CL2007002294A1 - COMPOUND N- (2-OXO-2-PROPOXIETIL) -BETA-Phenyl-D-Phenylalanyl-N - [(1-AMINO-6-ISOQUINOLINIL) METHYL] -L-PROLINAMIDE; PHARMACEUTICAL COMPOSITION; USE TO TREAT OR PREVENT DISEASES MEDIATED BY THROMBIN; AND COMPOUND N- (2-CARBOXIETIL) -BETA-FENIL-D-FENILALAN - Google Patents

COMPOUND N- (2-OXO-2-PROPOXIETIL) -BETA-Phenyl-D-Phenylalanyl-N - [(1-AMINO-6-ISOQUINOLINIL) METHYL] -L-PROLINAMIDE; PHARMACEUTICAL COMPOSITION; USE TO TREAT OR PREVENT DISEASES MEDIATED BY THROMBIN; AND COMPOUND N- (2-CARBOXIETIL) -BETA-FENIL-D-FENILALAN

Info

Publication number: CL2007002294A1
Authority: CL; Chile
Prior art keywords: beta; compound; propoxietil; isoquinolinil; fenilalan
Prior art date: 2006-08-08

Application number

CL200702294A

Other languages

Spanish (es)

Inventor

Robert Bennett David Gilfillan

Original Assignee

Organon Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-08

Filing date

2007-08-07

Publication date

2008-04-18

2007-08-07 Application filed by Organon Nv filed Critical Organon Nv

2008-04-18 Publication of CL2007002294A1 publication Critical patent/CL2007002294A1/en

Links

150000001875 compounds Chemical class 0.000 title 2
108090000190 Thrombin Proteins 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
230000001404 mediated effect Effects 0.000 title 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229960004072 thrombin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Crystallography & Structural Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)

CL200702294A 2006-08-08 2007-08-07 COMPOUND N- (2-OXO-2-PROPOXIETIL) -BETA-Phenyl-D-Phenylalanyl-N - [(1-AMINO-6-ISOQUINOLINIL) METHYL] -L-PROLINAMIDE; PHARMACEUTICAL COMPOSITION; USE TO TREAT OR PREVENT DISEASES MEDIATED BY THROMBIN; AND COMPOUND N- (2-CARBOXIETIL) -BETA-FENIL-D-FENILALAN CL2007002294A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP06118608		2006-08-08

Publications (1)

Publication Number	Publication Date
CL2007002294A1 true CL2007002294A1 (en)	2008-04-18

Family

ID=37561257

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200702294A CL2007002294A1 (en)	2006-08-08	2007-08-07	COMPOUND N- (2-OXO-2-PROPOXIETIL) -BETA-Phenyl-D-Phenylalanyl-N - [(1-AMINO-6-ISOQUINOLINIL) METHYL] -L-PROLINAMIDE; PHARMACEUTICAL COMPOSITION; USE TO TREAT OR PREVENT DISEASES MEDIATED BY THROMBIN; AND COMPOUND N- (2-CARBOXIETIL) -BETA-FENIL-D-FENILALAN

Country Status (21)

Country	Link
US (1)	US8299091B2 (en)
EP (1)	EP2054402B1 (en)
JP (1)	JP5271904B2 (en)
KR (1)	KR20090048496A (en)
CN (1)	CN101511816B (en)
AR (1)	AR062215A1 (en)
AU (1)	AU2007283596B2 (en)
BR (1)	BRPI0715384A2 (en)
CA (1)	CA2659154A1 (en)
CL (1)	CL2007002294A1 (en)
CO (1)	CO6150148A2 (en)
IL (1)	IL196783A (en)
MX (1)	MX2009001384A (en)
MY (1)	MY143949A (en)
NO (1)	NO20090448L (en)
NZ (1)	NZ574550A (en)
PE (1)	PE20080526A1 (en)
RU (1)	RU2437879C2 (en)
TW (1)	TWI389899B (en)
WO (1)	WO2008017650A1 (en)
ZA (1)	ZA200900903B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2644947C2 (en) *	2012-08-27	2018-02-15	Аррэй Байофарма Инк.	Serin / treonin kinase inhibitors for treating of hyperopliferative diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4115468A1 (en) *	1991-05-11	1992-11-12	Behringwerke Ag	AMIDINOPHENYLALANINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THE USE THESE AND THE MEANS THEREOF CONTAINING ANTICOAGULANTS
GB9322976D0 (en) *	1993-11-08	1994-01-05	Pfizer Ltd	Therapeutic agents
US5523308A (en) *	1995-06-07	1996-06-04	Costanzo; Michael J.	Peptidyl heterocycles useful in the treatment of thrombin related disorders
AU734615B2 (en) *	1996-12-06	2001-06-21	Cortech, Inc.	Serine protease inhibitors
IL123986A (en) *	1997-04-24	2011-10-31	Organon Nv	Serine protease inhibiting antithrombotic agents and pharmaceutical compositions comprising them
TW575567B (en)	1998-10-23	2004-02-11	Akzo Nobel Nv	Serine protease inhibitor
HRP20030017A2 (en) *	2000-07-12	2003-04-30	Akzo Nobel Nv	Thrombin inhibitors comprising an aminoisoquinoline group

2007
- 2007-07-18 TW TW096126164A patent/TWI389899B/en not_active IP Right Cessation
- 2007-08-06 CN CN2007800328071A patent/CN101511816B/en not_active Expired - Fee Related
- 2007-08-06 AR ARP070103455A patent/AR062215A1/en not_active Application Discontinuation
- 2007-08-06 JP JP2009523262A patent/JP5271904B2/en not_active Expired - Fee Related
- 2007-08-06 BR BRPI0715384-8A patent/BRPI0715384A2/en not_active IP Right Cessation
- 2007-08-06 KR KR1020097004645A patent/KR20090048496A/en not_active Ceased
- 2007-08-06 NZ NZ574550A patent/NZ574550A/en not_active IP Right Cessation
- 2007-08-06 US US12/376,529 patent/US8299091B2/en not_active Expired - Fee Related
- 2007-08-06 MX MX2009001384A patent/MX2009001384A/en active IP Right Grant
- 2007-08-06 RU RU2009107917/04A patent/RU2437879C2/en not_active IP Right Cessation
- 2007-08-06 EP EP07788235.5A patent/EP2054402B1/en active Active
- 2007-08-06 AU AU2007283596A patent/AU2007283596B2/en not_active Ceased
- 2007-08-06 CA CA002659154A patent/CA2659154A1/en not_active Abandoned
- 2007-08-06 WO PCT/EP2007/058111 patent/WO2008017650A1/en not_active Ceased
- 2007-08-07 MY MYPI20071301A patent/MY143949A/en unknown
- 2007-08-07 PE PE2007001050A patent/PE20080526A1/en not_active Application Discontinuation
- 2007-08-07 CL CL200702294A patent/CL2007002294A1/en unknown
2009
- 2009-01-29 IL IL196783A patent/IL196783A/en not_active IP Right Cessation
- 2009-01-29 NO NO20090448A patent/NO20090448L/en not_active Application Discontinuation
- 2009-02-06 ZA ZA200900903A patent/ZA200900903B/en unknown
- 2009-03-06 CO CO09023453A patent/CO6150148A2/en unknown

Also Published As

Publication number	Publication date
CN101511816B (en)	2013-01-02
IL196783A (en)	2013-03-24
RU2009107917A (en)	2010-09-20
KR20090048496A (en)	2009-05-13
TW200821294A (en)	2008-05-16
MX2009001384A (en)	2009-04-30
MY143949A (en)	2011-07-29
NO20090448L (en)	2009-02-05
JP5271904B2 (en)	2013-08-21
CN101511816A (en)	2009-08-19
WO2008017650A1 (en)	2008-02-14
ZA200900903B (en)	2010-06-30
TWI389899B (en)	2013-03-21
AU2007283596B2 (en)	2012-07-05
RU2437879C2 (en)	2011-12-27
CO6150148A2 (en)	2010-04-20
PE20080526A1 (en)	2008-06-13
NZ574550A (en)	2010-09-30
US20100305153A1 (en)	2010-12-02
IL196783A0 (en)	2009-11-18
BRPI0715384A2 (en)	2013-06-18
JP2010500321A (en)	2010-01-07
EP2054402B1 (en)	2013-11-27
AU2007283596A1 (en)	2008-02-14
AR062215A1 (en)	2008-10-22
US8299091B2 (en)	2012-10-30
EP2054402A1 (en)	2009-05-06
CA2659154A1 (en)	2008-02-14

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