CL2014001154A1 - Antibiotic derivative compounds of 2-oxo-oxazolidin-3,5-diyl of formula i; pharmaceutical composition; use for the prevention or treatment of a bacterial infection. - Google Patents
Antibiotic derivative compounds of 2-oxo-oxazolidin-3,5-diyl of formula i; pharmaceutical composition; use for the prevention or treatment of a bacterial infection.Info
- Publication number
- CL2014001154A1 CL2014001154A1 CL2014001154A CL2014001154A CL2014001154A1 CL 2014001154 A1 CL2014001154 A1 CL 2014001154A1 CL 2014001154 A CL2014001154 A CL 2014001154A CL 2014001154 A CL2014001154 A CL 2014001154A CL 2014001154 A1 CL2014001154 A1 CL 2014001154A1
- Authority
- CL
- Chile
- Prior art keywords
- oxazolidin
- diyl
- oxo
- prevention
- formula
- Prior art date
Links
- -1 2-oxo-oxazolidin-3,5-diyl Chemical group 0.000 title 1
- 208000035143 Bacterial infection Diseases 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
- 230000003115 biocidal effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2011054968 | 2011-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014001154A1 true CL2014001154A1 (en) | 2014-09-12 |
Family
ID=47258051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014001154A CL2014001154A1 (en) | 2011-11-08 | 2014-04-30 | Antibiotic derivative compounds of 2-oxo-oxazolidin-3,5-diyl of formula i; pharmaceutical composition; use for the prevention or treatment of a bacterial infection. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9079922B2 (en) |
| EP (1) | EP2776431B1 (en) |
| JP (1) | JP6030146B2 (en) |
| KR (1) | KR20140096337A (en) |
| AR (1) | AR088691A1 (en) |
| AU (1) | AU2012335207B2 (en) |
| BR (1) | BR112014011064A8 (en) |
| CA (1) | CA2854264A1 (en) |
| CL (1) | CL2014001154A1 (en) |
| ES (1) | ES2581056T3 (en) |
| HK (1) | HK1202288A1 (en) |
| IL (1) | IL232463A0 (en) |
| IN (1) | IN2014CN04126A (en) |
| MX (1) | MX344529B (en) |
| PH (1) | PH12014500831A1 (en) |
| PL (1) | PL2776431T3 (en) |
| RU (1) | RU2616609C2 (en) |
| SG (1) | SG11201401710PA (en) |
| TW (1) | TWI594996B (en) |
| WO (1) | WO2013068948A1 (en) |
| ZA (1) | ZA201404176B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101294962B1 (en) | 2008-10-07 | 2013-08-12 | 액테리온 파마슈티칼 리미티드 | tricyclic oxazolidinone antibiotic compounds |
| EA029361B1 (en) | 2013-04-16 | 2018-03-30 | Идорсиа Фармасьютиклз Лтд | Antibacterial biaromatic derivatives |
| AR096135A1 (en) | 2013-05-02 | 2015-12-09 | Actelion Pharmaceuticals Ltd | DERIVATIVES OF QUINOLONA |
| AR102256A1 (en) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | ANTIBACTERIAL BASIC BIAROMATIC DERIVATIVES WITH REPLACEMENT OF AMINOALCOXI |
| MA41169A (en) | 2014-12-17 | 2017-10-24 | Acraf | WIDE-SPECTRUM ANTIBACTERIAL COMPOUNDS |
| MA41168A (en) | 2014-12-17 | 2017-10-24 | Acraf | NEW ANTIBACTERIAL COMPOUNDS |
| GB201602235D0 (en) * | 2016-02-08 | 2016-03-23 | Redx Pharma Plc | Antibacterial compounds |
| US10487093B2 (en) | 2016-02-08 | 2019-11-26 | Redx Pharma Plc | Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds |
| EP3414246A1 (en) * | 2016-02-08 | 2018-12-19 | Redx Pharma PLC | Antibacterial compounds |
| DK3468975T3 (en) | 2016-06-08 | 2020-07-13 | Acraf | NEW ANTIBACTERIAL COMPOUNDS |
| TW201833120A (en) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | Aryloxazolidinone antibiotic compound |
| EP3634968B1 (en) * | 2017-06-08 | 2023-01-25 | Bugworks Research, Inc. | Heterocyclic compounds useful as anti-bacterial agents and method for production thereof |
| WO2019106693A1 (en) * | 2017-11-29 | 2019-06-06 | Bugworks Research India Pvt Ltd | Anti-bacterial heterocyclic compounds and their synthesis |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3149104A (en) | 1961-01-03 | 1964-09-15 | Sterling Drug Inc | 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters |
| CA1006521A (en) | 1972-12-18 | 1977-03-08 | Minoru Sugita | Piperazine derivatives and process for preparing them |
| SE444566B (en) | 1977-09-20 | 1986-04-21 | Bellon Labor Sa Roger | 7-DIALKYLAMINE-6-HALOGEN-4-OXO-1,4-DIHYDROQINOLINE-3-CARBOXYLIC ACID, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATION OF THEREOF |
| GB1598915A (en) | 1977-09-20 | 1981-09-23 | Bellon Labor Sa Roger | 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them |
| CS274601B2 (en) | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
| JPS62205060A (en) | 1986-03-04 | 1987-09-09 | Kyorin Pharmaceut Co Ltd | 8-substituted quinolonecarboxylic acid derivative |
| FI871419L (en) | 1986-03-31 | 1987-10-01 | Sankyo Co | QUINOLINE-3-CARBOXYLIC ACID DERIVATIVES, DERAS FRAMSTAELLNING OCH ANVAENDNING. |
| JP2631854B2 (en) | 1987-12-23 | 1997-07-16 | 藤本製薬株式会社 | Novel 1,8-naphthyridine derivative |
| DE4301246A1 (en) | 1993-01-19 | 1994-07-21 | Bayer Ag | Quinolone and naphthyridonecarboxylic acid derivatives |
| JPWO2004002973A1 (en) | 2002-06-28 | 2005-10-27 | 株式会社カネカ | Process for producing optically active 1-substituted amino-2,3-epoxypropane, synthetic intermediate thereof, and process for producing them |
| ES2308171T3 (en) * | 2003-04-30 | 2008-12-01 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | USE OF OXAZOLIDINONA-QUINOLIN HYBRID ANTIBIOTICS FOR THE TREATMENT OF ANTRAX AND OTHER INFECTIONS. |
| CA2549675C (en) * | 2003-12-18 | 2012-11-20 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Oxazolidinone-quinolone hybrid antibiotics |
| EP1771456A2 (en) | 2004-07-30 | 2007-04-11 | Palumed SA | Hybrid qa molecules wherein q is an aminoquinoline and a is an antibiotic residue, their synthesis and their uses as antibacterial agent |
| CA2578081A1 (en) | 2004-09-01 | 2006-03-09 | Ubitrak Inc. | System for gaming chip identification and counting |
| US20090156577A1 (en) | 2004-09-09 | 2009-06-18 | Benjamin Davis | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| WO2007118130A2 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Antibacterial agents |
| ATE544764T1 (en) * | 2006-11-10 | 2012-02-15 | Actelion Pharmaceuticals Ltd | 5-HYDROXYMETHYLOXAZOLIDINE-2-ONE DERIVATIVES |
| CL2008001002A1 (en) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION. |
| CL2008001003A1 (en) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION. |
| RU2492169C2 (en) * | 2007-12-18 | 2013-09-10 | Актелион Фармасьютиклз Лтд | 5-aminocyclylmethyloxazolidin-2-one derivatives |
| JP5404652B2 (en) * | 2008-02-22 | 2014-02-05 | アクテリオン ファーマシューティカルズ リミテッド | Oxazolidinone derivatives |
| KR101294962B1 (en) | 2008-10-07 | 2013-08-12 | 액테리온 파마슈티칼 리미티드 | tricyclic oxazolidinone antibiotic compounds |
| CA2738775A1 (en) * | 2008-10-10 | 2010-04-15 | Actelion Pharmaceuticals Ltd | 2-benzothiophenyl-and 2-naphthyl-0xaz0lidin0nes and their azaisostere analogues as antibacterial agents |
| MX2011003188A (en) * | 2008-10-10 | 2011-04-27 | Actelion Pharmaceuticals Ltd | Oxazolidinyl antibiotics. |
| TW201121965A (en) | 2009-09-28 | 2011-07-01 | Lg Life Sciences Ltd | Use of a quinolone derivative containing 7-(4-aminomethyl-3-oxime)pyrrolidine group that is capable of inducing granulocyte colony stimulating factor for treatment of neutropenia and recovery of hematopoiesis |
| CN101792443A (en) | 2010-03-09 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | Fluoro-carbostyril derivative as well as preparation method and application thereof |
-
2012
- 2012-11-07 JP JP2014540612A patent/JP6030146B2/en not_active Expired - Fee Related
- 2012-11-07 MX MX2014005637A patent/MX344529B/en active IP Right Grant
- 2012-11-07 EP EP12791863.9A patent/EP2776431B1/en not_active Not-in-force
- 2012-11-07 BR BR112014011064A patent/BR112014011064A8/en not_active Application Discontinuation
- 2012-11-07 US US14/356,896 patent/US9079922B2/en not_active Expired - Fee Related
- 2012-11-07 PL PL12791863.9T patent/PL2776431T3/en unknown
- 2012-11-07 HK HK15102622.5A patent/HK1202288A1/en unknown
- 2012-11-07 RU RU2014123109A patent/RU2616609C2/en not_active IP Right Cessation
- 2012-11-07 IN IN4126CHN2014 patent/IN2014CN04126A/en unknown
- 2012-11-07 PH PH1/2014/500831A patent/PH12014500831A1/en unknown
- 2012-11-07 WO PCT/IB2012/056236 patent/WO2013068948A1/en not_active Ceased
- 2012-11-07 TW TW101141423A patent/TWI594996B/en not_active IP Right Cessation
- 2012-11-07 SG SG11201401710PA patent/SG11201401710PA/en unknown
- 2012-11-07 KR KR1020147014957A patent/KR20140096337A/en not_active Abandoned
- 2012-11-07 AR ARP120104192A patent/AR088691A1/en unknown
- 2012-11-07 AU AU2012335207A patent/AU2012335207B2/en not_active Ceased
- 2012-11-07 ES ES12791863.9T patent/ES2581056T3/en active Active
- 2012-11-07 CA CA2854264A patent/CA2854264A1/en not_active Abandoned
-
2014
- 2014-04-30 CL CL2014001154A patent/CL2014001154A1/en unknown
- 2014-05-05 IL IL232463A patent/IL232463A0/en unknown
- 2014-06-06 ZA ZA2014/04176A patent/ZA201404176B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IN2014CN04126A (en) | 2015-07-10 |
| MX2014005637A (en) | 2014-06-23 |
| JP6030146B2 (en) | 2016-11-24 |
| RU2014123109A (en) | 2015-12-20 |
| TWI594996B (en) | 2017-08-11 |
| KR20140096337A (en) | 2014-08-05 |
| JP2014532754A (en) | 2014-12-08 |
| AU2012335207B2 (en) | 2017-05-25 |
| EP2776431A1 (en) | 2014-09-17 |
| PL2776431T3 (en) | 2016-11-30 |
| PH12014500831A1 (en) | 2019-08-07 |
| AU2012335207A1 (en) | 2014-07-03 |
| BR112014011064A2 (en) | 2017-06-13 |
| IL232463A0 (en) | 2014-06-30 |
| ES2581056T3 (en) | 2016-08-31 |
| WO2013068948A1 (en) | 2013-05-16 |
| HK1202288A1 (en) | 2015-09-25 |
| BR112014011064A8 (en) | 2017-12-26 |
| EP2776431B1 (en) | 2016-05-04 |
| SG11201401710PA (en) | 2014-09-26 |
| MX344529B (en) | 2016-12-19 |
| CN103917539A (en) | 2014-07-09 |
| RU2616609C2 (en) | 2017-04-18 |
| TW201326166A (en) | 2013-07-01 |
| ZA201404176B (en) | 2016-05-25 |
| US9079922B2 (en) | 2015-07-14 |
| US20150051188A1 (en) | 2015-02-19 |
| CA2854264A1 (en) | 2013-05-16 |
| AR088691A1 (en) | 2014-06-25 |
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