CL2014002929A1 - Composicion que comprende ácido poliinosínico - policitidílico (poli (i:c) ) y un polimero portador; y sus usos para el tratamiento de infecciones de las vías respiratorias altas. - Google Patents
Composicion que comprende ácido poliinosínico - policitidílico (poli (i:c) ) y un polimero portador; y sus usos para el tratamiento de infecciones de las vías respiratorias altas.Info
- Publication number
- CL2014002929A1 CL2014002929A1 CL2014002929A CL2014002929A CL2014002929A1 CL 2014002929 A1 CL2014002929 A1 CL 2014002929A1 CL 2014002929 A CL2014002929 A CL 2014002929A CL 2014002929 A CL2014002929 A CL 2014002929A CL 2014002929 A1 CL2014002929 A1 CL 2014002929A1
- Authority
- CL
- Chile
- Prior art keywords
- polyinosinic
- poly
- treatment
- composition
- upper respiratory
- Prior art date
Links
- 206010057190 Respiratory tract infections Diseases 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 229940115272 polyinosinic:polycytidylic acid Drugs 0.000 title 1
- 229920000642 polymer Polymers 0.000 title 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Otolaryngology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12166595 | 2012-05-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014002929A1 true CL2014002929A1 (es) | 2015-01-16 |
Family
ID=48430695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014002929A CL2014002929A1 (es) | 2012-05-03 | 2014-10-29 | Composicion que comprende ácido poliinosínico - policitidílico (poli (i:c) ) y un polimero portador; y sus usos para el tratamiento de infecciones de las vías respiratorias altas. |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9682096B2 (es) |
| EP (1) | EP2846767B1 (es) |
| JP (1) | JP6349304B2 (es) |
| KR (1) | KR102240042B1 (es) |
| CN (1) | CN104394846B (es) |
| AU (1) | AU2013255885C1 (es) |
| BR (1) | BR112014026957A8 (es) |
| CA (1) | CA2866230C (es) |
| CL (1) | CL2014002929A1 (es) |
| CO (1) | CO7101247A2 (es) |
| ES (1) | ES2911116T3 (es) |
| IN (1) | IN2014MN02359A (es) |
| MX (1) | MX2014013256A (es) |
| NZ (1) | NZ630040A (es) |
| RU (1) | RU2650636C2 (es) |
| SG (2) | SG10201607288VA (es) |
| WO (1) | WO2013164380A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2650636C2 (ru) | 2012-05-03 | 2018-04-16 | Янссен Сайенсиз Айрлэнд Юси | Составы на основе полиинозиновой-полицитидиловой кислоты (poly(i:с)) для лечения инфекций верхних дыхательных путей |
| CN105939709A (zh) * | 2013-11-06 | 2016-09-14 | 爱尔兰詹森科学公司 | 用于治疗上呼吸道感染的聚肌苷酸-聚胞苷酸(Poly(I:C))制剂 |
| GB201415381D0 (en) * | 2014-08-29 | 2014-10-15 | Algipharma As | Inhalable powder formulations of alginate oligomers |
| HK1251926A1 (zh) * | 2015-05-11 | 2019-05-03 | Janssen Sciences Ireland Uc | 用於预防和/或治疗上呼吸道感染的聚肌苷酸-聚胞苷酸(聚(i:c))豌豆淀粉制剂 |
| GB2555364A (en) | 2015-11-17 | 2018-04-25 | Grund IP Group | Novel pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and polyalkyleneimine |
| JP2018535277A (ja) * | 2015-11-30 | 2018-11-29 | ノヴァス・セラピューティクス・インコーポレーテッド | 耳科学的予防および処置のための組成物および方法 |
| CN110177545A (zh) | 2016-11-16 | 2019-08-27 | 爱尔兰詹森科学公司 | 用于预防上呼吸道感染的聚肌苷酸和聚胞苷酸的制剂 |
| US10849921B2 (en) | 2017-05-17 | 2020-12-01 | Bioncotech Therapeutics Sl | Pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine |
| CA3105281A1 (en) | 2018-06-29 | 2020-01-02 | Xinfu (Beijing) Medical Technology Co., Ltd. | Complex for enhancing immune response |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8723846D0 (en) | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
| US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| KR100259989B1 (ko) | 1991-10-01 | 2000-08-01 | 모리다 가쓰라 | 서방성 마이크로캡슐 제제 및 그의 제조법 |
| GB9606188D0 (en) * | 1996-03-23 | 1996-05-29 | Danbiosyst Uk | Pollysaccharide microspheres for the pulmonary delivery of drugs |
| MY118835A (en) | 1997-04-18 | 2005-01-31 | Ipsen Pharma Biotech | Sustained release compositions and the process for their preparation |
| CA2203843C (en) * | 1997-04-28 | 2013-07-23 | Her Majesty The Queen, In Right Of Canada, As Represented By The Ministe R Of National Defence | Liposome-encapsulated poly iclc |
| MA25590A1 (fr) * | 1998-09-14 | 2002-12-31 | Inhale Therapeutic Syst | Agent actif de delivraison de poudre seche |
| JP2004510724A (ja) * | 2000-10-06 | 2004-04-08 | ヤゴテック アーゲー | 分子量の低下した澱粉からなる微粒子中に埋め込まれた免疫学的活性物質を含むワクチン組成物 |
| WO2004041183A2 (en) | 2002-11-01 | 2004-05-21 | The Regents Of The University Of California | Methods of treating pulmonary fibrotic disorders |
| WO2004073729A1 (ja) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | 薬物の経鼻投与用組成物 |
| US20070219149A1 (en) | 2003-08-11 | 2007-09-20 | The Research Foundation For Microbial Diseases Of Osaka University | Novel Vaccine Containing Adjuvant Capable Of Inducing Mucosal Immunity |
| EP1697511A4 (en) | 2003-12-11 | 2007-11-21 | Vaxdesign Corp | IMMUNOTHERAPY COMPOSITIONS, METHODS FOR PREPARING AND USING THE SAME |
| CN101229378A (zh) | 2005-05-05 | 2008-07-30 | 国家淀粉及化学投资控股公司 | 用于送递活性剂的组合物 |
| US7838017B2 (en) | 2005-06-08 | 2010-11-23 | Newbiomed Pika Pte Ltd | Polyinosinic acid-polycytidylic acid-based adjuvant |
| US20070166239A1 (en) * | 2006-01-13 | 2007-07-19 | Haixiang Lin | Mucosal immunogenic substances comprising a polyinosinic acid - polycytidilic acid based adjuvant |
| GB0607534D0 (en) | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
| SI2046740T1 (sl) | 2006-07-22 | 2012-12-31 | Oxagen Limited | Spojine s crth2 antagonistiäśno aktivnostjo |
| CL2007002218A1 (es) | 2006-08-03 | 2008-03-14 | Celgene Corp Soc Organizada Ba | Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa. |
| AR067997A1 (es) * | 2007-08-24 | 2009-10-28 | Novartis Ag | Compuestos organicos |
| JP2009209086A (ja) * | 2008-03-04 | 2009-09-17 | Masami Moriyama | 粘膜投与型ワクチン |
| UA90013C2 (ru) * | 2008-03-19 | 2010-03-25 | Давид Анатолійович Нога | Фармацевтическая композиция, содержащая инсулин, и способ его получения |
| EP2116602A1 (en) | 2008-05-07 | 2009-11-11 | Institut Gustave Roussy | Combination products for treating cancer |
| CN102281870B (zh) * | 2008-12-10 | 2015-03-04 | 安徽中人科技有限责任公司 | 新型控释组合物 |
| CN101491503A (zh) | 2008-12-17 | 2009-07-29 | 天津瑞普生物技术股份有限公司 | 一种用于宠物的聚肌胞滴丸及其制备方法 |
| DK3098239T3 (da) | 2008-12-22 | 2020-01-20 | Targimmune Therapeutics Ag | Egfr-rettet dobbeltstrenget rna-vektor til systemisk cancerbehandling |
| CN101757018A (zh) * | 2008-12-24 | 2010-06-30 | 天津瑞普生物技术股份有限公司 | 一种用于畜禽的聚肌胞干粉及其制备方法 |
| ES2588183T3 (es) | 2009-03-31 | 2016-10-31 | Japan As Represented By Director-General Of National Institute Of Infectious Diseases | Procedimiento para la prevención de la gripe utilizando una vacuna para administración intranasal |
| EP2598145A1 (en) | 2010-07-28 | 2013-06-05 | Boehringer Ingelheim International GmbH | Pharmaceutical composition for treatment of respiratory and inflammatory diseases |
| US8431155B1 (en) | 2012-04-30 | 2013-04-30 | Veroscience Llc | Bromocriptine formulations |
| RU2650636C2 (ru) | 2012-05-03 | 2018-04-16 | Янссен Сайенсиз Айрлэнд Юси | Составы на основе полиинозиновой-полицитидиловой кислоты (poly(i:с)) для лечения инфекций верхних дыхательных путей |
| CN105939709A (zh) | 2013-11-06 | 2016-09-14 | 爱尔兰詹森科学公司 | 用于治疗上呼吸道感染的聚肌苷酸-聚胞苷酸(Poly(I:C))制剂 |
-
2013
- 2013-05-02 RU RU2014148544A patent/RU2650636C2/ru active
- 2013-05-02 BR BR112014026957A patent/BR112014026957A8/pt not_active Application Discontinuation
- 2013-05-02 CN CN201380023084.4A patent/CN104394846B/zh not_active Expired - Fee Related
- 2013-05-02 KR KR1020147028656A patent/KR102240042B1/ko not_active Expired - Fee Related
- 2013-05-02 NZ NZ630040A patent/NZ630040A/en not_active IP Right Cessation
- 2013-05-02 US US14/398,573 patent/US9682096B2/en not_active Expired - Fee Related
- 2013-05-02 AU AU2013255885A patent/AU2013255885C1/en not_active Ceased
- 2013-05-02 ES ES13722334T patent/ES2911116T3/es active Active
- 2013-05-02 SG SG10201607288VA patent/SG10201607288VA/en unknown
- 2013-05-02 MX MX2014013256A patent/MX2014013256A/es unknown
- 2013-05-02 JP JP2015509432A patent/JP6349304B2/ja not_active Expired - Fee Related
- 2013-05-02 IN IN2359MUN2014 patent/IN2014MN02359A/en unknown
- 2013-05-02 EP EP13722334.3A patent/EP2846767B1/en active Active
- 2013-05-02 WO PCT/EP2013/059079 patent/WO2013164380A1/en not_active Ceased
- 2013-05-02 SG SG11201406208QA patent/SG11201406208QA/en unknown
- 2013-05-02 CA CA2866230A patent/CA2866230C/en active Active
-
2014
- 2014-10-15 CO CO14228077A patent/CO7101247A2/es unknown
- 2014-10-29 CL CL2014002929A patent/CL2014002929A1/es unknown
-
2016
- 2016-06-13 US US15/180,603 patent/US9987300B2/en active Active
-
2018
- 2018-05-07 US US15/972,840 patent/US10485816B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201406208QA (en) | 2014-11-27 |
| KR20150008855A (ko) | 2015-01-23 |
| CA2866230A1 (en) | 2013-11-07 |
| US20160296551A1 (en) | 2016-10-13 |
| US20180325939A1 (en) | 2018-11-15 |
| CN104394846B (zh) | 2018-10-19 |
| HK1203390A1 (en) | 2015-10-30 |
| WO2013164380A1 (en) | 2013-11-07 |
| IN2014MN02359A (es) | 2015-08-14 |
| BR112014026957A2 (pt) | 2017-06-27 |
| KR102240042B1 (ko) | 2021-04-14 |
| CA2866230C (en) | 2020-08-18 |
| RU2650636C2 (ru) | 2018-04-16 |
| NZ630040A (en) | 2016-10-28 |
| SG10201607288VA (en) | 2016-10-28 |
| EP2846767B1 (en) | 2022-01-26 |
| AU2013255885C1 (en) | 2018-04-26 |
| JP2015515968A (ja) | 2015-06-04 |
| CO7101247A2 (es) | 2014-10-31 |
| US9987300B2 (en) | 2018-06-05 |
| JP6349304B2 (ja) | 2018-06-27 |
| US10485816B2 (en) | 2019-11-26 |
| AU2013255885B2 (en) | 2017-10-05 |
| US9682096B2 (en) | 2017-06-20 |
| US20150140042A1 (en) | 2015-05-21 |
| RU2014148544A (ru) | 2016-06-27 |
| MX2014013256A (es) | 2015-01-16 |
| ES2911116T3 (es) | 2022-05-17 |
| AU2013255885A1 (en) | 2014-09-25 |
| BR112014026957A8 (pt) | 2018-01-16 |
| EP2846767A1 (en) | 2015-03-18 |
| CN104394846A (zh) | 2015-03-04 |
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