CH616745A5 - Integral analytical element for the analysis of liquids. - Google Patents
Integral analytical element for the analysis of liquids. Download PDFInfo
- Publication number
- CH616745A5 CH616745A5 CH957475A CH957475A CH616745A5 CH 616745 A5 CH616745 A5 CH 616745A5 CH 957475 A CH957475 A CH 957475A CH 957475 A CH957475 A CH 957475A CH 616745 A5 CH616745 A5 CH 616745A5
- Authority
- CH
- Switzerland
- Prior art keywords
- layer
- substance
- reagent
- registration
- element according
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title claims description 80
- 238000004458 analytical method Methods 0.000 title claims description 38
- 239000000126 substance Substances 0.000 claims description 174
- 239000003153 chemical reaction reagent Substances 0.000 claims description 113
- 230000005855 radiation Effects 0.000 claims description 57
- 238000009826 distribution Methods 0.000 claims description 48
- 230000004888 barrier function Effects 0.000 claims description 39
- 229920000642 polymer Polymers 0.000 claims description 37
- 108010010803 Gelatin Proteins 0.000 claims description 27
- 229920000159 gelatin Polymers 0.000 claims description 27
- 239000008273 gelatin Substances 0.000 claims description 27
- 235000019322 gelatine Nutrition 0.000 claims description 27
- 235000011852 gelatine desserts Nutrition 0.000 claims description 27
- OMOVVBIIQSXZSZ-UHFFFAOYSA-N [6-(4-acetyloxy-5,9a-dimethyl-2,7-dioxo-4,5a,6,9-tetrahydro-3h-pyrano[3,4-b]oxepin-5-yl)-5-formyloxy-3-(furan-3-yl)-3a-methyl-7-methylidene-1a,2,3,4,5,6-hexahydroindeno[1,7a-b]oxiren-4-yl] 2-hydroxy-3-methylpentanoate Chemical compound CC12C(OC(=O)C(O)C(C)CC)C(OC=O)C(C3(C)C(CC(=O)OC4(C)COC(=O)CC43)OC(C)=O)C(=C)C32OC3CC1C=1C=COC=1 OMOVVBIIQSXZSZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000002243 precursor Substances 0.000 claims description 20
- 239000000758 substrate Substances 0.000 claims description 17
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000000084 colloidal system Substances 0.000 claims description 14
- 239000000049 pigment Substances 0.000 claims description 13
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 239000004408 titanium dioxide Substances 0.000 claims description 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 6
- 102000003992 Peroxidases Human genes 0.000 claims description 6
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 6
- 229920002301 cellulose acetate Polymers 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- 108040007629 peroxidase activity proteins Proteins 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 229920000936 Agarose Polymers 0.000 claims description 4
- 108010015776 Glucose oxidase Proteins 0.000 claims description 4
- 239000004366 Glucose oxidase Substances 0.000 claims description 4
- 229940116332 glucose oxidase Drugs 0.000 claims description 4
- 235000019420 glucose oxidase Nutrition 0.000 claims description 4
- 150000004676 glycans Chemical class 0.000 claims description 4
- 239000001023 inorganic pigment Substances 0.000 claims description 4
- 229920001282 polysaccharide Polymers 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- 239000004952 Polyamide Substances 0.000 claims description 2
- 239000006229 carbon black Substances 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 3
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- BBEAQIROQSPTKN-UHFFFAOYSA-N antipyrene Natural products C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 BBEAQIROQSPTKN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 108010046301 glucose peroxidase Proteins 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000010410 layer Substances 0.000 description 414
- 150000001875 compounds Chemical class 0.000 description 41
- 238000012360 testing method Methods 0.000 description 39
- 238000003892 spreading Methods 0.000 description 33
- 230000007480 spreading Effects 0.000 description 33
- 230000035699 permeability Effects 0.000 description 26
- 238000000034 method Methods 0.000 description 24
- 239000000306 component Substances 0.000 description 21
- 239000000243 solution Substances 0.000 description 20
- 238000006243 chemical reaction Methods 0.000 description 18
- 239000000463 material Substances 0.000 description 16
- 238000000576 coating method Methods 0.000 description 15
- 239000000975 dye Substances 0.000 description 15
- 230000008859 change Effects 0.000 description 14
- 230000000694 effects Effects 0.000 description 14
- 239000011148 porous material Substances 0.000 description 14
- 239000002904 solvent Substances 0.000 description 14
- 239000011248 coating agent Substances 0.000 description 13
- 239000012530 fluid Substances 0.000 description 13
- 238000005259 measurement Methods 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 12
- 239000006185 dispersion Substances 0.000 description 11
- 239000002657 fibrous material Substances 0.000 description 11
- 210000002966 serum Anatomy 0.000 description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 239000008103 glucose Substances 0.000 description 10
- 239000012528 membrane Substances 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 9
- 108090000790 Enzymes Proteins 0.000 description 9
- 239000002250 absorbent Substances 0.000 description 9
- 239000007795 chemical reaction product Substances 0.000 description 9
- 229940088598 enzyme Drugs 0.000 description 9
- 239000002245 particle Substances 0.000 description 9
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N 4-aminoantipyrine Chemical compound CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 8
- 230000002745 absorbent Effects 0.000 description 8
- 230000009471 action Effects 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 239000000835 fiber Substances 0.000 description 8
- 239000011230 binding agent Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 238000009827 uniform distribution Methods 0.000 description 7
- 238000005859 coupling reaction Methods 0.000 description 6
- 230000005670 electromagnetic radiation Effects 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 5
- 238000010168 coupling process Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 239000003605 opacifier Substances 0.000 description 5
- 238000002798 spectrophotometry method Methods 0.000 description 5
- 239000004793 Polystyrene Substances 0.000 description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 239000012790 adhesive layer Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 239000002612 dispersion medium Substances 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 230000005012 migration Effects 0.000 description 4
- 238000013508 migration Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 239000008199 coating composition Substances 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- -1 hydrogen ions Chemical class 0.000 description 3
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 102000003929 Transaminases Human genes 0.000 description 2
- 108090000340 Transaminases Proteins 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 238000004159 blood analysis Methods 0.000 description 2
- 239000012503 blood component Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000002706 hydrostatic effect Effects 0.000 description 2
- 238000005470 impregnation Methods 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- OIPPWFOQEKKFEE-UHFFFAOYSA-N orcinol Chemical compound CC1=CC(O)=CC(O)=C1 OIPPWFOQEKKFEE-UHFFFAOYSA-N 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000011236 particulate material Substances 0.000 description 2
- 230000003617 peroxidasic effect Effects 0.000 description 2
- 238000005554 pickling Methods 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
- 238000002310 reflectometry Methods 0.000 description 2
- 230000004043 responsiveness Effects 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000011787 zinc oxide Substances 0.000 description 2
- PWJNDVAKQLOWRZ-UHFFFAOYSA-N 1-hydroxynaphthalene-2-sulfonic acid Chemical compound C1=CC=C2C(O)=C(S(O)(=O)=O)C=CC2=C1 PWJNDVAKQLOWRZ-UHFFFAOYSA-N 0.000 description 1
- GLDQAMYCGOIJDV-UHFFFAOYSA-N 2,3-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC(O)=C1O GLDQAMYCGOIJDV-UHFFFAOYSA-N 0.000 description 1
- KGIGUEBEKRSTEW-UHFFFAOYSA-N 2-vinylpyridine Chemical class C=CC1=CC=CC=N1 KGIGUEBEKRSTEW-UHFFFAOYSA-N 0.000 description 1
- BLZLWVCVBBDMQI-UHFFFAOYSA-N 3-(2,5-dioxopyrrol-1-yl)propyl-dimethylazanium;chloride Chemical compound [Cl-].C[NH+](C)CCCN1C(=O)C=CC1=O BLZLWVCVBBDMQI-UHFFFAOYSA-N 0.000 description 1
- BOTGCZBEERTTDQ-UHFFFAOYSA-N 4-Methoxy-1-naphthol Chemical compound C1=CC=C2C(OC)=CC=C(O)C2=C1 BOTGCZBEERTTDQ-UHFFFAOYSA-N 0.000 description 1
- USGNZHHNWYDCTC-UHFFFAOYSA-N 4-amino-1,4-dihydropyrazol-5-one Chemical class NC1C=NNC1=O USGNZHHNWYDCTC-UHFFFAOYSA-N 0.000 description 1
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical class NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108010024957 Ascorbate Oxidase Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 229910000906 Bronze Inorganic materials 0.000 description 1
- 108010089254 Cholesterol oxidase Proteins 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- WZKXBGJNNCGHIC-UHFFFAOYSA-N Leucomalachite green Chemical compound C1=CC(N(C)C)=CC=C1C(C=1C=CC(=CC=1)N(C)C)C1=CC=CC=C1 WZKXBGJNNCGHIC-UHFFFAOYSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- JPYHHZQJCSQRJY-UHFFFAOYSA-N Phloroglucinol Natural products CCC=CCC=CCC=CCC=CCCCCC(=O)C1=C(O)C=C(O)C=C1O JPYHHZQJCSQRJY-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000011511 automated evaluation Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- UUVZSUXVPFUSRB-UHFFFAOYSA-M benzyl-[3-(2,5-dioxopyrrol-1-yl)propyl]-dimethylazanium;chloride Chemical compound [Cl-].C=1C=CC=CC=1C[N+](C)(C)CCCN1C(=O)C=CC1=O UUVZSUXVPFUSRB-UHFFFAOYSA-M 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- VCCBEIPGXKNHFW-UHFFFAOYSA-N biphenyl-4,4'-diol Chemical group C1=CC(O)=CC=C1C1=CC=C(O)C=C1 VCCBEIPGXKNHFW-UHFFFAOYSA-N 0.000 description 1
- 239000010974 bronze Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- QXJJQWWVWRCVQT-UHFFFAOYSA-K calcium;sodium;phosphate Chemical compound [Na+].[Ca+2].[O-]P([O-])([O-])=O QXJJQWWVWRCVQT-UHFFFAOYSA-K 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000009614 chemical analysis method Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000006103 coloring component Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- KUNSUQLRTQLHQQ-UHFFFAOYSA-N copper tin Chemical compound [Cu].[Sn] KUNSUQLRTQLHQQ-UHFFFAOYSA-N 0.000 description 1
- 150000001896 cresols Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000010217 densitometric analysis Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012954 diazonium Substances 0.000 description 1
- 150000001989 diazonium salts Chemical class 0.000 description 1
- 150000005169 dihydroxybenzoic acids Chemical class 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000000295 emission spectrum Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011152 fibreglass Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 229960001867 guaiacol Drugs 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001057 ionotropic effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 229910000464 lead oxide Inorganic materials 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229910052751 metal Chemical class 0.000 description 1
- 239000002184 metal Chemical class 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000013081 microcrystal Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 238000003541 multi-stage reaction Methods 0.000 description 1
- ZUVBIBLYOCVYJU-UHFFFAOYSA-N naphthalene-1,7-diol Chemical compound C1=CC=C(O)C2=CC(O)=CC=C21 ZUVBIBLYOCVYJU-UHFFFAOYSA-N 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- YEXPOXQUZXUXJW-UHFFFAOYSA-N oxolead Chemical compound [Pb]=O YEXPOXQUZXUXJW-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 150000004989 p-phenylenediamines Chemical class 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- QCDYQQDYXPDABM-UHFFFAOYSA-N phloroglucinol Chemical compound OC1=CC(O)=CC(O)=C1 QCDYQQDYXPDABM-UHFFFAOYSA-N 0.000 description 1
- 229960001553 phloroglucinol Drugs 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000001028 reflection method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012508 resin bead Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012764 semi-quantitative analysis Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000003232 water-soluble binding agent Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
- G01N33/525—Multi-layer analytical elements
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7425426A FR2280081A1 (fr) | 1974-07-23 | 1974-07-23 | Produit composite unitaire pour l'analyse chimique ou biologique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH616745A5 true CH616745A5 (en) | 1980-04-15 |
Family
ID=9141563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH957475A CH616745A5 (en) | 1974-07-23 | 1975-07-22 | Integral analytical element for the analysis of liquids. |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5818628B2 (fr) |
| BE (1) | BE831660A (fr) |
| CA (1) | CA1049910A (fr) |
| CH (1) | CH616745A5 (fr) |
| DE (1) | DE2532918C3 (fr) |
| FR (1) | FR2280081A1 (fr) |
| GB (1) | GB1519465A (fr) |
| SE (1) | SE427217B (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929751A1 (de) * | 1989-09-07 | 1991-03-21 | Guenter Keul | Teststreifen mit integriertem filter |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4050898A (en) * | 1976-04-26 | 1977-09-27 | Eastman Kodak Company | Integral analytical element |
| US4057394A (en) * | 1976-05-24 | 1977-11-08 | Miles Laboratories, Inc. | Test device and method for determining blood hemoglobin |
| DE2625834B2 (de) * | 1976-06-09 | 1978-10-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Bestimmung von Substraten oder Enzymaktivitäten |
| US4069017A (en) * | 1977-01-14 | 1978-01-17 | Eastman Kodak Company | Colorimetric assay for bilirubin |
| CA1095819A (fr) * | 1977-01-14 | 1981-02-17 | Eastman Kodak Company | Element pour l'analyse des liquides |
| CA1122889A (fr) * | 1977-08-08 | 1982-05-04 | Eastman Kodak Company | Ralentissement de la migration des especes identifiables a l'interieur d'elements employes pour le dosage des liquides |
| US4288228A (en) * | 1979-01-31 | 1981-09-08 | Technicon Instruments Corporation | Whole blood analyses and diffusion apparatus therefor |
| US4234316A (en) * | 1979-04-02 | 1980-11-18 | Fmc Corporation | Device for delivering measured quantities of reagents into assay medium |
| JPS56117152A (en) * | 1980-02-20 | 1981-09-14 | Agency Of Ind Science & Technol | Measuring apparatus of reaction |
| JPS5766359A (en) * | 1980-10-09 | 1982-04-22 | Fuji Photo Film Co Ltd | Sheet-like material for analysis |
| JPS57125847A (en) * | 1981-01-30 | 1982-08-05 | Konishiroku Photo Ind Co Ltd | Analysis element |
| JPS57144996A (en) * | 1981-02-27 | 1982-09-07 | Fuji Photo Film Co Ltd | Film for quantitative analysis |
| JPS57208997A (en) * | 1981-06-17 | 1982-12-22 | Fuji Photo Film Co Ltd | Liquid analyzing material for oxidase enzyme reaction system |
| EP0160847A1 (fr) * | 1984-04-09 | 1985-11-13 | Akademie der Wissenschaften der DDR | Produit d'analyse pour la défection du glucose, des oligosaccharides contenant le glucose et de l'acide urique |
| JPS62138198A (ja) * | 1985-12-10 | 1987-06-20 | Fuji Photo Film Co Ltd | 自己顕色性基質を含む乾式液体分析要素 |
| US5601997A (en) | 1995-02-03 | 1997-02-11 | Tchao; Ruy | Chemotaxis assay procedure |
| US20030180183A1 (en) | 1995-10-30 | 2003-09-25 | Takao Fukuoka | Method for measuring substance and testing piece |
| EP0860695B1 (fr) | 1995-10-30 | 2006-01-04 | Arkray, Inc. | Procédé pour mesurer un analyte et éprouvette de mesure |
| WO2006092980A1 (fr) | 2005-02-28 | 2006-09-08 | Fujifilm Corporation | Élément d’analyse par voie sèche |
| DE602008003242D1 (de) | 2007-01-17 | 2010-12-16 | Fujifilm Corp | Verfahren zur Messung tierischer Alpha-Amylase |
| JP5265257B2 (ja) | 2008-06-30 | 2013-08-14 | 富士フイルム株式会社 | 犬crp及び人crpを認識する抗体 |
| JP5292270B2 (ja) | 2009-12-21 | 2013-09-18 | 富士フイルム株式会社 | 犬crp測定用乾式分析要素 |
| DE102010001032B4 (de) * | 2010-01-19 | 2014-11-20 | Merete Management Gmbh | Indikationseinrichtung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3511608A (en) * | 1967-12-14 | 1970-05-12 | Harold P Anderson | Multiple layer paper test strip |
| US3663374A (en) * | 1970-08-14 | 1972-05-16 | Geomet | Method and apparatus for quantitating enzyme activity |
| DE2332760C3 (de) * | 1972-06-30 | 1982-03-04 | Eastman Kodak Co., 14650 Rochester, N.Y. | Material für die quantitative spektrophotometrische Analyse einer Flüssigkeit |
-
1974
- 1974-07-23 FR FR7425426A patent/FR2280081A1/fr active Granted
-
1975
- 1975-07-22 CA CA232,019A patent/CA1049910A/fr not_active Expired
- 1975-07-22 SE SE7508315A patent/SE427217B/xx not_active IP Right Cessation
- 1975-07-22 CH CH957475A patent/CH616745A5/de not_active IP Right Cessation
- 1975-07-23 BE BE158546A patent/BE831660A/fr not_active IP Right Cessation
- 1975-07-23 DE DE19752532918 patent/DE2532918C3/de not_active Expired
- 1975-07-23 GB GB3084075A patent/GB1519465A/en not_active Expired
- 1975-07-23 JP JP50089991A patent/JPS5818628B2/ja not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929751A1 (de) * | 1989-09-07 | 1991-03-21 | Guenter Keul | Teststreifen mit integriertem filter |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1049910A (fr) | 1979-03-06 |
| BE831660A (fr) | 1976-01-23 |
| JPS5818628B2 (ja) | 1983-04-14 |
| SE427217B (sv) | 1983-03-14 |
| FR2280081A1 (fr) | 1976-02-20 |
| DE2532918C3 (de) | 1981-12-17 |
| FR2280081B1 (fr) | 1978-02-17 |
| GB1519465A (en) | 1978-07-26 |
| SE7508315L (sv) | 1976-01-26 |
| DE2532918B2 (de) | 1979-09-13 |
| JPS5140191A (ja) | 1976-04-03 |
| DE2532918A1 (de) | 1976-02-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2532918C3 (de) | Integrales analytisches Element für die Analyse von Flüssigkeiten | |
| DE2801455C2 (de) | Mehrschichtiges analytisches Element für die Bestimmung von Amylase in Flüssigkeiten | |
| US4042335A (en) | Integral element for analysis of liquids | |
| DE2332760C3 (de) | Material für die quantitative spektrophotometrische Analyse einer Flüssigkeit | |
| US4050898A (en) | Integral analytical element | |
| US3992158A (en) | Integral analytical element | |
| DE69523693T2 (de) | Analysevorrichtung und Verfahren zur Analyse von biologischer Flüssigkeit | |
| DE2801477C2 (de) | Verfahren und analytisches Element für die Bestimmung von Bilirubin | |
| DE3222366C2 (fr) | ||
| DE1598153C3 (de) | Diagnostisches Mittel zum Nach weis der Inhaltsstoffe von Korperflus sigkeiten | |
| DE68927777T2 (de) | Testvorrichtung mit definiertem Volumen | |
| DE69714637T2 (de) | Reagenzteststreifen zum Nachweis von Glukose im Blut | |
| DE19781288B4 (de) | Opake Reaktionsmatrix zur Analyse von Vollblut | |
| DE2801476A1 (de) | Kolorimetrisches verfahren fuer die bestimmung von bilirubin | |
| DE2927345A1 (de) | Verfahren und vorrichtung zur analyse einer probe | |
| DE3202667A1 (de) | Analyseneinheit | |
| DE3783851T2 (de) | Integrales, mehrschichtiges element fuer analyse. | |
| JPH06504376A (ja) | 全血中の被分析物測定用テストキャリア | |
| EP1566637A1 (fr) | Bande d'analyse monocouche | |
| DE3222707C2 (fr) | ||
| DE3332144A1 (de) | Analytisches element | |
| DE2512586A1 (de) | Mehrschichtiges analytisches element fuer die quantitative bestimmung des cholesteringehaltes von fluessigkeiten | |
| DE2626367C2 (de) | Analytisches Material für die analytische Bestimmung eines Stoffes in einer Flüssigkeitsprobe | |
| DE3510992C2 (fr) | ||
| DE69731929T2 (de) | Trockenreagenz-Analysenelement |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased | ||
| PL | Patent ceased |