CL2011001343A1 - Pestivirus quimerico que comprende un virus de la diarrea viral bovina (bvdv) que expresa proteina erns de antilope; celula huesped que lo comprende; acido nucleico que lo codifica; composicion inmunogenica que comprende el pestivirus; vacuna marcadora que comprende el bvdv quimerico. - Google Patents

Pestivirus quimerico que comprende un virus de la diarrea viral bovina (bvdv) que expresa proteina erns de antilope; celula huesped que lo comprende; acido nucleico que lo codifica; composicion inmunogenica que comprende el pestivirus; vacuna marcadora que comprende el bvdv quimerico.

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Publication number
CL2011001343A1
CL2011001343A1 CL2011001343A CL2011001343A CL2011001343A1 CL 2011001343 A1 CL2011001343 A1 CL 2011001343A1 CL 2011001343 A CL2011001343 A CL 2011001343A CL 2011001343 A CL2011001343 A CL 2011001343A CL 2011001343 A1 CL2011001343 A1 CL 2011001343A1
Authority
CL
Chile
Prior art keywords
bvdv
pestivirus
chimeric
antilope
erns
Prior art date
Application number
CL2011001343A
Other languages
English (en)
Inventor
Robert Gerard Ankenbauer
Yugang Luo
Siao-Kun Wan Welch
Ying Yuan
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41665513&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2011001343(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of CL2011001343A1 publication Critical patent/CL2011001343A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/116—Togaviridae (F); Matonaviridae (F); Flaviviridae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24361—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A PESTIVIRUS QUIMÉRICOS QUE TIENEN UTILIDAD COMO COMPOSICIONES INMUNOGÉNICAS Y VACUNAS. TAMBIÉN SE DESCRIBEN EN EL PRESENTE DOCUMENTO PROCEDIMIENTOS Y KITS PARA TRATAR O EVITAR LA DISPERSIÓN DE INFECCIÓN CON VIRUS DE LA DIARREA VIRAL BOVINA, ASÍ COMO PROCEDIMIENTOS Y KITS PARA DIFERENCIAR ENTRE ANIMALES VACUNADOS Y ANIMALES INFECTADOS CON VIRUS DE TIPO SILVESTRE.        
CL2011001343A 2008-12-03 2011-06-03 Pestivirus quimerico que comprende un virus de la diarrea viral bovina (bvdv) que expresa proteina erns de antilope; celula huesped que lo comprende; acido nucleico que lo codifica; composicion inmunogenica que comprende el pestivirus; vacuna marcadora que comprende el bvdv quimerico. CL2011001343A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11959408P 2008-12-03 2008-12-03
US17336309P 2009-04-28 2009-04-28

Publications (1)

Publication Number Publication Date
CL2011001343A1 true CL2011001343A1 (es) 2012-03-23

Family

ID=41665513

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011001343A CL2011001343A1 (es) 2008-12-03 2011-06-03 Pestivirus quimerico que comprende un virus de la diarrea viral bovina (bvdv) que expresa proteina erns de antilope; celula huesped que lo comprende; acido nucleico que lo codifica; composicion inmunogenica que comprende el pestivirus; vacuna marcadora que comprende el bvdv quimerico.

Country Status (20)

Country Link
US (2) US9567375B2 (es)
EP (1) EP2373785B1 (es)
JP (1) JP5744748B2 (es)
KR (1) KR101453146B1 (es)
CN (1) CN102239251B (es)
AR (1) AR075484A1 (es)
AU (1) AU2009323784B2 (es)
BR (1) BRPI0920982A8 (es)
CA (1) CA2744750C (es)
CL (1) CL2011001343A1 (es)
CO (1) CO6440541A2 (es)
ES (1) ES2681685T3 (es)
ME (1) ME01140B (es)
MX (1) MX2011005820A (es)
NZ (1) NZ592979A (es)
RU (2) RU2524426C2 (es)
TW (1) TWI485248B (es)
UY (1) UY32274A (es)
WO (1) WO2010064164A1 (es)
ZA (1) ZA201104508B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013006515B1 (pt) * 2010-09-21 2020-04-28 Intervet Int Bv vacina de combinação, e, método para a fabricação de uma vacina de combinação
JP6080850B2 (ja) * 2011-08-24 2017-02-15 ゾエティス・サービシーズ・エルエルシー 改善されたワクチン診断法
EP3233890B1 (en) * 2014-12-19 2019-02-06 Intervet International B.V. Pestivirus
BR112018013400A2 (pt) * 2015-12-30 2018-12-18 Intervet Int Bv vacina marcadora de pestivírus
DE102018110208A1 (de) * 2018-04-27 2019-10-31 Stiftung Tierärztliche Hochschule Hannover Gentechnisch veränderte Pestiviren und deren Verwendung als Markerimpfstoff
GB201910730D0 (en) * 2019-07-26 2019-09-11 Randox Teoranta Bovine Pathogen Array
CN111057132B (zh) * 2019-10-16 2022-01-07 四川农业大学 牛病毒性腹泻病毒e0蛋白氨基酸及制备方法
CN110665002B (zh) * 2019-10-29 2023-01-24 信阳市动物疫病预防控制中心 一种用于防治牛病毒性腹泻的抗体制剂及其制备方法
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
JP6976621B1 (ja) 2021-02-04 2021-12-08 株式会社Icst 検査器具、検査キットおよび検査方法
CN112961224B (zh) * 2021-03-26 2022-09-27 中国农业大学 牛病毒性腹泻病毒1型病毒样颗粒的制备及应用
CN114773438B (zh) * 2022-05-24 2023-06-13 中国农业科学院兰州兽医研究所 一种牛病毒性腹泻病毒e0截短蛋白、制备方法及应用
CN115364207A (zh) * 2022-06-17 2022-11-22 华中农业大学 用于防治牛病毒性腹泻病的疫苗组合物及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593873A (en) * 1986-01-27 1997-01-14 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5709865A (en) * 1994-11-10 1998-01-20 Biostar Inc. Immunogenic composition against Bovine Viral Diarrhea Virus II glycoprotein 53 (BVDV-II gp53)
US6001613A (en) * 1996-05-24 1999-12-14 Board Of Regents Of University Of Nebraska Plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus, chimeric derivatives thereof, and method of producing an infectious bovine viral diarrhea virus using said plasmid
US6060457A (en) * 1996-06-20 2000-05-09 Universite De Montreal DNA plasmid vaccine for immunization of animals against BVDV
EP0982402A1 (en) 1998-08-14 2000-03-01 Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) Pestivirus vaccination
RU2158306C2 (ru) * 1999-01-19 2000-10-27 Институт экспериментальной ветеринарии Сибири и Дальнего Востока СО РАСХН Способ выявления вируса вирусной диареи (болезни слизистых оболочек) крупного рогатого скота с помощью специфических олигонуклеотидных праймеров в полимеразной цепной реакции
EP1170367A1 (en) * 2000-06-27 2002-01-09 Bayer Ag BVDV virus-like particles
DE10143813A1 (de) * 2001-09-06 2003-04-10 Boehringer Ingelheim Vetmed Infektiöser Rindervirusdiarrhoe-Virusklon
US7361357B2 (en) * 2003-07-29 2008-04-22 Pfizer Inc. Safe mutant viral vaccines
US20090068223A1 (en) * 2005-11-15 2009-03-12 Boehringer Ingelheim Vetmedica, Inc. Combination vaccine comprising an attenuated bovine viral diarrhea virus

Also Published As

Publication number Publication date
ES2681685T3 (es) 2018-09-14
MX2011005820A (es) 2011-06-21
EP2373785A1 (en) 2011-10-12
ZA201104508B (en) 2012-11-28
US20100136055A1 (en) 2010-06-03
JP2012510285A (ja) 2012-05-10
TW201024416A (en) 2010-07-01
CN102239251A (zh) 2011-11-09
JP5744748B2 (ja) 2015-07-08
CO6440541A2 (es) 2012-05-15
KR20110091579A (ko) 2011-08-11
RU2011121044A (ru) 2013-01-10
EP2373785B1 (en) 2018-06-27
ME01140B (me) 2013-03-20
CA2744750A1 (en) 2010-06-10
KR101453146B1 (ko) 2014-10-27
WO2010064164A1 (en) 2010-06-10
TWI485248B (zh) 2015-05-21
BRPI0920982A8 (pt) 2017-09-19
CN102239251B (zh) 2014-04-23
RU2524426C2 (ru) 2014-07-27
NZ592979A (en) 2012-08-31
AR075484A1 (es) 2011-04-06
US20170151321A1 (en) 2017-06-01
US9567375B2 (en) 2017-02-14
AU2009323784B2 (en) 2013-08-15
AU2009323784A1 (en) 2010-06-10
RU2013141044A (ru) 2015-03-20
CA2744750C (en) 2018-10-09
BRPI0920982A2 (pt) 2016-10-04
UY32274A (es) 2010-06-30

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