CL2009001008A1 - Metodo de preparacion de derivados de tiofeno por reaccion entre un fenil acrilonitrilo y una acetamida. - Google Patents

Metodo de preparacion de derivados de tiofeno por reaccion entre un fenil acrilonitrilo y una acetamida.

Info

Publication number
CL2009001008A1
CL2009001008A1 CL2009001008A CL2009001008A CL2009001008A1 CL 2009001008 A1 CL2009001008 A1 CL 2009001008A1 CL 2009001008 A CL2009001008 A CL 2009001008A CL 2009001008 A CL2009001008 A CL 2009001008A CL 2009001008 A1 CL2009001008 A1 CL 2009001008A1
Authority
CL
Chile
Prior art keywords
acetamide
reaction
thiophene derivatives
phenyl acrylonitrile
preparing thiophene
Prior art date
Application number
CL2009001008A
Other languages
English (en)
Inventor
Matthew Ball
Martin Frances Jones
Fiona Ruth Kenley
John David Pittam
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2009001008A1 publication Critical patent/CL2009001008A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de compuestos derivados de 3-(carbamoilamino)-5-arilo-tiofeno-2-carboxamida, a partirde 2-tioacetamida y un derivado de 3-cloro-3-fenilpropil-2-enenitrilo; composición farmacéutica que comprende dichos compuestos, útiles para el tratamiento del cáncer.
CL2009001008A 2008-04-28 2009-04-28 Metodo de preparacion de derivados de tiofeno por reaccion entre un fenil acrilonitrilo y una acetamida. CL2009001008A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4832908P 2008-04-28 2008-04-28

Publications (1)

Publication Number Publication Date
CL2009001008A1 true CL2009001008A1 (es) 2010-08-20

Family

ID=40786810

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009001008A CL2009001008A1 (es) 2008-04-28 2009-04-28 Metodo de preparacion de derivados de tiofeno por reaccion entre un fenil acrilonitrilo y una acetamida.

Country Status (15)

Country Link
US (1) US20110112144A1 (es)
EP (1) EP2283012A1 (es)
JP (1) JP2011518870A (es)
KR (1) KR20110014613A (es)
CN (1) CN102119159A (es)
AR (1) AR071513A1 (es)
AU (1) AU2009241656A1 (es)
BR (1) BRPI0911808A2 (es)
CA (1) CA2722339A1 (es)
CL (1) CL2009001008A1 (es)
IL (1) IL208918A0 (es)
MX (1) MX2010011870A (es)
RU (1) RU2010147864A (es)
TW (1) TW200948352A (es)
WO (1) WO2009133389A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101967141A (zh) * 2010-10-13 2011-02-09 信实生物医药（上海）有限公司 一种Chk蛋白激酶拮抗剂AZD-7762的制备方法
LT3157566T (lt) 2014-06-17 2019-08-12 Vertex Pharmaceuticals Incorporated Vėžio gydymo būdas, panaudojant chk1 ir atr inhibitorių derinį
HK1258570A1 (zh) 2015-09-30 2019-11-15 Vertex Pharmaceuticals Inc. 使用dna损伤剂及atr抑制剂的组合治疗癌症的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL166510A0 (en) * 2002-08-09 2006-01-15 Nps Pharma Inc 1,2,4"oxadiazole as modulators of metabotropic glutamate receptor-5
BRPI0418351A (pt) * 2004-01-05 2007-05-08 Astrazeneca Ab composto ou um sal farmaceuticamente aceitável do mesmo, métodos de limitar a proliferação celular em um humano ou animal, de tratamento de um humano ou animal sofrendo de cáncer, de tratamento de profilaxia de cáncer, de tratamento de um humano ou animal sofrendo de uma doença neoplásica, de tratamento de um humano ou animal sofrendo de uma doença prolifetativa de tratamento de cáncer, para o tratamento de infecções associadas com cáncer, para o tratamento profilático de infecções associadas com cáncer, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, método de inibir a chk1 quinase, e, processo para a preparação de um composto ou um sal farmaceuticamente aceitável do mesmo
WO2005077345A1 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Compounds for the treatment of gastro-esophageal reflux disease

Also Published As

Publication number Publication date
JP2011518870A (ja) 2011-06-30
US20110112144A1 (en) 2011-05-12
WO2009133389A1 (en) 2009-11-05
CA2722339A1 (en) 2009-11-05
RU2010147864A (ru) 2012-06-10
IL208918A0 (en) 2011-01-31
EP2283012A1 (en) 2011-02-16
CN102119159A (zh) 2011-07-06
KR20110014613A (ko) 2011-02-11
TW200948352A (en) 2009-12-01
BRPI0911808A2 (pt) 2016-10-18
AR071513A1 (es) 2010-06-23
MX2010011870A (es) 2010-12-20
AU2009241656A1 (en) 2009-11-05

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