CH685283A5 - Composizioni dietetiche ipocolesterolemizzanti. - Google Patents
Composizioni dietetiche ipocolesterolemizzanti. Download PDFInfo
- Publication number
- CH685283A5 CH685283A5 CH2840/93A CH284093A CH685283A5 CH 685283 A5 CH685283 A5 CH 685283A5 CH 2840/93 A CH2840/93 A CH 2840/93A CH 284093 A CH284093 A CH 284093A CH 685283 A5 CH685283 A5 CH 685283A5
- Authority
- CH
- Switzerland
- Prior art keywords
- sitosteroii
- soy protein
- cholesterol
- compositions according
- compositions
- Prior art date
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- 235000007882 dietary composition Nutrition 0.000 title claims abstract description 5
- 239000000203 mixture Substances 0.000 claims abstract description 11
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 32
- 108010073771 Soybean Proteins Proteins 0.000 claims description 17
- 229940001941 soy protein Drugs 0.000 claims description 17
- 235000012000 cholesterol Nutrition 0.000 claims description 16
- 239000002671 adjuvant Substances 0.000 claims description 4
- 235000013399 edible fruits Nutrition 0.000 claims description 4
- 239000013589 supplement Substances 0.000 claims description 4
- 239000003826 tablet Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 230000002195 synergetic effect Effects 0.000 claims description 3
- 235000009508 confectionery Nutrition 0.000 claims description 2
- 102000038379 digestive enzymes Human genes 0.000 claims description 2
- 108091007734 digestive enzymes Proteins 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 235000015110 jellies Nutrition 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 229940083492 sitosterols Drugs 0.000 abstract description 3
- LGJMUZUPVCAVPU-ANOYILKDSA-N (3s,8r,9s,10s,13r,14s,17r)-17-[(2r,5s)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical class C1CC2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@H](CC)C(C)C)[C@@]1(C)CC2 LGJMUZUPVCAVPU-ANOYILKDSA-N 0.000 abstract description 2
- 235000015500 sitosterol Nutrition 0.000 abstract description 2
- 235000010469 Glycine max Nutrition 0.000 abstract 1
- 244000068988 Glycine max Species 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 12
- 235000005911 diet Nutrition 0.000 description 8
- 230000037213 diet Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 235000019359 magnesium stearate Nutrition 0.000 description 6
- 235000013305 food Nutrition 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- -1 amino acids phospholipids Chemical class 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 108010011485 Aspartame Proteins 0.000 description 2
- 108010004032 Bromelains Proteins 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 239000000605 aspartame Substances 0.000 description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
- 235000010357 aspartame Nutrition 0.000 description 2
- 229960003438 aspartame Drugs 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 235000019835 bromelain Nutrition 0.000 description 2
- 239000007910 chewable tablet Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000014105 formulated food Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 230000000260 hypercholesteremic effect Effects 0.000 description 1
- 230000000871 hypocholesterolemic effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 239000000978 natural dye Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 229940073490 sodium glutamate Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000979 synthetic dye Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000003966 vascular damage Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G4/126—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/346—Finished or semi-finished products in the form of powders, paste or liquids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
- A23G2200/04—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing vitamins, antibiotics, other medicaments
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Description
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CH 685 283 A5
Descrizione
La presente invenzione si riferisce ad una composizione orale costituita da una associazione di sostanze di origine naturale atte a svolgere una azione ipocolesterolemizzante.
I danni a livello vascolare che una condizione d'ipercolesterolemia può causare sono molteplici, e un equilibrato apporto nutrizionale gioca un ruolo di primaria importanza nella prevenzione di queste alterazioni.
Le popolazioni più esposte a questo tipo di patologia sono le società più ricche in cui ii regime alimentare oltre che sbilanciato spesso risulta essere superiore al fabbisogno giornaliero.
I possibili interventi sul parametro ematico colesteroiemico possono essere di tipo farmacologico o di tipo preventio con modifica o integrazione del regime alimentare.
L'invenzione verte su una preparazione orale della associazione di proteine della soja a sitosteroii, quali integratori della abituale dieta alimentare: essa è caracterizzata nelle rivendicazioni seguenti.
L'influenza sulla nutrizione delle proteine della soja è conosciuta sia in condizioni normocolesterolemi-che che in condizioni ipercolesterolemiche.
I sitosteroii, in particolare i beta-sitosteroli, sono sostanze ampiamente utilizzate in trattamenti ipoco-lesterolemizzanti.
La loro struttura chimica, simile al colesterolo, diversa per un gruppo etilico legato al carbonio in posizione 24 conferisce a queste sostanze un comportamento di assorbimento assai diverso dal colesterolo.
Queste sostanze a differenza del colesterolo presente negli alimenti, non vengono assorbite ed interferiscono nell'assorbimento del colesterolo assunto. Il limitato assorbimento alimentare provoca un conseguente e significativo effetto ipocolesterolemizzante.
I trattamenti ipocolesterolemizzanti con proteine della soja o con sitosteroii descritti in bibliografia si riferiscono ad elevati quantitativi pro/die. In alcuni studi si descrivono diete di 10-15 g/die di proteine isolate della soja o di 12 g/die per sitosteroii.
L'invenzione verte sull'attività sinergica delle due sostanze ipocolesterolemizzanti che se associate, possono ridurre di circa 10 volte la dose/die da utilizzare in una dieta ipocolesterolemizzante.
L'effetto sinergico rivendicato dall'invenzione permette di somministrare bassi quantitativi di integratori ipocolesterolemizzanti e per lunghi periodi con una conseguente diminuzione di rischio sitosterolemico.
La dose giornaliera della associazione ipocolesterolemizzante può quindi essere di 1-2 g/die dell'associazione.
Le composizioni dietetiche dell'invenzione possono contenere da 50 a 2000 mg di proteine della soja. La dose unitaria di sitosteroii può variare da 10 a 1000 mg.
I rapporti ponderali tra proteine della soja e sitosteroii non sono critici e saranno generalmente compresi tra 1:1 e 10:1.
Le composizioni oggetto dell'invenzione possono inoltre contenere altri principi attivi o integratori ad attività coadiuvante, complementare o utile. Esempi di questi elementi utilmente impiegabili allo scopo sono:
sali minerali vitamine enzimi digestivi fibre solubili fibre insolubili aminoacidi fosfolipidi
Le composizioni oggetto dell'invenzione sono preparate ricorrendo a tecniche ed eccipienti convenzionali. Tali composizioni vengono preparate miscelando proteine della soja e sitosteroii con eccipienti fisiologicamente accettabili e di aspetto, colore e sapore gradevole. Tra gli eccipienti noti per uso alimentare sono compresi diluenti, edulcoranti, leganti, coadiuvanti del sapore, lubrificanti, antiaderenti, coloranti naturali e sintetici, solubilizzanti, tensioattivi, conservanti.
Esempi di diluenti sono: cellulosa microcristallina, lattosio, glicina, amido di riso, saccarosio, fruttosio, sorbitolo; esempi di leganti sono: salda d'amido, pvp, metilceliulosa; esempi di coadiuvanti del sapore sono: acido citrico, acido tartarico, sodio cloruro, sodio glutamato, mentolo; esempi di lubrificanti sono: PEG, magnesio stearato, acido stearico, talco.
Esempi di composizioni dietetiche comprendono: compresse, masticabili, effervescenti, deglutitoli e rivestite, confetti, capsule, capsule di gelatina molle, sciroppo, bevande alla frutta, bustine granulari, gelatine di frutta, caramelle.
Di seguito vengono (lescritti alcuni esempi di formulazioni dietetiche ipocolesterolemizzanti secondo l'invenzione:
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CH 685 283 A5
Compresse rivestite nucleo
proteine della soja mg 500
sitosteroii mg 100
lattosio mg 90
magnesio stearato mg 10
rivestimento
metilcellulosa mg 10
titanio biossido mg 2
PEG 6000
mg 3
talco mg 5
Compresse proteine della soja mg 300
sitosteroii mg 200
amido di mais mg 30
pvp mg 20
lattosio mg 50
talco mg 10
magnesio stearato mg 5
Granulato per sospensione estemporanea proteine della soja mg 800
sitosteroii mg 200
saccarosio mg 2000
sodio saccarinato mg 20
aroma mela mg 50
Capsule proteine della soja mg 100
sitosteroii mg 100
magnesio stearato mg 10
silice precipitata mg 5
involucro
gelatina alimentare mg 100
3
5
10
15
20
25
30
35
40
45
50
55
CH 685 283 A5
Compresse masticabili proteine della soja mg 300
sitosteroii mg 200
mannite mg 500
pvp mg 20
sorbitolo mg 100
aspartame mg 3
magnesio stearato mg 5
Le preparazioni dietetiche a base di proteine della soja/sitosteroli possono essere associate a sostanze quali fibre alimentari (solubili od insolubili) per dare prodotti dietetici ipocolesteroiemizzanti-sazianti. Di seguito viene descritto un esempio formulativo:
Ipocolesterolemizzante-Saziante
Granulato per sospensione estemporanea proteine della soja mg
800
sitosteroii mg
200
gomma guar mg
2000
saccarosio mg
1000
sodio saccarinato mg
20
aroma arancio mg
50
L'associazione ipocolesterolemizzante associata ad enzimi di origine vegetale quale la bromelina può dare prodotti dietetici ipocolesterolemizzanti-digestivi.
Di seguito si descrive un esempio formulativo:
Ipocolesterolemizzante-Digestiva
Compresse masticabili proteine della soja mg 300
sitosteroii mg 200
bromelina mg 10
mannite mg 500
pvp mg 20
sorbitolo mg 100
aspartame mg 3
magnesio stearato mg 5
Claims (5)
1. Composizioni dietetiche ipocolesterolemizzanti orali contenenti proteine di soja in associazione sinergica con sitosteroii.
2. Composizioni secondo la rivendicazione 1, contenenti da 50 mg a 2000 mg di proteine della soja e da 10 mg a 1000 mg di sitosteroii per unità.
3. Composizioni secondo una delle rivendicazioni precedenti contenenti altri principi attivi o integratori ad attività coadiuvante.
4. Composizioni secondo una delle rivendicazioni 2 o 3, contenenti inoltre almeno un mezzo scelto nel gruppo costituito da: sali minerali, vitamine, enzimi digestivi, fibre solubili, fibre insolubili aminoacidi e fosfolipidi.
5. Composizioni secondo una delle rivendicazioni precedenti sotto forma di compresse masticabili, effervescenti, deglutitoli e rivestite, capsule, sciroppo, bevande alla frutta, bustine granulari, gelatine di frutta, caramelle.
4
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2840/93A CH685283A5 (it) | 1993-09-21 | 1993-09-21 | Composizioni dietetiche ipocolesterolemizzanti. |
| DE69414821T DE69414821T2 (de) | 1993-09-21 | 1994-09-12 | Diätetische cholesterinsenkende zubereitungen, die sojaproteine und sitosterine enthalten |
| EP94924978A EP0669835B1 (en) | 1993-09-21 | 1994-09-12 | Dietary hypocholesterolaemic compositions comprising soya proteins and sitosterols |
| AT94924978T ATE173631T1 (de) | 1993-09-21 | 1994-09-12 | Diätetische cholesterinsenkende zubereitungen, die sojaproteine und sitosterine enthalten |
| JP7509669A JPH08503964A (ja) | 1993-09-21 | 1994-09-12 | 食餌療法の低コレステロール血組成物 |
| PCT/IB1994/000274 WO1995008342A1 (en) | 1993-09-21 | 1994-09-12 | Dietary hypocholesterolaemic compositions comprising soya proteins and sitosterols |
| DK94924978T DK0669835T3 (da) | 1993-09-21 | 1994-09-12 | Diætetiske hypocholesterolæmiske sammensætninger indeholdende sojaproteiner og sitosteroler |
| ES94924978T ES2126772T3 (es) | 1993-09-21 | 1994-09-12 | Composiciones hipocolesterolemicas dieteticas que comprenden proteinas de soja y sitosteroles. |
| GR990400543T GR3029458T3 (en) | 1993-09-21 | 1999-02-19 | Dietary hypocholesterolaemic compositions comprising soya proteins and sitosterols. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2840/93A CH685283A5 (it) | 1993-09-21 | 1993-09-21 | Composizioni dietetiche ipocolesterolemizzanti. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH685283A5 true CH685283A5 (it) | 1995-05-31 |
Family
ID=4242777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH2840/93A CH685283A5 (it) | 1993-09-21 | 1993-09-21 | Composizioni dietetiche ipocolesterolemizzanti. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0669835B1 (it) |
| JP (1) | JPH08503964A (it) |
| AT (1) | ATE173631T1 (it) |
| CH (1) | CH685283A5 (it) |
| DE (1) | DE69414821T2 (it) |
| DK (1) | DK0669835T3 (it) |
| ES (1) | ES2126772T3 (it) |
| GR (1) | GR3029458T3 (it) |
| WO (1) | WO1995008342A1 (it) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998003084A1 (en) * | 1996-07-18 | 1998-01-29 | Nutricor, Inc. | Nutritious food preparations and methods for making them |
| FI120290B (fi) * | 1996-12-30 | 2009-09-15 | Mirador Res Oy Ltd | Menetelmä, jonka avulla voidaan valmistaa sellaisia mausteseos-, ruoan ainesosa- ja elintarvikekoostumuksia, jotka alentavat seerumin kolesterolia |
| FI108110B (fi) * | 1997-06-13 | 2001-11-30 | Danisco Finland Oy | Elintarvike- ja eläinravitsemusalalla käyttökelpoinen esiseos, menetelmä sen valmistamiseksi ja sen käyttö |
| AU779014B2 (en) * | 1999-04-23 | 2005-01-06 | Archer-Daniels-Midland Company | Composition for and method of reducing low density lipoprotein cholesterol concentration |
| US6544566B1 (en) * | 1999-04-23 | 2003-04-08 | Protein Technologies International, Inc. | Composition containing plant sterol, soy protein and isoflavone for reducing LDL cholesterol |
| US6677327B1 (en) * | 1999-11-24 | 2004-01-13 | Archer-Daniels-Midland Company | Phytosterol and phytostanol compositions |
| MXPA02007248A (es) | 2000-01-28 | 2002-12-09 | Procter & Gamble | Compuestos de arginina con sabor aceptable y usos de los mismos para la salud cardiovascular. |
| DE10063288A1 (de) * | 2000-12-19 | 2002-07-04 | Wesergold Getraenkeindustrie G | Früchte-, Gemüse-, Milch- und/oder Weinmischgetränk mit zugesetzten Phytosterinen sowie Verfahren zu dessen Herstellung |
| FI20010780A0 (fi) | 2001-04-12 | 2001-04-12 | Raisio Benecol Oy | Parannetut koostumukset |
| FI20012553A0 (fi) * | 2001-12-21 | 2001-12-21 | Raisio Benecol Oy | Syötävät koostumukset |
| CA2794424C (en) | 2004-03-29 | 2019-06-04 | Wyeth Llc | Multi-vitamin and mineral nutritional supplements |
| DE102005039836A1 (de) | 2005-08-23 | 2007-03-01 | Cognis Ip Management Gmbh | Sterolesterpulver |
| JP5393690B2 (ja) * | 2007-10-09 | 2014-01-22 | ハーキュリーズ・インコーポレーテッド | 架橋剤含有接着剤組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1427253A (en) * | 1973-05-07 | 1976-03-10 | Kaneda T | Antilipemic composition containing unsaponifiable matter of soybean oil |
| DE2834227A1 (de) * | 1978-08-04 | 1980-02-28 | Merck Patent Gmbh | Hypo- beta -lipoproteinaemisches diaetetikum, verfahren zu seiner herstellung und verwendung |
-
1993
- 1993-09-21 CH CH2840/93A patent/CH685283A5/it not_active IP Right Cessation
-
1994
- 1994-09-12 EP EP94924978A patent/EP0669835B1/en not_active Expired - Lifetime
- 1994-09-12 AT AT94924978T patent/ATE173631T1/de not_active IP Right Cessation
- 1994-09-12 DK DK94924978T patent/DK0669835T3/da active
- 1994-09-12 JP JP7509669A patent/JPH08503964A/ja active Pending
- 1994-09-12 DE DE69414821T patent/DE69414821T2/de not_active Expired - Fee Related
- 1994-09-12 WO PCT/IB1994/000274 patent/WO1995008342A1/en not_active Ceased
- 1994-09-12 ES ES94924978T patent/ES2126772T3/es not_active Expired - Lifetime
-
1999
- 1999-02-19 GR GR990400543T patent/GR3029458T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE173631T1 (de) | 1998-12-15 |
| DK0669835T3 (da) | 1999-08-09 |
| JPH08503964A (ja) | 1996-04-30 |
| GR3029458T3 (en) | 1999-05-28 |
| DE69414821D1 (de) | 1999-01-07 |
| ES2126772T3 (es) | 1999-04-01 |
| EP0669835A1 (en) | 1995-09-06 |
| WO1995008342A1 (en) | 1995-03-30 |
| DE69414821T2 (de) | 1999-07-08 |
| EP0669835B1 (en) | 1998-11-25 |
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| PL | Patent ceased |