CL2014001017A1 - Compuestos derivados de ciclohexilamina, agonistas ß2 y antagonistas muscarinicos m3; compuestos intermediarios; composicion farmaceutica que los comprende; metodo para tratar una condicion fisiologica o enfermedad; y producto de combinacion que comprende al compuesto y a un corticosteroide o un inhiidor de pde4. - Google Patents
Compuestos derivados de ciclohexilamina, agonistas ß2 y antagonistas muscarinicos m3; compuestos intermediarios; composicion farmaceutica que los comprende; metodo para tratar una condicion fisiologica o enfermedad; y producto de combinacion que comprende al compuesto y a un corticosteroide o un inhiidor de pde4.Info
- Publication number
- CL2014001017A1 CL2014001017A1 CL2014001017A CL2014001017A CL2014001017A1 CL 2014001017 A1 CL2014001017 A1 CL 2014001017A1 CL 2014001017 A CL2014001017 A CL 2014001017A CL 2014001017 A CL2014001017 A CL 2014001017A CL 2014001017 A1 CL2014001017 A1 CL 2014001017A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- corticosteroid
- cyclohexylamine
- agonists
- treat
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 3
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 title 2
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
- 229940124748 beta 2 agonist Drugs 0.000 title 1
- 239000013066 combination product Substances 0.000 title 1
- 229940127555 combination product Drugs 0.000 title 1
- 239000003246 corticosteroid Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003149 muscarinic antagonist Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
- 230000004962 physiological condition Effects 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11382343.9A EP2592077A1 (en) | 2011-11-11 | 2011-11-11 | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| US201161563911P | 2011-11-28 | 2011-11-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001017A1 true CL2014001017A1 (es) | 2014-06-06 |
Family
ID=45033907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001017A CL2014001017A1 (es) | 2011-11-11 | 2014-04-21 | Compuestos derivados de ciclohexilamina, agonistas ß2 y antagonistas muscarinicos m3; compuestos intermediarios; composicion farmaceutica que los comprende; metodo para tratar una condicion fisiologica o enfermedad; y producto de combinacion que comprende al compuesto y a un corticosteroide o un inhiidor de pde4. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20140303127A1 (es) |
| EP (2) | EP2592077A1 (es) |
| JP (1) | JP2014532749A (es) |
| KR (1) | KR20140093228A (es) |
| CN (1) | CN104024245A (es) |
| AR (1) | AR088829A1 (es) |
| AU (1) | AU2012333988A1 (es) |
| BR (1) | BR112014010577A2 (es) |
| CA (1) | CA2849872A1 (es) |
| CL (1) | CL2014001017A1 (es) |
| CO (1) | CO6940417A2 (es) |
| CR (1) | CR20140182A (es) |
| EA (1) | EA201400569A1 (es) |
| HK (1) | HK1197240A1 (es) |
| IL (1) | IL232478A0 (es) |
| MX (1) | MX2014004433A (es) |
| PE (1) | PE20141231A1 (es) |
| PH (1) | PH12014501057A1 (es) |
| SG (1) | SG11201401980YA (es) |
| UY (1) | UY34447A (es) |
| WO (1) | WO2013068554A1 (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20110083U1 (it) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | Piastra per la costruzione di carrelli per aeroplani |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| ES2750523T3 (es) | 2012-12-18 | 2020-03-26 | Almirall Sa | Derivados de ciclohexil y quinuclidinil carbamato que tienen actividades de agonista beta2 adrenérgicos y antagonistas muscarínicos M3 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TWI641373B (zh) * | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| TW201517906A (zh) * | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| US11435340B2 (en) | 2014-06-09 | 2022-09-06 | Biometry Inc. | Low cost test strip and method to measure analyte |
| US11175268B2 (en) | 2014-06-09 | 2021-11-16 | Biometry Inc. | Mini point of care gas chromatographic test strip and method to measure analytes |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| EP3487407B1 (en) | 2016-07-19 | 2024-10-02 | Biometry Inc. | Methods of and systems for measuring analytes using batch calibratable test strips |
| JP7013446B2 (ja) * | 2016-08-16 | 2022-02-15 | ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド | Ｇａｂａ（ａ）受容体モジュレーター、及び、喘息における気道過敏及び炎症を抑制するための方法 |
| CN106397149B (zh) * | 2016-08-26 | 2019-05-21 | 大连奇凯医药科技有限公司 | 五氟苯甲醛的制备方法 |
| JP7164542B2 (ja) | 2017-04-06 | 2022-11-01 | インベンティバ | 新規な化合物であるｙａｐ／ｔａｚ－ｔｅａｄ相互作用阻害剤、および悪性中皮腫の治療でのその使用 |
| CN108947949B (zh) * | 2017-05-19 | 2022-08-19 | 泰州华元医药科技有限公司 | 抗焦虑氘代化合物及其医药用途 |
| EP3632908A1 (en) | 2018-10-02 | 2020-04-08 | Inventiva | Inhibitors of the yap/taz-tead interaction and their use in the treatment of cancer |
| CN113544121A (zh) * | 2019-06-06 | 2021-10-22 | 中国医药研究开发中心有限公司 | 具有β2受体激动及M受体拮抗活性的杂环衍生物及其医药用途 |
| AU2020407664A1 (en) | 2019-12-20 | 2022-08-18 | Tenaya Therapeutics, Inc. | Fluoroalkyl-oxadiazoles and uses thereof |
| CA3196035A1 (en) | 2020-09-28 | 2022-03-31 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Fused tricyclic derivative and pharmaceutical application thereof |
| WO2022172296A1 (en) * | 2021-02-12 | 2022-08-18 | Gbr Laboratories Private Limited | A process for preparing navafenterol and intermediates thereof |
| AU2022270657A1 (en) | 2021-05-04 | 2023-11-16 | Tenaya Therapeutics, Inc. | 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef |
| CN119053593A (zh) * | 2022-03-25 | 2024-11-29 | 正大天晴药业集团股份有限公司 | 稠合三并环衍生物或其可药用盐的结晶 |
| WO2025245591A1 (en) * | 2024-05-31 | 2025-12-04 | Aché Laboratórios Farmacêuticos S.A. | Compounds, process for obtaining the compounds, intermediate compounds, reagent compounds, pharmaceutical compositions, pharmaceutical combinations, medicaments, uses and methods of treatment |
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| PT1616592E (pt) | 2004-07-16 | 2010-12-10 | Almirall Sa | Inalador para administração de fármacos em pó e um cartucho de pó para utilização com este inalador |
| TWI374883B (en) | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
| TW200811104A (en) | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
| US20080149110A1 (en) | 2006-12-22 | 2008-06-26 | Charles Craig Baldwin | Awake airway, including two variants |
| GB0702413D0 (en) * | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | New chemical compounds |
| WO2008149110A1 (en) | 2007-06-08 | 2008-12-11 | Argenta Discovery Limited | Bicyclor [2.2.1] hept-7-ylamine derivatives and their use in the treatment of diseases and conditions in which m3 muscarinic receptor activity and beta-adrenergic activity are implicated |
| PE20090907A1 (es) | 2007-07-21 | 2009-08-05 | Boehringer Ingelheim Int | Nuevos medicamentos pulverulentos que contienen tiotropio y salmeterol, asi como lactosa como excipiente |
| HRP20120968T1 (hr) | 2008-02-06 | 2013-01-31 | Astrazeneca Ab | Spojevi |
| EP2196465A1 (en) | 2008-12-15 | 2010-06-16 | Almirall, S.A. | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
-
2011
- 2011-11-11 EP EP11382343.9A patent/EP2592077A1/en not_active Withdrawn
-
2012
- 2012-11-09 WO PCT/EP2012/072311 patent/WO2013068554A1/en not_active Ceased
- 2012-11-09 EP EP12783239.2A patent/EP2776426A1/en not_active Withdrawn
- 2012-11-09 MX MX2014004433A patent/MX2014004433A/es unknown
- 2012-11-09 US US14/357,400 patent/US20140303127A1/en not_active Abandoned
- 2012-11-09 BR BR112014010577A patent/BR112014010577A2/pt not_active Application Discontinuation
- 2012-11-09 SG SG11201401980YA patent/SG11201401980YA/en unknown
- 2012-11-09 EA EA201400569A patent/EA201400569A1/ru unknown
- 2012-11-09 AU AU2012333988A patent/AU2012333988A1/en not_active Abandoned
- 2012-11-09 JP JP2014540485A patent/JP2014532749A/ja active Pending
- 2012-11-09 PH PH1/2014/501057A patent/PH12014501057A1/en unknown
- 2012-11-09 HK HK14110761.0A patent/HK1197240A1/xx unknown
- 2012-11-09 PE PE2014000514A patent/PE20141231A1/es not_active Application Discontinuation
- 2012-11-09 CN CN201280055204.4A patent/CN104024245A/zh active Pending
- 2012-11-09 KR KR1020147012483A patent/KR20140093228A/ko not_active Withdrawn
- 2012-11-09 CA CA2849872A patent/CA2849872A1/en not_active Abandoned
- 2012-11-09 AR ARP120104239A patent/AR088829A1/es unknown
- 2012-11-12 UY UY0001034447A patent/UY34447A/es not_active Application Discontinuation
-
2014
- 2014-04-14 CO CO14080688A patent/CO6940417A2/es unknown
- 2014-04-21 CL CL2014001017A patent/CL2014001017A1/es unknown
- 2014-04-23 CR CR20140182A patent/CR20140182A/es unknown
- 2014-05-05 IL IL232478A patent/IL232478A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012333988A1 (en) | 2014-05-29 |
| PH12014501057A1 (en) | 2014-06-16 |
| WO2013068554A1 (en) | 2013-05-16 |
| PE20141231A1 (es) | 2014-09-11 |
| HK1197240A1 (en) | 2015-01-09 |
| IL232478A0 (en) | 2014-06-30 |
| EP2592077A1 (en) | 2013-05-15 |
| US20140303127A1 (en) | 2014-10-09 |
| CO6940417A2 (es) | 2014-05-09 |
| KR20140093228A (ko) | 2014-07-25 |
| CR20140182A (es) | 2014-05-27 |
| JP2014532749A (ja) | 2014-12-08 |
| BR112014010577A2 (pt) | 2017-05-02 |
| CN104024245A (zh) | 2014-09-03 |
| EP2776426A1 (en) | 2014-09-17 |
| SG11201401980YA (en) | 2014-05-29 |
| CA2849872A1 (en) | 2013-05-16 |
| MX2014004433A (es) | 2014-06-05 |
| AR088829A1 (es) | 2014-07-10 |
| EA201400569A1 (ru) | 2014-10-30 |
| UY34447A (es) | 2013-06-28 |
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