CH613938A5 - Process for the preparation of N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexylamine, and the compound prepared by the process - Google Patents

Process for the preparation of N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexylamine, and the compound prepared by the process

Info

Publication number: CH613938A5
Authority: CH; Switzerland
Prior art keywords: amino; methylcyclohexylamine; dibromobenzyl; preparation; compound prepared
Prior art date: 1973-03-15

Application number

CH366874A

Other languages

English (en)

Inventor

Arto Karjalainen

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-03-15

Filing date

1974-03-15

Publication date

1979-10-31

1973-07-02 Priority claimed from FI2122/73A external-priority patent/FI55647C/fi

1974-03-15 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1979-10-31 Publication of CH613938A5 publication Critical patent/CH613938A5/xx

Links

OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title abstract 2
239000002253 acid Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
GHUMSGGCKVMYGH-UHFFFAOYSA-N (2-amino-3,5-dibromophenyl)methanol Chemical compound NC1=C(Br)C=C(Br)C=C1CO GHUMSGGCKVMYGH-UHFFFAOYSA-N 0.000 abstract 1
XTUVJUMINZSXGF-UHFFFAOYSA-N N-methylcyclohexylamine Chemical compound CNC1CCCCC1 XTUVJUMINZSXGF-UHFFFAOYSA-N 0.000 abstract 1
PAMIQIKDUOTOBW-UHFFFAOYSA-N N-methylcyclohexylamine Natural products CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
239000003434 antitussive agent Substances 0.000 abstract 1
229940124584 antitussives Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
210000003097 mucus Anatomy 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
210000002345 respiratory system Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CH366874A 1973-03-15 1974-03-15 Process for the preparation of N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexylamine, and the compound prepared by the process CH613938A5 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI78673		1973-03-15
FI2122/73A FI55647C (fi)	1973-07-02	1973-07-02	Foerfarande foer framstaellning av terapeutiskt vaerdefull 2-amino-n-cyklohexyl-3,5-dibrom-n-metylbensylamin och dess syraadditionssalter

Publications (1)

Publication Number	Publication Date
CH613938A5 true CH613938A5 (en)	1979-10-31

Family

ID=26156383

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH366874A CH613938A5 (en)	1973-03-15	1974-03-15	Process for the preparation of N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexylamine, and the compound prepared by the process

Country Status (11)

Country	Link
JP (1)	JPS5328906B2 (fr)
AT (1)	AT333249B (fr)
BG (1)	BG23745A3 (fr)
CH (1)	CH613938A5 (fr)
DE (1)	DE2411848A1 (fr)
ES (1)	ES424272A1 (fr)
HU (1)	HU166949B (fr)
NL (1)	NL7403155A (fr)
NO (1)	NO139558C (fr)
RO (1)	RO69817A (fr)
SE (2)	SE396216B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8771807B2 (en) *	2011-05-24	2014-07-08	Air Products And Chemicals, Inc.	Organoaminosilane precursors and methods for making and using same
CN102924295B (zh) *	2012-10-09	2014-10-29	石家庄东方药业有限公司	一种盐酸溴己新晶体及其制备方法和用途
CN103145564B (zh) *	2013-03-15	2014-06-18	湖北美林药业有限公司	盐酸溴己新化合物及其药物组合物
CN109535010B (zh) *	2018-12-27	2021-10-26	广州一品红制药有限公司	一种盐酸溴己新的制备方法

1973
- 1973-07-18 SE SE7310071A patent/SE396216B/xx unknown
- 1973-07-31 NO NO306373A patent/NO139558C/no unknown
1974
- 1974-03-08 NL NL7403155A patent/NL7403155A/xx not_active Application Discontinuation
- 1974-03-12 DE DE2411848A patent/DE2411848A1/de active Pending
- 1974-03-13 BG BG026039A patent/BG23745A3/xx unknown
- 1974-03-13 RO RO7800574A patent/RO69817A/fr unknown
- 1974-03-13 HU HUTO000957 patent/HU166949B/hu unknown
- 1974-03-14 AT AT212974A patent/AT333249B/de not_active IP Right Cessation
- 1974-03-14 ES ES424272A patent/ES424272A1/es not_active Expired
- 1974-03-15 CH CH366874A patent/CH613938A5/xx not_active IP Right Cessation
- 1974-03-15 JP JP2986274A patent/JPS5328906B2/ja not_active Expired
1975
- 1975-12-09 SE SE7513882A patent/SE7513882L/ not_active Application Discontinuation

Also Published As

Publication number	Publication date
SE7513882L (sv)	1975-12-09
NO139558B (no)	1978-12-27
ES424272A1 (es)	1976-05-16
RO69817A (fr)	1980-12-30
SE396216B (sv)	1977-09-12
NO139558C (no)	1979-04-04
NL7403155A (fr)	1974-09-17
BG23745A3 (en)	1977-10-12
AT333249B (de)	1976-11-10
ATA212974A (de)	1976-03-15
HU166949B (fr)	1975-06-28
JPS5328906B2 (fr)	1978-08-17
JPS5046643A (fr)	1975-04-25
DE2411848A1 (de)	1974-09-26

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Legal Events

Date	Code	Title	Description
1988-11-30	PL	Patent ceased
2024-10-31	PL	Patent ceased