CL2014002257A1 - Compuestos derivados de 6-alquinilo piridinas, como mimeticos smac; composicion farmaceutica que los comprende; y su uso para el tratamiento y/o prevencion del cancer. - Google Patents

Compuestos derivados de 6-alquinilo piridinas, como mimeticos smac; composicion farmaceutica que los comprende; y su uso para el tratamiento y/o prevencion del cancer.

Info

Publication number: CL2014002257A1
Authority: CL; Chile
Prior art keywords: cancer; prevention; treatment; pharmaceutical composition; compounds derived
Prior art date: 2012-02-27

Application number

CL2014002257A

Other languages

English (en)

Inventor

Ulrich Reiser

Gerd Bader

Walter Spevak

Andreas Steffen

Alastair L Parkes

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-02-27

Filing date

2014-08-25

Publication date

2014-12-05

2014-08-25 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2014-12-05 Publication of CL2014002257A1 publication Critical patent/CL2014002257A1/es

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

CL2014002257A 2012-02-27 2014-08-25 Compuestos derivados de 6-alquinilo piridinas, como mimeticos smac; composicion farmaceutica que los comprende; y su uso para el tratamiento y/o prevencion del cancer. CL2014002257A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP12157199		2012-02-27

Publications (1)

Publication Number	Publication Date
CL2014002257A1 true CL2014002257A1 (es)	2014-12-05

Family

ID=47748636

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2014002257A CL2014002257A1 (es)	2012-02-27	2014-08-25	Compuestos derivados de 6-alquinilo piridinas, como mimeticos smac; composicion farmaceutica que los comprende; y su uso para el tratamiento y/o prevencion del cancer.

Country Status (39)

Country	Link
US (1)	US8859541B2 (es)
EP (1)	EP2819996B1 (es)
JP (1)	JP5969054B2 (es)
KR (1)	KR102038585B1 (es)
CN (1)	CN104169257B (es)
AP (1)	AP3999A (es)
AR (1)	AR090159A1 (es)
AU (1)	AU2013225173B2 (es)
BR (1)	BR112014021027B1 (es)
CA (1)	CA2865467C (es)
CL (1)	CL2014002257A1 (es)
CO (1)	CO7061075A2 (es)
CY (1)	CY1118859T1 (es)
DK (1)	DK2819996T3 (es)
EA (1)	EA026497B1 (es)
EC (1)	ECSP14018375A (es)
ES (1)	ES2619958T3 (es)
GE (2)	GEAP201813584A (es)
HR (1)	HRP20170536T1 (es)
HU (1)	HUE031992T2 (es)
IL (1)	IL234106A (es)
IN (1)	IN2014DN06896A (es)
LT (1)	LT2819996T (es)
ME (1)	ME02627B (es)
MX (1)	MX345493B (es)
MY (1)	MY170938A (es)
NZ (1)	NZ628583A (es)
PE (1)	PE20141828A1 (es)
PH (1)	PH12014501913A1 (es)
PL (1)	PL2819996T3 (es)
PT (1)	PT2819996T (es)
RS (1)	RS55793B1 (es)
SG (1)	SG11201405230XA (es)
SI (1)	SI2819996T1 (es)
TN (1)	TN2014000361A1 (es)
TW (1)	TWI586649B (es)
UA (1)	UA113077C2 (es)
UY (1)	UY34643A (es)
WO (1)	WO2013127729A1 (es)

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Publication number	Priority date	Publication date	Assignee	Title
US9278978B2 (en)	2013-08-23	2016-03-08	Boehringer Ingelheim International Gmbh	6-Alkynyl Pyridine
WO2015130922A2 (en) *	2014-02-26	2015-09-03	The Trustees Of The University Of Pennsylvania	Small molecule hsp70 inhibitors
AR101479A1 (es)	2014-08-11	2016-12-21	Boehringer Ingelheim Int	Derivados de 6-alquinil-piridina
WO2016079527A1 (en)	2014-11-19	2016-05-26	Tetralogic Birinapant Uk Ltd	Combination therapy
WO2016097773A1 (en)	2014-12-19	2016-06-23	Children's Cancer Institute	Therapeutic iap antagonists for treating proliferative disorders
JP6533997B2 (ja) *	2014-12-26	2019-06-26	株式会社ヤクルト本社	Ｚｎｆ１４３阻害活性を有する化合物およびその利用
ES2774501T3 (es)	2015-05-18	2020-07-21	Sun Pharma Advanced Res Co Ltd	Etinos de amidoheteroaril aroil hidrazida novedosos
JP2019516681A (ja) *	2016-05-04	2019-06-20	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法
AU2017266291B2 (en)	2016-05-19	2021-07-01	Boehringer Ingelheim International Gmbh	Process for the manufacture of 6-alkynyl-pyridine derivatives
RU2768887C2 (ru) *	2017-03-15	2022-03-25	Сан Фарма Эдвансд Рисёч Компани Лимитед	Новая аморфная дисперсия (5-{ 5-[n'-(2-хлор-6-метилбензоил)гидразинокарбонил]-2-метил-фенилэтинил} -пиридин-2-ил)амида циклопропанкарбоновой кислоты
AU2018241944A1 (en) *	2017-03-31	2019-08-15	Boehringer Ingelheim International Gmbh	Anticancer combination therapy
MX2020003242A (es)	2017-09-22	2020-09-18	Jubilant Epipad LLC	Compuestos heterociclicos como inhibidores de pad.
AU2018352142B2 (en)	2017-10-18	2022-08-25	Jubilant Epipad LLC	Imidazo-pyridine compounds as PAD inhibitors
KR20200085836A (ko)	2017-11-06	2020-07-15	주빌런트 프로델 엘엘씨	Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체
BR112020010322A2 (pt)	2017-11-24	2020-11-17	Jubilant Episcribe Llc	composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer
SG11202008950PA (en)	2018-03-13	2020-10-29	Jubilant Prodel LLC	Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
CN113453678A (zh)	2018-11-26	2021-09-28	德彪药业国际股份公司	Hiv感染的联合治疗
TWI894135B (zh)	2019-01-25	2025-08-21	德商百靈佳殷格翰國際股份有限公司	編碼ccl21之重組棒狀病毒
MX2022003628A (es)	2019-09-25	2022-07-21	Debiopharm Int Sa	Regímenes de dosificación para el tratamiento de pacientes con carcinoma de células escamosas avanzado localmente.
BR112022023753A2 (pt)	2020-06-03	2022-12-20	Boehringer Ingelheim Int	Rhabdovírus recombinante que codifica para uma proteína de fusão fc de domínio extracelular cd80
EP4361146A4 (en) *	2021-06-22	2025-06-18	Alchemedicine, Inc.	Compound, endothelin-a receptor antagonist and pharmaceutical composition

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WO2004005248A1 (en) *	2002-07-02	2004-01-15	Novartis Ag	Peptide inhibitors of smac protein binding to inhibitor of apoptosis proteins (iap)
US20060205740A1 (en) *	2003-08-14	2006-09-14	Reno Michael J	Chemical compounds
JP2008545780A (ja) *	2005-06-08	2008-12-18	ノバルティスアクチエンゲゼルシャフト	有機化合物
WO2007101347A1 (en)	2006-03-07	2007-09-13	Aegera Therapeutics Inc.	Bir domain binding compounds
PE20110220A1 (es) *	2006-08-02	2011-04-11	Novartis Ag	DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS
ATE542798T1 (de)	2006-12-07	2012-02-15	Novartis Ag	Organische verbindungen
JP2012500272A (ja) *	2008-08-16	2012-01-05	ジェネンテック，インコーポレイテッド	Ｉａｐのアザインドールインヒビター

2013
- 2013-02-19 US US13/769,934 patent/US8859541B2/en active Active
- 2013-02-25 ME MEP-2017-53A patent/ME02627B/me unknown
- 2013-02-25 JP JP2014558141A patent/JP5969054B2/ja active Active
- 2013-02-25 WO PCT/EP2013/053689 patent/WO2013127729A1/en not_active Ceased
- 2013-02-25 NZ NZ628583A patent/NZ628583A/en unknown
- 2013-02-25 HU HUE13705799A patent/HUE031992T2/en unknown
- 2013-02-25 LT LTEP13705799.8T patent/LT2819996T/lt unknown
- 2013-02-25 SG SG11201405230XA patent/SG11201405230XA/en unknown
- 2013-02-25 PL PL13705799T patent/PL2819996T3/pl unknown
- 2013-02-25 GE GEAP201813584A patent/GEAP201813584A/en unknown
- 2013-02-25 BR BR112014021027-6A patent/BR112014021027B1/pt active IP Right Grant
- 2013-02-25 AP AP2014007873A patent/AP3999A/en active
- 2013-02-25 HR HRP20170536TT patent/HRP20170536T1/hr unknown
- 2013-02-25 EP EP13705799.8A patent/EP2819996B1/en active Active
- 2013-02-25 CN CN201380011072.XA patent/CN104169257B/zh active Active
- 2013-02-25 AU AU2013225173A patent/AU2013225173B2/en active Active
- 2013-02-25 SI SI201330585A patent/SI2819996T1/sl unknown
- 2013-02-25 RS RS20170250A patent/RS55793B1/sr unknown
- 2013-02-25 UA UAA201410431A patent/UA113077C2/uk unknown
- 2013-02-25 GE GEAP201313584A patent/GEP20186899B/en unknown
- 2013-02-25 KR KR1020147026641A patent/KR102038585B1/ko active Active
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- 2013-02-25 PE PE2014001306A patent/PE20141828A1/es not_active Application Discontinuation
- 2013-02-25 CA CA2865467A patent/CA2865467C/en active Active
- 2013-02-25 MY MYPI2014002481A patent/MY170938A/en unknown
- 2013-02-25 DK DK13705799.8T patent/DK2819996T3/en active
- 2013-02-25 MX MX2014010249A patent/MX345493B/es active IP Right Grant
- 2013-02-25 IN IN6896DEN2014 patent/IN2014DN06896A/en unknown
- 2013-02-25 PT PT137057998T patent/PT2819996T/pt unknown
- 2013-02-25 ES ES13705799.8T patent/ES2619958T3/es active Active
- 2013-02-26 TW TW102106769A patent/TWI586649B/zh not_active IP Right Cessation
- 2013-02-26 AR ARP130100586A patent/AR090159A1/es unknown
- 2013-02-27 UY UY0001034643A patent/UY34643A/es unknown
2014
- 2014-08-13 IL IL234106A patent/IL234106A/en active IP Right Grant
- 2014-08-25 CL CL2014002257A patent/CL2014002257A1/es unknown
- 2014-08-26 TN TNP2014000361A patent/TN2014000361A1/fr unknown
- 2014-08-26 PH PH12014501913A patent/PH12014501913A1/en unknown
- 2014-08-27 CO CO14188599A patent/CO7061075A2/es unknown
- 2014-09-11 EC ECIEPI201418375A patent/ECSP14018375A/es unknown
2017
- 2017-03-16 CY CY20171100329T patent/CY1118859T1/el unknown

Also Published As

Publication number	Publication date
GEAP201813584A (en)	2018-06-25
GEP20186899B (en)	2018-10-10
AU2013225173A1 (en)	2014-08-28
CY1118859T1 (el)	2018-01-10
CA2865467A1 (en)	2013-09-06
KR102038585B1 (ko)	2019-10-30
RS55793B1 (sr)	2017-08-31
EA026497B1 (ru)	2017-04-28
MX2014010249A (es)	2014-11-12
HUE031992T2 (en)	2017-08-28
JP2015512879A (ja)	2015-04-30
AU2013225173B2 (en)	2017-02-23
US20130225567A1 (en)	2013-08-29
IL234106A (en)	2017-08-31
PH12014501913B1 (en)	2014-11-24
MX345493B (es)	2017-02-02
BR112014021027A2 (es)	2017-06-20
CA2865467C (en)	2020-12-01
CN104169257A (zh)	2014-11-26
EP2819996A1 (en)	2015-01-07
DK2819996T3 (en)	2017-04-10
TW201348205A (zh)	2013-12-01
US8859541B2 (en)	2014-10-14
ME02627B (me)	2017-06-20
PT2819996T (pt)	2017-04-04
ES2619958T3 (es)	2017-06-27
KR20140129266A (ko)	2014-11-06
EP2819996B1 (en)	2017-01-04
PL2819996T3 (pl)	2017-07-31
CO7061075A2 (es)	2014-09-19
SG11201405230XA (en)	2014-09-26
TWI586649B (zh)	2017-06-11
IL234106A0 (en)	2014-09-30
CN104169257B (zh)	2017-01-18
AP3999A (en)	2017-01-12
BR112014021027B1 (pt)	2022-07-12
AR090159A1 (es)	2014-10-22
ECSP14018375A (es)	2015-09-30
HRP20170536T1 (hr)	2017-06-02
TN2014000361A1 (en)	2015-12-21
JP5969054B2 (ja)	2016-08-10
PH12014501913A1 (en)	2014-11-24
NZ628583A (en)	2016-03-31
UY34643A (es)	2013-09-02
PE20141828A1 (es)	2014-12-05
AP2014007873A0 (en)	2014-08-31
LT2819996T (lt)	2017-03-10
MY170938A (en)	2019-09-19
WO2013127729A1 (en)	2013-09-06
UA113077C2 (xx)	2016-12-12
SI2819996T1 (sl)	2017-04-26
HK1201267A1 (en)	2015-08-28
IN2014DN06896A (es)	2015-05-15
EA201400965A1 (ru)	2015-01-30

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