CL2004000293A1 - COMPOUNDS DERIVED FROM DIHYDROFENANTRIDIN-SULFONAMIDS REPLACED, ITS SALTS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; INTERMEDIARY COMPOUNDS; AND ITS USE IN THE TREATMENT OF TYPE II DIABETES, ALZHEIMER, SENILE DEMENTIA, ASTHMA, COL - Google Patents

COMPOUNDS DERIVED FROM DIHYDROFENANTRIDIN-SULFONAMIDS REPLACED, ITS SALTS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; INTERMEDIARY COMPOUNDS; AND ITS USE IN THE TREATMENT OF TYPE II DIABETES, ALZHEIMER, SENILE DEMENTIA, ASTHMA, COL

Info

Publication number
CL2004000293A1
CL2004000293A1 CL200400293A CL2004000293A CL2004000293A1 CL 2004000293 A1 CL2004000293 A1 CL 2004000293A1 CL 200400293 A CL200400293 A CL 200400293A CL 2004000293 A CL2004000293 A CL 2004000293A CL 2004000293 A1 CL2004000293 A1 CL 2004000293A1
Authority
CL
Chile
Prior art keywords
compounds
dihydrofenantridin
sulfonamids
col
alzheimer
Prior art date
Application number
CL200400293A
Other languages
Spanish (es)
Inventor
Stephen Bryans Patrick Justin
Original Assignee
Pfizer Inc Soc Anonima Org Baj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc Soc Anonima Org Baj filed Critical Pfizer Inc Soc Anonima Org Baj
Publication of CL2004000293A1 publication Critical patent/CL2004000293A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION QUE CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN CATALIZADOR ACIDO. USO DE LOS COMPUESTOS PARA TRATAR LA DISMINORREA Y LOS SIGUIENTES INTERMEDIARIOS EN LA PREPARACION DE LOS COMPUESTO DE FORMULA (I).PREPARATION PROCEDURE THAT CONSISTS OF REACTIONING A FORMULA COMPOUND (II) WITH AN ACID CATALYST. USE OF THE COMPOUNDS TO TREAT THE DISMINORREA AND THE FOLLOWING INTERMEDIARIES IN THE PREPARATION OF THE FORMULA COMPOUND (I)

CL200400293A 2003-02-19 2004-02-18 COMPOUNDS DERIVED FROM DIHYDROFENANTRIDIN-SULFONAMIDS REPLACED, ITS SALTS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; INTERMEDIARY COMPOUNDS; AND ITS USE IN THE TREATMENT OF TYPE II DIABETES, ALZHEIMER, SENILE DEMENTIA, ASTHMA, COL CL2004000293A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0303852.8A GB0303852D0 (en) 2003-02-19 2003-02-19 Triazole compounds useful in therapy

Publications (1)

Publication Number Publication Date
CL2004000293A1 true CL2004000293A1 (en) 2005-01-07

Family

ID=9953327

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400293A CL2004000293A1 (en) 2003-02-19 2004-02-18 COMPOUNDS DERIVED FROM DIHYDROFENANTRIDIN-SULFONAMIDS REPLACED, ITS SALTS; PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION; INTERMEDIARY COMPOUNDS; AND ITS USE IN THE TREATMENT OF TYPE II DIABETES, ALZHEIMER, SENILE DEMENTIA, ASTHMA, COL

Country Status (11)

Country Link
CN (1) CN1751047A (en)
AR (1) AR043210A1 (en)
CL (1) CL2004000293A1 (en)
GB (1) GB0303852D0 (en)
GT (1) GT200400020A (en)
NL (1) NL1025527C2 (en)
PA (1) PA8596101A1 (en)
PE (1) PE20050222A1 (en)
TW (1) TW200500367A (en)
UY (1) UY28201A1 (en)
WO (1) WO2004074291A1 (en)

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WO2006114706A1 (en) * 2005-04-26 2006-11-02 Pfizer Limited Triazole derivatives as vasopressin antagonists
PE20110537A1 (en) 2008-11-13 2011-08-04 Hoffmann La Roche ESPIRO-5,6-DIHIDRO-4H-2,3,5,10B-TETRAAZA-BENZO [E] BLUEENS AS ANTAGONISTS OF V1a
PL2358714T3 (en) * 2008-11-18 2012-12-31 Hoffmann La Roche Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
SG171846A1 (en) 2008-11-28 2011-07-28 Hoffmann La Roche Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
WO2010114894A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted heterocyclic compounds
EP2501685A1 (en) * 2009-11-16 2012-09-26 Mellitech [1,5]-diazocin derivatives
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) * 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) * 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) * 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) * 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
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US8828989B2 (en) * 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
KR20140082765A (en) * 2011-10-05 2014-07-02 에프. 호프만-라 로슈 아게 Cyclohexyl-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenes as v1a antagonists
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AR095079A1 (en) 2013-03-12 2015-09-16 Hoffmann La Roche DERIVATIVES OF OCTAHIDRO-PIRROLO [3,4-C] -PIRROL AND PIRIDINA-FENILO
JP6427192B2 (en) 2013-08-19 2018-11-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ V1a Antagonist for Treating Phase Shift Sleep Disorders
NO3074400T3 (en) 2013-11-26 2018-04-14
CN105793263B (en) 2013-12-05 2019-08-23 豪夫迈·罗氏有限公司 Synthesis of a benzo[E]azulene compound and its crystal form
EP3122751B1 (en) 2014-03-26 2019-10-30 F.Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
MA39792B1 (en) 2014-03-26 2019-12-31 Hoffmann La Roche Bicyclic compounds as inhibitors of autotaxin (atx) and lysophosphatidic acid (lpa) production
MA41898A (en) 2015-04-10 2018-02-13 Hoffmann La Roche BICYCLIC QUINAZOLINONE DERIVATIVES
MX387736B (en) 2015-09-04 2025-03-18 Hoffmann La Roche PHENOXYMETHYL DERIVATIVES.
KR20180054634A (en) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 As a dual auto-thixin (ATX) / carbonic anhydrase (CA) inhibitor,
PE20180451A1 (en) 2015-09-24 2018-03-05 Hoffmann La Roche NEW BICYCLE COMPOUNDS AS ATX INHIBITORS
MX2017015034A (en) 2015-09-24 2018-04-13 Hoffmann La Roche New bicyclic compounds as dual atx/ca inhibitors.
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CN110382484B (en) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 New bicyclic compounds as ATX inhibitors
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Also Published As

Publication number Publication date
GB0303852D0 (en) 2003-03-26
NL1025527C2 (en) 2005-03-14
PE20050222A1 (en) 2005-04-13
TW200500367A (en) 2005-01-01
NL1025527A1 (en) 2004-08-23
AR043210A1 (en) 2005-07-20
PA8596101A1 (en) 2005-08-04
CN1751047A (en) 2006-03-22
WO2004074291A1 (en) 2004-09-02
UY28201A1 (en) 2004-09-30
GT200400020A (en) 2004-09-21

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