CL2013003602A1 - Compuestos derivados de benzoimidazol (indol) de analogos de espirocarbamato o sus sales como antagonistas de trpv4; composicion farmaceutica que los comprende, util para el tratamiento de aterosclerosis, trastornos relacionados con edema intestinal, trastornos pulmonares, enfermedad cardiovascular, disfuncion renal, osteoartritis, entre otras. - Google Patents

Compuestos derivados de benzoimidazol (indol) de analogos de espirocarbamato o sus sales como antagonistas de trpv4; composicion farmaceutica que los comprende, util para el tratamiento de aterosclerosis, trastornos relacionados con edema intestinal, trastornos pulmonares, enfermedad cardiovascular, disfuncion renal, osteoartritis, entre otras.

Info

Publication number
CL2013003602A1
CL2013003602A1 CL2013003602A CL2013003602A CL2013003602A1 CL 2013003602 A1 CL2013003602 A1 CL 2013003602A1 CL 2013003602 A CL2013003602 A CL 2013003602A CL 2013003602 A CL2013003602 A CL 2013003602A CL 2013003602 A1 CL2013003602 A1 CL 2013003602A1
Authority
CL
Chile
Prior art keywords
disorders
benzoimidazole
osteoarthritis
atherosclerosis
indole
Prior art date
Application number
CL2013003602A
Other languages
English (en)
Inventor
Mui Cheung
Carl Brooks
Hilary Schenck Eidam
Krista B Goodman
Marlys Hammond
Mark A Hilfiker
Tram H Hoang
Jaclyn R Patterson
Patrick Stoy
Guosen Ye
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47558389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2013003602(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Ip No 2 Ltd filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of CL2013003602A1 publication Critical patent/CL2013003602A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D419/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CL2013003602A 2011-06-17 2013-12-16 Compuestos derivados de benzoimidazol (indol) de analogos de espirocarbamato o sus sales como antagonistas de trpv4; composicion farmaceutica que los comprende, util para el tratamiento de aterosclerosis, trastornos relacionados con edema intestinal, trastornos pulmonares, enfermedad cardiovascular, disfuncion renal, osteoartritis, entre otras. CL2013003602A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161498110P 2011-06-17 2011-06-17

Publications (1)

Publication Number Publication Date
CL2013003602A1 true CL2013003602A1 (es) 2014-07-04

Family

ID=47558389

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013003602A CL2013003602A1 (es) 2011-06-17 2013-12-16 Compuestos derivados de benzoimidazol (indol) de analogos de espirocarbamato o sus sales como antagonistas de trpv4; composicion farmaceutica que los comprende, util para el tratamiento de aterosclerosis, trastornos relacionados con edema intestinal, trastornos pulmonares, enfermedad cardiovascular, disfuncion renal, osteoartritis, entre otras.

Country Status (38)

Country Link
US (1) US9187464B2 (es)
EP (2) EP2721016B1 (es)
JP (1) JP5969017B2 (es)
KR (1) KR101870003B1 (es)
CN (1) CN103732583B (es)
AR (1) AR086958A1 (es)
AU (1) AU2012284540B2 (es)
BR (1) BR112013032391B1 (es)
CA (1) CA2839743C (es)
CL (1) CL2013003602A1 (es)
CO (1) CO6821953A2 (es)
CR (1) CR20130671A (es)
CY (1) CY1117792T1 (es)
DK (1) DK2721016T3 (es)
DO (1) DOP2013000307A (es)
EA (1) EA023616B1 (es)
ES (2) ES2569193T3 (es)
HR (1) HRP20160539T1 (es)
HU (1) HUE029594T2 (es)
IL (1) IL229872A (es)
JO (1) JO3154B1 (es)
MA (1) MA35184B1 (es)
ME (1) ME02416B (es)
MX (1) MX337440B (es)
MY (1) MY173521A (es)
PE (1) PE20141943A1 (es)
PH (1) PH12013502463A1 (es)
PL (1) PL2721016T3 (es)
PT (1) PT2721016E (es)
RS (1) RS54858B1 (es)
SG (1) SG195106A1 (es)
SI (1) SI2721016T1 (es)
SM (1) SMT201600150B (es)
TW (1) TWI538912B (es)
UA (1) UA113963C2 (es)
UY (1) UY34138A (es)
WO (1) WO2013012500A1 (es)
ZA (1) ZA201308816B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2595606T3 (es) * 2011-06-17 2017-01-02 Glaxosmithkline Intellectual Property (No. 2) Limited Antagonistas TRPV4
ES2571409T3 (es) 2011-06-17 2016-05-25 Glaxosmithkline Intellectual Property (No 2) Ltd Antagonistas espiro-cíclicos de TRPV4
EP2832731A4 (en) 2012-03-27 2015-08-19 Shionogi & Co AROMATIC HETEROCYCLIC CHAIN 5-CORE DERIVED DERIVATIVE HAVING TRPV4 INHIBITORY ACTIVITY
WO2015046193A1 (ja) 2013-09-25 2015-04-02 塩野義製薬株式会社 Trpv4阻害活性を有する芳香族複素環式アミン誘導体
WO2017199199A1 (en) 2016-05-19 2017-11-23 Glaxosmithkline Intellectual Property (No.2) Limited Trpv4 antagonist
US10968209B2 (en) 2016-05-19 2021-04-06 Glaxosmithkline Intellectual Property (No.2) Limited TRPV4 antagonist
CN115626935B (zh) 2016-10-03 2025-07-15 詹森药业有限公司 用作prmt5抑制剂的单环和双环系统取代的卡巴核苷类似物
WO2018185701A1 (en) 2017-04-06 2018-10-11 Glaxosmithkline Intellectual Property (No.2) Limited Trpv4 antagonists as antitussive agents
KR102731924B1 (ko) * 2017-11-01 2024-11-19 브리스톨-마이어스 스큅 컴퍼니 파르네소이드 x 수용체 조정제로서의 스피로시클릭 화합물
WO2021170811A1 (en) 2020-02-27 2021-09-02 Glaxosmithkline Intellectual Property (No.2) Limited Method of treating eye disease using trpv4 antagonists
WO2021221169A1 (en) 2020-04-30 2021-11-04 Raqualia Pharma Inc. Pyrimidin-4(3h)-one derivatives as trpv4 antagonists
CN111704613B (zh) * 2020-06-23 2021-07-06 中国人民解放军军事科学院军事医学研究院 咪唑类衍生物及其作为trpv4抑制剂的用途
KR20230041680A (ko) * 2020-07-16 2023-03-24 라퀄리아 파마 인코포레이티드 안구 질환 치료제로서의 trpv4 억제제
CA3261160A1 (en) 2022-07-08 2024-01-11 Actio Biosciences, Inc. COMPOUNDS AND THERAPEUTIC METHODS
WO2024217429A1 (zh) * 2023-04-18 2024-10-24 河北乌图药业有限公司 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用
CN120225516A (zh) * 2023-04-18 2025-06-27 河北乌图药业有限公司 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用
CN120641413A (zh) * 2023-04-18 2025-09-12 河北乌图药业有限公司 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用
WO2024217452A1 (zh) * 2023-04-18 2024-10-24 河北乌图药业有限公司 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用
CN121175303A (zh) * 2023-04-18 2025-12-19 河北乌图药业有限公司 化合物及其在慢性乙型肝炎、肝纤维化、肝癌的治疗中的应用
CN121511242A (zh) * 2023-07-07 2026-02-10 爱克堤欧生物科学股份有限公司 Trpv4拮抗剂的固体形式
CN117945917A (zh) * 2023-12-26 2024-04-30 衢州康鹏化学有限公司 一种3-氟-4-硝基苯甲酸的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE482945T1 (de) * 1998-05-26 2010-10-15 Chugai Pharmaceutical Co Ltd Heterozyklische indolderivate und mono- oder diazaindol-derivate
CA2531619A1 (en) * 2003-07-16 2005-01-27 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
WO2007059608A1 (en) * 2005-11-23 2007-05-31 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2007067756A2 (en) 2005-12-08 2007-06-14 Amphora Discovery Corporation Certain chemical entities, compositions, and methods for modulating trpv1
JP5858557B2 (ja) * 2005-12-22 2016-02-10 ハイドラ バイオサイエンシズ インコーポレイテッドHydra Biosciences,Inc. 疼痛を処置するためのtrpa1阻害剤
TW200819457A (en) * 2006-08-30 2008-05-01 Actelion Pharmaceuticals Ltd Spiro antibiotic derivatives
JP2010517967A (ja) * 2007-02-01 2010-05-27 グラクソ グループ リミテッド 摂食障害の治療のための1−オキサ−3−アザスピロ[4,5]デカン−2−オン誘導体
GB0707934D0 (en) * 2007-04-24 2007-05-30 Glaxo Group Ltd Chemical compounds
US7998982B2 (en) * 2007-08-09 2011-08-16 Abbott Laboratories Amide derivatives as TRPV1 antagonists
TW200944520A (en) * 2008-01-29 2009-11-01 Glaxo Group Ltd Spiro compounds as NPY Y5 receptor antagonists
JP5607046B2 (ja) * 2008-07-25 2014-10-15 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Trpv4拮抗薬
JP2012006837A (ja) * 2008-09-30 2012-01-12 Mochida Pharmaceut Co Ltd 2−インドールアクリルアミド類縁体
US8742110B2 (en) * 2010-08-18 2014-06-03 Merck Sharp & Dohme Corp. Spiroxazolidinone compounds
ES2571409T3 (es) * 2011-06-17 2016-05-25 Glaxosmithkline Intellectual Property (No 2) Ltd Antagonistas espiro-cíclicos de TRPV4
ES2595606T3 (es) * 2011-06-17 2017-01-02 Glaxosmithkline Intellectual Property (No. 2) Limited Antagonistas TRPV4

Also Published As

Publication number Publication date
PT2721016E (pt) 2016-06-06
EP2721016A4 (en) 2014-10-08
HK1195068A1 (zh) 2014-10-31
UA113963C2 (xx) 2017-04-10
MX2013014898A (es) 2014-03-21
IL229872A (en) 2017-03-30
MX337440B (es) 2016-03-03
EA201490037A1 (ru) 2015-12-30
CY1117792T1 (el) 2017-05-17
TWI538912B (zh) 2016-06-21
BR112013032391B1 (pt) 2020-11-24
MA35184B1 (fr) 2014-06-02
WO2013012500A1 (en) 2013-01-24
HRP20160539T1 (hr) 2016-06-17
CN103732583A (zh) 2014-04-16
TW201313705A (zh) 2013-04-01
PH12013502463A1 (en) 2014-01-20
AU2012284540A1 (en) 2013-04-04
PL2721016T3 (pl) 2017-01-31
SMT201600150B (it) 2016-07-01
SG195106A1 (en) 2013-12-30
JP5969017B2 (ja) 2016-08-10
ES2569193T3 (es) 2016-05-09
EP2721016A1 (en) 2014-04-23
CN103732583B (zh) 2015-12-23
EP3121177B1 (en) 2018-08-01
AU2012284540B2 (en) 2014-08-28
US9187464B2 (en) 2015-11-17
SI2721016T1 (sl) 2016-06-30
EA023616B1 (ru) 2016-06-30
NZ618221A (en) 2015-02-27
CA2839743A1 (en) 2013-01-24
JP2014518214A (ja) 2014-07-28
MY173521A (en) 2020-01-30
EP2721016B1 (en) 2016-04-06
PE20141943A1 (es) 2014-12-28
KR20140041733A (ko) 2014-04-04
CR20130671A (es) 2014-02-04
BR112013032391A2 (pt) 2016-08-16
KR101870003B1 (ko) 2018-06-22
US20140121206A1 (en) 2014-05-01
EP3121177A1 (en) 2017-01-25
CA2839743C (en) 2017-03-28
UY34138A (es) 2013-01-03
AR086958A1 (es) 2014-02-05
DK2721016T3 (en) 2016-06-06
CO6821953A2 (es) 2013-12-31
ZA201308816B (en) 2015-02-25
ME02416B (me) 2016-09-20
RS54858B1 (sr) 2016-10-31
HUE029594T2 (en) 2017-03-28
ES2688733T3 (es) 2018-11-06
JO3154B1 (ar) 2017-09-20
DOP2013000307A (es) 2014-06-01

Similar Documents

Publication Publication Date Title
CL2013003602A1 (es) Compuestos derivados de benzoimidazol (indol) de analogos de espirocarbamato o sus sales como antagonistas de trpv4; composicion farmaceutica que los comprende, util para el tratamiento de aterosclerosis, trastornos relacionados con edema intestinal, trastornos pulmonares, enfermedad cardiovascular, disfuncion renal, osteoartritis, entre otras.
CL2014001212A1 (es) Compuestos heterobiciclicos condensados, inhibidores de fosfodiesterasa tipo 10a; composicion farmaceutica que los comprende; y metodo para tratar un trastorno seleccionado entre trastornos neurologicos y trastornos psiquiatricos.
CL2014003277A1 (es) Compuestos derivados heterociclicos sustituidos por carboxamida o sulfonamida, como moduladores para el receptor nuclear huerfano rorgama; composicion farmaceutica que los comprende, util para el tratamiento de artritis reumatoide, lupus eritematoso, psoriasis, esclerosis multiple, diabetes tipo 1, colitis ulcerosa, enfermedad pulmonar obstructiva cronica, entre otras.
ECSP18048718A (es) Imidazolilimidazoles condensados como compuestos antivirales
CO6741217A2 (es) Modulares de receptor de glucagón
EA201200239A1 (ru) Бициклические арильные аналоги сфингозин 1-фосфата
GT201600085A (es) Composiciones y métodos para modular los receptores x farnesoides
CL2015000080A1 (es) Compuestos derivados de purinas macrociclicas y sus sales; composicion farmaceutica que los comprende, util para el tratamiento de un trastorno en el que interviene la modulacion de tlr7, tales como infecciones viricas, trastornos inmunitarios o inflamatorios.
CL2014002541A1 (es) Compuestos derivados de imidazol fusionado con heterociclos, como inhibidores de diacilglicerol aciltransferasa 2; composicion farmaceutica que los comprende, util para el tratamiento de diabetes tipo i y ii, enfermedad cardiaca coronaria, artritis, trombosis, alzheimer, entre otras enfermedades.
CO6990728A2 (es) 4-fenil-piridinas sustituidas para el tratamiento de enfermedades relacionadas con el receptor de nk1
CL2014000642A1 (es) Compuestos derivados de indazol-3-carboxamidas, como inhibidores de la ruta de señalizacion de wnt/b-catenina; composicion farmaceutica que los comprende; y su uso para el tratamiento de cancer, artritis reumatoide, infecciones micoticas y viricas, enfermedad de parkinson, un trastorno fibrotico, entre otras enfermedades.
CL2014000746A1 (es) Compuestos derivados de 3-pirimidin-4-il-oxazolidin-2-ona y sus sales, como inhibidores de las proteinas idh mutantes; composicion farmaceutica que los comprende, utiles para el tratamiento de trastornos de la proliferacion celular tal como el cancer.
CL2015000956A1 (es) Compuestos derivados de pirrolotriazinona como inhibidores de pi3k; composicion farmaceutica que los comprende; combinacion farmaceutica; uso para tratar enfermedades respiratorias, autoinmunes, trastornos neurologicos, cardiovasculares, metabolicos, entre otros.
MX2016014308A (es) Compuestos y composiciones como agonistas del receptor tipo toll 7.
ECSP11011517A (es) Compuestos antivirales
CL2014001205A1 (es) Compuestos derivados de purina, sus sales y solvatos farmaceuticamente aceptables; composicion farmaceutica que los comprende, util para el tratamiento de un trastorno en el que interviene la modulacion de tlr7, tal como infecciones viricas, trastornos inmunitarios o inflamatorios.
CL2014003388A1 (es) Compuestos derivados de triazolona, como inhibidores de mpges-1; proceso de preparacion de dichos compuestos; composicion farmaceutica que los comprende, util para el tratamiento de inflamacion, asma, epoc, artritis, enfermedad de parkinson y enfermedades autoinmunes, entre otras enfermedades.
GT201300123A (es) Sal(es) de dimetil-amida del acido 7-ciclopentil-2-(5-piperazin-1-il-piridin-2-il-amino)-7h-pirrolo-(2,3-d)-pirimidin-6-carboxilico y procesos para su elaboracion
EA201492281A1 (ru) Соединения n-арилтриазола в качестве антагонистов рецепторов лизофосфатидной кислоты (lpar)
CL2013002546A1 (es) Compuestos derivados de benzodioxano con actividad inhibidora de leucotrieno a4 hidrolasa(lat4h), composicion farmaceutica que los comprende, uso para preparar un medicamento para el tratamiento de enfermedades cardiovasculares tales como ateroesclerosis, infarto de miocardio, apoplejia, aneurisma de aorta, hipertension pulmonar arterial, entre otras.
ECSP10010296A (es) Derivados de alcanos azabiciclicos sustituidos con biarilo como moduladores de la actividad de los receptores nicotinicos de acetilcolina
CL2013003512A1 (es) Compuestos derivados de 7-(heterociclilo, arilo o heteroarilo) de piridopirazinas o sus sales; composicion farmaceutica que los comprende, utiles para el tratamiento de una enfermedad mediada por ptk quinasa tales como asma alergica, rinitis alergica, artritis reumatoide, esclerosis multiple, lupus, leucopenia, entre otras enfermedades.
ES2529890T8 (es) Agentes para el tratamiento de trastornos que implican la modulación de los receptores rianodina
EA201171488A1 (ru) Lxr модуляторы
DK3103797T3 (da) 2,5-dioxoimidazolidin-1-yl-3-phenylurinstofderivater som formylpeptidreceptor-lignende-1- (fprl-1) receptormodulatorer