CH681545A5 - - Google Patents

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Info

Publication number: CH681545A5
Authority: CH; Switzerland
Prior art keywords: cells; cell; broth; fermenter; cell separator
Prior art date: 1989-02-15

Application number

CH39990A

Other languages

German (de)

English (en)

Inventor

Nakano Ryusei

Takai Masao

Sasaki Kiyoshi

Matsuzaki Harumi

Ishida Masahiko

Furukawa Tokinobu

Murakami Sei

Katoh Kenji

Original Assignee

Hitachi Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-15

Filing date

1990-02-08

Publication date

1993-04-15

1990-02-08 Application filed by Hitachi Ltd filed Critical Hitachi Ltd

1993-04-15 Publication of CH681545A5 publication Critical patent/CH681545A5/de

Links

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230000015572 biosynthetic process Effects 0.000 claims description 49
238000000034 method Methods 0.000 claims description 28
239000000126 substance Substances 0.000 claims description 28
239000012533 medium component Substances 0.000 claims description 22
239000002699 waste material Substances 0.000 claims description 17
238000000926 separation method Methods 0.000 claims description 13
238000001802 infusion Methods 0.000 claims description 12
238000004140 cleaning Methods 0.000 claims description 10
239000012510 hollow fiber Substances 0.000 claims description 9
230000002441 reversible effect Effects 0.000 claims description 9
230000002209 hydrophobic effect Effects 0.000 claims description 7
238000003756 stirring Methods 0.000 claims description 6
230000001954 sterilising effect Effects 0.000 claims description 4
238000004659 sterilization and disinfection Methods 0.000 claims description 4
238000002156 mixing Methods 0.000 claims description 2
239000012092 media component Substances 0.000 claims 3
210000004027 cell Anatomy 0.000 description 102
239000007789 gas Substances 0.000 description 12
238000000108 ultra-filtration Methods 0.000 description 11
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238000005194 fractionation Methods 0.000 description 8
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230000010412 perfusion Effects 0.000 description 6
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206010010774 Constipation Diseases 0.000 description 4
230000010261 cell growth Effects 0.000 description 4
238000001914 filtration Methods 0.000 description 4
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238000011069 regeneration method Methods 0.000 description 4
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238000004113 cell culture Methods 0.000 description 3
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239000007952 growth promoter Substances 0.000 description 3
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239000013076 target substance Substances 0.000 description 3
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
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238000004062 sedimentation Methods 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 1
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102000004877 Insulin Human genes 0.000 description 1
108090001061 Insulin Proteins 0.000 description 1
102000014150 Interferons Human genes 0.000 description 1
108010050904 Interferons Proteins 0.000 description 1
102000015696 Interleukins Human genes 0.000 description 1
108010063738 Interleukins Proteins 0.000 description 1
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208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
206010035226 Plasma cell myeloma Diseases 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
102000004338 Transferrin Human genes 0.000 description 1
108090000901 Transferrin Proteins 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
210000003719 b-lymphocyte Anatomy 0.000 description 1
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238000007664 blowing Methods 0.000 description 1
239000012888 bovine serum Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
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230000005484 gravity Effects 0.000 description 1
210000004408 hybridoma Anatomy 0.000 description 1
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244000005700 microbiome Species 0.000 description 1
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239000001301 oxygen Substances 0.000 description 1
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230000002093 peripheral effect Effects 0.000 description 1
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102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000001223 reverse osmosis Methods 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000012581 transferrin Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products

Landscapes

Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Health & Medical Sciences (AREA)
Sustainable Development (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CH39990A 1989-02-15 1990-02-08 CH681545A5 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP3360589		1989-02-15
JP13605089		1989-05-31

Publications (1)

Publication Number	Publication Date
CH681545A5 true CH681545A5 (fr)	1993-04-15

Family

ID=26372332

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CH39990A CH681545A5 (fr)	1989-02-15	1990-02-08

Country Status (2)

Country	Link
CH (1)	CH681545A5 (fr)
DE (1)	DE4002994A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102004032318B4 (de) *	2004-07-02	2015-08-20	Technische Hochschule Mittelhessen	Herstellung einer konzentrierten Lösung aus biologischen Substanzen

1990
- 1990-02-01 DE DE19904002994 patent/DE4002994A1/de not_active Withdrawn
- 1990-02-08 CH CH39990A patent/CH681545A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE4002994A1 (de)	1990-08-16

Legal Events

Date	Code	Title	Description
1994-10-31	PL	Patent ceased
2024-10-31	PL	Patent ceased

Publication	Publication Date	Title
DE68914412T2 (de)	1994-08-25	Methode, System und Apparat zur Züchtung von Zellen.
DE69924642T2 (de)	2006-02-09	Wasserfiltration mittels unterwassermembranen
DE69434052T2 (de)	2005-02-10	Partikelabscheider für säugetier-zellkultur
EP0155237B1 (fr)	1989-05-31	Procédé et appareil pour la culture de cellules humaines, animales, végétales ainsi que de cellules hybrides et de micro-organismes
DE69305163T2 (de)	1997-04-03	Reaktor mit veraenderlichem volumen und zellkulturverfahren
DE69329706T2 (de)	2001-03-29	Methode und gerät zum kultivieren von biomasse-partikeln
EP0200032A2 (fr)	1986-11-05	Procédé de séparation de composés d'origine biotechnologique de haute qualité par microfiltration tangentielle
DE19648519A1 (de)	1998-06-04	Verfahren und Anlage zur Stofftrennung mittels Membranfiltration
EP0229872B1 (fr)	1989-08-16	Procédé de séparation par membrane et installation pour séparer les liquides des suspensions de fermentation
EP0771231B1 (fr)	2001-12-05	Procede et installation de filtration a courant transversal pour separer un liquide d'une substance coulante
DE4204708A1 (de)	1992-08-20	Filtrationssystem
DE2513751A1 (de)	1975-10-09	Ultrafiltrationsanlage
DE68921974T2 (de)	1995-08-03	Bioreaktor.
EP0307737B1 (fr)	1992-11-25	Procédé pour la séparation de produits préparés par des procédés biotechnologiques d'un milieu de fermentation par filtration tangentielle et/ou ultrafiltration
DE69006695T2 (de)	1994-05-26	Verfahren und System für Zellkulturen.
DE3241315T1 (de)	1985-01-24	Verfahren und Vorrichtung zum hochwirksamen Ultrafiltrieren komplexer fließfähiger Medien
EP0224800B1 (fr)	1993-02-03	Méthode et appareil pour la culture de cellules
EP1280885B1 (fr)	2005-10-19	Procede pour separer des cellules viables d'insectes ou de mammiferes de suspensions cellulaires
EP1277831B1 (fr)	2006-11-22	Procédé et appareil de production de biomasse microbiènne à partir d'un système de culture cellulaire
EP0353422B1 (fr)	1992-11-25	Procédé et appareil de filtration
EP1226227B1 (fr)	2006-09-20	Procede de culture de cellules, module membranaire, utilisation d'un module membranaire et systeme de reaction pour la culture de cellules
EP0164608B1 (fr)	1989-11-15	Appareil pour la séparation de produits d'un mélange produit-substrat
DE3850652T2 (de)	1994-10-27	Zellenzuchtverfahren und vorrichtung.
CH681545A5 (fr)	1993-04-15
CH639002A5 (de)	1983-10-31	Verfahren und vorrichtung zur kontinuierlichen ultrafiltration von fluessigkeiten.