CL2014002403A1 - Method for enantioselective preparation and purification of 2 (s) -amino-6-boronohexanoic acid (abh) from the dissolution of bpb-ni-gly in tetrahydrofuran, neutralization and subsequent extraction with dichloromethane, dissolution in a C1-C5 alcohol , cooling to achieve bpb precipitation, obtaining abh and its subsequent purification. - Google Patents

Method for enantioselective preparation and purification of 2 (s) -amino-6-boronohexanoic acid (abh) from the dissolution of bpb-ni-gly in tetrahydrofuran, neutralization and subsequent extraction with dichloromethane, dissolution in a C1-C5 alcohol , cooling to achieve bpb precipitation, obtaining abh and its subsequent purification.

Info

Publication number: CL2014002403A1
Authority: CL; Chile
Prior art keywords: abh; bpb; dissolution; purification; subsequent
Prior art date: 2014-09-11

Application number

CL2014002403A

Other languages

Spanish (es)

Inventor

Marcelo Daniel Preite

Mujica Juan Manuel Manriquez

Vargas Jordan Mauricio Correa

Aguera Rodrigo Manuel Iturriaga

Toledo Paola Cecilia Casanello

Leyton Bernardo Javier Krause

Original Assignee

Univ Pontificia Catolica Chile

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-09-11

Filing date

2014-09-11

Publication date

2015-01-09

2014-09-11 Application filed by Univ Pontificia Catolica Chile filed Critical Univ Pontificia Catolica Chile

2014-09-11 Priority to CL2014002403A priority Critical patent/CL2014002403A1/en

2015-01-09 Publication of CL2014002403A1 publication Critical patent/CL2014002403A1/en

2015-08-20 Priority to PCT/CL2015/050035 priority patent/WO2016037298A1/en

Links

YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 title 3
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title 2
238000004090 dissolution Methods 0.000 title 2
238000000746 purification Methods 0.000 title 2
HFKKMXCOJQIYAH-YFKPBYRVSA-N (S)-2-amino-6-boronohexanoic acid Chemical compound OC(=O)[C@@H](N)CCCCB(O)O HFKKMXCOJQIYAH-YFKPBYRVSA-N 0.000 title 1
238000001816 cooling Methods 0.000 title 1
238000000605 extraction Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
238000006386 neutralization reaction Methods 0.000 title 1
238000001556 precipitation Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CL2014002403A 2014-09-11 2014-09-11 Method for enantioselective preparation and purification of 2 (s) -amino-6-boronohexanoic acid (abh) from the dissolution of bpb-ni-gly in tetrahydrofuran, neutralization and subsequent extraction with dichloromethane, dissolution in a C1-C5 alcohol , cooling to achieve bpb precipitation, obtaining abh and its subsequent purification. CL2014002403A1 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
CL2014002403A CL2014002403A1 (en)	2014-09-11	2014-09-11	Method for enantioselective preparation and purification of 2 (s) -amino-6-boronohexanoic acid (abh) from the dissolution of bpb-ni-gly in tetrahydrofuran, neutralization and subsequent extraction with dichloromethane, dissolution in a C1-C5 alcohol , cooling to achieve bpb precipitation, obtaining abh and its subsequent purification.
PCT/CL2015/050035 WO2016037298A1 (en)	2014-09-11	2015-08-20	Method for the enantioselective synthesis of 2(s)-amino-6-boronohexanoic acid (abh) and purification thereof

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CL2014002403A CL2014002403A1 (en)	2014-09-11	2014-09-11	Method for enantioselective preparation and purification of 2 (s) -amino-6-boronohexanoic acid (abh) from the dissolution of bpb-ni-gly in tetrahydrofuran, neutralization and subsequent extraction with dichloromethane, dissolution in a C1-C5 alcohol , cooling to achieve bpb precipitation, obtaining abh and its subsequent purification.

Publications (1)

Publication Number	Publication Date
CL2014002403A1 true CL2014002403A1 (en)	2015-01-09

Family

ID=53404015

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL2014002403A CL2014002403A1 (en)	2014-09-11	2014-09-11	Method for enantioselective preparation and purification of 2 (s) -amino-6-boronohexanoic acid (abh) from the dissolution of bpb-ni-gly in tetrahydrofuran, neutralization and subsequent extraction with dichloromethane, dissolution in a C1-C5 alcohol , cooling to achieve bpb precipitation, obtaining abh and its subsequent purification.

Country Status (2)

Country	Link
CL (1)	CL2014002403A1 (en)
WO (1)	WO2016037298A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2019173188A1 (en)	2018-03-05	2019-09-12	Arcus Biosciences, Inc.	Arginase inhibitors
EP3880685B1 (en)	2018-11-16	2025-06-18	Arcus Biosciences, Inc.	Inhibitors of arg1 and/or arg2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU9797998A (en) *	1997-10-10	1999-05-03	Trustees Of The University Of Pennsylvania, The	Compositions and methods for inhibiting arginase activity

2014
- 2014-09-11 CL CL2014002403A patent/CL2014002403A1/en unknown
2015
- 2015-08-20 WO PCT/CL2015/050035 patent/WO2016037298A1/en not_active Ceased

Also Published As

Publication number	Publication date
WO2016037298A1 (en)	2016-03-17

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