CH93576A - Process for the production of phenylglycine. - Google Patents
Process for the production of phenylglycine.Info
- Publication number
- CH93576A CH93576A CH93576DA CH93576A CH 93576 A CH93576 A CH 93576A CH 93576D A CH93576D A CH 93576DA CH 93576 A CH93576 A CH 93576A
- Authority
- CH
- Switzerland
- Prior art keywords
- sep
- production
- phenylglycine
- salt
- aniline
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 6
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 title description 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 8
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 150000002505 iron Chemical class 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung von Plienylglyciu. Vorliegende Erfindung betrifft ein neues Verfahren zur Herstellung von Phenylglycin durch Verwendung von Trichloräthylen und Anilin in einem einzigen technischen Vorgang, indem man diese beiden in Wasser suspen dierten Körper mit einer alkalisch wirkenden Substanz, z.
B. 1@alkmilcb, unter Druck und bei einer Temperatur von ungefähr 1-10 <B>bis-</B> <B>1900</B> C erhitzt, bis daU) die ganze verwendete Menge in Phen3-lglycinaalz umgewandelt ist.
Dieses Herstellungsverfahren kann ohne Verwendung von Alkohol als Lösungsmittel und ohneAbsönderung der einzelnen Zwischen produkte ausgeführt werden. <I>Beispiel</I> Man erhitzt in einem finit Rührer ver- sehenen Autoklav en
EMI0001.0028
132 <SEP> Gewichtsteile <SEP> Triclilor < itlivlen
<tb> 100 <SEP> Kalk
<tb> 800 <SEP> ..
<SEP> Wasser
<tb> 280 <SEP> Anilin lütt die Temperatur bis zu ungefähr 180"C steigen, und lä1>t das Gemisch bei dieser Temperatur unter stetem Rühren während 2-1 Stunden stelieii. Der I;bersehuss von Anilin wird abdestilliert. Der Rückstand besteht aus einem Gemisch von Calciunisalz des Phenyl- glycins, einer Li;
sung von C'alciunicliloi-id und unverändertem Kalk. -Man filtriert nach dein Erkalten. Die kleine -Menge des Calciiun- salzes des Plienylgl3-cins, welche in der Mut terlauge bleibt, kann<B>als,</B> Eisensalz ausgefällt werden. Der feste auf dein Filter zurück bleibende Rest wird mit kohlensaurem oder kaustiscbein Alkali gekocht, uni das Alkali salz des Plienylgycins in Lösung zu erhalten.
Diese Lesung wird endlich bis zur Trockne eingedampft.
Process for the preparation of Plienylglyciu. The present invention relates to a new process for the production of phenylglycine by using trichlorethylene and aniline in a single technical process by these two suspended bodies in water with an alkaline substance, e.g.
B. 1 @ alkmilcb, heated under pressure and at a temperature of about 1-10 <B> to </B> <B> 1900 </B> C until the whole amount used is converted into phen3-glycine salt .
This manufacturing process can be carried out without the use of alcohol as a solvent and without the individual intermediate products being separated off. <I> Example </I> The autoclave is heated in a finite stirrer
EMI0001.0028
132 <SEP> parts by weight <SEP> Triclilor <itlivlen
<tb> 100 <SEP> lime
<tb> 800 <SEP> ..
<SEP> water
<tb> 280 <SEP> aniline causes the temperature to rise to approximately 180 ° C., and the mixture is left at this temperature with constant stirring for 2-1 hours. The excess aniline is distilled off. The residue persists from a mixture of calcium salt of phenylglycine, a Li;
Solution of C'alciunicliloi-id and unchanged lime. - You filter after you have cooled down. The small amount of the calcium salt of Plienylgl3-cin which remains in the mother liquor can be precipitated as an iron salt. The solid residue remaining on the filter is boiled with carbonate or caustic alkali in order to keep the alkali salt of plienylgycine in solution.
This reading is finally evaporated to dryness.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH93576T | 1920-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH93576A true CH93576A (en) | 1922-03-16 |
Family
ID=4351125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH93576D CH93576A (en) | 1920-11-16 | 1920-11-16 | Process for the production of phenylglycine. |
Country Status (1)
| Country | Link |
|---|---|
| CH (1) | CH93576A (en) |
-
1920
- 1920-11-16 CH CH93576D patent/CH93576A/en unknown
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