CL2010001528A1 - Compounds derived from substituted 7-phenoxychroman-4-carboxylic acid; Preparation process; intermediate compound; pharmaceutical composition of said compound; and its use as an antagonist of prostaglandin d2 receptors (pgd2) to treat immunological disorders, allergic diseases, inflammatory disorders. - Google Patents

Compounds derived from substituted 7-phenoxychroman-4-carboxylic acid; Preparation process; intermediate compound; pharmaceutical composition of said compound; and its use as an antagonist of prostaglandin d2 receptors (pgd2) to treat immunological disorders, allergic diseases, inflammatory disorders.

Info

Publication number
CL2010001528A1
CL2010001528A1 CL2010001528A CL2010001528A CL2010001528A1 CL 2010001528 A1 CL2010001528 A1 CL 2010001528A1 CL 2010001528 A CL2010001528 A CL 2010001528A CL 2010001528 A CL2010001528 A CL 2010001528A CL 2010001528 A1 CL2010001528 A1 CL 2010001528A1
Authority
CL
Chile
Prior art keywords
compound
phenoxychroman
pgd2
prostaglandin
antagonist
Prior art date
Application number
CL2010001528A
Other languages
Spanish (es)
Inventor
Christopher T Clark
Adam Cook
Robert Kirk Delisle
George A Doherty
Kevin W Hunt
Ganghyeok Kim
Todd Romoff
Laurence E Burgess
Christopher P Corrette
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of CL2010001528A1 publication Critical patent/CL2010001528A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

COMPUESTOS DE LA FÓRMULA I, E INTERMEDIARIOS DE FÓRMULA LE, VI Y IV, SEGÚN EN DONDE A1, A2, PG, W, L, G, R7A, R7B, R8, R9, R10, P3, P2 Y Z2 TIENEN LAS DEFINICIONES QUE SE DIERON EN LA MEMORIA DESCRIPTIVA, SON MODULADORES DE RECEPTOR DE DP2 QUE SON ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES INMUNOLÓGICAS.COMPOUNDS OF FORMULA I, AND INTERMEDIARIES OF FORMULA LE, VI AND IV, ACCORDING TO WHERE A1, A2, PG, W, L, G, R7A, R7B, R8, R9, R10, P3, P2 AND Z2 HAVE THE DEFINITIONS THAT GIVEN IN THE DESCRIPTIVE MEMORY, THEY ARE DP2 RECEIVER MODULATORS THAT ARE USEFUL IN THE TREATMENT OF IMMUNE DISEASES.

CL2010001528A 2008-06-25 2010-12-23 Compounds derived from substituted 7-phenoxychroman-4-carboxylic acid; Preparation process; intermediate compound; pharmaceutical composition of said compound; and its use as an antagonist of prostaglandin d2 receptors (pgd2) to treat immunological disorders, allergic diseases, inflammatory disorders. CL2010001528A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7561508P 2008-06-25 2008-06-25

Publications (1)

Publication Number Publication Date
CL2010001528A1 true CL2010001528A1 (en) 2011-07-01

Family

ID=40996727

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2010001528A CL2010001528A1 (en) 2008-06-25 2010-12-23 Compounds derived from substituted 7-phenoxychroman-4-carboxylic acid; Preparation process; intermediate compound; pharmaceutical composition of said compound; and its use as an antagonist of prostaglandin d2 receptors (pgd2) to treat immunological disorders, allergic diseases, inflammatory disorders.

Country Status (32)

Country Link
US (4) US8569522B2 (en)
EP (3) EP2826774B1 (en)
JP (2) JP5753780B2 (en)
KR (1) KR101728175B1 (en)
CN (2) CN103450138B (en)
AR (1) AR072301A1 (en)
AU (1) AU2009262274B2 (en)
BR (1) BRPI0915513B8 (en)
CA (1) CA2729217C (en)
CL (1) CL2010001528A1 (en)
CO (1) CO6362002A2 (en)
CR (1) CR20110037A (en)
CY (1) CY1115650T1 (en)
DK (1) DK2307397T3 (en)
ES (2) ES2524314T3 (en)
HR (1) HRP20140988T1 (en)
IL (2) IL210198A (en)
MX (1) MX2011000173A (en)
MY (2) MY161425A (en)
NZ (1) NZ590437A (en)
PH (1) PH12014500079B1 (en)
PL (1) PL2307397T3 (en)
PT (1) PT2307397E (en)
RS (1) RS53665B1 (en)
RU (1) RU2507200C2 (en)
SG (2) SG2014013544A (en)
SI (1) SI2307397T1 (en)
TW (2) TWI476186B (en)
UA (1) UA104867C2 (en)
UY (1) UY31938A (en)
WO (1) WO2009158426A1 (en)
ZA (1) ZA201100604B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5753780B2 (en) 2008-06-25 2015-07-22 アレイ バイオファーマ、インコーポレイテッド 6-substituted phenoxycyclomancarboxylic acid derivatives
CA2748099C (en) * 2008-12-22 2017-02-28 Array Biopharma Inc. 7-phenoxychroman carboxylic acid derivatives
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
TWI654180B (en) 2012-06-29 2019-03-21 美商艾佛艾姆希公司 Fungicidal heterocyclic carboxamide
TW201507722A (en) * 2013-04-30 2015-03-01 Bayer Cropscience Ag N-(2-halogen-2-phenethyl)carboxamides as nematicides and endoparasiticides
WO2015126750A1 (en) 2014-02-19 2015-08-27 Array Biopharma Inc. BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO TREATMENT WITH A CRTh2 INHIBITOR
CN111057003A (en) * 2019-12-06 2020-04-24 广安凯特制药有限公司 Synthetic method of sitagliptin intermediate 5, 7-dichloro-1, 2,3, 4-tetrahydroisoquinoline
SE2151519A1 (en) * 2021-12-10 2023-06-11 Amidea Sweden Ab 2-(2,5-dimethoxyphenyl)ethanamine and uses thereof
CN114181039A (en) * 2021-12-23 2022-03-15 凯美克(上海)医药科技有限公司 Synthetic method of 4, 4-diphenyl-3-buten-1-ol
WO2025046475A1 (en) * 2023-08-29 2025-03-06 제이더블유중외제약 주식회사 Heterocyclic derivative for use in treating atopic dermatitis

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059609A (en) 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
US5006550A (en) * 1989-12-29 1991-04-09 Allergan, Inc. Chroman esters of phenols and benzoic acids having retinoid-like activity
US5952326A (en) 1997-12-10 1999-09-14 Pfizer Inc. Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases
DE19850131A1 (en) * 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon and chromanone derivatives
EP1178984B1 (en) 1999-05-21 2003-03-19 Pfizer Products Inc. 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
WO2002022556A1 (en) * 2000-09-14 2002-03-21 Mitsubishi Pharma Corporation Novel amide derivatives and medicinal use thereof ugs
WO2003029239A1 (en) * 2001-10-04 2003-04-10 Wyeth Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
NZ541234A (en) 2002-12-20 2008-06-30 Amgen Inc Asthma and allergic inflammation modulators
EP1856040A4 (en) * 2005-02-25 2009-09-23 Lilly Co Eli Novel lipoxygenase inhibitors
GB0611781D0 (en) * 2006-06-14 2006-07-26 Argenta Discovery Ltd 2-Oxo-2H-Chromene Compounds
SG174069A1 (en) 2006-08-21 2011-09-29 Array Biopharma Inc 4-substituted phenoxyphenylacetic acid derivatives
WO2008054675A2 (en) * 2006-10-31 2008-05-08 Merck & Co., Inc. Antidiabetic bicyclic compounds
US7960567B2 (en) * 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
US8362056B2 (en) * 2007-11-05 2013-01-29 Array Biopharma Inc. 4-heteroaryl-substituted phenoxyphenylacetic acid derivatives
JP5753780B2 (en) 2008-06-25 2015-07-22 アレイ バイオファーマ、インコーポレイテッド 6-substituted phenoxycyclomancarboxylic acid derivatives
CA2748099C (en) * 2008-12-22 2017-02-28 Array Biopharma Inc. 7-phenoxychroman carboxylic acid derivatives

Also Published As

Publication number Publication date
TWI436990B (en) 2014-05-11
CN102131794A (en) 2011-07-20
KR20110027798A (en) 2011-03-16
SG2014013528A (en) 2014-07-30
NZ590437A (en) 2012-07-27
ES2582161T3 (en) 2016-09-09
CO6362002A2 (en) 2012-01-20
TW201022222A (en) 2010-06-16
EP2826774A1 (en) 2015-01-21
IL210198A (en) 2015-10-29
MY161425A (en) 2017-04-14
IL210198A0 (en) 2011-03-31
US20140221342A1 (en) 2014-08-07
RU2507200C2 (en) 2014-02-20
ES2524314T3 (en) 2014-12-05
HRP20140988T1 (en) 2014-12-05
BRPI0915513A2 (en) 2016-01-26
US9556139B2 (en) 2017-01-31
US8716498B2 (en) 2014-05-06
US20110105463A1 (en) 2011-05-05
IL241754A0 (en) 2015-11-30
MY185134A (en) 2021-04-30
EP2307397B1 (en) 2014-08-20
JP2014122241A (en) 2014-07-03
PT2307397E (en) 2014-10-29
PH12014500079A1 (en) 2015-02-09
UY31938A (en) 2011-01-31
BRPI0915513B1 (en) 2019-11-19
SI2307397T1 (en) 2014-11-28
AU2009262274B2 (en) 2013-08-01
US8569522B2 (en) 2013-10-29
CA2729217A1 (en) 2009-12-30
PH12014500079B1 (en) 2015-02-09
MX2011000173A (en) 2011-06-20
IL241754A (en) 2017-02-28
WO2009158426A1 (en) 2009-12-30
AU2009262274A1 (en) 2009-12-30
US20150232442A1 (en) 2015-08-20
CR20110037A (en) 2011-03-14
US9096567B2 (en) 2015-08-04
TWI476186B (en) 2015-03-11
TW201427965A (en) 2014-07-16
RU2011102595A (en) 2012-07-27
EP3144303B1 (en) 2018-09-26
AR072301A1 (en) 2010-08-18
CA2729217C (en) 2016-09-06
ZA201100604B (en) 2015-08-26
CN103450138B (en) 2015-04-08
EP2307397A1 (en) 2011-04-13
BRPI0915513B8 (en) 2021-05-25
JP2011526290A (en) 2011-10-06
EP2826774B1 (en) 2016-05-25
HK1155735A1 (en) 2012-05-25
RS53665B1 (en) 2015-04-30
DK2307397T3 (en) 2014-11-03
KR101728175B1 (en) 2017-04-18
CN103450138A (en) 2013-12-18
US20140005418A1 (en) 2014-01-02
EP3144303A1 (en) 2017-03-22
UA104867C2 (en) 2014-03-25
CN102131794B (en) 2013-09-25
SG2014013544A (en) 2014-07-30
CY1115650T1 (en) 2017-01-04
JP5753780B2 (en) 2015-07-22
PL2307397T3 (en) 2015-02-27

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