CL2011002194A1 - Formulacion que comprende anticuerpo en un regulador de histidina-arginina ph 4.5 a 6.5; articulo de manufactura que comprende dicha formulacion; metodo para estabilizar un anticuerpo en una formulacion farmaceutica acuosa. - Google Patents

Formulacion que comprende anticuerpo en un regulador de histidina-arginina ph 4.5 a 6.5; articulo de manufactura que comprende dicha formulacion; metodo para estabilizar un anticuerpo en una formulacion farmaceutica acuosa.

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Publication number
CL2011002194A1
CL2011002194A1 CL2011002194A CL2011002194A CL2011002194A1 CL 2011002194 A1 CL2011002194 A1 CL 2011002194A1 CL 2011002194 A CL2011002194 A CL 2011002194A CL 2011002194 A CL2011002194 A CL 2011002194A CL 2011002194 A1 CL2011002194 A1 CL 2011002194A1
Authority
CL
Chile
Prior art keywords
formulation
antibody
histidine
arginine
stabilize
Prior art date
Application number
CL2011002194A
Other languages
English (en)
Inventor
Osi Esue
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CL2011002194A1 publication Critical patent/CL2011002194A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Formulación que comprende anticuerpo en un regulador de histidina-arginina pH 4.5 a 6.5; artículo de manufactura que comprende dicha formulación; método para estabilizar un anticuerpo en una formulación farmacéutica acuosa.
CL2011002194A 2009-03-06 2011-09-06 Formulacion que comprende anticuerpo en un regulador de histidina-arginina ph 4.5 a 6.5; articulo de manufactura que comprende dicha formulacion; metodo para estabilizar un anticuerpo en una formulacion farmaceutica acuosa. CL2011002194A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15833109P 2009-03-06 2009-03-06

Publications (1)

Publication Number Publication Date
CL2011002194A1 true CL2011002194A1 (es) 2012-07-20

Family

ID=42154725

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2011002194A CL2011002194A1 (es) 2009-03-06 2011-09-06 Formulacion que comprende anticuerpo en un regulador de histidina-arginina ph 4.5 a 6.5; articulo de manufactura que comprende dicha formulacion; metodo para estabilizar un anticuerpo en una formulacion farmaceutica acuosa.

Country Status (18)

Country Link
US (1) US8318161B2 (es)
EP (1) EP2403874A1 (es)
JP (1) JP2012519706A (es)
KR (1) KR20110128333A (es)
CN (1) CN102414221A (es)
AR (1) AR076640A1 (es)
AU (1) AU2010221156A1 (es)
BR (1) BRPI1006519A2 (es)
CA (1) CA2754528A1 (es)
CL (1) CL2011002194A1 (es)
IL (1) IL214956A0 (es)
MX (1) MX2011009306A (es)
PE (1) PE20120359A1 (es)
RU (1) RU2011140498A (es)
SG (1) SG174258A1 (es)
TW (1) TW201039854A (es)
WO (1) WO2010102241A1 (es)
ZA (1) ZA201106503B (es)

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AU2010221156A1 (en) 2011-09-22
WO2010102241A1 (en) 2010-09-10
KR20110128333A (ko) 2011-11-29
ZA201106503B (en) 2012-11-28
BRPI1006519A2 (pt) 2016-08-09
US20100239567A1 (en) 2010-09-23
TW201039854A (en) 2010-11-16
IL214956A0 (en) 2011-11-30
SG174258A1 (en) 2011-10-28
US8318161B2 (en) 2012-11-27
EP2403874A1 (en) 2012-01-11
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CA2754528A1 (en) 2010-09-10

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