CL2013000596A1 - Moleculas de union a vegf; molecula de acido nucleico que la codifica; celula hospedante; composicion farmaceutica; uso de la composicion para tratar efectos sobre la angiogenesis mediados por el vegf. - Google Patents

Moleculas de union a vegf; molecula de acido nucleico que la codifica; celula hospedante; composicion farmaceutica; uso de la composicion para tratar efectos sobre la angiogenesis mediados por el vegf.

Info

Publication number: CL2013000596A1
Authority: CL; Chile
Prior art keywords: vegf; composition; union; encodes; molecules
Prior art date: 2010-09-03

Application number

CL2013000596A

Other languages

English (en)

Inventor

Andreas Gschwind

Eric Borges

Joachim Boucneau

Tavernier Evelyn De

Joost Kolkman

Pascal Merchiers

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-09-03

Filing date

2013-03-01

Publication date

2014-02-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43530923&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2013000596(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-03-01 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2014-02-14 Publication of CL2013000596A1 publication Critical patent/CL2013000596A1/es

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

CL2013000596A 2010-09-03 2013-03-01 Moleculas de union a vegf; molecula de acido nucleico que la codifica; celula hospedante; composicion farmaceutica; uso de la composicion para tratar efectos sobre la angiogenesis mediados por el vegf. CL2013000596A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP10175318		2010-09-03

Publications (1)

Publication Number	Publication Date
CL2013000596A1 true CL2013000596A1 (es)	2014-02-14

Family

ID=43530923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2013000596A CL2013000596A1 (es)	2010-09-03	2013-03-01	Moleculas de union a vegf; molecula de acido nucleico que la codifica; celula hospedante; composicion farmaceutica; uso de la composicion para tratar efectos sobre la angiogenesis mediados por el vegf.

Country Status (17)

Country	Link
US (6)	US20120225081A1 (es)
EP (2)	EP2727939A3 (es)
JP (1)	JP5979504B2 (es)
KR (1)	KR101844875B1 (es)
CN (1)	CN103209995B (es)
AR (1)	AR082892A1 (es)
AU (1)	AU2011298281B2 (es)
BR (1)	BR112013005151A2 (es)
CA (1)	CA2808696C (es)
CL (1)	CL2013000596A1 (es)
EA (1)	EA029277B1 (es)
IL (1)	IL224800B (es)
MX (1)	MX353813B (es)
NZ (1)	NZ607394A (es)
PH (1)	PH12013500410B1 (es)
UY (1)	UY33588A (es)
WO (1)	WO2012028716A1 (es)

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KR101541478B1 (ko) *	2013-05-31	2015-08-05	동아쏘시오홀딩스 주식회사	항-vegf 항체 및 이를 포함하는 암 또는 신생혈관형성관련 질환의 예방, 진단 또는 치료용 약학 조성물
US9388239B2 (en) *	2014-05-01	2016-07-12	Consejo Nacional De Investigation Cientifica	Anti-human VEGF antibodies with unusually strong binding affinity to human VEGF-A and cross reactivity to human VEGF-B
EP3078674B1 (en) *	2015-01-06	2020-09-23	Zhuhai Essex Bio-pharmaceutical Co., Ltd.	Anti-vegf antibody
AU2017229687A1 (en) *	2016-03-08	2018-09-20	Takeda Pharmaceutical Company Limited	Inducible binding proteins and methods of use
US12128102B2 (en)	2016-03-08	2024-10-29	Takeda Pharmaceutical Company Limited	Constrained conditionally activated binding proteins
AU2017324983B2 (en) *	2016-09-07	2025-03-20	Saksin Lifesciences Pvt Ltd	Synthetic antibodies against VEGF and their uses
WO2018175319A1 (en) *	2017-03-20	2018-09-27	Allergan, Inc.	Heavy chain only antibodies to vegf
IL273119B2 (en)	2017-09-08	2023-10-01	Maverick Therapeutics Inc	Binding proteins are activated under limited conditions
EP4592313A3 (en)	2019-03-05	2025-11-19	Takeda Pharmaceutical Company Limited	Constrained conditionally activated binding proteins
CN110452297B (zh) *	2019-09-03	2020-04-14	上海洛启生物医药技术有限公司	抗vegf单域抗体及其应用
US12540188B2 (en)	2020-08-05	2026-02-03	Synthekine, Inc.	IL10Rα/IL2Rγ synthetic cytokines
US12018085B2 (en)	2020-08-05	2024-06-25	Synthekine, Inc.	Interferon-gamma R2 (IFNGR2) binding molecules comprising single-domain antibodies and method of use thereof to treat autoimmune and inflammatory diseases
CA3190486A1 (en)	2020-08-05	2022-02-10	Synthekine, Inc.	Il10 receptor binding molecules and methods of use
WO2022032005A2 (en)	2020-08-05	2022-02-10	Synthekine, Inc.	Il10rb binding molecules and methods of use
US12122839B2 (en)	2020-08-05	2024-10-22	Synthekine, Inc.	IFNGR binding synthetic cytokines and methods of use
WO2022031964A2 (en) *	2020-08-05	2022-02-10	Synthekine, Inc.	Ifngr1 binding molecules and methods of use
AR124917A1 (es) *	2021-02-19	2023-05-17	Dotbio Pte Ltd	Moléculas de unión a vegfa
AU2022327397A1 (en) *	2021-08-13	2024-03-14	Innovent Biologics (Suzhou) Co., Ltd.	Anti-vegf a and -vegf c bispecific antibody and use thereof
CN115724968B (zh) *	2021-08-27	2023-08-08	三优生物医药(上海)有限公司	Vegf结合分子及其用途
CN113896805B (zh) *	2021-12-13	2022-02-25	上海惠盾因泰生物科技有限公司	一种vegf-crm197重组融合蛋白疫苗及其制备方法和应用
WO2024055995A1 (zh) *	2022-09-14	2024-03-21	寻济生物科技（北京）有限公司	一种抗vegfa融合蛋白及其制备方法和应用
EP4582447A4 (en) *	2022-09-14	2026-01-21	Quaerite Biopharm Res Beijing Co Ltd	ANTI-VEGFA ANTIBODY OR ANTIGEN BINDING FRAGMENT OF THESE AND ITS USE
CN116284405B (zh) *	2023-03-15	2024-03-19	中国科学技术大学	靶向cd150蛋白的纳米抗体及其应用
CN118085081B (zh) *	2024-04-19	2024-06-21	云南大学	一种特异性结合vegf的纳米抗体及用途
WO2026055310A1 (en) *	2024-09-06	2026-03-12	Merck Sharp & Dohme Llc	Multivalent fzd4, wnt co-receptor, and vegf binding molecules and uses thereof

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US9527925B2 (en) *	2011-04-01	2016-12-27	Boehringer Ingelheim International Gmbh	Bispecific binding molecules binding to VEGF and ANG2

2011
- 2011-09-01 US US13/223,563 patent/US20120225081A1/en not_active Abandoned
- 2011-09-02 NZ NZ607394A patent/NZ607394A/en unknown
- 2011-09-02 AU AU2011298281A patent/AU2011298281B2/en not_active Ceased
- 2011-09-02 KR KR1020137008330A patent/KR101844875B1/ko not_active Expired - Fee Related
- 2011-09-02 EP EP13190391.6A patent/EP2727939A3/en not_active Withdrawn
- 2011-09-02 JP JP2013526488A patent/JP5979504B2/ja active Active
- 2011-09-02 BR BR112013005151-5A patent/BR112013005151A2/pt not_active Application Discontinuation
- 2011-09-02 MX MX2013002379A patent/MX353813B/es active IP Right Grant
- 2011-09-02 PH PH1/2013/500410A patent/PH12013500410B1/en unknown
- 2011-09-02 WO PCT/EP2011/065199 patent/WO2012028716A1/en not_active Ceased
- 2011-09-02 CA CA2808696A patent/CA2808696C/en active Active
- 2011-09-02 CN CN201180052278.8A patent/CN103209995B/zh active Active
- 2011-09-02 UY UY0001033588A patent/UY33588A/es unknown
- 2011-09-02 AR ARP110103226A patent/AR082892A1/es not_active Application Discontinuation
- 2011-09-02 EA EA201300311A patent/EA029277B1/ru not_active IP Right Cessation
- 2011-09-02 EP EP11749454.2A patent/EP2611830A1/en not_active Withdrawn
2013
- 2013-02-19 IL IL224800A patent/IL224800B/en active IP Right Grant
- 2013-03-01 CL CL2013000596A patent/CL2013000596A1/es unknown
2015
- 2015-12-18 US US14/974,343 patent/US20160200806A1/en not_active Abandoned
2017
- 2017-12-05 US US15/831,754 patent/US20180201671A1/en not_active Abandoned
2020
- 2020-06-17 US US16/903,888 patent/US20200308267A1/en not_active Abandoned
2022
- 2022-06-21 US US17/844,812 patent/US20220363744A1/en not_active Abandoned
2024
- 2024-01-11 US US18/409,969 patent/US20240141030A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EA029277B1 (ru)	2018-03-30
MX2013002379A (es)	2013-05-09
EP2727939A3 (en)	2014-05-21
EP2611830A1 (en)	2013-07-10
US20220363744A1 (en)	2022-11-17
KR101844875B1 (ko)	2018-04-03
KR20130101045A (ko)	2013-09-12
US20240141030A1 (en)	2024-05-02
CN103209995A (zh)	2013-07-17
JP2013541939A (ja)	2013-11-21
WO2012028716A1 (en)	2012-03-08
EP2727939A2 (en)	2014-05-07
AR082892A1 (es)	2013-01-16
IL224800B (en)	2020-03-31
AU2011298281A1 (en)	2013-03-14
US20160200806A1 (en)	2016-07-14
PH12013500410B1 (en)	2022-02-11
CA2808696C (en)	2016-12-20
MX353813B (es)	2018-01-31
BR112013005151A2 (pt)	2020-08-04
NZ607394A (en)	2014-12-24
PH12013500410A1 (en)	2013-04-15
EA201300311A1 (ru)	2013-08-30
CA2808696A1 (en)	2012-03-08
AU2011298281B2 (en)	2015-02-05
JP5979504B2 (ja)	2016-08-24
US20200308267A1 (en)	2020-10-01
US20120225081A1 (en)	2012-09-06
UY33588A (es)	2012-03-30
CN103209995B (zh)	2015-11-25
US20180201671A1 (en)	2018-07-19

Publication	Publication Date	Title
CL2013000596A1 (es)	2014-02-14	Moleculas de union a vegf; molecula de acido nucleico que la codifica; celula hospedante; composicion farmaceutica; uso de la composicion para tratar efectos sobre la angiogenesis mediados por el vegf.
HUS2300027I1 (hu)	2023-12-28	BCMA (CD269/TNFRSF17)-kötõ fehérjék
CL2014000631A1 (es)	2014-09-26	Molecula de union que se une a cd134 (ox40); molecula de acido nucleico que la codifica; vector; celula huesped; proceso de preparacion; composicion farmaceutica que la comprende; y su uso para tratar cancer.
CL2009000379A1 (es)	2012-02-24	Anticuerpo monoclonal aislado especifico contra los ligandos angiopoyetina 1 y 2 del receptor tie 2; fragmento del mismo; molecula de acido nucleico que lo codifica; vector; celula huesped; metodo de preparacion; composicion farmaceutica que lo comprende; y su uso para inhibir la angiogenesis no deseada tal como cancer.
CL2014002072A1 (es)	2015-01-23	Polipéptidos de unión a cx3cr1; molecula de acido nucleico que lo codifica; composicion farmaceutica que lo contiene; metodo de elaboracion del peptido; usos del peptido; kit que contiene el peptido.
CL2013000669A1 (es)	2014-02-14	Agente de union a cd33 que se une al cd33 humano; molecula de adn que codifica la region variable de cadena pesada de un agente de union a cd33; vector de expresion; celula hospedante; metodo para reducir agente de unión a cd33; composicion farmaceutica; uso de la composicion farmaceutica para disminuir el numero de celulas que expresan el cd33 sobre su superficie.
CL2013000459A1 (es)	2014-01-31	Anticuerpo aislado o fragmento que se enlaza a un estado inactivo de un receptor her; composicion farmaceutica que lo comprende; uso del anticuerpo para tratar cancer.
CL2015000094A1 (es)	2015-06-19	Compuestos derivados de imidazotriazincarbonitrilos, inhibidores de la proteina cinasa; composicion farmaceutica que los comprende; y su uso para tratar el cancer, psoriasis y artritis reumatoide.
BRPI0925099A2 (pt)	2018-10-16	composição tópica contendo ibuprofeno
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