CH622947A5 - Process for the production of a pharmaceutical composition which is in solid form and contains bismuth - Google Patents

Process for the production of a pharmaceutical composition which is in solid form and contains bismuth Download PDF

Info

Publication number: CH622947A5
Authority: CH; Switzerland
Prior art keywords: bismuth; solution; preheated; solid form; liquid
Prior art date: 1974-01-18

Application number

CH51075A

Other languages

German (de)

English (en)

Inventor

Christopher John Mcloughlin

Ross Brock Himstedt

Original Assignee

Gist Brocades Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-01-18

Filing date

1975-01-16

Publication date

1981-05-15

1975-01-16 Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv

1981-05-15 Publication of CH622947A5 publication Critical patent/CH622947A5/de

Links

238000000034 method Methods 0.000 title claims description 17
JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 title claims description 9
239000007787 solid Substances 0.000 title claims description 9
229910052797 bismuth Inorganic materials 0.000 title claims description 8
238000004519 manufacturing process Methods 0.000 title description 2
239000008194 pharmaceutical composition Substances 0.000 title description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 14
238000002360 preparation method Methods 0.000 claims description 11
239000000843 powder Substances 0.000 claims description 10
229910021529 ammonia Inorganic materials 0.000 claims description 7
KKMOSYLWYLMHAL-UHFFFAOYSA-N 2-bromo-6-nitroaniline Chemical compound NC1=C(Br)C=CC=C1[N+]([O-])=O KKMOSYLWYLMHAL-UHFFFAOYSA-N 0.000 claims description 6
239000007921 spray Substances 0.000 claims description 5
238000001694 spray drying Methods 0.000 claims description 5
239000007858 starting material Substances 0.000 claims description 4
150000005846 sugar alcohols Polymers 0.000 claims description 4
238000001035 drying Methods 0.000 claims description 3
239000000825 pharmaceutical preparation Substances 0.000 claims description 2
239000007788 liquid Substances 0.000 description 17
239000000243 solution Substances 0.000 description 10
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 5
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
208000025865 Ulcer Diseases 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
231100000397 ulcer Toxicity 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
229930006000 Sucrose Natural products 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
238000010438 heat treatment Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
239000005720 sucrose Substances 0.000 description 3
FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
102000057297 Pepsin A Human genes 0.000 description 2
108090000284 Pepsin A Proteins 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
150000008044 alkali metal hydroxides Chemical class 0.000 description 2
150000001621 bismuth Chemical class 0.000 description 2
239000002775 capsule Substances 0.000 description 2
235000012730 carminic acid Nutrition 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
239000003085 diluting agent Substances 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
239000000463 material Substances 0.000 description 2
210000004798 organs belonging to the digestive system Anatomy 0.000 description 2
239000000047 product Substances 0.000 description 2
HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
239000012265 solid product Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
206010012713 Diaphragmatic hernia Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
229910001854 alkali hydroxide Inorganic materials 0.000 description 1
229960004543 anhydrous citric acid Drugs 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
229960004645 bismuth subcitrate Drugs 0.000 description 1
ZQUAVILLCXTKTF-UHFFFAOYSA-H bismuth;tripotassium;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [K+].[K+].[K+].[Bi+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O ZQUAVILLCXTKTF-UHFFFAOYSA-H 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
229960004106 citric acid Drugs 0.000 description 1
150000001860 citric acid derivatives Chemical class 0.000 description 1
201000005890 congenital diaphragmatic hernia Diseases 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
150000002016 disaccharides Chemical class 0.000 description 1
YSVBPNGJESBVRM-UHFFFAOYSA-L disodium;4-[(1-oxido-4-sulfonaphthalen-2-yl)diazenyl]naphthalene-1-sulfonate Chemical compound [Na+].[Na+].C1=CC=C2C(N=NC3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)O)=CC=C(S([O-])(=O)=O)C2=C1 YSVBPNGJESBVRM-UHFFFAOYSA-L 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
230000002183 duodenal effect Effects 0.000 description 1
230000000694 effects Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
QGWDKKHSDXWPET-UHFFFAOYSA-E pentabismuth;oxygen(2-);nonahydroxide;tetranitrate Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[O-2].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O QGWDKKHSDXWPET-UHFFFAOYSA-E 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
239000008213 purified water Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/29—Antimony or bismuth compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/02—Ammonia; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Inorganic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CH51075A 1974-01-18 1975-01-16 Process for the production of a pharmaceutical composition which is in solid form and contains bismuth CH622947A5 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ZA00740385A ZA74385B (en)	1974-01-18	1974-01-18	Pharmaceutical compositions

Publications (1)

Publication Number	Publication Date
CH622947A5 true CH622947A5 (en)	1981-05-15

Family

ID=25567281

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH51075A CH622947A5 (en)	1974-01-18	1975-01-16	Process for the production of a pharmaceutical composition which is in solid form and contains bismuth

Country Status (18)

Country	Link
JP (1)	JPS5837284B2 (fr)
AT (1)	AT349150B (fr)
AU (1)	AU485660B2 (fr)
BE (1)	BE824509A (fr)
CA (1)	CA1040532A (fr)
CH (1)	CH622947A5 (fr)
DE (1)	DE2501787A1 (fr)
DK (1)	DK151770C (fr)
ES (1)	ES433908A1 (fr)
FI (1)	FI750113A7 (fr)
FR (1)	FR2258177B1 (fr)
GB (1)	GB1478742A (fr)
IE (1)	IE40361B1 (fr)
IT (1)	IT1036072B (fr)
LU (1)	LU71668A1 (fr)
NL (1)	NL185130C (fr)
SE (1)	SE437930B (fr)
ZA (1)	ZA74385B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3901508A1 (de) *	1989-01-19	1990-07-26	Falk Pharma Gmbh	Wismut enthaltendes praeparat in fester form, arzneimittel worin es enthalten ist und verfahren zu seiner herstellung

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU179474B (en) *	1978-02-24	1982-10-28	Laszlo Gyarmati	Process for preparing solid oral pharmaceutical compositons with increased length of activity and with a regulated release of the active material
US4801608A (en) *	1981-09-22	1989-01-31	Gist-Brocades N. V.	Bismuth containing composition and method for the preparation thereof
PT75550B (en) *	1981-09-22	1984-12-12	Gist Brocades Nv	Bismuth containing composition and method for the preparation thereof
WO1986005981A1 (fr) *	1985-04-18	1986-10-23	Borody Thomas J	Traitement de la dyspepsie non ulcereuse avec des sels de bismuth
US4748113A (en) *	1985-06-13	1988-05-31	Marshall Barry J	Compositions and methods for the diagnosis of gastrointestinal disorders involving urease
ATE79261T1 (de) *	1985-06-13	1992-08-15	Barry James M D Marshall	Verfahren zur behandlung von magen-darmstoerungen.
US5256684A (en) *	1985-06-13	1993-10-26	The Procter & Gamble Company	Methods and compositions for the treatment of gastrointestinal disorders
DE3650504T2 (de) *	1985-06-13	1996-10-31	Marshall Barry James	Verfahren und Zusammensetzungen zur Behandlung von gastrointestinalen Störungen
EP0363502B1 (fr) *	1988-10-08	1991-09-25	Dr. R. Pfleger Chemische Fabrik Gmbh	Formulation liquide contenant du bismuth, procédé pour la préparer et son utilisation
IT1229502B (it) *	1989-01-25	1991-09-03	Euroresearch Srl	Composizioni contenenti bismuto idonee per uso terapeutico.
IE893167A1 (en) *	1989-10-04	1991-04-24	Ulso Lab Ltd	Preparation of orally administrable liquids for use in¹therapy
KR100193933B1 (ko) *	1990-07-20	1999-06-15	에밀리오 캠포레시, 존 페르구손	비스무트와 폴리아크릴레이트와의 수용성 착체, 이의 제조 방법 및 상기 착체 또는 다른 비스무트염을 함유하는 궤양성 대장염 치료용 약제학적 조성물
US5192752A (en) *	1991-01-14	1993-03-09	The Procter & Gamble Company	Swallowable pharmaceutical compositions containing colloidal bismuth subcitrate
US5834002A (en)	1994-05-02	1998-11-10	Josman Laboratories, Inc.	Chewing gum containing colloidal bismuth subcitrate
US6902738B2 (en)	1994-05-02	2005-06-07	Josman Laboratories, Inc.	Topical oral dosage forms containing bismuth compounds
US6426085B1 (en)	1994-05-02	2002-07-30	Josman Laboratories Inc.	Use of bismuth-containing compounds in topical oral dosage forms for the treatment of halitosis
US6379651B1 (en)	1995-02-07	2002-04-30	Josman Laboratories	Oral-topical dosage forms for delivering antibacterials/antibiotics to oral cavity to eradicate H. pylori as a concomitant treatment for peptic ulcers and other gastro-intestinal diseases
US6372784B1 (en)	1995-02-07	2002-04-16	Josman Laboratories, Inc.	Bismuth-containing compounds in topical dosage forms for treatment of corneal and dermal wounds
MX9703918A (es)	1997-05-28	1998-11-30	J Marshall M D Barry	Procedimiento para preparar un producto farmaceutico reactivo para deteccion de desorden gastrointestinal causado por bacteria en el tracto gastrointestinal superior.
US6929926B2 (en)	2001-10-15	2005-08-16	Barry J. Marshall	Composition for the detection of gastrointestinal disorders
USD467348S1 (en)	2001-10-15	2002-12-17	Kimberly-Clark Worldwide, Inc.	Diagnostic test carrier
US6998250B2 (en)	2001-10-15	2006-02-14	Donald J. McMichael	Method for detecting Helicobacter pylori
USD485359S1 (en)	2001-10-15	2004-01-13	Kimberly-Clark Worldwide, Inc.	Specimen-handling tool
US7008777B2 (en)	2001-10-15	2006-03-07	Barry J. Marshall	System for the detection of urease and method for using same
USD469881S1 (en)	2001-12-17	2003-02-04	Kimberly-Clark Worldwide, Inc.	Two-well diagnostic test kit with specimen-handling tool
USD471639S1 (en)	2001-12-17	2003-03-11	Kimberly-Clark Worldwide, Inc.	Tool for handling a specimen
USD484988S1 (en)	2001-12-17	2004-01-06	Kimberly-Clark Worldwide, Inc.	Diagnostic test kit with specimen-handling tool
USD470597S1 (en)	2001-12-17	2003-02-18	Kimberly-Clark Worldwide, Inc.	Diagnostic test kit
USD470596S1 (en)	2001-12-17	2003-02-18	Kimberly-Clark Worldwide, Inc.	Test kit specimen-handling tool
USD470241S1 (en)	2001-12-17	2003-02-11	Kimberly-Clark Worldwide, Inc.	Specimen-handling tool
US6783976B2 (en)	2001-12-21	2004-08-31	Kimberly-Clark Worldwide, Inc.	Carrier and specimen-handling tool for use in diagnostic testing

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1963781A1 (de) *	1968-12-23	1970-07-09	Serfontein Willem Jacob	Verbesserte Wismuth-Praeparate
DE1900268A1 (de) *	1968-12-23	1969-09-04	Serfontein Willem Jacob	Wismuth-Komplex-Praeparat

1974
- 1974-01-18 ZA ZA00740385A patent/ZA74385B/xx unknown
1975
- 1975-01-14 AU AU77293/75A patent/AU485660B2/en not_active Expired
- 1975-01-16 CH CH51075A patent/CH622947A5/de not_active IP Right Cessation
- 1975-01-16 JP JP50007408A patent/JPS5837284B2/ja not_active Expired
- 1975-01-17 AT AT31875A patent/AT349150B/de not_active IP Right Cessation
- 1975-01-17 CA CA218,092A patent/CA1040532A/fr not_active Expired
- 1975-01-17 LU LU71668A patent/LU71668A1/xx unknown
- 1975-01-17 FI FI750113A patent/FI750113A7/fi not_active Application Discontinuation
- 1975-01-17 DE DE19752501787 patent/DE2501787A1/de active Granted
- 1975-01-17 SE SE7500501A patent/SE437930B/xx not_active IP Right Cessation
- 1975-01-17 IT IT67104/75A patent/IT1036072B/it active
- 1975-01-17 GB GB2146/75A patent/GB1478742A/en not_active Expired
- 1975-01-17 NL NLAANVRAGE7500552,A patent/NL185130C/xx not_active IP Right Cessation
- 1975-01-17 ES ES433908A patent/ES433908A1/es not_active Expired
- 1975-01-17 BE BE152481A patent/BE824509A/fr not_active IP Right Cessation
- 1975-01-17 FR FR7501521A patent/FR2258177B1/fr not_active Expired
- 1975-01-17 IE IE86/75A patent/IE40361B1/xx unknown
- 1975-01-17 DK DK012675A patent/DK151770C/da not_active IP Right Cessation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3901508A1 (de) *	1989-01-19	1990-07-26	Falk Pharma Gmbh	Wismut enthaltendes praeparat in fester form, arzneimittel worin es enthalten ist und verfahren zu seiner herstellung

Also Published As

Publication number	Publication date
IE40361L (en)	1975-07-18
IT1036072B (it)	1979-10-30
DK12675A (fr)	1975-09-15
IE40361B1 (en)	1979-05-09
DE2501787C2 (fr)	1987-11-12
GB1478742A (en)	1977-07-06
SE437930B (sv)	1985-03-25
NL185130B (nl)	1989-09-01
AU7729375A (en)	1976-07-15
AT349150B (de)	1979-03-26
FR2258177A1 (fr)	1975-08-18
BE824509A (fr)	1975-07-17
LU71668A1 (fr)	1975-06-24
CA1040532A (fr)	1978-10-17
ATA31875A (de)	1978-08-15
JPS50116623A (fr)	1975-09-12
FR2258177B1 (fr)	1978-07-21
JPS5837284B2 (ja)	1983-08-15
NL185130C (nl)	1990-02-01
DE2501787A1 (de)	1975-07-24
DK151770B (da)	1988-01-04
ZA74385B (en)	1975-08-27
FI750113A7 (fr)	1975-07-19
DK151770C (da)	1989-11-06
SE7500501L (fr)	1975-07-21
NL7500552A (nl)	1975-07-22
ES433908A1 (es)	1976-11-16
AU485660B2 (en)	1977-07-28

Legal Events

Date	Code	Title	Description
1992-04-15	PUE	Assignment	Owner name: BROCADES-PHARMA B.V.
1994-09-30	PL	Patent ceased
2024-10-31	PL	Patent ceased

Publication	Publication Date	Title
DE2501787C2 (fr)	1987-11-12
DE68904121T2 (de)	1993-05-06	Ibuprofen-cyclodextrin-einschlusskomplexe enthaltende pharmazeutische zubereitungen.
DE3915347C2 (de)	1994-11-03	Harzadsorbate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE2636152C2 (de)	1980-11-06	Verfahren zur Herstellung von Dragees
DD238529A5 (de)	1986-08-27	Verfahren zur herstellung einer pharmazeutischen zubereitung mit einem gehalt an ibuprofen
DE2128674A1 (de)	1971-12-16	Clathratverbindungen
DE3855323T2 (de)	1996-10-10	Galenische 2-beta-Mimetik-Formen für die per- und sublinguale Verabreichung
DE69814850T2 (de)	2004-03-11	Paracetamol enthaltende schlickbare tablette
DE2332484A1 (de)	1974-01-10	Lutschpastillen mit verzoegerter freigabe
DE69108022T3 (de)	2000-04-20	Arzneimittel.
DE1802394C2 (de)	1984-06-28	Arzneimittel mit antihypertensiver Wirkung, die [(2,6-Dichlorbenzyliden)-amino]-guanidin oder ein Säureadditionssalz davon enthalten
DD144719A5 (de)	1980-11-05	Verfahren zur gewinnung einer natuerlichen polarfraktion mit antipsoriatischer wirksamkeit
DE2517413A1 (de)	1975-11-13	Dermatologisch verwendbares mittel
DE69012932T2 (de)	1995-05-04	Zubereitung für schäumendes Präparat.
DE1915798C3 (de)	1978-04-27	Antacidum-Präparat in Form einer wäßrigen Suspension
DE2166355C2 (de)	1983-12-08	Verwendung von d,1-Sobrerol bei der Balsamtherapie der Atemwege
DE3203310A1 (de)	1982-12-02	Pharmazeutische zusammensetzung zur behandlung von erkrankungen der mundhoehle
DE2519528C2 (fr)	1989-09-21
DE3632334C2 (fr)	1989-11-02
DE2510663B2 (de)	1978-03-23	Aluminiumpolyhydroxisulfat sowie dieses enthaltendes Arzneimittel
DE69100053T2 (de)	1993-10-21	Arzneimittelzusammensetzung in stabiler wässriger Suspensionsform auf der Basis von Sucralfat und einem Antacidum sowie Verfahren zu ihrer Herstellung.
DE1936723C2 (de)	1983-12-22	Salze von Chinarindenalkoloiden und Verfahren zu ihrer Herstellung
DE3419129A1 (de)	1985-11-28	Nifedipinpraeparate und verfahren zu ihrer herstellung
EP0429856B1 (fr)	1994-01-19	Préparations pharmaceutiques contenant un sel métallique de l'ibuprofène et son procédé de fabrication
DE2951132C2 (fr)	1988-12-22

CH622947A5 - Process for the production of a pharmaceutical composition which is in solid form and contains bismuth - Google Patents

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