compounds of the annexed formula I <IMAGE> are prepared in which every R1 and R2 independently of one another represents hydrogen or methyl, R3 and R4 represent halogen, -CF3, C2-C4-alkyl, C1-C3-alkoxy or C3-C4-alkenyl and n and m represent 0, 1 or 2, but where the sum of n and m is not 0 if both R1 denote CH3 and both R2 denote H, and their acid addition salts with pharmaceutically acceptable acids. To do this, the appropriate optionally substituted 3-chloro-1-phenoxy-1-phenylpropane is reacted with ammonia or an amine of the formula NHR1R1 and the compound obtained is optionally converted into its acid addition salt. The compounds of the formula I can be used as psychotropic agents, in particular as antidepressants.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/432,379 US4314081A (en) | 1974-01-10 | 1974-01-10 | Arloxyphenylpropylamines |
| CH10275A CH609675A5 (en) | 1974-01-10 | 1975-01-07 | |
| KR1019750000261A KR800001009B1 (en) | 1975-01-09 | 1975-01-09 | Process for the preparation of aryloxy phenyl-propylamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH609331A5 true CH609331A5 (en) | 1979-02-28 |
Family
ID=27171785
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH222878A CH609331A5 (en) | 1974-01-10 | 1975-01-07 | Process for the preparation of 3-aryloxy-3-phenyl-propylamines |
| CH222978A CH609332A5 (en) | 1974-01-10 | 1975-01-07 | Process for the preparation of novel 3-aryloxy-3-phenyl-propylamines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH222978A CH609332A5 (en) | 1974-01-10 | 1975-01-07 | Process for the preparation of novel 3-aryloxy-3-phenyl-propylamines |
Country Status (1)
| Country | Link |
|---|---|
| CH (2) | CH609331A5 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0318727A3 (en) * | 1987-12-01 | 1990-09-12 | A/S Ferrosan | Aryloxphenylpropylamines and their preparation and use |
| EP0399504A3 (en) * | 1989-05-26 | 1992-02-12 | Novo Nordisk A/S | Aryloxyphenylpropylamines their preparation and use |
-
1975
- 1975-01-07 CH CH222878A patent/CH609331A5/en not_active IP Right Cessation
- 1975-01-07 CH CH222978A patent/CH609332A5/en not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0318727A3 (en) * | 1987-12-01 | 1990-09-12 | A/S Ferrosan | Aryloxphenylpropylamines and their preparation and use |
| EP0399504A3 (en) * | 1989-05-26 | 1992-02-12 | Novo Nordisk A/S | Aryloxyphenylpropylamines their preparation and use |
Also Published As
| Publication number | Publication date |
|---|---|
| CH609332A5 (en) | 1979-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |