CL2013003111A1 - Metodo para la preparacion de una composicion farmaceutica que contiene un transportador de oxigeno purificado y termicamente estable, que contiene el transportador de oxigeno hemoglobina, donde la hemoglobina incluye a hemoglobina polimerica entrecruzada. - Google Patents

Metodo para la preparacion de una composicion farmaceutica que contiene un transportador de oxigeno purificado y termicamente estable, que contiene el transportador de oxigeno hemoglobina, donde la hemoglobina incluye a hemoglobina polimerica entrecruzada.

Info

Publication number
CL2013003111A1
CL2013003111A1 CL2013003111A CL2013003111A CL2013003111A1 CL 2013003111 A1 CL2013003111 A1 CL 2013003111A1 CL 2013003111 A CL2013003111 A CL 2013003111A CL 2013003111 A CL2013003111 A CL 2013003111A CL 2013003111 A1 CL2013003111 A1 CL 2013003111A1
Authority
CL
Chile
Prior art keywords
hemoglobin
oxygen transporter
pharmaceutical composition
composition containing
purified
Prior art date
Application number
CL2013003111A
Other languages
English (en)
Inventor
Sui Yi Kwok
Bing Lou Wong
Original Assignee
Billion King International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Billion King International Ltd filed Critical Billion King International Ltd
Publication of CL2013003111A1 publication Critical patent/CL2013003111A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Método para producir una composición farmacéutica que contiene un trasportador de oxígeno purificado y térmicamente estable derivado de hemoglobina.
CL2013003111A 2011-04-29 2013-10-28 Metodo para la preparacion de una composicion farmaceutica que contiene un transportador de oxigeno purificado y termicamente estable, que contiene el transportador de oxigeno hemoglobina, donde la hemoglobina incluye a hemoglobina polimerica entrecruzada. CL2013003111A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201113097183A 2011-04-29 2011-04-29
US13/217,337 US8084581B1 (en) 2011-04-29 2011-08-25 Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus

Publications (1)

Publication Number Publication Date
CL2013003111A1 true CL2013003111A1 (es) 2014-08-29

Family

ID=45349825

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013003111A CL2013003111A1 (es) 2011-04-29 2013-10-28 Metodo para la preparacion de una composicion farmaceutica que contiene un transportador de oxigeno purificado y termicamente estable, que contiene el transportador de oxigeno hemoglobina, donde la hemoglobina incluye a hemoglobina polimerica entrecruzada.

Country Status (19)

Country Link
US (1) US8084581B1 (es)
EP (1) EP2702067B1 (es)
KR (1) KR20140031915A (es)
AP (1) AP2013007232A0 (es)
AU (1) AU2012249996A1 (es)
BR (1) BR112013027756A2 (es)
CA (1) CA2834508A1 (es)
CL (1) CL2013003111A1 (es)
DK (1) DK2702067T3 (es)
EA (1) EA020891B1 (es)
ES (1) ES2668674T3 (es)
IL (1) IL229107B (es)
MA (1) MA35067B1 (es)
MX (1) MX353814B (es)
MY (1) MY162401A (es)
PH (1) PH12013502222B1 (es)
SG (1) SG194677A1 (es)
WO (1) WO2012148832A2 (es)
ZA (1) ZA201308059B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2659831B1 (en) 2003-12-18 2016-11-30 Metronom Health, Inc. Stabilized oxygen transport matrix
US8730976B2 (en) 2004-08-17 2014-05-20 Cisco Technology, Inc. System and method for preventing erroneous link aggregation due to component relocation
CN103781489B (zh) 2011-09-06 2017-03-29 黄炳镠 用于基于血红蛋白的氧载体的口服递送
US9636404B2 (en) * 2013-05-13 2017-05-02 Vision Global Holdings Ltd. Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging
US9814759B2 (en) 2014-07-02 2017-11-14 Cheer Global Ltd. Pharmaceutical composition comprising recombinant hemoglobin protein or subunit-based therapeutic agent for cancer targeting treatment
US9763889B2 (en) 2015-06-29 2017-09-19 Billion King International Ltd. Oral delivery system for hemoglobin based oxygen carriers
CN108135929B (zh) * 2015-09-02 2021-10-12 梅特罗诺姆中国Ip控股公司 使用光-酶分析物传感器进行连续健康监测的系统和方法
US10052290B2 (en) 2016-02-04 2018-08-21 Billion King International Ltd. Enteric-coated hemoglobin multiparticulate for oral delivery of hemoglobin based oxygen carriers
CA3070172A1 (en) 2017-07-18 2019-01-24 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925344A (en) * 1973-04-11 1975-12-09 Community Blood Council Plasma protein substitute
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4529719A (en) 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
FR2548671B1 (fr) 1983-07-07 1986-05-02 Merieux Inst Procede de preparation de globine a partir d'hemoglobine et globine obtenue par ce procede
US5281579A (en) * 1984-03-23 1994-01-25 Baxter International Inc. Purified virus-free hemoglobin solutions and method for making same
US4831012A (en) 1984-03-23 1989-05-16 Baxter International Inc. Purified hemoglobin solutions and method for making same
USRE34271E (en) 1984-06-27 1993-06-01 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4600531A (en) 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4598064A (en) 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
US5464814A (en) 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
JPH0750329B2 (ja) 1986-06-23 1995-05-31 富士写真フイルム株式会社 画像形成材料
US5084558A (en) 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
CA1312009C (en) 1986-11-10 1992-12-29 Carl W. Rausch Extra pure semi-synthetic blood substitute
US5955581A (en) 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5753616A (en) 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5189146A (en) 1987-05-05 1993-02-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Pasteurizable, freeze-driable hemoglobin-based blood substitute
JP2592973B2 (ja) 1988-06-15 1997-03-19 バクスター インターナショナル インコーポレーテッド 架橋ヘモグロビンの精製方法
US5439882A (en) 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
WO1992003153A1 (en) * 1990-08-17 1992-03-05 Baxter International Inc. Hemoglobin-oligomer based composition and method to make same
US5250665A (en) 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
US5344393A (en) 1992-02-28 1994-09-06 Alliance Pharmaceutical Corp. Use of synthetic oxygen carriers to facilitate oxygen delivery
US6187744B1 (en) 1992-03-11 2001-02-13 Michael W. Rooney Methods and compositions for regulating the intravascular flow and oxygenating activity of hemoglobin in a human or animal subject
US5840851A (en) 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5767089A (en) 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5807831A (en) 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
TW381022B (en) 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5824781A (en) 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5741893A (en) 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5631219A (en) 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
AU691297B2 (en) 1994-05-13 1998-05-14 Miltenyi Biotec Gmbh Sterile and pyrogen-free columns coupled to protein for binding and removal of substances from blood
SE9500724D0 (sv) 1994-06-23 1995-02-24 Pharmacia Ab Filtrering
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US5895810A (en) 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US5865784A (en) 1995-06-07 1999-02-02 Alliance Pharmaceutical Corp. Method of hemodilution facilitated by monitoring oxygenation status
US5952470A (en) * 1995-06-07 1999-09-14 Biopure Corporation Method for separating unmodified hemoglobin from cross-linked hemoglobin
US5691453A (en) 1995-06-07 1997-11-25 Biopure Corporation Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC
US5741894A (en) 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
CA2236794A1 (en) 1995-11-30 1997-06-05 Bruce A. Kerwin Method for control of functionality during cross-linking of hemoglobins
KR100439410B1 (ko) 1996-03-21 2004-09-08 셍게발드 베르파쿤겐 게엠베하 다층포일,그제조방법및그이용
ES2243994T5 (es) 1996-04-19 2009-10-29 Grifols Inc. Procedimiento para la inactivacion virica de proteinas de la sangre liofilizadas.
ATE302019T1 (de) 1997-02-28 2005-09-15 Univ California Verfahren und zusammensetzungen zur optimierung des sauerstofftransportes in zellfreien systemen
US5814601A (en) 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
CN1203900C (zh) 1998-01-06 2005-06-01 塞鲁斯公司 用于淬灭生物材料中病原体灭活剂的方法
US6894150B1 (en) 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US6518010B2 (en) 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
JP2004538264A (ja) 2001-04-18 2004-12-24 ノースフィールド ラボラトリーズ 安定化ヘモグロビン溶液の保管のための可撓性容器システム
JP4260417B2 (ja) 2001-05-23 2009-04-30 ノバルティス アクチエンゲゼルシャフト 溶液を輸送し脱酸素するためのシステム及び方法
US7038016B2 (en) 2001-08-21 2006-05-02 Apex Bioscience, Inc. Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
US20050164915A1 (en) 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20030153491A1 (en) 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
CA2511494A1 (en) 2002-12-23 2004-07-15 Seetharama A. Acharya Non-hypertensive polyethylene glycol-modified hemoglobin as oxygen carrier
US7135553B2 (en) 2003-01-29 2006-11-14 Northfield Laboratories, Inc. Polymerized hemoglobin solutions having reduced amounts of tetramer and method for preparing
US7135554B1 (en) * 2004-01-27 2006-11-14 Biopure Corporation Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
AU2005302256B2 (en) 2004-10-29 2011-01-20 Cerus Corporation Improved quenching methods for red blood cell inactivation process
WO2007065265A1 (en) 2005-12-08 2007-06-14 Ronald Kluger Cross-linking reagents for hemoglobin and hemoglobin products cross-linked therewith
US7759306B2 (en) 2006-05-16 2010-07-20 Simoni Jan S Methods of treating acute blood loss
US7795401B2 (en) 2006-09-06 2010-09-14 National Chung Cheng University Modified hemoglobin with allosteric effector conjugated
US7494974B2 (en) 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
US7989593B1 (en) 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition

Also Published As

Publication number Publication date
WO2012148832A8 (en) 2013-04-25
PH12013502222A1 (en) 2014-02-10
MA35067B1 (fr) 2014-04-03
AU2012249996A1 (en) 2013-11-21
NZ617344A (en) 2015-12-24
EP2702067A4 (en) 2015-12-30
KR20140031915A (ko) 2014-03-13
SG194677A1 (en) 2013-12-30
US8084581B1 (en) 2011-12-27
DK2702067T3 (en) 2018-05-22
EA201101154A1 (ru) 2012-10-30
PH12013502222B1 (en) 2019-01-18
AP2013007232A0 (en) 2013-11-30
BR112013027756A2 (pt) 2017-01-03
IL229107A0 (en) 2013-12-31
IL229107B (en) 2018-06-28
EP2702067A2 (en) 2014-03-05
ES2668674T3 (es) 2018-05-21
EA020891B1 (ru) 2015-02-27
WO2012148832A2 (en) 2012-11-01
EP2702067B1 (en) 2018-02-21
MY162401A (en) 2017-06-15
MX2013012614A (es) 2014-08-22
CA2834508A1 (en) 2012-11-01
ZA201308059B (en) 2020-02-26
MX353814B (es) 2018-01-31

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