CH621801A5 - Process for the preparation of polyhalosteroids - Google Patents

Process for the preparation of polyhalosteroids Download PDF

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Publication number
CH621801A5
CH621801A5 CH1615175A CH1615175A CH621801A5 CH 621801 A5 CH621801 A5 CH 621801A5 CH 1615175 A CH1615175 A CH 1615175A CH 1615175 A CH1615175 A CH 1615175A CH 621801 A5 CH621801 A5 CH 621801A5
Authority
CH
Switzerland
Prior art keywords
acid
dione
diene
methyl
pregna
Prior art date
Application number
CH1615175A
Other languages
German (de)
English (en)
Inventor
Jaroslav Dr Kalvoda
Georg Dr Anner
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to CH1615175A priority Critical patent/CH621801A5/de
Priority to DE19762655570 priority patent/DE2655570A1/de
Priority to NZ182836A priority patent/NZ182836A/xx
Priority to GB51463/76A priority patent/GB1537130A/en
Priority to DK557876A priority patent/DK143708C/da
Priority to AT913976A priority patent/AT357703B/de
Priority to IL51087A priority patent/IL51087A/xx
Priority to IE2700/76A priority patent/IE44473B1/en
Priority to SE7613920A priority patent/SE423903B/xx
Priority to ES454120A priority patent/ES454120A1/es
Priority to NL7613791A priority patent/NL7613791A/xx
Priority to CA267,605A priority patent/CA1056371A/fr
Priority to ZA767382A priority patent/ZA767382B/xx
Priority to BE173138A priority patent/BE849268A/fr
Priority to DD7600196266A priority patent/DD128683A5/xx
Priority to AU20472/76A priority patent/AU508224B2/en
Priority to FR7637257A priority patent/FR2334363A1/fr
Priority to HU76CI1705A priority patent/HU175583B/hu
Priority to JP14932676A priority patent/JPS5289662A/ja
Priority to AT81079A priority patent/AT363199B/de
Priority to AT0081179A priority patent/AT363200B/de
Priority to AT0081279A priority patent/AT363201B/de
Priority to CH841579A priority patent/CH622270A5/de
Priority to CH841479A priority patent/CH621802A5/de
Priority to CH841679A priority patent/CH622271A5/de
Publication of CH621801A5 publication Critical patent/CH621801A5/de
Priority to US06/601,746 priority patent/US4619921A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH1615175A 1975-12-12 1975-12-12 Process for the preparation of polyhalosteroids CH621801A5 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
CH1615175A CH621801A5 (en) 1975-12-12 1975-12-12 Process for the preparation of polyhalosteroids
DE19762655570 DE2655570A1 (de) 1975-12-12 1976-12-08 Neue polyhalogensteroide und verfahren zu ihrer herstellung
NZ182836A NZ182836A (en) 1975-12-12 1976-12-09 9 ,21-dihalo-6 -fluoro-11 ,17 -dihydroxy 16 -methyl-pregna-1,4-diene-3,20-diones
GB51463/76A GB1537130A (en) 1975-12-12 1976-12-09 6,9,21-trihalo-steroids of the pregnane series
BE173138A BE849268A (fr) 1975-12-12 1976-12-10 Nouveaux steroides polyhalogenes et procede pour leur preparation
AU20472/76A AU508224B2 (en) 1975-12-12 1976-12-10 9 21-dihalogeno-11 17 -dihydroxy-6 -fluro-16-methyl-pregna-1,4-diene-3,20-diones
IL51087A IL51087A (en) 1975-12-12 1976-12-10 6 -fluoro-9 ,21-dihalogeno-11 -hydroxy-17 -(lower alkanoyloxy)-16 -methyl-pregna-184-diene-3,20-dione compounds,their manufacture and pharmaceutical compositions containing them
IE2700/76A IE44473B1 (en) 1975-12-12 1976-12-10 6,9,21-trihalo-steroids of the pregnane series
SE7613920A SE423903B (sv) 1975-12-12 1976-12-10 Forfarande for framstellning av 9 alfa, 21-dihalogen-11 beta,17 alfa-dihydroxi-6 alfa-flour-16 alfa-metyl-pregna-1,4-dien-3,20-dion-estrar
ES454120A ES454120A1 (es) 1975-12-12 1976-12-10 Procedimiento para la obtencion de polihalogenoesteroides.
NL7613791A NL7613791A (nl) 1975-12-12 1976-12-10 Werkwijze voor de bereiding van polyhalogeen- steroiden.
CA267,605A CA1056371A (fr) 1975-12-12 1976-12-10 Steroides polyhalogenes et procede de fabrication
ZA767382A ZA767382B (en) 1975-12-12 1976-12-10 New polyhalogeno-steroids and processes for their manufacture
DK557876A DK143708C (da) 1975-12-12 1976-12-10 Analogifremgangsmaade til fremstilling af 17alfa-acyloxy-9alfa,21-dihalogen-11beta-hydroxy-6alfa-fluor-16alfa-methyl-pregna-1,4-dien-3,20-dion-forbindelser
DD7600196266A DD128683A5 (de) 1975-12-12 1976-12-10 Verfahren zur herstellung neuer polyhalogensteroide
AT913976A AT357703B (de) 1975-12-12 1976-12-10 Verfahren zur herstellung von neuen 9alpha,21- dihalogen-11beta, 17alfa-dihydroxy-6alfa-fluor- 16alfa-methyl-pregna-1,4-dien-3,20-dion-ver- bindungen
FR7637257A FR2334363A1 (fr) 1975-12-12 1976-12-10 Nouveaux steroides polyhalogenes utiles comme medicaments et procede pour leur preparation
HU76CI1705A HU175583B (hu) 1975-12-12 1976-12-10 Sposob poluchenija novykh poligalosteroidov
JP14932676A JPS5289662A (en) 1975-12-12 1976-12-11 Novel polyhalogenoosteroid and preparation thereof
AT81079A AT363199B (de) 1975-12-12 1979-02-02 Verfahren zur herstellung von neuen 9alpha,21-dihalogen-11beta,17alpha-dihydroxy-6alpha-flour-16alpha-methyl-pregna-1,4-dien-3,20-dion-verbindungen
AT0081179A AT363200B (de) 1975-12-12 1979-02-02 Verfahren zur herstellung von neuen 9alpha, 21-dihalogen-11beta, 17alpha-dihydroxy-6alpha-
AT0081279A AT363201B (de) 1975-12-12 1979-02-02 Verfahren zur herstellung von neuen 9alpha,21-dihalogen-11beta,17alpha-dihydroxy-6alpha-
CH841579A CH622270A5 (en) 1975-12-12 1979-09-18 Process for the preparation of polyhalosteroids
CH841479A CH621802A5 (en) 1975-12-12 1979-09-18 Process for the preparation of polyhalosteroids
CH841679A CH622271A5 (en) 1975-12-12 1979-09-18 Process for the preparation of polyhalosteroids
US06/601,746 US4619921A (en) 1975-12-12 1984-04-20 Polyhalogeno-steroids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1615175A CH621801A5 (en) 1975-12-12 1975-12-12 Process for the preparation of polyhalosteroids

Publications (1)

Publication Number Publication Date
CH621801A5 true CH621801A5 (en) 1981-02-27

Family

ID=4414846

Family Applications (4)

Application Number Title Priority Date Filing Date
CH1615175A CH621801A5 (en) 1975-12-12 1975-12-12 Process for the preparation of polyhalosteroids
CH841679A CH622271A5 (en) 1975-12-12 1979-09-18 Process for the preparation of polyhalosteroids
CH841579A CH622270A5 (en) 1975-12-12 1979-09-18 Process for the preparation of polyhalosteroids
CH841479A CH621802A5 (en) 1975-12-12 1979-09-18 Process for the preparation of polyhalosteroids

Family Applications After (3)

Application Number Title Priority Date Filing Date
CH841679A CH622271A5 (en) 1975-12-12 1979-09-18 Process for the preparation of polyhalosteroids
CH841579A CH622270A5 (en) 1975-12-12 1979-09-18 Process for the preparation of polyhalosteroids
CH841479A CH621802A5 (en) 1975-12-12 1979-09-18 Process for the preparation of polyhalosteroids

Country Status (4)

Country Link
BE (1) BE849268A (fr)
CH (4) CH621801A5 (fr)
SE (1) SE423903B (fr)
ZA (1) ZA767382B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118271385A (zh) * 2024-04-01 2024-07-02 湖南玉新药业有限公司 卤倍他索丙酸酯粗品的精制方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118271385A (zh) * 2024-04-01 2024-07-02 湖南玉新药业有限公司 卤倍他索丙酸酯粗品的精制方法

Also Published As

Publication number Publication date
ZA767382B (en) 1977-11-30
CH622271A5 (en) 1981-03-31
BE849268A (fr) 1977-06-10
SE7613920L (sv) 1977-06-13
CH622270A5 (en) 1981-03-31
SE423903B (sv) 1982-06-14
CH621802A5 (en) 1981-02-27

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