CL2009001238A1 - Compuestos derivados de acido l-glutamico marcado con [f-18] y derivados de l-glutamina marcada con [f-18]; procedimiento de preparacion; conjunto de diagnostico por imagenes; composiciones farmaceuticas; y uso para el diagnostico por imagenes de enfermedades tumorales. - Google Patents

Compuestos derivados de acido l-glutamico marcado con [f-18] y derivados de l-glutamina marcada con [f-18]; procedimiento de preparacion; conjunto de diagnostico por imagenes; composiciones farmaceuticas; y uso para el diagnostico por imagenes de enfermedades tumorales.

Info

Publication number
CL2009001238A1
CL2009001238A1 CL2009001238A CL2009001238A CL2009001238A1 CL 2009001238 A1 CL2009001238 A1 CL 2009001238A1 CL 2009001238 A CL2009001238 A CL 2009001238A CL 2009001238 A CL2009001238 A CL 2009001238A CL 2009001238 A1 CL2009001238 A1 CL 2009001238A1
Authority
CL
Chile
Prior art keywords
labeled
imaging
pharmaceutical compositions
glutamic acid
derivatives
Prior art date
Application number
CL2009001238A
Other languages
English (en)
Inventor
L Dinkelborg
K Graham
M Berndt
N Koglin
H Schmitt-Willich
M Friebe
L Lehmann
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of CL2009001238A1 publication Critical patent/CL2009001238A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Compuestos derivados de ácido l-glutámico marcado con [f-18] y derivados de l-glutamina marcada con [f-18]; procedimiento de preparación; conjunto de diagnóstico por imágenes; composiciones farmacéuticas; y uso para el diagnóstico por imágenes de enfermedades tumorales.
CL2009001238A 2008-05-20 2009-05-20 Compuestos derivados de acido l-glutamico marcado con [f-18] y derivados de l-glutamina marcada con [f-18]; procedimiento de preparacion; conjunto de diagnostico por imagenes; composiciones farmaceuticas; y uso para el diagnostico por imagenes de enfermedades tumorales. CL2009001238A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08075508A EP2123619A1 (de) 2008-05-20 2008-05-20 Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
CL2009001238A1 true CL2009001238A1 (es) 2010-06-04

Family

ID=39767162

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009001238A CL2009001238A1 (es) 2008-05-20 2009-05-20 Compuestos derivados de acido l-glutamico marcado con [f-18] y derivados de l-glutamina marcada con [f-18]; procedimiento de preparacion; conjunto de diagnostico por imagenes; composiciones farmaceuticas; y uso para el diagnostico por imagenes de enfermedades tumorales.

Country Status (13)

Country Link
US (1) US20110104057A1 (es)
EP (2) EP2123619A1 (es)
JP (1) JP2011522799A (es)
KR (1) KR20110009166A (es)
CN (1) CN102036936A (es)
AR (1) AR073843A1 (es)
CA (1) CA2723459A1 (es)
CL (1) CL2009001238A1 (es)
PA (1) PA8827201A1 (es)
PE (1) PE20100140A1 (es)
TW (1) TW201008586A (es)
UY (1) UY31836A (es)
WO (1) WO2009141079A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101495924B1 (ko) * 2006-11-01 2015-02-25 바이엘 파마 악티엔게젤샤프트 [ｆ-１８]-표지된 ｌ-글루탐산, [ｆ-１８]-표지된 ｌ-글루타민, 이들의 유도체 및 이들의 용도 및 이들의 제조 방법
EP2454230A1 (en) * 2009-07-11 2012-05-23 Bayer Pharma Aktiengesellschaft Radiolabelling method using cycloalkyl groups
MX2012005733A (es) * 2009-11-17 2013-01-22 Bayer Ip Gmbh Metodo de produccion de derivados de acido glutamico marcados con f-18.
EP2520556A1 (en) * 2011-05-03 2012-11-07 Bayer Pharma Aktiengesellschaft Radiolabeled amino acids for diagnostic imaging
CN103333079B (zh) * 2013-07-03 2016-08-17 广东回旋医药科技股份有限公司 亚氨基酸类pet显像剂及其制备方法与应用
CN106631863B (zh) * 2016-09-06 2018-08-17 中山大学附属第一医院 亚谷氨酸类pet显像剂的放射合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1461184A (fr) 1964-12-23 1966-01-07 Takeda Chemical Industries Ltd Procédé de préparation d'isoxazolidones substituées en position 5
GB1474377A (en) 1973-09-11 1977-05-25 Beecham Group Ltd Naphthalene derivatives
AU748737B2 (en) 1998-01-21 2002-06-13 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
WO2002014261A2 (en) * 2000-08-10 2002-02-21 Eli Lilly And Company 4-substituted d-glutamic acid derivatives for use as antibiotic
JP2006516547A (ja) * 2002-08-02 2006-07-06 マリンクロッド・インコーポレイテッド 放射性標識アミノ酸類似体、それらの製造および使用
KR101495924B1 (ko) * 2006-11-01 2015-02-25 바이엘 파마 악티엔게젤샤프트 [ｆ-１８]-표지된 ｌ-글루탐산, [ｆ-１８]-표지된 ｌ-글루타민, 이들의 유도체 및 이들의 용도 및 이들의 제조 방법

Also Published As

Publication number Publication date
CN102036936A (zh) 2011-04-27
PE20100140A1 (es) 2010-03-21
UY31836A (es) 2010-01-05
JP2011522799A (ja) 2011-08-04
PA8827201A1 (es) 2009-12-16
TW201008586A (en) 2010-03-01
WO2009141079A8 (de) 2010-11-18
EP2123619A1 (de) 2009-11-25
WO2009141079A1 (de) 2009-11-26
US20110104057A1 (en) 2011-05-05
KR20110009166A (ko) 2011-01-27
AR073843A1 (es) 2010-12-09
EP2280915A1 (de) 2011-02-09
CA2723459A1 (en) 2009-11-26

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