CL2014001823A1 - Procedimiento de preparacion estereoselectiva de un compuesto derivado de 9-hidroxi-5-oxo-1,4-diaza-espiro [5.5] undecano; compuestos intermediarios; uso en el tratamiento de enfermedades tumorales, enfermedades del pulmon y de las vias respiratorias. - Google Patents

Procedimiento de preparacion estereoselectiva de un compuesto derivado de 9-hidroxi-5-oxo-1,4-diaza-espiro [5.5] undecano; compuestos intermediarios; uso en el tratamiento de enfermedades tumorales, enfermedades del pulmon y de las vias respiratorias.

Info

Publication number
CL2014001823A1
CL2014001823A1 CL2014001823A CL2014001823A CL2014001823A1 CL 2014001823 A1 CL2014001823 A1 CL 2014001823A1 CL 2014001823 A CL2014001823 A CL 2014001823A CL 2014001823 A CL2014001823 A CL 2014001823A CL 2014001823 A1 CL2014001823 A1 CL 2014001823A1
Authority
CL
Chile
Prior art keywords
diseases
undecano
diaza
spiro
oxo
Prior art date
Application number
CL2014001823A
Other languages
English (en)
Inventor
Juergen Schnaubelt
Wenjun Tang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2014001823A1 publication Critical patent/CL2014001823A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CL2014001823A 2012-02-09 2014-07-09 Procedimiento de preparacion estereoselectiva de un compuesto derivado de 9-hidroxi-5-oxo-1,4-diaza-espiro [5.5] undecano; compuestos intermediarios; uso en el tratamiento de enfermedades tumorales, enfermedades del pulmon y de las vias respiratorias. CL2014001823A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12154688 2012-02-09

Publications (1)

Publication Number Publication Date
CL2014001823A1 true CL2014001823A1 (es) 2015-03-06

Family

ID=47678813

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014001823A CL2014001823A1 (es) 2012-02-09 2014-07-09 Procedimiento de preparacion estereoselectiva de un compuesto derivado de 9-hidroxi-5-oxo-1,4-diaza-espiro [5.5] undecano; compuestos intermediarios; uso en el tratamiento de enfermedades tumorales, enfermedades del pulmon y de las vias respiratorias.

Country Status (14)

Country Link
US (1) US8629146B2 (es)
EP (1) EP2812317B1 (es)
JP (1) JP6105631B2 (es)
KR (1) KR20140128318A (es)
CN (1) CN104080775A (es)
AU (1) AU2013218119A1 (es)
BR (1) BR112014019196A8 (es)
CA (1) CA2862520A1 (es)
CL (1) CL2014001823A1 (es)
EA (1) EA201400882A1 (es)
IL (1) IL233370A (es)
MX (1) MX2014009033A (es)
PH (1) PH12014501760B1 (es)
WO (1) WO2013117568A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4575507A (en) * 1985-05-29 1986-03-11 Pfizer Inc. Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JP4776882B2 (ja) 2002-03-30 2011-09-21 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 二環式複素環化合物、これらの化合物を含む医薬組成物、それらの使用及びそれらの調製方法
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
JP2009518450A (ja) 2005-12-12 2009-05-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 二環式複素環化合物、その化合物を含む薬剤、その使用及び製造方法
US8497369B2 (en) * 2008-02-07 2013-07-30 Boehringer Ingelheim International Gmbh Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production
EP2289881A1 (de) * 2009-08-06 2011-03-02 Boehringer Ingelheim International GmbH Verfahren zur stereoselektiven Synthese bicyclischer Heterocyclen
AP3531A (en) 2011-02-01 2016-01-13 Boehringer Ingelheim Int 9-[4-(3-chlor-2-fluor-phenylamino)-7-methoxy-quinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one dimaleate, use thereof as a drug, and production thereof

Also Published As

Publication number Publication date
JP2015506966A (ja) 2015-03-05
KR20140128318A (ko) 2014-11-05
IL233370A0 (en) 2014-08-31
US20130211081A1 (en) 2013-08-15
PH12014501760A1 (en) 2014-11-10
PH12014501760B1 (en) 2014-11-10
US8629146B2 (en) 2014-01-14
WO2013117568A1 (de) 2013-08-15
AU2013218119A1 (en) 2014-07-17
CA2862520A1 (en) 2013-08-15
EA201400882A1 (ru) 2015-01-30
MX2014009033A (es) 2014-10-17
EP2812317A1 (de) 2014-12-17
BR112014019196A8 (pt) 2017-07-11
BR112014019196A2 (es) 2017-06-20
IL233370A (en) 2015-04-30
EP2812317B1 (de) 2016-02-03
JP6105631B2 (ja) 2017-03-29
CN104080775A (zh) 2014-10-01

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