CL2009001088A1 - Forma cristalina (ii) de (1r,4r)-4-(1,1-dimetiletilsulfonamido)-n-(5-(trifluorometil) piridin-2-il) ciclohexancarboxamida; procesos de preparacion; utiles como antagonistas del receptor npyy5. - Google Patents

Forma cristalina (ii) de (1r,4r)-4-(1,1-dimetiletilsulfonamido)-n-(5-(trifluorometil) piridin-2-il) ciclohexancarboxamida; procesos de preparacion; utiles como antagonistas del receptor npyy5.

Info

Publication number
CL2009001088A1
CL2009001088A1 CL2009001088A CL2009001088A CL2009001088A1 CL 2009001088 A1 CL2009001088 A1 CL 2009001088A1 CL 2009001088 A CL2009001088 A CL 2009001088A CL 2009001088 A CL2009001088 A CL 2009001088A CL 2009001088 A1 CL2009001088 A1 CL 2009001088A1
Authority
CL
Chile
Prior art keywords
useful
dimethylethylsulfonamido
cyclohexanecarboxamide
pyridin
trifluoromethyl
Prior art date
Application number
CL2009001088A
Other languages
English (en)
Inventor
Sugata Yoshihide
Ide Yutaka
Sakata Teruo
Omura Sohei
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of CL2009001088A1 publication Critical patent/CL2009001088A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedimiento de preparación de compuestos derivados de piridinamida y sus cristales; compuestos intermediarios; útiles como antagonistas del receptor NPYY5.
CL2009001088A 2008-05-08 2009-05-06 Forma cristalina (ii) de (1r,4r)-4-(1,1-dimetiletilsulfonamido)-n-(5-(trifluorometil) piridin-2-il) ciclohexancarboxamida; procesos de preparacion; utiles como antagonistas del receptor npyy5. CL2009001088A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2008122154 2008-05-08

Publications (1)

Publication Number Publication Date
CL2009001088A1 true CL2009001088A1 (es) 2011-06-17

Family

ID=41264672

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009001088A CL2009001088A1 (es) 2008-05-08 2009-05-06 Forma cristalina (ii) de (1r,4r)-4-(1,1-dimetiletilsulfonamido)-n-(5-(trifluorometil) piridin-2-il) ciclohexancarboxamida; procesos de preparacion; utiles como antagonistas del receptor npyy5.

Country Status (14)

Country Link
US (1) US20110060145A1 (es)
EP (1) EP2275410A4 (es)
JP (2) JP4756565B2 (es)
KR (1) KR101278359B1 (es)
CN (1) CN102015647A (es)
AR (1) AR071695A1 (es)
AU (1) AU2009245113A1 (es)
CA (1) CA2723133A1 (es)
CL (1) CL2009001088A1 (es)
MX (1) MX2010011835A (es)
RU (1) RU2010144412A (es)
TW (1) TWI369350B (es)
WO (1) WO2009136617A1 (es)
ZA (1) ZA201007364B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2010107040A1 (ja) * 2009-03-19 2012-09-20 塩野義製薬株式会社 Ｎｐｙｙ５受容体拮抗剤を含有する固形製剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1249233T1 (sl) * 1999-11-26 2009-02-28 Shionogi & Co Antagonisti NPYY5
ES2350031T3 (es) * 2002-03-12 2011-01-17 SHIONOGI & CO., LTD. Procedimiento para la preparación de derivados de ácido trans-4-amino-1-ciclohexanocarboxílico.
JP4636525B2 (ja) * 2004-03-12 2011-02-23 塩野義製薬株式会社 トランス−４−アミノ−１−シクロヘキサンカルボン酸エチルエステルの塩およびその製造方法
US8115030B2 (en) * 2005-03-31 2012-02-14 Shionogi & Co., Ltd. Process for the preparation of sulfomate-carboxylate derivatives
US20100076081A1 (en) * 2006-09-28 2010-03-25 Sohei Omura Method for producing salt of 4-sulfinylamino-1-cyclohexanecarboxylic acid

Also Published As

Publication number Publication date
CN102015647A (zh) 2011-04-13
JP2011178790A (ja) 2011-09-15
KR20110004898A (ko) 2011-01-14
EP2275410A4 (en) 2012-05-09
JP5234856B2 (ja) 2013-07-10
TWI369350B (en) 2012-08-01
EP2275410A1 (en) 2011-01-19
MX2010011835A (es) 2010-11-25
AU2009245113A1 (en) 2009-11-12
CA2723133A1 (en) 2009-11-12
US20110060145A1 (en) 2011-03-10
ZA201007364B (en) 2012-01-25
TW200948783A (en) 2009-12-01
RU2010144412A (ru) 2012-06-20
JPWO2009136617A1 (ja) 2011-09-08
JP4756565B2 (ja) 2011-08-24
AR071695A1 (es) 2010-07-07
KR101278359B1 (ko) 2013-06-25
WO2009136617A1 (ja) 2009-11-12

Similar Documents

Publication Publication Date Title
CY1122468T1 (el) Κρυσταλλικη μορφη διθειικου αναστολεα κινασης jak και μια μεθοδος παρασκευης αυτου
TW201129555A (en) Process for the manufacture of dabigatrane etexilate
MX2010012298A (es) Activadores de glucocinasa.
PE20091324A1 (es) Compuestos espiro como antagonistas del receptor npy y5
EA201200174A1 (ru) Производные оксазина и их применение в качестве ингибиторов bace для лечения неврологических нарушений
PE20170004A1 (es) Inhibidores de biaril cinasa
PE20160664A1 (es) Compuestos heteroaromaticos y su uso como ligandos d1 de dopamina
CL2007002949A1 (es) Forma cristalina del compuesto 2-cloro-5-(3,6-dihidro-3-metil-2,6-dioxo-4-(trifluorometil)-1-(2h)-pirimidinil)-4-fluoro-n-((metil(1-metiletil)amino)sulfonil)benzamida; proceso para la preparacion de dicha forma cristalina; composicion fitoprotectora;
PE20141421A1 (es) 4-fenil-piridinas sustituidas para el tratamiento de enfermedades relacionadas con el receptor de nk1
EP2687510A4 (en) PROCESS FOR THE PREPARATION OF 2,3-DICHLORPYRIDINE
MX2014006210A (es) Derivados de 2-(fenil o pirid-3-il)aminopirimidina como moduladores de proteina cinasa 2 de repeticion rica en leucina (lrrk2) para el tratamiento de la enfermedad de parkinson.
PH12016502523A1 (en) Crystalline salts of (s)-6-((1-acetylpiperidin-4-yl)amino)-n-(3-(3,4-dihydroisoquinolin-2(1h)-yl)-2-hydroxypropyl)pyrimidine-4-carboxamide
MY160785A (en) Manufacturing process for pyrimidine derivatives
IN2012DN01983A (es)
WO2013150545A8 (en) Process for preparation of benzimidazole derivatives and salts thereof
CL2011003009A1 (es) Proceso de preparacion de compuestos derivados de 4-fenil-3,5-(tio)piranodionas; compuesto intermediario; y preparacion de dicho intermediario.
MY167575A (en) Heterocyclic compounds and use thereof as modulators of type iii receptor tyrosine kinases
TW201613931A (en) Form crystal of bisulfate of janus kinase (JAK) inhibitor and preparation method thereof
EA201691997A1 (ru) Производные 2,4-тиазолинидона в лечении расстройств центральной нервной системы
WO2012015999A3 (en) Process for the preparation of imatinib mesylate
WO2013111163A3 (en) Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof
WO2012107890A3 (en) Crystal forms of lurasidone chlorhydrate
WO2008131946A3 (de) Substituierte amid-derivate
EA201071120A1 (ru) Способ получения гетероарилбензопроизводных сульфаматов и кристаллической формы n-((2s)-6-хлор-2,3-дигидро-l,4-бензодиоксин-2-ил)метилсульфамида
PE20141168A1 (es) Derivados de pirazolidin-3-ona