CL2015002152A1 - Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh - Google Patents

Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh

Info

Publication number
CL2015002152A1
CL2015002152A1 CL2015002152A CL2015002152A CL2015002152A1 CL 2015002152 A1 CL2015002152 A1 CL 2015002152A1 CL 2015002152 A CL2015002152 A CL 2015002152A CL 2015002152 A CL2015002152 A CL 2015002152A CL 2015002152 A1 CL2015002152 A1 CL 2015002152A1
Authority
CL
Chile
Prior art keywords
vrsh
hybridomas
secreted
antigen
diagnosis
Prior art date
Application number
CL2015002152A
Other languages
English (en)
Inventor
Ramirez Susan Marcela Bueno
Parra Alexis Mikes Kalergis
Alarcon Jorge Eugenio Mora
Original Assignee
Pontificia Universidad Católica De Chile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pontificia Universidad Católica De Chile filed Critical Pontificia Universidad Católica De Chile
Priority to CL2015002152A priority Critical patent/CL2015002152A1/es
Publication of CL2015002152A1 publication Critical patent/CL2015002152A1/es
Priority to PE2018000144A priority patent/PE20180576A1/es
Priority to ES18203701T priority patent/ES2786637T3/es
Priority to CA2994219A priority patent/CA2994219C/en
Priority to PT182037010T priority patent/PT3517546T/pt
Priority to PE2021001936A priority patent/PE20220004A1/es
Priority to BR112018002031-1A priority patent/BR112018002031B1/pt
Priority to ES16832387T priority patent/ES2784888T3/es
Priority to CN201680052944.0A priority patent/CN108474017B/zh
Priority to KR1020187005939A priority patent/KR102679351B1/ko
Priority to PCT/IB2016/054424 priority patent/WO2017021815A2/en
Priority to PT168323871T priority patent/PT3328884T/pt
Priority to US15/748,979 priority patent/US10858419B2/en
Priority to EP16832387.1A priority patent/EP3328884B1/en
Priority to EP18203701.0A priority patent/EP3517546B1/en
Priority to RU2018103933A priority patent/RU2716990C2/ru
Priority to MX2018001244A priority patent/MX2018001244A/es
Priority to UY0001036820A priority patent/UY36820A/es
Priority to ARP160102326A priority patent/AR105541A1/es
Priority to MX2022010471A priority patent/MX2022010471A/es
Priority to CONC2018/0001010A priority patent/CO2018001010A2/es
Priority to ZA2018/00938A priority patent/ZA201800938B/en
Priority to US17/087,103 priority patent/US11873331B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
CL2015002152A 2015-07-31 2015-07-31 Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh CL2015002152A1 (es)

Priority Applications (23)

Application Number Priority Date Filing Date Title
CL2015002152A CL2015002152A1 (es) 2015-07-31 2015-07-31 Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh
MX2018001244A MX2018001244A (es) 2015-07-31 2016-07-25 Anticuerpos monoclonales especificos para el antigeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrsh.
PCT/IB2016/054424 WO2017021815A2 (en) 2015-07-31 2016-07-25 Monoclonal antibodies specifically for the antigen p of the human respiratory syncytial virus, produced and secreted by the cells hybridomas, useful for detection and diagnostic of the infection caused by rsv
US15/748,979 US10858419B2 (en) 2015-07-31 2016-07-25 Monoclonal antibodies specifically for the antigen P of the human respiratory syncytial virus, produced and secreted by the cells hybridomas, useful for detection and diagnostic of the infection caused by RSV
CA2994219A CA2994219C (en) 2015-07-31 2016-07-25 Monoclonal antibodies specifically for the antigen p of the human respiratory syncytial virus, produced and secreted by the cells hybridomas, useful for detection and diagnostic of the infection caused by rsv.
PT182037010T PT3517546T (pt) 2015-07-31 2016-07-25 Anticorpo monoclonal específico para a proteína p do vírus sincicial respiratório humano e seu uso para a deteção e o diagnóstico de infeção por rsv
PE2021001936A PE20220004A1 (es) 2015-07-31 2016-07-25 Anticuerpos monoclonales especificos para el antigeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrsh
BR112018002031-1A BR112018002031B1 (pt) 2015-07-31 2016-07-25 Anticorpo monoclonal ou um fragmento do mesmo que se liga àproteína p do vírus sincicial respiratório humano (vsr), conjunto desequências de nucleotídeos que codificam o referido anticorpo monoclonalou fragmento do mesmo, método in vitro e/ou ex vivo para diagnóstico deinfecção por vsr em uma amostra biológica e kit de diagnóstico para detectarvsr
ES16832387T ES2784888T3 (es) 2015-07-31 2016-07-25 Anticuerpo monoclonal específico para la proteína P del Virus Respiratorio Sincicial humano y uso del mismo para la detección y diagnóstico de infección por VRS
CN201680052944.0A CN108474017B (zh) 2015-07-31 2016-07-25 用于检测呼吸道合胞病毒抗原p的单克隆抗体
KR1020187005939A KR102679351B1 (ko) 2015-07-31 2016-07-25 인간 호흡기 세포융합 바이러스의 인단백질에 특이적인 단클론 항체 및 사용 방법
PE2018000144A PE20180576A1 (es) 2015-07-31 2016-07-25 ANTICUERPOS MONOCLONALES ESPECIFICOS PARA EL ANTIGENO P DEL VIRUS RESPIRATORIO SINCICIAL HUMANO (VRSh), PRODUCIDOS Y SECRETADOS POR HIBRIDOMAS CELULARES, UTILES PARA LA DETECCION Y EL DIAGNOSTICO DE LA INFECCION CAUSADA POR VRSh
PT168323871T PT3328884T (pt) 2015-07-31 2016-07-25 Anticorpo monoclonal específico para a proteína p do vírus sincicial respiratório humano e seu uso para a deteção e o diagnóstico de infeção por rsv
ES18203701T ES2786637T3 (es) 2015-07-31 2016-07-25 Anticuerpo monoclonal específico para la proteína P del Virus Respiratorio Sincicial humano y uso del mismo para la detección y diagnóstico de infección por VRS
EP16832387.1A EP3328884B1 (en) 2015-07-31 2016-07-25 Monoclonal antibody specific for protein p of the human respiratory syncytial virus and use thereof for the detection and diagnosis of rsv infection
EP18203701.0A EP3517546B1 (en) 2015-07-31 2016-07-25 Monoclonal antibody specific for protein p of the human respiratory syncytial virus and use thereof for the detection and diagnosis of rsv infection
RU2018103933A RU2716990C2 (ru) 2015-07-31 2016-07-25 Моноклональные антитела с ориентировкой на антиген Р респираторно-синцитиального вируса человека, получаемые и секретируемые из клеточных гибридом, используемые для обнаружения и диагностики инфекции, вызываемой респираторно-синцитиальным вирусом
UY0001036820A UY36820A (es) 2015-07-31 2016-07-27 Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnóstico de la infección causada por vrsh
ARP160102326A AR105541A1 (es) 2015-07-31 2016-07-29 ANTICUERPOS MONOCLONALES ESPECÍFICOS PARA EL ANTÍGENO P DEL VIRUS RESPIRATORIO SINCICIAL HUMANO (VRSh), PRODUCIDOS Y SECRETADOS POR HIBRIDOMAS CELULARES, ÚTILES PARA LA DETECCIÓN Y EL DIAGNÓSTICO DE LA INFECCIÓN CAUSADA POR VRSh
MX2022010471A MX2022010471A (es) 2015-07-31 2018-01-29 Anticuerpos monoclonales especificos para el antigeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, utiles para la deteccion y el diagnostico de la infeccion causada por vrsh.
CONC2018/0001010A CO2018001010A2 (es) 2015-07-31 2018-01-30 Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnóstico de la infección causada por vrsh
ZA2018/00938A ZA201800938B (en) 2015-07-31 2018-02-12 Monoclonal antibodies specifically for phosphoprotein of the human respiratory syncytial virus and the methods of use
US17/087,103 US11873331B2 (en) 2015-07-31 2020-11-02 Monoclonal antibodies specifically for the antigen P of the human respiratory syncytial virus, produced and secreted by the cells hybridomas, useful for detection and diagnostic of the infection caused by RSV

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CL2015002152A CL2015002152A1 (es) 2015-07-31 2015-07-31 Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh

Publications (1)

Publication Number Publication Date
CL2015002152A1 true CL2015002152A1 (es) 2016-06-03

Family

ID=56610056

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002152A CL2015002152A1 (es) 2015-07-31 2015-07-31 Anticuerpos monoclonales específicos para el antígeno p del virus respiratorio sincicial humano (vrsh), producidos y secretados por hibridomas celulares, útiles para la detección y el diagnostico de la infección causada por vrsh

Country Status (16)

Country Link
US (2) US10858419B2 (es)
EP (2) EP3517546B1 (es)
KR (1) KR102679351B1 (es)
CN (1) CN108474017B (es)
AR (1) AR105541A1 (es)
CA (1) CA2994219C (es)
CL (1) CL2015002152A1 (es)
CO (1) CO2018001010A2 (es)
ES (2) ES2784888T3 (es)
MX (2) MX2018001244A (es)
PE (2) PE20180576A1 (es)
PT (2) PT3328884T (es)
RU (1) RU2716990C2 (es)
UY (1) UY36820A (es)
WO (1) WO2017021815A2 (es)
ZA (1) ZA201800938B (es)

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Publication number Priority date Publication date Assignee Title
DE102017127857B4 (de) * 2017-11-24 2023-10-12 Lipozyt Marker UG (haftungsbeschränkt) Verwendung des ADIPOQ Genexpressionslevels zur Einordnung eines Probanden in Risikogruppen bei der Prognose oder Diagnose einer Diabetes mellitus Typ II Erkrankung
EP3848389A4 (en) * 2018-09-03 2022-04-13 Pontificia Universidad Católica De Chile SPECIFIC MONOCLONAL ANTIBODIES AGAINST HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) N-ANTIGEN FOR TREATMENT, DETECTION AND DIAGNOSIS OF INFECTION
CL2018003869A1 (es) 2018-12-28 2021-01-15 Univ Pontificia Catolica Chile Anticuerpos monoclonales específicos para la proteína quimérica l del virus de la parainfluenza humana (piv), secuencias nucleotídicas; método y kit de diagnóstico de infección producida por piv
EP3825591B1 (en) 2019-11-22 2025-08-06 Hamilton Sundstrand Corporation Hydraulic damping valve
CN113354734B (zh) * 2021-07-14 2021-12-14 北京祥瑞生物制品有限公司 一种快速检测病毒的试剂盒及其制备方法
CN115925909B (zh) * 2022-09-27 2023-07-21 深圳重链生物科技有限公司 抗呼吸道合胞病毒抗体及其相关应用
CN115838419B (zh) * 2022-09-27 2023-06-30 深圳重链生物科技有限公司 抗呼吸道合胞病毒抗体及其相关应用

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US5824307A (en) 1991-12-23 1998-10-20 Medimmune, Inc. Human-murine chimeric antibodies against respiratory syncytial virus
US7223410B1 (en) * 1994-08-05 2007-05-29 Sanofi Pasteur Limited Inactivated respiratory syncytial viral vaccines
US6258529B1 (en) * 1994-12-01 2001-07-10 Oravax, Inc. PCR amplification of rearranged genomic variable regions of immunoglobulin genes
US7527787B2 (en) * 2005-10-19 2009-05-05 Ibc Pharmaceuticals, Inc. Multivalent immunoglobulin-based bioactive assemblies
US20040096451A1 (en) * 2002-07-25 2004-05-20 Young James F. Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies
TWI344991B (en) * 2002-02-21 2011-07-11 Medimmune Vaccines Inc Metapneumovirus strains as vaccine formulations and as vectors for expression of heterologous antigenic sequences
JP2007531491A (ja) * 2002-09-27 2007-11-08 メディミューン・ヴァクシンズ・インコーポレーテッド 呼吸器合胞体ウイルスにおける機能的突然変異
CN101287762A (zh) * 2005-08-15 2008-10-15 阿拉纳治疗有限公司 具有新世界灵长类构架区的经改造的抗体
CN102245767B (zh) * 2008-10-31 2013-09-18 东丽株式会社 人cxcl1蛋白质的免疫学测定方法
CL2011003002A1 (es) * 2011-11-25 2012-05-25 Univ Pontificia Catolica Chile Anticuerpo monoclonal o un fragmento del mismo que se une a la proteina m2-1 del virus respiratorio sincicial (vrs) humano; secuencias nucleotidicas; composicion farmaceutica; metodo de diagnostico de infeccion producida por vrs; kit; y uso de dicho anticuerpo para preparar un medicamento.

Also Published As

Publication number Publication date
MX2022010471A (es) 2022-09-19
CA2994219C (en) 2024-02-20
EP3517546A1 (en) 2019-07-31
KR20180030919A (ko) 2018-03-26
CA2994219A1 (en) 2017-02-09
WO2017021815A3 (en) 2017-05-11
MX2018001244A (es) 2018-04-24
EP3517546B1 (en) 2020-02-26
PE20220004A1 (es) 2022-01-05
UY36820A (es) 2017-01-31
KR102679351B1 (ko) 2024-06-27
CN108474017A (zh) 2018-08-31
RU2716990C2 (ru) 2020-03-17
ES2786637T3 (es) 2020-10-13
WO2017021815A2 (en) 2017-02-09
BR112018002031A2 (pt) 2018-09-11
RU2018103933A (ru) 2019-08-28
EP3328884B1 (en) 2020-01-01
CN108474017B (zh) 2021-08-27
PT3517546T (pt) 2020-05-22
EP3328884A2 (en) 2018-06-06
CO2018001010A2 (es) 2018-04-30
PT3328884T (pt) 2020-04-08
US10858419B2 (en) 2020-12-08
RU2018103933A3 (es) 2019-08-28
ZA201800938B (en) 2019-07-31
US20180327483A1 (en) 2018-11-15
PE20180576A1 (es) 2018-04-04
AR105541A1 (es) 2017-10-11
US20210070844A1 (en) 2021-03-11
EP3328884A4 (en) 2018-06-06
ES2784888T3 (es) 2020-10-01
US11873331B2 (en) 2024-01-16

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