CH91108A - Process for the preparation of silver thioglycolylaminophenol. - Google Patents

Process for the preparation of silver thioglycolylaminophenol.

Info

Publication number
CH91108A
CH91108A CH91108DA CH91108A CH 91108 A CH91108 A CH 91108A CH 91108D A CH91108D A CH 91108DA CH 91108 A CH91108 A CH 91108A
Authority
CH
Switzerland
Prior art keywords
silver
thioglycolylaminophenol
preparation
water
sulphide
Prior art date
Application number
Other languages
German (de)
Inventor
F Hoffmann- Aktiengesellschaft
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH91108A publication Critical patent/CH91108A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

  

  Verfahren zur Darstellung von     Silbertliloglykolylaminoplienol.       Es ist bekannt,     daP,    die     Alkalisalze    der       Thioglykolsäure    mit Silbersalzen     Komplex-          verbindungen    eingehen., in welchen das     Silber     als komplexes Anion vorhanden ist und sich  mit den     gebräuchlichen    Reagenzien nicht     mehr     nachweisen lässt (Rosenheim,     Ztschr.    f.     anorg.     Chemie 41. (1904 S. 23l).

   Diese komplex  bildende Fähigkeit der     Thioacylgruppe    ist,  wie gefunden wurde, auch     vorhanden,    wenn  sie in aromatische     Verbindungeu        eingeführt     wird.  



  Die Bildung solcher     komplexer    Silber  verbindungen, in welchen die komplexbildende  Komponente     einen    substituierten oder nicht  substituierten aromatischen     Kern        erthält,    ist  von grosser Wichtigkeit,     indem    die Einfüh  rung der     verschiedenen    aromatischen     Kerne     gestattet,

   die chemischen     und    biochemischen  Eigenschaften der Silbersalze in     mannigfacher     Weise zu verändern und so die     parasitotroperr     und     organotropen        Fähigkeiten    der Silberver  bindungen     zweckmässig    einzustellen.  



  Gegenstand der vorliegenden     Erfindung     ist ein Verfahren zur Darstellung     voll        Silber-          thioglykolylamirrophenol,    darin bestehend, dass    man auf     Tliioglvl,:olylamirroplrenol    Silbersalze  einwirken     lässt.    Das     Silberthiglykolylamirro-          phenol    ist in Wasser leicht     löslich.    Es schei  det weder auf Zusatz von     Koclisalzliisrrng     Silberchlorid, noch auf Zusatz von     Schwefel-          wasserstoffwasNer    oder     Anrrnorrsulfid    Silber  ab.  



  Es soll für     theral>eutische    Zwecke     Ver-          wendung    finden.  



  <I>Beispiel:</I>  1,3 'feile     Thioglykolylarnirropheriol    (her  gestellt durch Versetzen einer alkalischen       Lösung        roll        Chloracet5-hrmirroplienol    mit einer       atriumsulfidlt@snng    und     Ausfällen    des     Reak-          tionsprodulites    mit Säure,     ein    amorphes,  gelbes Pulver vom     Sehrnelzpunkt        1()5")    wer  den in 5     Teilen        5'-'        "iger        --Natronlauge    gelöst,

         dazu        tropfenweise   <B>1.0,7</B> Teile     1,69",'"iger          Silberrritratli>surrg    gefügt und mit Alkohol  gefällt. Das     entstandene        Silberthioglykolyl-          aminoplrerrol    ist in Wasser leicht löslich.



  Process for the preparation of silver liloglycolylaminoplienol. It is known that the alkali salts of thioglycolic acid form complex compounds with silver salts in which the silver is present as a complex anion and can no longer be detected with the usual reagents (Rosenheim, Ztschr. F. Anorg. Chemie 41. ( 1904 p. 23l).

   This complexing ability of the thioacyl group has been found to be also present when introduced into aromatic compounds.



  The formation of such complex silver compounds, in which the complex-forming component contains a substituted or unsubstituted aromatic nucleus, is of great importance, since the introduction of the various aromatic nuclei allows

   to change the chemical and biochemical properties of the silver salts in a variety of ways and thus expediently adjust the parasitotropic and organotropic capabilities of the silver compounds.



  The present invention relates to a process for the preparation of full silver thioglycolylamirrophenol, which consists in allowing silver salts to act on thioglycolvl,: olylamirroplrenol. The silver thiglycolylamirrophenol is easily soluble in water. Silver chloride does not separate from the addition of co-crystalline salt, nor from the addition of hydrogen sulfide or mineral sulfide.



  It is to be used for therapeutic purposes.



  <I> Example: </I> 1,3 'file thioglykolylarnirropheriol (produced by adding an alkaline solution to chloracet5-hrmirroplienol with an atrium sulfide solution and precipitating the reaction product with acid, an amorphous, yellow powder with a melting point of 1 ) 5 ") who dissolved in 5 parts of 5'- '" sodium hydroxide solution,

         add drop by drop <B> 1.0.7 </B> parts 1.69 ", '" iger Silberrritratli> surrg and precipitated with alcohol. The resulting silver thioglycolyl aminoprerrol is easily soluble in water.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung von Silber- thiobIyl-zolylaniirropherrol, dadurch gekerrn- zeichnet, dafä man auf Thioglykolylamino- phenol Silbersalze einwirken lässt. Das Silber thioglykolylaminophenol ist in Wasser leicht löslich. Es scheidet weder auf Zusatz von Kochsalzlösung Silberchlorid, noch auf Zii- ratz von Schwefelwasserstoffwasser oder Am- monsulfid Silbersulfid ab. Es soll für therapeutische Zwecke Ver- wenden finden. PATENT CLAIM: Process for the preparation of silver thiobyl-zolylaniirropherrole, characterized by the fact that silver salts are allowed to act on thioglycolylaminophenol. The silver thioglycolylaminophenol is easily soluble in water. It does not deposit silver chloride on addition of saline solution, nor on hydrogen sulphide water or ammonium sulphide silver sulphide. It should be used for therapeutic purposes.
CH91108D 1920-12-01 1920-12-01 Process for the preparation of silver thioglycolylaminophenol. CH91108A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH91108T 1920-12-01
CH90809T 1920-12-01

Publications (1)

Publication Number Publication Date
CH91108A true CH91108A (en) 1922-01-16

Family

ID=25704249

Family Applications (1)

Application Number Title Priority Date Filing Date
CH91108D CH91108A (en) 1920-12-01 1920-12-01 Process for the preparation of silver thioglycolylaminophenol.

Country Status (1)

Country Link
CH (1) CH91108A (en)

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