CL2009001019A1 - Compuestos derivados de pirrolo[1,2-c]imidazol-3-ona, imidazo[indol-3-ona e imidazo[1,5-a]piridin-3-ona sustituidos; procedeimiento de preparacion; su composicion farmaceutica; utiles en el tratamiento de la diabetes, obesidad, trastornos de ingesta d comida o dislepidemia. - Google Patents
Compuestos derivados de pirrolo[1,2-c]imidazol-3-ona, imidazo[indol-3-ona e imidazo[1,5-a]piridin-3-ona sustituidos; procedeimiento de preparacion; su composicion farmaceutica; utiles en el tratamiento de la diabetes, obesidad, trastornos de ingesta d comida o dislepidemia.Info
- Publication number
- CL2009001019A1 CL2009001019A1 CL2009001019A CL2009001019A CL2009001019A1 CL 2009001019 A1 CL2009001019 A1 CL 2009001019A1 CL 2009001019 A CL2009001019 A CL 2009001019A CL 2009001019 A CL2009001019 A CL 2009001019A CL 2009001019 A1 CL2009001019 A1 CL 2009001019A1
- Authority
- CL
- Chile
- Prior art keywords
- imidazo
- obesity
- diabetes
- useful
- treatment
- Prior art date
Links
- 208000030814 Eating disease Diseases 0.000 title abstract 2
- 208000019454 Feeding and Eating disease Diseases 0.000 title abstract 2
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 235000014632 disordered eating Nutrition 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- DYBPHASIZGHLDG-UHFFFAOYSA-N pyrrolo[1,2-c]imidazol-3-one Chemical compound C1=CN2C(=O)N=CC2=C1 DYBPHASIZGHLDG-UHFFFAOYSA-N 0.000 title 1
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados de imidazolidinona inhibidores de 11b-hsd1, procedimiento de preparación, composición farmacéutica, útil para el tratamiento o la profilaxis de la diabetes, la obesidad, trastornos de la ingestión de comida o las dislipidemias.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08155430 | 2008-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2009001019A1 true CL2009001019A1 (es) | 2011-01-07 |
Family
ID=40790778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2009001019A CL2009001019A1 (es) | 2008-04-30 | 2009-04-29 | Compuestos derivados de pirrolo[1,2-c]imidazol-3-ona, imidazo[indol-3-ona e imidazo[1,5-a]piridin-3-ona sustituidos; procedeimiento de preparacion; su composicion farmaceutica; utiles en el tratamiento de la diabetes, obesidad, trastornos de ingesta d comida o dislepidemia. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8124636B2 (es) |
| EP (1) | EP2280970B1 (es) |
| JP (1) | JP2011520790A (es) |
| KR (1) | KR20110008198A (es) |
| CN (1) | CN102015706B (es) |
| AR (1) | AR071512A1 (es) |
| AU (1) | AU2009242248A1 (es) |
| BR (1) | BRPI0910549A2 (es) |
| CA (1) | CA2722487A1 (es) |
| CL (1) | CL2009001019A1 (es) |
| ES (1) | ES2445094T3 (es) |
| IL (1) | IL208626A0 (es) |
| MX (1) | MX2010011642A (es) |
| PE (1) | PE20091811A1 (es) |
| RU (1) | RU2538986C2 (es) |
| TW (1) | TW200946535A (es) |
| WO (1) | WO2009132986A1 (es) |
| ZA (1) | ZA201007431B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| MX2012015102A (es) | 2010-07-06 | 2013-05-01 | Astrazeneca Ab | Agentes terapeuticos 976. |
| US8497288B2 (en) * | 2011-05-09 | 2013-07-30 | Hoffmann-La Roche Inc. | Hexahydropyrroloimidazolone compounds |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP3235813A1 (en) | 2016-04-19 | 2017-10-25 | Cidqo 2012, S.L. | Aza-tetra-cyclo derivatives |
| AU2020363354A1 (en) * | 2019-10-07 | 2022-04-21 | D.E. Shaw Research, Llc | Aryl heterobicyclic compounds as Kv1.3 potassium shaker channel blockers |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3809390A1 (de) * | 1988-03-16 | 1989-09-28 | Schering Ag | Perhydro-imidazopyridine und -pyrroloimidazole, verfahren zu ihrer herstellung und ihre verwendung als herbizide mittel |
| EP1142879B1 (en) * | 1998-12-24 | 2007-10-10 | Astellas Pharma Inc. | Imidazole compounds and medicinal use thereof |
| EP1404325A2 (en) | 2001-05-29 | 2004-04-07 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
| TW200407324A (en) * | 2002-05-17 | 2004-05-16 | Bristol Myers Squibb Co | Bicyclic modulators of androgen receptor function |
| KR101197672B1 (ko) * | 2004-08-30 | 2012-11-07 | 얀센 파마슈티카 엔.브이. | 11-베타 하이드록시스테로이드 데하이드로게나제저해제로서 트리사이클릭 락탐 유도체 |
| EP2039695A4 (en) * | 2006-07-11 | 2010-09-15 | Takeda Pharmaceutical | BICYCLIC HETEROCYLIC COMPOUND AND ITS USE |
| WO2008044656A1 (fr) * | 2006-10-06 | 2008-04-17 | Taisho Pharmaceutical Co., Ltd. | Dérivé d'imidazolidinone |
| RU2439062C2 (ru) * | 2006-10-19 | 2012-01-10 | Ф.Хоффманн-Ля Рош Аг | Производные имидазолона и имидазолидинона как 11в-hsd1 ингибиторы при диабете |
-
2009
- 2009-04-16 US US12/424,587 patent/US8124636B2/en not_active Expired - Fee Related
- 2009-04-21 CA CA2722487A patent/CA2722487A1/en not_active Abandoned
- 2009-04-21 BR BRPI0910549A patent/BRPI0910549A2/pt not_active IP Right Cessation
- 2009-04-21 CN CN200980115164.6A patent/CN102015706B/zh not_active Expired - Fee Related
- 2009-04-21 RU RU2010148534/04A patent/RU2538986C2/ru not_active IP Right Cessation
- 2009-04-21 WO PCT/EP2009/054701 patent/WO2009132986A1/en not_active Ceased
- 2009-04-21 JP JP2011506654A patent/JP2011520790A/ja active Pending
- 2009-04-21 AU AU2009242248A patent/AU2009242248A1/en not_active Abandoned
- 2009-04-21 ES ES09738030.7T patent/ES2445094T3/es active Active
- 2009-04-21 MX MX2010011642A patent/MX2010011642A/es active IP Right Grant
- 2009-04-21 EP EP09738030.7A patent/EP2280970B1/en not_active Not-in-force
- 2009-04-21 KR KR1020107024234A patent/KR20110008198A/ko not_active Ceased
- 2009-04-27 PE PE2009000571A patent/PE20091811A1/es not_active Application Discontinuation
- 2009-04-28 TW TW098114080A patent/TW200946535A/zh unknown
- 2009-04-28 AR ARP090101500A patent/AR071512A1/es not_active Application Discontinuation
- 2009-04-29 CL CL2009001019A patent/CL2009001019A1/es unknown
-
2010
- 2010-10-11 IL IL208626A patent/IL208626A0/en unknown
- 2010-10-18 ZA ZA2010/07431A patent/ZA201007431B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200946535A (en) | 2009-11-16 |
| EP2280970A1 (en) | 2011-02-09 |
| BRPI0910549A2 (pt) | 2016-04-19 |
| PE20091811A1 (es) | 2009-11-21 |
| CN102015706A (zh) | 2011-04-13 |
| AU2009242248A1 (en) | 2009-11-05 |
| CA2722487A1 (en) | 2009-11-05 |
| RU2538986C2 (ru) | 2015-01-10 |
| IL208626A0 (en) | 2010-12-30 |
| ZA201007431B (en) | 2013-03-27 |
| MX2010011642A (es) | 2010-11-25 |
| AR071512A1 (es) | 2010-06-23 |
| US20090275573A1 (en) | 2009-11-05 |
| RU2010148534A (ru) | 2012-06-10 |
| CN102015706B (zh) | 2014-07-16 |
| KR20110008198A (ko) | 2011-01-26 |
| WO2009132986A1 (en) | 2009-11-05 |
| ES2445094T3 (es) | 2014-02-28 |
| JP2011520790A (ja) | 2011-07-21 |
| EP2280970B1 (en) | 2014-01-08 |
| US8124636B2 (en) | 2012-02-28 |
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