CL2015003343A1 - Composición farmacéutica que comprende un agente terapéutico modificado en base a hemoglobina, para el tratamiento para tratar el cáncer, e imágenes de diagnóstico. - Google Patents

Composición farmacéutica que comprende un agente terapéutico modificado en base a hemoglobina, para el tratamiento para tratar el cáncer, e imágenes de diagnóstico.

Info

Publication number
CL2015003343A1
CL2015003343A1 CL2015003343A CL2015003343A CL2015003343A1 CL 2015003343 A1 CL2015003343 A1 CL 2015003343A1 CL 2015003343 A CL2015003343 A CL 2015003343A CL 2015003343 A CL2015003343 A CL 2015003343A CL 2015003343 A1 CL2015003343 A1 CL 2015003343A1
Authority
CL
Chile
Prior art keywords
pharmaceutical composition
therapeutic agent
hemoglobin
treatment
agent based
Prior art date
Application number
CL2015003343A
Other languages
English (en)
Inventor
Bing Lou Wong
Sui Yi Kwok
Norman Fung Man Wai
Man Kin Wong
Cornelia Wing Yin Man
Original Assignee
Vision Global Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vision Global Holdings Ltd filed Critical Vision Global Holdings Ltd
Publication of CL2015003343A1 publication Critical patent/CL2015003343A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6445—Haemoglobin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043—Fluorescein, used in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Inorganic Chemistry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)

Abstract

AGENTE TERAPÉUTICO BASADO EN HEMOGLOBINA MODIFICADA PARA TRATAMIENTO DIRIGIDO AL CÁNCER, E IMAGENOLOGÍA DE DIAGNÓSTICO; COMPOSICIÓN FARMACÉUTICA QUE LO COMPRENDE; Y MÉTODO DE PREPARACIÓN.
CL2015003343A 2013-05-13 2015-11-13 Composición farmacéutica que comprende un agente terapéutico modificado en base a hemoglobina, para el tratamiento para tratar el cáncer, e imágenes de diagnóstico. CL2015003343A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361822463P 2013-05-13 2013-05-13
US14/275,885 US9636404B2 (en) 2013-05-13 2014-05-13 Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging

Publications (1)

Publication Number Publication Date
CL2015003343A1 true CL2015003343A1 (es) 2016-08-05

Family

ID=51864923

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015003343A CL2015003343A1 (es) 2013-05-13 2015-11-13 Composición farmacéutica que comprende un agente terapéutico modificado en base a hemoglobina, para el tratamiento para tratar el cáncer, e imágenes de diagnóstico.

Country Status (19)

Country Link
US (2) US9636404B2 (es)
EP (1) EP3001813B1 (es)
JP (1) JP6392855B2 (es)
KR (1) KR102013015B1 (es)
CN (1) CN105407911B (es)
AU (1) AU2014265659B2 (es)
BR (1) BR112015028340A2 (es)
CA (1) CA2911414C (es)
CL (1) CL2015003343A1 (es)
EA (1) EA032164B1 (es)
IL (1) IL242422B (es)
MA (1) MA38571B1 (es)
MX (1) MX362001B (es)
MY (1) MY176175A (es)
PH (1) PH12015502536A1 (es)
SA (1) SA515370134B1 (es)
SG (1) SG11201509042YA (es)
TW (1) TWI610685B (es)
WO (1) WO2014186301A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9636404B2 (en) * 2013-05-13 2017-05-02 Vision Global Holdings Ltd. Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging
EP3079668A1 (en) 2013-12-09 2016-10-19 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
US9814759B2 (en) * 2014-07-02 2017-11-14 Cheer Global Ltd. Pharmaceutical composition comprising recombinant hemoglobin protein or subunit-based therapeutic agent for cancer targeting treatment
KR102508023B1 (ko) 2014-09-03 2023-03-10 이뮤노젠 아이엔씨 세포-결합제 및 세포독성 약물을 포함하는 콘주게이트
TR201606102A2 (tr) * 2016-05-10 2016-10-21 Tolgay Tuyan Ilhan Karin i̇çi̇ uygulanan kanser tedavi̇leri̇nde oksi̇jen konsantrasyonu ölçümü yapabi̇len ve veri̇len oksi̇jen dozaji üzeri̇nde deği̇şi̇kli̇k yapmayi sağlayan ci̇haz
CA3028589A1 (en) * 2016-06-21 2017-12-28 Therapure Biopharma Inc. Hemoglobin-targeted drug delivery for the treatment of cancer
CN116474108A (zh) * 2016-12-14 2023-07-25 普渡研究基金会 成纤维细胞活化蛋白(fap)-靶向成像和治疗
US11560384B2 (en) 2017-05-04 2023-01-24 University Of Utah Research Foundation Benzonorbornadiene derivatives and reactions thereof
CN107153771B (zh) * 2017-05-17 2020-06-30 许昌学院 一种药物分子的同步控制方法及其应用
CA3070172A1 (en) 2017-07-18 2019-01-24 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making
EP3999529A4 (en) * 2019-07-19 2023-07-12 Cheer Global Limited HEMOGLOBIN-BASED THERAPEUTIC AGENT
CN114577557B (zh) * 2020-11-30 2024-06-18 中国科学院大连化学物理研究所 一种基于催化酶激活的靶向交联剂在蛋白分析中的应用
CN114605338B (zh) * 2022-05-11 2022-10-28 深圳厚存纳米药业有限公司 一种含尿嘧啶衍生物的纳米粒、核酸纳米复合物及其制备方法和用途
CN116068189A (zh) * 2023-04-07 2023-05-05 吉林重明生物科技有限公司 早期癌检测试剂及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4584130A (en) * 1985-03-29 1986-04-22 University Of Maryland Intramolecularly cross-linked hemoglobin and method of preparation
EP0206448B1 (en) * 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US5688488A (en) * 1989-04-03 1997-11-18 Purdue Research Foundation Composition and method for tumor imaging
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
EP0611306B1 (en) * 1991-11-08 1998-07-08 Somatogen, Inc. Hemoglobins as drug delivery agents
JPH09512796A (ja) * 1994-04-29 1997-12-22 ザ キュレイターズ オブ ザ ユニヴァーシティー オブ ミズーリー 治療用の放射性製薬のための二官能性キレート剤の調製に使用するチオエーテル化合物
US5998361A (en) * 1996-10-18 1999-12-07 University Of Maryland At Baltimore Polymerized hemoglobin
US20050059576A1 (en) * 1998-04-30 2005-03-17 Adamson J. Gordon Targeted delivery of antiviral compounds through hemoglobin bioconjugates
CA2236344A1 (en) * 1998-04-30 1999-10-30 Hemosol Inc. Hemoglobin-haptoglobin complexes
EP1469011B1 (en) * 2003-04-17 2007-11-07 Ezio Panzeri Hemoglobin conjugates
US7235639B2 (en) 2003-04-23 2007-06-26 Ezio Panzeri Hemoglobin conjugates
WO2010059315A1 (en) * 2008-11-18 2010-05-27 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
US7989593B1 (en) * 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US8048856B1 (en) * 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US8084581B1 (en) * 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) * 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
US20140106004A1 (en) * 2012-10-12 2014-04-17 Bing Lou Wong Hemoglobin-based oxygen carrier-containing pharmaceutical composition for cancer targeting treatment and prevention of cancer recurrence
US9636404B2 (en) * 2013-05-13 2017-05-02 Vision Global Holdings Ltd. Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging

Also Published As

Publication number Publication date
US20140335018A1 (en) 2014-11-13
US9636404B2 (en) 2017-05-02
US20170266285A1 (en) 2017-09-21
KR20160007536A (ko) 2016-01-20
CA2911414A1 (en) 2014-11-20
EA032164B1 (ru) 2019-04-30
AU2014265659B2 (en) 2017-03-30
MA38571B1 (fr) 2018-10-31
SG11201509042YA (en) 2015-12-30
CA2911414C (en) 2018-09-11
PH12015502536B1 (en) 2016-02-22
MA38571A1 (fr) 2017-10-31
WO2014186301A1 (en) 2014-11-20
MX2015015555A (es) 2016-05-09
JP2016518447A (ja) 2016-06-23
WO2014186301A8 (en) 2015-02-05
BR112015028340A2 (pt) 2017-09-19
CN105407911A (zh) 2016-03-16
MX362001B (es) 2019-01-03
TW201517921A (zh) 2015-05-16
SA515370134B1 (ar) 2017-10-18
IL242422B (en) 2019-02-28
EP3001813B1 (en) 2019-03-27
JP6392855B2 (ja) 2018-09-19
MY176175A (en) 2020-07-24
EA201501065A1 (ru) 2016-04-29
HK1223037A1 (en) 2017-07-21
US10322180B2 (en) 2019-06-18
AU2014265659A1 (en) 2015-11-19
EP3001813A4 (en) 2017-01-11
TWI610685B (zh) 2018-01-11
PH12015502536A1 (en) 2016-02-22
EP3001813A1 (en) 2016-04-06
KR102013015B1 (ko) 2019-08-21
HK1222574A1 (zh) 2017-07-07
CN105407911B (zh) 2020-05-12

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