CH629531A5 - Process for the preparation of the antibiotic A-30912 mixture and of factors A, B, C, D, E, F and G in this antibiotic mixture - Google Patents

Process for the preparation of the antibiotic A-30912 mixture and of factors A, B, C, D, E, F and G in this antibiotic mixture Download PDF

Info

Publication number: CH629531A5
Authority: CH; Switzerland
Prior art keywords: antibiotic; factor; mixture; factors; medium
Prior art date: 1975-10-02

Application number

CH1241376A

Other languages

German (de)

English (en)

Inventor

Marvin Martin Hoehn

Karl Heinz Michel

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-10-02

Filing date

1976-09-30

Publication date

1982-04-30

1976-09-30 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1982-04-30 Publication of CH629531A5 publication Critical patent/CH629531A5/de

Links

230000003115 biocidal effect Effects 0.000 title claims description 71
239000000203 mixture Substances 0.000 title claims description 58
238000000034 method Methods 0.000 title claims description 14
238000002360 preparation method Methods 0.000 title claims description 4
238000000855 fermentation Methods 0.000 claims description 22
230000004151 fermentation Effects 0.000 claims description 22
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
235000015097 nutrients Nutrition 0.000 claims description 9
239000000126 substance Substances 0.000 claims description 8
229910052757 nitrogen Inorganic materials 0.000 claims description 5
150000003839 salts Chemical class 0.000 claims description 4
241000228212 Aspergillus Species 0.000 claims description 2
150000001720 carbohydrates Chemical class 0.000 claims description 2
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 76
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 44
239000002609 medium Substances 0.000 description 35
FAUOJMHVEYMQQG-HVYQDZECSA-N echinocandin B Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCC\C=C/C\C=C/CCCCC)[C@@H](C)O)=CC=C(O)C=C1 FAUOJMHVEYMQQG-HVYQDZECSA-N 0.000 description 24
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FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 4
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238000012474 bioautography Methods 0.000 description 3
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229910021641 deionized water Inorganic materials 0.000 description 3
230000037304 dermatophytes Effects 0.000 description 3
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VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 3
235000013379 molasses Nutrition 0.000 description 3
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HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
238000005903 acid hydrolysis reaction Methods 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
229940121375 antifungal agent Drugs 0.000 description 2
239000003429 antifungal agent Substances 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
238000009395 breeding Methods 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
239000000284 extract Substances 0.000 description 2
239000008103 glucose Substances 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
230000007062 hydrolysis Effects 0.000 description 2
238000006460 hydrolysis reaction Methods 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
239000000463 material Substances 0.000 description 2
235000013372 meat Nutrition 0.000 description 2
244000005700 microbiome Species 0.000 description 2
239000011707 mineral Substances 0.000 description 2
235000010755 mineral Nutrition 0.000 description 2
235000019319 peptone Nutrition 0.000 description 2
239000000049 pigment Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
239000013587 production medium Substances 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
238000000926 separation method Methods 0.000 description 2
239000001509 sodium citrate Substances 0.000 description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
235000013619 trace mineral Nutrition 0.000 description 2
239000011573 trace mineral Substances 0.000 description 2
239000012808 vapor phase Substances 0.000 description 2
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
241000303945 Alyssum murale Species 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
241000351920 Aspergillus nidulans Species 0.000 description 1
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
241000282465 Canis Species 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
244000223760 Cinnamomum zeylanicum Species 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
240000006927 Foeniculum vulgare Species 0.000 description 1
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244000168141 Geotrichum candidum Species 0.000 description 1
235000017388 Geotrichum candidum Nutrition 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
241001221585 Keratinomyces Species 0.000 description 1
239000005909 Kieselgur Substances 0.000 description 1
238000002768 Kirby-Bauer method Methods 0.000 description 1
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
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229910002651 NO3 Inorganic materials 0.000 description 1
241000818707 Nannizzia incurvata Species 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
240000007817 Olea europaea Species 0.000 description 1
241000364057 Peoria Species 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
241001045770 Trichophyton mentagrophytes Species 0.000 description 1
241001609979 Trichophyton quinckeanum Species 0.000 description 1
241000223229 Trichophyton rubrum Species 0.000 description 1
241001609978 Trichophyton terrestre Species 0.000 description 1
241001480048 Trichophyton tonsurans Species 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 description 1
239000003463 adsorbent Substances 0.000 description 1
238000010564 aerobic fermentation Methods 0.000 description 1
239000012675 alcoholic extract Substances 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229960004217 benzyl alcohol Drugs 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
239000012888 bovine serum Substances 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
239000002026 chloroform extract Substances 0.000 description 1
235000017803 cinnamon Nutrition 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
239000000470 constituent Substances 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
239000013078 crystal Substances 0.000 description 1
239000013530 defoamer Substances 0.000 description 1
238000001514 detection method Methods 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
235000019797 dipotassium phosphate Nutrition 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
108010062092 echinocandin B Proteins 0.000 description 1
238000010828 elution Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
210000000416 exudates and transudate Anatomy 0.000 description 1
239000004744 fabric Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000005187 foaming Methods 0.000 description 1
239000012634 fragment Substances 0.000 description 1
239000010931 gold Substances 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
239000012535 impurity Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000002198 insoluble material Substances 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
239000008101 lactose Substances 0.000 description 1
-1 latose Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
235000013923 monosodium glutamate Nutrition 0.000 description 1
239000004223 monosodium glutamate Substances 0.000 description 1
239000012454 non-polar solvent Substances 0.000 description 1
238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000003910 polypeptide antibiotic agent Substances 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000012807 shake-flask culturing Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
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238000003860 storage Methods 0.000 description 1
230000037303 wrinkles Effects 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Compounds Of Unknown Constitution (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CH1241376A 1975-10-02 1976-09-30 Process for the preparation of the antibiotic A-30912 mixture and of factors A, B, C, D, E, F and G in this antibiotic mixture CH629531A5 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US61910775A	1975-10-02	1975-10-02

Publications (1)

Publication Number	Publication Date
CH629531A5 true CH629531A5 (en)	1982-04-30

Family

ID=24480483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH1241376A CH629531A5 (en)	1975-10-02	1976-09-30	Process for the preparation of the antibiotic A-30912 mixture and of factors A, B, C, D, E, F and G in this antibiotic mixture

Country Status (28)

Country	Link
JP (1)	JPS5242801A (fr)
AR (1)	AR209993A1 (fr)
AT (1)	AT346479B (fr)
AU (1)	AU506777B2 (fr)
BE (1)	BE846829A (fr)
BG (1)	BG25380A3 (fr)
CA (1)	CA1080145A (fr)
CH (1)	CH629531A5 (fr)
CS (1)	CS212776B2 (fr)
DD (1)	DD127442A5 (fr)
DE (1)	DE2643485A1 (fr)
DK (1)	DK143608C (fr)
ES (1)	ES452021A1 (fr)
FR (1)	FR2326200A1 (fr)
GB (2)	GB1499710A (fr)
GR (1)	GR61730B (fr)
HU (1)	HU173445B (fr)
IE (1)	IE43663B1 (fr)
IL (1)	IL50429A (fr)
NL (1)	NL7610808A (fr)
NZ (1)	NZ182123A (fr)
PL (1)	PL103996B1 (fr)
PT (1)	PT65617B (fr)
RO (1)	RO69985A (fr)
SE (1)	SE7610943L (fr)
SU (1)	SU620215A3 (fr)
YU (1)	YU236076A (fr)
ZA (1)	ZA765320B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5452797A (en) *	1977-10-04	1979-04-25	Meiji Seika Kaisha Ltd	Novel antibiotic substance bn-200, and its preparation
CA1170598A (fr) *	1979-12-13	1984-07-10	Bernard J. Abbott	Methode de preparation de noyaux peptidiques cycliques
GB2180464A (en) *	1985-09-18	1987-04-01	British Gas Corp	Gas-solid phase reactions and apparatus therefor
FI76004B (fi) *	1986-03-24	1988-05-31	Seppo Kalervo Ruottu	Cirkulationsmassareaktor.

1976
- 1976-09-06 IE IE1974/76A patent/IE43663B1/en unknown
- 1976-09-07 ZA ZA00765320A patent/ZA765320B/xx unknown
- 1976-09-08 IL IL50429A patent/IL50429A/xx unknown
- 1976-09-16 GR GR51709A patent/GR61730B/el unknown
- 1976-09-20 CA CA261,528A patent/CA1080145A/fr not_active Expired
- 1976-09-21 NZ NZ182123A patent/NZ182123A/xx unknown
- 1976-09-21 PT PT65617A patent/PT65617B/pt unknown
- 1976-09-22 JP JP51114357A patent/JPS5242801A/ja active Pending
- 1976-09-23 GB GB39477/76A patent/GB1499710A/en not_active Expired
- 1976-09-23 AU AU18080/76A patent/AU506777B2/en not_active Expired
- 1976-09-24 BG BG034273A patent/BG25380A3/xx unknown
- 1976-09-27 DE DE19762643485 patent/DE2643485A1/de not_active Withdrawn
- 1976-09-27 YU YU02360/76A patent/YU236076A/xx unknown
- 1976-09-27 GB GB39954/76A patent/GB1565821A/en not_active Expired
- 1976-09-29 CS CS766294A patent/CS212776B2/cs unknown
- 1976-09-29 NL NL7610808A patent/NL7610808A/xx not_active Application Discontinuation
- 1976-09-29 SU SU762404253A patent/SU620215A3/ru active
- 1976-09-30 CH CH1241376A patent/CH629531A5/de not_active IP Right Cessation
- 1976-09-30 DK DK440276A patent/DK143608C/da active
- 1976-09-30 ES ES452021A patent/ES452021A1/es not_active Expired
- 1976-10-01 DD DD195092A patent/DD127442A5/xx unknown
- 1976-10-01 BE BE1007661A patent/BE846829A/fr unknown
- 1976-10-01 AT AT730976A patent/AT346479B/de not_active IP Right Cessation
- 1976-10-01 AR AR264953A patent/AR209993A1/es active
- 1976-10-01 SE SE7610943A patent/SE7610943L/ not_active Application Discontinuation
- 1976-10-01 FR FR7629604A patent/FR2326200A1/fr active Granted
- 1976-10-01 PL PL1976192798A patent/PL103996B1/pl unknown
- 1976-10-01 HU HU76EI703A patent/HU173445B/hu unknown
- 1976-10-02 RO RO7687891A patent/RO69985A/fr unknown

Also Published As

Publication number	Publication date
SU620215A3 (ru)	1978-08-15
ZA765320B (en)	1978-04-26
PT65617B (en)	1978-04-05
AR209993A1 (es)	1977-06-15
ES452021A1 (es)	1977-12-01
AT346479B (de)	1978-11-10
YU236076A (en)	1983-04-30
GR61730B (en)	1978-12-30
IL50429A (en)	1979-11-30
NL7610808A (nl)	1977-04-05
IE43663L (en)	1977-04-02
DK143608B (da)	1981-09-14
GB1565821A (en)	1980-04-23
DD127442A5 (fr)	1977-09-21
SE7610943L (sv)	1977-04-03
JPS5242801A (en)	1977-04-04
GB1499710A (en)	1978-02-01
HU173445B (hu)	1979-05-28
DK143608C (da)	1982-02-15
BE846829A (fr)	1977-04-01
AU506777B2 (en)	1980-01-24
PL103996B1 (pl)	1979-07-31
CA1080145A (fr)	1980-06-24
AU1808076A (en)	1978-04-06
FR2326200B1 (fr)	1980-03-07
CS212776B2 (en)	1982-03-26
PT65617A (en)	1976-10-01
DE2643485A1 (de)	1977-04-14
IE43663B1 (en)	1981-04-22
FR2326200A1 (fr)	1977-04-29
BG25380A3 (en)	1978-09-15
ATA730976A (de)	1978-03-15
IL50429A0 (en)	1976-11-30
RO69985A (fr)	1981-05-15
DK440276A (da)	1977-04-03
NZ182123A (en)	1978-06-02

Legal Events

Date	Code	Title	Description
1985-05-31	PL	Patent ceased
2024-10-31	PL	Patent ceased

Publication	Publication Date	Title
DE3051175C2 (fr)	1989-12-21
US4024245A (en)	1977-05-17	Antibiotic A-30912 and process for production thereof
DE68910213T2 (de)	1994-04-07	Antibiotikum R106.
DE2509820A1 (de)	1976-02-05	Aculeacin-antibiotika
DE2463138C2 (de)	1984-07-05	Das Antibiotikum Cyclosporin B (S 7481/F-2), seine Herstellung und Verwendung
DE3013246C2 (fr)	1987-11-19
DD153213A5 (de)	1981-12-30	Verfahren zur herstellung der die faktoren a,b,d und h von a-30912 enthaltenden antibiotikummischung a-42355 sowie der einzelnen faktoren
CH639978A5 (de)	1983-12-15	Neue antibiotika und verfahren zu ihrer herstellung.
CH630957A5 (de)	1982-07-15	Verfahren zur herstellung von neuen antibiotischen verbindungen auf basis eines bohemsaeurekomplexes.
DD153834A5 (de)	1982-02-03	Verfahren zur herstellung eines neuen faktors von antibiotikum a-30912
DE2167325C2 (de)	1984-05-24	Antibiotikum A-201B und Verfahren zu seiner Herstellung
DE68906825T2 (de)	1993-10-07	Glycosid-Antibiotika BU-3608D und BU-3608E.
CH668974A5 (de)	1989-02-15	Antitumor-antibiotikum.
CH629531A5 (en)	1982-04-30	Process for the preparation of the antibiotic A-30912 mixture and of factors A, B, C, D, E, F and G in this antibiotic mixture
DE2402956C2 (de)	1985-06-13	Antibioticum A-287 und Verfahren zu seiner Herstellung
DE69718141T2 (de)	2003-08-21	Fungizid
EP0304400B1 (fr)	1994-02-09	Dérivés de phénanthridine, procédé pour leur préparation et moyen pour suivre le procédé
DE2643487A1 (de)	1977-04-21	Antibioticum a-22082 und verfahren zu seiner herstellung
DE69214737T2 (de)	1997-02-20	Antibiotika NK374186A, NK374186B, NK374186B3 und NK374186C3, Verfahren zu ihrer Herstellung und ihre Verwendung
EP0546474A1 (fr)	1993-06-16	Pseurotine F1/F2, nouveaux métabolites de Aspergillus fumigatus, procédé pour leur préparation et leur utilisation comme antagonistes de apomorphine
DE3881566T2 (de)	1993-09-16	Antitumor-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
DE2817113A1 (de)	1978-11-16	Hydroxynovobiocinartige verbindungen und verfahren zu ihrer herstellung
DE1793766C3 (de)	1978-11-02	Antibiotikum A 3823
EP0546475A1 (fr)	1993-06-16	Pseurotine A et D biologiquement actifs, nouveaux métabolites de Apsergillus fumigatus, procédé pour leur préparation et leur utilisation comme antagonistes de apomosphine
DE69902537T2 (de)	2003-01-09	Eine verbindung, wf002, ein verfahren zu ihrer herstellung und ihre verwendung