CL2009001192A1 - Compuestos derivados de 2-(4-carboxiciclohexilamino)-4-(1-indolil)pirimidina, inhibidores de jnk; proceso de preparacion; composicion farmaceutica que los comprende; y su uso para tratar o prevenir trastornos autoinmunes, inflamatorios, metabolicos, enfermedad neurologica, cancer. - Google Patents

Compuestos derivados de 2-(4-carboxiciclohexilamino)-4-(1-indolil)pirimidina, inhibidores de jnk; proceso de preparacion; composicion farmaceutica que los comprende; y su uso para tratar o prevenir trastornos autoinmunes, inflamatorios, metabolicos, enfermedad neurologica, cancer.

Info

Publication number
CL2009001192A1
CL2009001192A1 CL2009001192A CL2009001192A CL2009001192A1 CL 2009001192 A1 CL2009001192 A1 CL 2009001192A1 CL 2009001192 A CL2009001192 A CL 2009001192A CL 2009001192 A CL2009001192 A CL 2009001192A CL 2009001192 A1 CL2009001192 A1 CL 2009001192A1
Authority
CL
Chile
Prior art keywords
cancer
pharmaceutical composition
inflammatory
carboxycyclohexylamino
indolyl
Prior art date
Application number
CL2009001192A
Other languages
English (en)
Inventor
Patrick Dunn James
Heather Hogg Joan
Michael Goldstein David
Bartolome Arzeno Humberto
Gong Leyi
Han Xiaochun
Alam
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2009001192A1 publication Critical patent/CL2009001192A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos inhibidores de jnk, procedimiento de preparación, composición farmacéutica, útiles para tratar o prevenir trastornos autoinmunes, trastornos inflamatorios, trastornos metabólicos, una enfermedad neurológica o cáncer.
CL2009001192A 2008-05-16 2009-05-15 Compuestos derivados de 2-(4-carboxiciclohexilamino)-4-(1-indolil)pirimidina, inhibidores de jnk; proceso de preparacion; composicion farmaceutica que los comprende; y su uso para tratar o prevenir trastornos autoinmunes, inflamatorios, metabolicos, enfermedad neurologica, cancer. CL2009001192A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5389608P 2008-05-16 2008-05-16

Publications (1)

Publication Number Publication Date
CL2009001192A1 true CL2009001192A1 (es) 2010-08-13

Family

ID=40937466

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009001192A CL2009001192A1 (es) 2008-05-16 2009-05-15 Compuestos derivados de 2-(4-carboxiciclohexilamino)-4-(1-indolil)pirimidina, inhibidores de jnk; proceso de preparacion; composicion farmaceutica que los comprende; y su uso para tratar o prevenir trastornos autoinmunes, inflamatorios, metabolicos, enfermedad neurologica, cancer.

Country Status (18)

Country Link
US (1) US8183254B2 (es)
EP (1) EP2283009B1 (es)
JP (1) JP5329648B2 (es)
KR (1) KR101368079B1 (es)
CN (1) CN102015689B (es)
AR (1) AR071789A1 (es)
AU (1) AU2009248233A1 (es)
BR (1) BRPI0912564A2 (es)
CA (1) CA2722158A1 (es)
CL (1) CL2009001192A1 (es)
ES (1) ES2392788T3 (es)
IL (1) IL208916A0 (es)
MX (1) MX2010012249A (es)
PE (1) PE20091968A1 (es)
RU (1) RU2504545C2 (es)
TW (1) TW200948804A (es)
WO (1) WO2009138340A1 (es)
ZA (1) ZA201007178B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2572247C2 (ru) * 2010-06-04 2016-01-10 Ф. Хоффманн-Ля Рош Аг Производные 2-амино-пиримидина в качестве ингибиторов jnk
CN102918046A (zh) * 2010-06-04 2013-02-06 霍夫曼-拉罗奇有限公司 Jnk的抑制剂
EP3234110B1 (en) 2014-12-18 2024-02-28 President and Fellows of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED ß CELLS AND USES THEREOF
CN106810536A (zh) * 2015-11-30 2017-06-09 甘李药业股份有限公司 一种蛋白激酶抑制剂及其制备方法和医药用途
WO2017204626A1 (en) 2016-05-24 2017-11-30 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Combination therapy - combined map2k4/map3k1 and mek/erk inhibition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000213A1 (en) * 1999-06-30 2001-01-04 Merck & Co., Inc. Src kinase inhibitor compounds
JP4523289B2 (ja) * 2002-04-25 2010-08-11 メルク セローノ ソシエテ アノニム 脳虚血障害又はｃｎｓ障害の処置のための薬剤としてのピペラジンベンゾチアゾール
WO2006038001A1 (en) * 2004-10-06 2006-04-13 Celltech R & D Limited Aminopyrimidine derivatives as jnk inhibitors
GB0500492D0 (en) * 2005-01-11 2005-02-16 Cyclacel Ltd Compound
WO2008028860A1 (en) * 2006-09-08 2008-03-13 F. Hoffmann-La Roche Ag Benzotriazole kinase modulators
EP2102194A1 (en) * 2006-12-08 2009-09-23 F. Hoffmann-Roche AG Substituted pyrimidines and their use as jnk modulators

Also Published As

Publication number Publication date
IL208916A0 (en) 2011-01-31
EP2283009A1 (en) 2011-02-16
RU2010151475A (ru) 2012-06-27
TW200948804A (en) 2009-12-01
MX2010012249A (es) 2010-12-06
KR101368079B1 (ko) 2014-03-14
BRPI0912564A2 (pt) 2019-09-24
CA2722158A1 (en) 2009-11-19
JP5329648B2 (ja) 2013-10-30
JP2011520824A (ja) 2011-07-21
KR20100137567A (ko) 2010-12-30
ES2392788T3 (es) 2012-12-13
RU2504545C2 (ru) 2014-01-20
EP2283009B1 (en) 2012-08-29
AR071789A1 (es) 2010-07-14
CN102015689A (zh) 2011-04-13
PE20091968A1 (es) 2010-01-15
AU2009248233A1 (en) 2009-11-19
CN102015689B (zh) 2014-01-08
US20090318484A1 (en) 2009-12-24
WO2009138340A1 (en) 2009-11-19
US8183254B2 (en) 2012-05-22
ZA201007178B (en) 2013-03-27

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