CH617458A5 - Use of filamentary structures containing encapsulated fumarase for the enzymatic production of l-malic acid - Google Patents

Use of filamentary structures containing encapsulated fumarase for the enzymatic production of l-malic acid Download PDF

Info

Publication number: CH617458A5
Authority: CH; Switzerland
Prior art keywords: malic acid; enzyme; fumarase; malic; solution
Prior art date: 1973-03-30

Application number

CH412274A

Other languages

English (en)

Italian (it)

Inventor

Franco Morisi

Rosanna Mosti

Mario Bettonte

Original Assignee

Snam Progetti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-03-30

Filing date

1974-03-25

Publication date

1980-05-30

1974-03-25 Application filed by Snam Progetti filed Critical Snam Progetti

1980-05-30 Publication of CH617458A5 publication Critical patent/CH617458A5/it

Links

230000002255 enzymatic effect Effects 0.000 title description 12
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 title description 5
238000004519 manufacturing process Methods 0.000 title description 5
108010036781 Fumarate Hydratase Proteins 0.000 title description 4
102100036160 Fumarate hydratase, mitochondrial Human genes 0.000 title description 2
229940116298 l- malic acid Drugs 0.000 title 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 26
239000000243 solution Substances 0.000 description 19
108090000790 Enzymes Proteins 0.000 description 18
102000004190 Enzymes Human genes 0.000 description 18
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 16
238000000034 method Methods 0.000 description 12
239000001530 fumaric acid Substances 0.000 description 11
229920000642 polymer Polymers 0.000 description 10
239000001630 malic acid Substances 0.000 description 9
229920002284 Cellulose triacetate Polymers 0.000 description 7
NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 7
230000000694 effects Effects 0.000 description 7
239000008363 phosphate buffer Substances 0.000 description 7
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 6
239000000835 fiber Substances 0.000 description 6
230000000813 microbial effect Effects 0.000 description 5
239000001744 Sodium fumarate Substances 0.000 description 4
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 4
MSJMDZAOKORVFC-SEPHDYHBSA-L disodium fumarate Chemical compound [Na+].[Na+].[O-]C(=O)\C=C\C([O-])=O MSJMDZAOKORVFC-SEPHDYHBSA-L 0.000 description 4
239000000839 emulsion Substances 0.000 description 4
229940050411 fumarate Drugs 0.000 description 4
235000011090 malic acid Nutrition 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
229940005573 sodium fumarate Drugs 0.000 description 4
235000019294 sodium fumarate Nutrition 0.000 description 4
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
239000004952 Polyamide Substances 0.000 description 3
241000589774 Pseudomonas sp. Species 0.000 description 3
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 3
150000001252 acrylic acid derivatives Chemical class 0.000 description 3
238000010564 aerobic fermentation Methods 0.000 description 3
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
229910052921 ammonium sulfate Inorganic materials 0.000 description 3
239000001166 ammonium sulphate Substances 0.000 description 3
235000011130 ammonium sulphate Nutrition 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
150000001875 compounds Chemical class 0.000 description 3
229920001577 copolymer Polymers 0.000 description 3
150000002734 metacrylic acid derivatives Chemical class 0.000 description 3
150000007523 nucleic acids Chemical class 0.000 description 3
102000039446 nucleic acids Human genes 0.000 description 3
108020004707 nucleic acids Proteins 0.000 description 3
229920002647 polyamide Polymers 0.000 description 3
229920000098 polyolefin Polymers 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000011541 reaction mixture Substances 0.000 description 3
239000000758 substrate Substances 0.000 description 3
238000002604 ultrasonography Methods 0.000 description 3
229920001567 vinyl ester resin Polymers 0.000 description 3
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
229910021380 Manganese Chloride Inorganic materials 0.000 description 2
GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
239000003054 catalyst Substances 0.000 description 2
238000000855 fermentation Methods 0.000 description 2
230000004151 fermentation Effects 0.000 description 2
235000013305 food Nutrition 0.000 description 2
239000012535 impurity Substances 0.000 description 2
239000011565 manganese chloride Substances 0.000 description 2
235000002867 manganese chloride Nutrition 0.000 description 2
230000020477 pH reduction Effects 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
229920002554 vinyl polymer Polymers 0.000 description 2
239000001729 Ammonium fumarate Substances 0.000 description 1
ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
102000007327 Protamines Human genes 0.000 description 1
108010007568 Protamines Proteins 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
239000002253 acid Substances 0.000 description 1
235000019297 ammonium fumarate Nutrition 0.000 description 1
CKKXWJDFFQPBQL-SEPHDYHBSA-N azane;(e)-but-2-enedioic acid Chemical compound N.N.OC(=O)\C=C\C(O)=O CKKXWJDFFQPBQL-SEPHDYHBSA-N 0.000 description 1
235000010633 broth Nutrition 0.000 description 1
239000000872 buffer Substances 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
-1 citric acid Chemical class 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000006911 enzymatic reaction Methods 0.000 description 1
239000012467 final product Substances 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
229940049920 malate Drugs 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
239000000203 mixture Substances 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
229920002037 poly(vinyl butyral) polymer Polymers 0.000 description 1
229950008679 protamine sulfate Drugs 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
239000002994 raw material Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
238000005406 washing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties

Landscapes

Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Textile Engineering (AREA)
Biomedical Technology (AREA)
Dispersion Chemistry (AREA)
Manufacturing & Machinery (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

CH412274A 1973-03-30 1974-03-25 Use of filamentary structures containing encapsulated fumarase for the enzymatic production of l-malic acid CH617458A5 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT22377/73A IT981777B (it)	1973-03-30	1973-03-30	Procedimento per la produzione enzimatica di acido l malico

Publications (1)

Publication Number	Publication Date
CH617458A5 true CH617458A5 (en)	1980-05-30

Family

ID=11195439

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH412274A CH617458A5 (en)	1973-03-30	1974-03-25	Use of filamentary structures containing encapsulated fumarase for the enzymatic production of l-malic acid

Country Status (11)

Country	Link
JP (1)	JPS547875B2 (fr)
BE (1)	BE812860A (fr)
CH (1)	CH617458A5 (fr)
CS (1)	CS182252B2 (fr)
DD (1)	DD111067A5 (fr)
FR (1)	FR2223351B1 (fr)
GB (1)	GB1426137A (fr)
IT (1)	IT981777B (fr)
LU (1)	LU69744A1 (fr)
NL (1)	NL7404353A (fr)
ZA (1)	ZA742031B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3310849A1 (de) *	1983-03-25	1984-09-27	Chemische Werke Hüls AG, 4370 Marl	Verfahren zur biotechnologischen herstellung von l-aepfelsaeure
US4734368A (en) *	1984-03-23	1988-03-29	Huels Aktiengesellschaft	Process for the bioconversion of fumarate to L-malate
DE19705962A1 (de)	1997-02-17	1998-08-20	Hoechst Ag	Kugelförmige, gefärbte Polyesterpartikel, Verfahren zu deren Herstellung sowie deren Verwendung für Pulverlacke

1973
- 1973-03-30 IT IT22377/73A patent/IT981777B/it active
1974
- 1974-03-19 GB GB1219874A patent/GB1426137A/en not_active Expired
- 1974-03-25 FR FR7410073A patent/FR2223351B1/fr not_active Expired
- 1974-03-25 CH CH412274A patent/CH617458A5/it not_active IP Right Cessation
- 1974-03-26 BE BE142477A patent/BE812860A/fr not_active IP Right Cessation
- 1974-03-28 JP JP3554674A patent/JPS547875B2/ja not_active Expired
- 1974-03-28 DD DD177530A patent/DD111067A5/xx unknown
- 1974-03-29 CS CS7400002285A patent/CS182252B2/cs unknown
- 1974-03-29 ZA ZA00742031A patent/ZA742031B/xx unknown
- 1974-03-29 NL NL7404353A patent/NL7404353A/xx unknown
- 1974-03-29 LU LU69744A patent/LU69744A1/xx unknown

Also Published As

Publication number	Publication date
DE2415310B2 (de)	1976-04-08
GB1426137A (en)	1976-02-25
NL7404353A (fr)	1974-10-02
DE2415310A1 (de)	1974-10-10
BE812860A (fr)	1974-09-26
JPS547875B2 (fr)	1979-04-10
CS182252B2 (en)	1978-04-28
ZA742031B (en)	1975-03-26
LU69744A1 (fr)	1974-07-17
FR2223351A1 (fr)	1974-10-25
FR2223351B1 (fr)	1978-07-21
JPS49126887A (fr)	1974-12-04
IT981777B (it)	1974-10-10
DD111067A5 (fr)	1975-01-20
AU6692974A (en)	1975-09-25

Legal Events

Date	Code	Title	Description
1982-05-28	PUE	Assignment	Owner name: ANIC S.P.A.
1985-11-29	PL	Patent ceased
2024-10-31	PL	Patent ceased

Publication	Publication Date	Title
Lockwood et al.	1941	The production of gluconic acid and 2-keto-gluconic acid from glucose by species of Pseudomonas and Phytomonas
Pfeifer et al.	1952	Itaconic acid by fermentation with Aspergillus terreus
DE2444849A1 (de)	1975-07-31	Verfahren zur herstellung organischer saeuren durch biologische hydrolyse
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KR890003956A (ko)	1989-04-19	L-아미노산 함유 발효액으로부터 l-아미노산을 회수하는 방법
FR2452507A1 (fr)	1980-10-24	Procede de preparation de membranes anisotropiques, nouveaux produits ainsi obtenus et leurs utilisations en particulier pour la separation de gaz
DE2400323C2 (de)	1982-11-11	Neue Glucose-Isomerase und ihre Herstellung
CH617458A5 (en)	1980-05-30	Use of filamentary structures containing encapsulated fumarase for the enzymatic production of l-malic acid
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DE2415310C3 (de)	1976-11-25	Verfahren zur enzymatischen Herstellung von L-Äpfelsäure
DE2221046A1 (de)	1973-11-15	Antibiotika und verfahren zu ihrer herstellung
NO149779B (no)	1984-03-12	Fremgangsmaate for fremstilling av d-(-)-fenylgycinforbindelser ved enzymatisk hydantoinhydrolyse
DE3533198A1 (de)	1987-03-19	Verfahren zur fermentativen herstellung von l-aminosaeuren aus (alpha)-ketocarbonsaeuren