CL2014003014A1 - Proceso para la preparacion de un compuesto derivado de undecapeptidos ciclicos que comprende los pasos de: acilar la ciclosporina a, abrir el anillo de la acetil-ciclosporina a formada y cristalizar el anillo abierto para obtener un compuesto de formula 3 o de formula 4; compuesto undecapeptido ciclico de formula 3 y de formula 4. - Google Patents

Proceso para la preparacion de un compuesto derivado de undecapeptidos ciclicos que comprende los pasos de: acilar la ciclosporina a, abrir el anillo de la acetil-ciclosporina a formada y cristalizar el anillo abierto para obtener un compuesto de formula 3 o de formula 4; compuesto undecapeptido ciclico de formula 3 y de formula 4.

Info

Publication number
CL2014003014A1
CL2014003014A1 CL2014003014A CL2014003014A CL2014003014A1 CL 2014003014 A1 CL2014003014 A1 CL 2014003014A1 CL 2014003014 A CL2014003014 A CL 2014003014A CL 2014003014 A CL2014003014 A CL 2014003014A CL 2014003014 A1 CL2014003014 A1 CL 2014003014A1
Authority
CL
Chile
Prior art keywords
formula
compound
cyclosporine
cyclic
ring
Prior art date
Application number
CL2014003014A
Other languages
English (en)
Inventor
Fabrice Gallou
Bernard Riss
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48444372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014003014(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2014003014A1 publication Critical patent/CL2014003014A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CL2014003014A 2012-05-09 2014-11-07 Proceso para la preparacion de un compuesto derivado de undecapeptidos ciclicos que comprende los pasos de: acilar la ciclosporina a, abrir el anillo de la acetil-ciclosporina a formada y cristalizar el anillo abierto para obtener un compuesto de formula 3 o de formula 4; compuesto undecapeptido ciclico de formula 3 y de formula 4. CL2014003014A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261644616P 2012-05-09 2012-05-09

Publications (1)

Publication Number Publication Date
CL2014003014A1 true CL2014003014A1 (es) 2015-03-06

Family

ID=48444372

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014003014A CL2014003014A1 (es) 2012-05-09 2014-11-07 Proceso para la preparacion de un compuesto derivado de undecapeptidos ciclicos que comprende los pasos de: acilar la ciclosporina a, abrir el anillo de la acetil-ciclosporina a formada y cristalizar el anillo abierto para obtener un compuesto de formula 3 o de formula 4; compuesto undecapeptido ciclico de formula 3 y de formula 4.

Country Status (24)

Country Link
US (2) US20150087808A1 (es)
EP (1) EP2847211A1 (es)
JP (3) JP2015517481A (es)
KR (1) KR20150006435A (es)
CN (2) CN104284902A (es)
AR (1) AR090964A1 (es)
AU (2) AU2013257989A1 (es)
BR (1) BR112014027648A2 (es)
CA (1) CA2868940A1 (es)
CL (1) CL2014003014A1 (es)
CO (1) CO7141428A2 (es)
EA (1) EA024903B1 (es)
EC (1) ECSP14030537A (es)
HK (1) HK1202555A1 (es)
IL (1) IL235428A0 (es)
IN (1) IN2014DN08483A (es)
MA (1) MA20150231A1 (es)
MX (1) MX2014013613A (es)
PE (1) PE20142433A1 (es)
PH (1) PH12014502499A1 (es)
SG (1) SG11201406303XA (es)
TN (1) TN2014000411A1 (es)
TW (1) TW201350508A (es)
WO (1) WO2013167703A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105693820A (zh) * 2014-11-27 2016-06-22 武汉药明康德新药开发有限公司 一种降解环孢菌素a的方法
CN110799523A (zh) 2017-05-12 2020-02-14 中外制药株式会社 用于制备环状有机化合物的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401177B (de) * 1993-10-22 1996-07-25 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
AU759480B2 (en) * 1998-07-01 2003-04-17 Debiopharm S.A. Novel cyclosporin with improved activity profile
WO2000046239A1 (fr) * 1999-02-05 2000-08-10 Debiopharm S.A. Derives de cyclosporine et procede de preparation desdits derives
US6995139B2 (en) * 2001-04-20 2006-02-07 Debiopharm S.A. Cyclic undecapeptide pro-drugs and uses thereof
MXPA04003625A (es) * 2001-10-19 2004-12-02 Sotechnika Inc Sintesis de analogos de ciclosporina.
TW200505946A (en) 2003-04-08 2005-02-16 Hoffmann La Roche Process for preparation of cyclosporin a analog
DK1793844T3 (da) 2004-10-01 2011-03-21 Debiopharm Sa Anvendelse af [D-MeAla]3-[EtVal]4-cyklosporin til behandling af hepatitis C-infektion
WO2006063470A1 (en) * 2004-12-17 2006-06-22 Isotechnika Inc. Metabolites of cyclosporin analogs
US8450281B2 (en) 2007-01-04 2013-05-28 Debiopharm S.A. Non-immunosuppressive cyclosporin for treatment of Ullrich congenital muscular dystrophy
US8394763B2 (en) 2007-09-26 2013-03-12 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US7910378B2 (en) * 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
WO2009098533A1 (en) 2008-02-08 2009-08-13 Debiopharm Sa Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
CN102202679B (zh) 2008-11-06 2014-05-07 帝柏奥研究制药有限公司 环十一缩酚酸肽化合物及其作为药物的用途
EP2376524B1 (en) * 2008-12-31 2017-03-15 Cypralis Limited Derivatives of cyclosporin a
KR20110111321A (ko) * 2009-01-30 2011-10-10 이난타 파마슈티칼스, 인코포레이티드 Ｃ형 간염을 예방하거나 치료하기 위한 사이클로스포린 유사체
US9573978B2 (en) * 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection

Also Published As

Publication number Publication date
WO2013167703A1 (en) 2013-11-14
US20150087808A1 (en) 2015-03-26
KR20150006435A (ko) 2015-01-16
SG11201406303XA (en) 2014-11-27
WO2013167703A9 (en) 2014-11-20
IL235428A0 (en) 2014-12-31
CO7141428A2 (es) 2014-12-12
CN104284902A (zh) 2015-01-14
IN2014DN08483A (es) 2015-05-08
TN2014000411A1 (en) 2015-12-21
TW201350508A (zh) 2013-12-16
AR090964A1 (es) 2014-12-17
EA201492036A1 (ru) 2015-02-27
BR112014027648A2 (pt) 2017-06-27
MA20150231A1 (fr) 2015-07-31
EA024903B1 (ru) 2016-10-31
AU2016222370A1 (en) 2016-09-15
US20160304554A1 (en) 2016-10-20
AU2016222370B2 (en) 2017-10-05
JP2015517481A (ja) 2015-06-22
HK1202555A1 (en) 2015-10-02
AU2013257989A1 (en) 2014-10-23
CN108715606A (zh) 2018-10-30
US9840534B2 (en) 2017-12-12
ECSP14030537A (es) 2015-09-30
JP2020033349A (ja) 2020-03-05
PE20142433A1 (es) 2015-02-02
MX2014013613A (es) 2015-02-12
EP2847211A1 (en) 2015-03-18
PH12014502499A1 (en) 2014-12-22
CA2868940A1 (en) 2013-11-14
JP2018035154A (ja) 2018-03-08

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