CH642545A5 - Mittel gegen magensaeure, verfahren zu seiner herstellung und dieses mittel enthaltende, arzneimittelzubereitung. - Google Patents

Mittel gegen magensaeure, verfahren zu seiner herstellung und dieses mittel enthaltende, arzneimittelzubereitung. Download PDF

Info

Publication number: CH642545A5
Authority: CH; Switzerland
Prior art keywords: weight; aluminum; magnesium; calculated; agent
Prior art date: 1977-11-04

Application number

CH1134778A

Other languages

German (de)

English (en)

Inventor

Hat Auf Nennung Verzichtet Erfinder

Original Assignee

Hypolab Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-11-04

Filing date

1978-11-03

Publication date

1984-04-30

1978-11-03 Application filed by Hypolab Sa filed Critical Hypolab Sa

1984-04-30 Publication of CH642545A5 publication Critical patent/CH642545A5/de

Links

239000003795 chemical substances by application Substances 0.000 title claims description 15
239000002253 acid Substances 0.000 title claims description 11
238000002360 preparation method Methods 0.000 title claims description 5
238000000034 method Methods 0.000 title claims 8
238000004519 manufacturing process Methods 0.000 title description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 35
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
229910000019 calcium carbonate Inorganic materials 0.000 claims description 10
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 8
239000011575 calcium Substances 0.000 claims description 8
239000000725 suspension Substances 0.000 claims description 8
UOVKYUCEFPSRIJ-UHFFFAOYSA-D hexamagnesium;tetracarbonate;dihydroxide;pentahydrate Chemical compound O.O.O.O.O.[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O UOVKYUCEFPSRIJ-UHFFFAOYSA-D 0.000 claims description 7
239000011777 magnesium Substances 0.000 claims description 7
229940031958 magnesium carbonate hydroxide Drugs 0.000 claims description 7
229910052791 calcium Inorganic materials 0.000 claims description 6
229910052782 aluminium Inorganic materials 0.000 claims description 5
229910052749 magnesium Inorganic materials 0.000 claims description 5
239000000395 magnesium oxide Substances 0.000 claims description 5
210000004211 gastric acid Anatomy 0.000 claims description 4
206010020601 Hyperchlorhydria Diseases 0.000 claims description 2
DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims description 2
230000002496 gastric effect Effects 0.000 claims description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 4
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 4
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 4
229940024546 aluminum hydroxide gel Drugs 0.000 claims 4
SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 claims 4
239000003513 alkali Substances 0.000 claims 3
VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims 2
229940024545 aluminum hydroxide Drugs 0.000 claims 1
239000000969 carrier Substances 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
159000000003 magnesium salts Chemical class 0.000 claims 1
239000011159 matrix material Substances 0.000 claims 1
239000003159 antacid agent Substances 0.000 description 25
229940069428 antacid Drugs 0.000 description 24
230000001458 anti-acid effect Effects 0.000 description 17
239000000047 product Substances 0.000 description 10
230000000694 effects Effects 0.000 description 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
239000000203 mixture Substances 0.000 description 6
238000003756 stirring Methods 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
230000003139 buffering effect Effects 0.000 description 4
210000004051 gastric juice Anatomy 0.000 description 3
239000000499 gel Substances 0.000 description 3
229910000021 magnesium carbonate Inorganic materials 0.000 description 3
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 3
239000000320 mechanical mixture Substances 0.000 description 3
238000006386 neutralization reaction Methods 0.000 description 3
239000002245 particle Substances 0.000 description 3
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
206010010774 Constipation Diseases 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
239000000872 buffer Substances 0.000 description 2
-1 chlorine ions Chemical class 0.000 description 2
238000001816 cooling Methods 0.000 description 2
238000007416 differential thermogravimetric analysis Methods 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
239000001095 magnesium carbonate Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
OUHCLAKJJGMPSW-UHFFFAOYSA-L magnesium;hydrogen carbonate;hydroxide Chemical compound O.[Mg+2].[O-]C([O-])=O OUHCLAKJJGMPSW-UHFFFAOYSA-L 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000012429 reaction media Substances 0.000 description 2
238000002411 thermogravimetry Methods 0.000 description 2
230000004580 weight loss Effects 0.000 description 2
ZPLCXHWYPWVJDL-UHFFFAOYSA-N 4-[(4-hydroxyphenyl)methyl]-1,3-oxazolidin-2-one Chemical compound C1=CC(O)=CC=C1CC1NC(=O)OC1 ZPLCXHWYPWVJDL-UHFFFAOYSA-N 0.000 description 1
KYARBIJYVGJZLB-UHFFFAOYSA-N 7-amino-4-hydroxy-2-naphthalenesulfonic acid Chemical compound OC1=CC(S(O)(=O)=O)=CC2=CC(N)=CC=C21 KYARBIJYVGJZLB-UHFFFAOYSA-N 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
206010012735 Diarrhoea Diseases 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 description 1
ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
229940015826 dihydroxyaluminum aminoacetate Drugs 0.000 description 1
GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
206010016766 flatulence Diseases 0.000 description 1
230000027119 gastric acid secretion Effects 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
229960001340 histamine Drugs 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229940099273 magnesium trisilicate Drugs 0.000 description 1
229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
235000019793 magnesium trisilicate Nutrition 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
239000001525 mentha piperita l. herb oil Substances 0.000 description 1
239000013081 microcrystal Substances 0.000 description 1
235000019477 peppermint oil Nutrition 0.000 description 1
230000008855 peristalsis Effects 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229960001407 sodium bicarbonate Drugs 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CH1134778A 1977-11-04 1978-11-03 Mittel gegen magensaeure, verfahren zu seiner herstellung und dieses mittel enthaltende, arzneimittelzubereitung. CH642545A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19772749506 DE2749506A1 (de)	1977-11-04	1977-11-04	Mittel gegen magensaeure, verfahren zu seiner herstellung und dieses mittel enthaltende pharmazeutische zubereitung

Publications (1)

Publication Number	Publication Date
CH642545A5 true CH642545A5 (de)	1984-04-30

Family

ID=6023066

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH1134778A CH642545A5 (de)	1977-11-04	1978-11-03	Mittel gegen magensaeure, verfahren zu seiner herstellung und dieses mittel enthaltende, arzneimittelzubereitung.

Country Status (10)

Country	Link
AR (1)	AR216706A1 (it)
AT (1)	AT365928B (it)
BE (1)	BE871767A (it)
CA (1)	CA1111767A (it)
CH (1)	CH642545A5 (it)
DE (1)	DE2749506A1 (it)
FR (1)	FR2407719A1 (it)
GB (1)	GB2008942B (it)
IL (1)	IL55793A0 (it)
IT (1)	IT1106221B (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2262287A (en) *	1991-12-11	1993-06-16	Evode Ltd	Flame-retardant filler for thermoplastic compositions
US8257750B2 (en) *	1999-04-30	2012-09-04	Kibow Biotech, Inc.	Calcium carbonate compositions for preventing or treating hyperphosphatemia
WO2018229789A1 (en)	2017-06-12	2018-12-20	Council Of Scientific & Industrial Research	An inorganic base antacid compound with improved and novel properties

1977
- 1977-11-04 DE DE19772749506 patent/DE2749506A1/de not_active Ceased
1978
- 1978-10-24 IT IT51610/78A patent/IT1106221B/it active
- 1978-10-25 IL IL7855793A patent/IL55793A0/xx not_active IP Right Cessation
- 1978-10-31 AT AT0777578A patent/AT365928B/de not_active IP Right Cessation
- 1978-11-02 GB GB7842940A patent/GB2008942B/en not_active Expired
- 1978-11-03 BE BE191540A patent/BE871767A/xx not_active IP Right Cessation
- 1978-11-03 CH CH1134778A patent/CH642545A5/de not_active IP Right Cessation
- 1978-11-03 AR AR274343A patent/AR216706A1/es active
- 1978-11-03 CA CA315,797A patent/CA1111767A/en not_active Expired
- 1978-11-06 FR FR7831323A patent/FR2407719A1/fr active Granted

Also Published As

Publication number	Publication date
GB2008942A (en)	1979-06-13
GB2008942B (en)	1982-05-06
DE2749506A1 (de)	1979-05-10
BE871767A (fr)	1979-03-01
IT1106221B (it)	1985-11-11
FR2407719A1 (fr)	1979-06-01
FR2407719B1 (it)	1981-12-04
AR216706A1 (es)	1980-01-15
IL55793A0 (en)	1978-12-17
ATA777578A (de)	1981-07-15
CA1111767A (en)	1981-11-03
AT365928B (de)	1982-02-25
IT7851610A0 (it)	1978-10-24

Legal Events

Date	Code	Title	Description
1996-07-15	PL	Patent ceased

Publication	Publication Date	Title
DE69617659T4 (de)	2007-09-27	Pharmazeutische zusammensetzungen, welche ausgewählte lanthancarbonathydrate enthalten
DE2905256C2 (de)	1986-12-11	Basisches Aluminium-magnesium-carbonat
CH639845A5 (en)	1983-12-15	Solid depot pharmaceutical preparations and process for their production
DE1916535C3 (de)	1975-06-05	Komplexe aus wasserlöslichen Salzen von sulfatierten Polysacchariden und basischen Aluminiumsalzen und Verfahren zu deren Herstellung
DE2332484A1 (de)	1974-01-10	Lutschpastillen mit verzoegerter freigabe
DE2936078C2 (de)	1982-03-11	Synthetisches Magnesiumaluminiumsilikat und dieses enthaltendes pharmazeutisches Präparat
DE2824191C2 (it)	1987-06-11
DE69433012T2 (de)	2004-06-09	Verfahren zur herstellung von oralen dosierungsformulierungen enthaltend diclofenac
DE3019032C2 (de)	1983-09-01	Antacider Wirkstoff auf Magnesium-Aluminiumhydroxid-Basis, seine Herstellung und Verwendung
DE2317768C3 (de)	1979-06-21	Verfahren zur Herstellung eines antazid wirkenden Arzneimittels
DE69919963T2 (de)	2005-09-22	Magnesiumoxid enthaltendes Abführmittel
EP0286781A2 (de)	1988-10-19	Pharmazeutische Zubereitung zur Behandlung von Erkrankungen des Magen-Darm-Traktes
DE2510663C3 (de)	1981-08-06	Aluminiumpolyhydroxisulfat, Verfahren zur Herstellung sowie dieses enthaltendes Arzneimittel
CH642545A5 (de)	1984-04-30	Mittel gegen magensaeure, verfahren zu seiner herstellung und dieses mittel enthaltende, arzneimittelzubereitung.
DE2323924A1 (de)	1973-11-29	Wiedersuspendierbare getrocknete antiacidische mischungen
DE3315606C2 (it)	1988-05-26
DE69224793T2 (de)	1998-11-19	Magnesiumhaltiges Arzneimittel mit verlängerter Wirkstoffabgabe
DE69100053T2 (de)	1993-10-21	Arzneimittelzusammensetzung in stabiler wässriger Suspensionsform auf der Basis von Sucralfat und einem Antacidum sowie Verfahren zu ihrer Herstellung.
DE2523108A1 (de)	1975-12-18	Heilmittel gegen sichelzellenanaemie
DE1617277C3 (de)	1979-10-31	Verfahren zur Herstellung eines flüssigen Antazidums
AT383342B (de)	1987-06-25	Verfahren zur herstellung von modifiziertem ton
DE2157201A1 (de)	1973-05-30	Verbesserte orale applikationsform von raubasin
DE2523394A1 (de)	1975-12-11	Pharmazeutische zubereitung
DE1593765A1 (de)	1970-12-10	Chelatkomplexverbindung,Verfahren zu ihrer Herstellung,sowie diese Verbindung enthaltende pharmazeutische Praeparate
EP0136502A2 (de)	1985-04-10	Verwendung von Eisen(II)-, Zink- und Magnesiumsalzen und ihren Mischsalzen zur Substitution von Eisen, Zink und Magnesium