CL2014002976A1 - Metodo de analisis de una muestra biologica de un sujeto con cancer utilizando biomarcadores tnf, ripk1, cxl10, ccl5, nfkbia, herc5, cdyl, stk39 y mapk14 para la terapia inhibitoria con iap. - Google Patents
Metodo de analisis de una muestra biologica de un sujeto con cancer utilizando biomarcadores tnf, ripk1, cxl10, ccl5, nfkbia, herc5, cdyl, stk39 y mapk14 para la terapia inhibitoria con iap.Info
- Publication number
- CL2014002976A1 CL2014002976A1 CL2014002976A CL2014002976A CL2014002976A1 CL 2014002976 A1 CL2014002976 A1 CL 2014002976A1 CL 2014002976 A CL2014002976 A CL 2014002976A CL 2014002976 A CL2014002976 A CL 2014002976A CL 2014002976 A1 CL2014002976 A1 CL 2014002976A1
- Authority
- CL
- Chile
- Prior art keywords
- cxl10
- cdyl
- stk39
- herc5
- ripk1
- Prior art date
Links
- 101150015388 CDYL gene Proteins 0.000 title 1
- 101100457345 Danio rerio mapk14a gene Proteins 0.000 title 1
- 101100457347 Danio rerio mapk14b gene Proteins 0.000 title 1
- 108700012928 MAPK14 Proteins 0.000 title 1
- 102000054819 Mitogen-activated protein kinase 14 Human genes 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 101150091206 Nfkbia gene Proteins 0.000 title 1
- 238000004458 analytical method Methods 0.000 title 1
- 239000012472 biological sample Substances 0.000 title 1
- 239000000090 biomarker Substances 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- -1 herc5 Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261642899P | 2012-05-04 | 2012-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2014002976A1 true CL2014002976A1 (es) | 2015-02-13 |
Family
ID=48407833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2014002976A CL2014002976A1 (es) | 2012-05-04 | 2014-11-03 | Metodo de analisis de una muestra biologica de un sujeto con cancer utilizando biomarcadores tnf, ripk1, cxl10, ccl5, nfkbia, herc5, cdyl, stk39 y mapk14 para la terapia inhibitoria con iap. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9353419B2 (es) |
| EP (1) | EP2844764B1 (es) |
| JP (1) | JP6513019B2 (es) |
| KR (1) | KR20150011822A (es) |
| CN (1) | CN104284988A (es) |
| AU (1) | AU2013256182A1 (es) |
| BR (1) | BR112014027413A2 (es) |
| CA (1) | CA2871995A1 (es) |
| CL (1) | CL2014002976A1 (es) |
| ES (1) | ES2593046T3 (es) |
| IL (1) | IL235315A0 (es) |
| MA (1) | MA37475A1 (es) |
| MX (1) | MX2014013429A (es) |
| PH (1) | PH12014502461A1 (es) |
| RU (1) | RU2014148779A (es) |
| SG (1) | SG11201406837TA (es) |
| TN (1) | TN2014000443A1 (es) |
| TW (1) | TW201347760A (es) |
| WO (1) | WO2013166344A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| TW201632516A (zh) | 2014-12-11 | 2016-09-16 | 哈佛大學校長及研究員協會 | 細胞壞死抑制劑與相關方法 |
| JP2021501802A (ja) * | 2017-11-01 | 2021-01-21 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | アポトーシスタンパク質の阻害剤を標的とする新規な薬剤 |
| US11358950B2 (en) | 2017-11-13 | 2022-06-14 | Chia Tai Tiangqing Pharmaceutical Group Co., Ltd. | SMAC mimetics used as IAP inhibitors and use thereof |
| TW202543617A (zh) * | 2024-03-06 | 2025-11-16 | 日商大鵬藥品工業股份有限公司 | 生物標記 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| GB0215823D0 (en) | 2002-07-09 | 2002-08-14 | Astrazeneca Ab | Quinazoline derivatives |
| EP1578777B1 (en) | 2002-07-15 | 2008-11-26 | The Trustees of Princeton University | Iap binding compounds |
| WO2005069888A2 (en) | 2004-01-16 | 2005-08-04 | The Regents Of The University Of Michigan | Smac peptidomimetics and the uses thereof |
| JP2007522116A (ja) | 2004-01-16 | 2007-08-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | コンホメーションが制約されたＳｍａｃ模倣物およびその使用 |
| EP1740173A4 (en) | 2004-03-23 | 2009-05-27 | Genentech Inc | AZABICYCLOOCTAN IAP INHIBITORS |
| CA2560162C (en) | 2004-04-07 | 2013-05-21 | Novartis Ag | Inhibitors of iap |
| ES2524449T3 (es) | 2004-07-02 | 2014-12-09 | Genentech, Inc. | Inhibidores de IAP |
| WO2006010118A2 (en) | 2004-07-09 | 2006-01-26 | The Regents Of The University Of Michigan | Conformationally constrained smac mimetics and the uses thereof |
| WO2006017295A2 (en) | 2004-07-12 | 2006-02-16 | Idun Pharmaceuticals, Inc. | Tetrapeptide analogs |
| US7456209B2 (en) | 2004-07-15 | 2008-11-25 | Tetralogic Pharmaceuticals Corporation | IAP binding compounds |
| EA019420B1 (ru) | 2004-12-20 | 2014-03-31 | Дженентех, Инк. | Пирролидиновые ингибиторы иап (ингибиторов апоптоза) |
| WO2007072225A2 (en) * | 2005-12-01 | 2007-06-28 | Medical Prognosis Institute | Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| CN101529254A (zh) * | 2006-10-19 | 2009-09-09 | 诺瓦提斯公司 | 有机化合物 |
| CA2665838A1 (en) * | 2006-10-19 | 2008-05-15 | Novartis Ag | Organic compounds |
| MX2009011783A (es) | 2007-04-30 | 2009-12-04 | Genentech Inc | Inhibidores de iap. |
| US20120015352A1 (en) | 2009-01-29 | 2012-01-19 | Otto-Von-Guericke-Universitat Magdeburg | Method of determining sensitivity of human or non-human animal cells to an iap antagonist |
| CA3161998A1 (en) * | 2009-02-11 | 2010-08-19 | Caris Mpi, Inc. | Molecular profiling of tumors |
| US20120196793A1 (en) * | 2009-09-18 | 2012-08-02 | Firestone Brant G | Biomarkers for iap inhibitor compounds |
| CN101956014B (zh) | 2010-09-30 | 2014-05-28 | 中山大学 | 一种用于鼻咽癌早期诊断的外周血7个基因标志物的检测试剂盒 |
-
2013
- 2013-05-03 CN CN201380022814.9A patent/CN104284988A/zh active Pending
- 2013-05-03 MA MA37475A patent/MA37475A1/fr unknown
- 2013-05-03 JP JP2015510469A patent/JP6513019B2/ja not_active Expired - Fee Related
- 2013-05-03 ES ES13721886.3T patent/ES2593046T3/es active Active
- 2013-05-03 SG SG11201406837TA patent/SG11201406837TA/en unknown
- 2013-05-03 BR BR112014027413A patent/BR112014027413A2/pt not_active IP Right Cessation
- 2013-05-03 US US14/398,596 patent/US9353419B2/en not_active Expired - Fee Related
- 2013-05-03 EP EP13721886.3A patent/EP2844764B1/en active Active
- 2013-05-03 CA CA 2871995 patent/CA2871995A1/en not_active Abandoned
- 2013-05-03 MX MX2014013429A patent/MX2014013429A/es unknown
- 2013-05-03 RU RU2014148779A patent/RU2014148779A/ru not_active Application Discontinuation
- 2013-05-03 WO PCT/US2013/039362 patent/WO2013166344A1/en not_active Ceased
- 2013-05-03 AU AU2013256182A patent/AU2013256182A1/en not_active Abandoned
- 2013-05-03 KR KR1020147033716A patent/KR20150011822A/ko not_active Withdrawn
- 2013-05-03 TW TW102115948A patent/TW201347760A/zh unknown
-
2014
- 2014-10-21 TN TN2014000443A patent/TN2014000443A1/fr unknown
- 2014-10-23 IL IL235315A patent/IL235315A0/en unknown
- 2014-11-03 CL CL2014002976A patent/CL2014002976A1/es unknown
- 2014-11-04 PH PH12014502461A patent/PH12014502461A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2593046T3 (es) | 2016-12-05 |
| KR20150011822A (ko) | 2015-02-02 |
| EP2844764A1 (en) | 2015-03-11 |
| WO2013166344A1 (en) | 2013-11-07 |
| AU2013256182A1 (en) | 2014-11-13 |
| MX2014013429A (es) | 2014-12-08 |
| EP2844764B1 (en) | 2016-06-22 |
| TN2014000443A1 (en) | 2016-03-30 |
| US9353419B2 (en) | 2016-05-31 |
| PH12014502461A1 (en) | 2014-12-22 |
| JP6513019B2 (ja) | 2019-05-15 |
| CA2871995A1 (en) | 2013-11-07 |
| MA37475A1 (fr) | 2016-05-31 |
| HK1202589A1 (zh) | 2015-10-02 |
| CN104284988A (zh) | 2015-01-14 |
| BR112014027413A2 (pt) | 2017-06-27 |
| US20150105434A1 (en) | 2015-04-16 |
| TW201347760A (zh) | 2013-12-01 |
| SG11201406837TA (en) | 2014-11-27 |
| JP2015523056A (ja) | 2015-08-13 |
| RU2014148779A (ru) | 2016-06-27 |
| IL235315A0 (en) | 2014-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3054285A4 (en) | Biochip for raman quantitative analysis of biological samples | |
| IL257441B (en) | Devices and methods for bio/chemical tests with simplified steps, small samples, accelerated speed and easy to use | |
| MX356986B (es) | Metodo para detectar aductos de nucleosomas. | |
| WO2013066369A3 (en) | Methods for detecting graft-versus-host disease | |
| WO2013107459A3 (en) | Microrna for diagnosis of pancreatic cancer and/or prognosis of patients with pancreatic cancer by blood samples | |
| EP3175247A4 (en) | Instrument for analyzing biological samples and reagents | |
| PT2663402T (pt) | Sistemas, métodos e aparelhos para gerar imagem de uma amostra para análise biológica ou química | |
| SG11201500371VA (en) | Methods of detecting dna, rna and protein in biological samples | |
| EP3207499A4 (en) | Methods and systems for classifying biological samples, including optimization of analyses and use of correlation | |
| EP2780465A4 (en) | METHOD, DEVICES AND KITS FOR OBTAINING AND ANALYZING CELLS | |
| IL246060B (en) | Biosensors for biological or chemical analysis and methods of manufacturing the same | |
| WO2011121454A3 (en) | Direct nucleic acid analysis | |
| BR112013022735A2 (pt) | aparelho para processamento de uma amostra, aparelho para processamento de uma pluralidade de amostras, método para detectar a presença ou ausência de um analito em uma amostra e método para detectar a presença ou ausência de um analito em uma pluralidade de amostras | |
| MX2013014153A (es) | Biomarcadores paa terapia de inhibidor de hedgehog. | |
| MX2016011377A (es) | Metodo para diagnosticar cancer colorrectal a partir de una muestra de heces humanas por pcr cuantitativa, cebadores y equipo. | |
| GB201219137D0 (en) | Direct nucleic acid amplification kit, reagent and method | |
| EP2672270A4 (en) | Specimen analysis system, specimen analysis device, and specimen analysis method | |
| EP3176268A4 (en) | Novel biomarker for predicting sensitivity to egfr-targeting agent, and use thereof | |
| CL2014002976A1 (es) | Metodo de analisis de una muestra biologica de un sujeto con cancer utilizando biomarcadores tnf, ripk1, cxl10, ccl5, nfkbia, herc5, cdyl, stk39 y mapk14 para la terapia inhibitoria con iap. | |
| MX2015012319A (es) | Sistemas de instrumento analitico. | |
| EP3166726A4 (en) | Devices and kits for collection, storage and analysis of samples and methods of production and use thereof | |
| EP3056567A4 (en) | Pcr primer set for bacterial dna amplification, kit for detecting and/or identifying bacterial species, and method for detecting and/or identifying bacterial species | |
| EP3007824A4 (en) | Rna/protein/dna preferential fluid sample collection system and methods | |
| EP3256849A4 (en) | Devices, solutions and methods for sample collection related applications, analysis and diagnosis | |
| WO2012135749A3 (en) | Biomarkers for predicting sensitivity to cancer treatments |