CL2008003184A1 - Compuestos derivados de arilindenopirimidinas antagonistas de receptores de adenosina a2a, composicion farmaceutica que los contiene y su uso en trastornos neurodegenerativos o motores tales como parkinson, mal de huntington, atrofia sistemica multiple, degeneracion corticobasal, alzheimer, depresion y ansiedad, entre otros. - Google Patents

Compuestos derivados de arilindenopirimidinas antagonistas de receptores de adenosina a2a, composicion farmaceutica que los contiene y su uso en trastornos neurodegenerativos o motores tales como parkinson, mal de huntington, atrofia sistemica multiple, degeneracion corticobasal, alzheimer, depresion y ansiedad, entre otros.

Info

Publication number
CL2008003184A1
CL2008003184A1 CL2008003184A CL2008003184A CL2008003184A1 CL 2008003184 A1 CL2008003184 A1 CL 2008003184A1 CL 2008003184 A CL2008003184 A CL 2008003184A CL 2008003184 A CL2008003184 A CL 2008003184A CL 2008003184 A1 CL2008003184 A1 CL 2008003184A1
Authority
CL
Chile
Prior art keywords
arilindenopyrimidines
huntington
neurodegenerative
adenosine
anxiety
Prior art date
Application number
CL2008003184A
Other languages
English (en)
Spanish (es)
Inventor
Brian C Shook
Paul F Jackson
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2008003184A1 publication Critical patent/CL2008003184A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CL2008003184A 2007-10-25 2008-10-24 Compuestos derivados de arilindenopirimidinas antagonistas de receptores de adenosina a2a, composicion farmaceutica que los contiene y su uso en trastornos neurodegenerativos o motores tales como parkinson, mal de huntington, atrofia sistemica multiple, degeneracion corticobasal, alzheimer, depresion y ansiedad, entre otros. CL2008003184A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98245607P 2007-10-25 2007-10-25

Publications (1)

Publication Number Publication Date
CL2008003184A1 true CL2008003184A1 (es) 2009-10-16

Family

ID=40225283

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003184A CL2008003184A1 (es) 2007-10-25 2008-10-24 Compuestos derivados de arilindenopirimidinas antagonistas de receptores de adenosina a2a, composicion farmaceutica que los contiene y su uso en trastornos neurodegenerativos o motores tales como parkinson, mal de huntington, atrofia sistemica multiple, degeneracion corticobasal, alzheimer, depresion y ansiedad, entre otros.

Country Status (13)

Country Link
US (1) US20090111804A1 (de)
EP (1) EP2220053B1 (de)
JP (1) JP2011500833A (de)
CN (1) CN101835760A (de)
AR (1) AR069026A1 (de)
AT (1) ATE509012T1 (de)
AU (1) AU2008316821A1 (de)
CL (1) CL2008003184A1 (de)
PA (1) PA8801401A1 (de)
PE (1) PE20091345A1 (de)
TW (1) TW200934496A (de)
UY (1) UY31421A1 (de)
WO (1) WO2009055548A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110105540A1 (en) * 2009-10-29 2011-05-05 Jackson Paul F 2-AMINO-9-[4-(4-METHOXY-PHENOXY)-PIPERIDIN-1-YL]-4-PHENYL-INDENO[1,2-D]PYRIMIDIN-5-ONE AND ITS USE AS A HIGHLY SELECTIVE ADENOSINE A2a RECEPTOR ANTAGONIST
WO2011101861A1 (en) 2010-01-29 2011-08-25 Msn Laboratories Limited Process for preparation of dpp-iv inhibitors
KR20250004779A (ko) 2022-04-13 2025-01-08 길리애드 사이언시즈, 인코포레이티드 Trop-2 발현 암을 치료하기 위한 병용 요법
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors
CN121405671A (zh) * 2024-07-24 2026-01-27 复旦大学 一种三环嘧啶类化合物衍生物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19627430A1 (de) * 1996-07-08 1998-01-15 Bayer Ag Bicyclisch kondensierte Pyridine
US5939432A (en) * 1997-10-29 1999-08-17 Medco Research, Inc. Thiophenes useful for modulating the adenosine receptor
PT921125E (pt) * 1997-12-05 2002-06-28 Hoffmann La Roche Derivados de 1,38-triaza-espiro 4,5 decan-4-ona
US20040127510A1 (en) * 2002-04-16 2004-07-01 Heintzelman Geoffrey R. Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
AU2003275430A1 (en) * 2003-10-03 2005-05-19 Ortho-Mcneil Pharmaceutical, Inc. Arylindenopyridines and arylindenopyridines and their use as adenosine a2a receptor antagonist

Also Published As

Publication number Publication date
US20090111804A1 (en) 2009-04-30
EP2220053B1 (de) 2011-05-11
TW200934496A (en) 2009-08-16
JP2011500833A (ja) 2011-01-06
ATE509012T1 (de) 2011-05-15
WO2009055548A1 (en) 2009-04-30
PE20091345A1 (es) 2009-09-24
CN101835760A (zh) 2010-09-15
PA8801401A1 (es) 2009-05-15
AU2008316821A1 (en) 2009-04-30
UY31421A1 (es) 2009-04-30
AR069026A1 (es) 2009-12-23
EP2220053A1 (de) 2010-08-25

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