CL2016001488A1 - Quinazolin-thf-aminas como inhibidores de pde1 - Google Patents
Quinazolin-thf-aminas como inhibidores de pde1Info
- Publication number
- CL2016001488A1 CL2016001488A1 CL2016001488A CL2016001488A CL2016001488A1 CL 2016001488 A1 CL2016001488 A1 CL 2016001488A1 CL 2016001488 A CL2016001488 A CL 2016001488A CL 2016001488 A CL2016001488 A CL 2016001488A CL 2016001488 A1 CL2016001488 A1 CL 2016001488A1
- Authority
- CL
- Chile
- Prior art keywords
- quinazolin
- thf
- amines
- pde1 inhibitors
- pde1
- Prior art date
Links
- 229940121836 Phosphodiesterase 1 inhibitor Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPUESTOS DERIVADOS DE N-(TETRAHIDROFURAN-3-IL)QUINAZOLIN-4-AMINA SUSTITUIDOS, INHIBIDORES DE PDE1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201300707 | 2013-12-19 | ||
| DKPA201400249 | 2014-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2016001488A1 true CL2016001488A1 (es) | 2016-12-09 |
Family
ID=52350066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2016001488A CL2016001488A1 (es) | 2013-12-19 | 2016-06-14 | Quinazolin-thf-aminas como inhibidores de pde1 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20150175584A1 (es) |
| EP (1) | EP3083607B1 (es) |
| JP (1) | JP6419832B2 (es) |
| KR (1) | KR20160098269A (es) |
| CN (1) | CN105829300B (es) |
| AP (1) | AP2016009293A0 (es) |
| AU (1) | AU2014368601B2 (es) |
| BR (1) | BR112016013946A8 (es) |
| CA (1) | CA2933299A1 (es) |
| CL (1) | CL2016001488A1 (es) |
| CR (1) | CR20160282A (es) |
| DO (1) | DOP2016000152A (es) |
| EA (1) | EA201691108A1 (es) |
| EC (1) | ECSP16061208A (es) |
| ES (1) | ES2728079T3 (es) |
| GE (1) | GEP201706764B (es) |
| IL (1) | IL246230A0 (es) |
| MX (1) | MX2016007945A (es) |
| PE (1) | PE20160855A1 (es) |
| PH (1) | PH12016501173A1 (es) |
| RU (1) | RU2016125315A (es) |
| SG (1) | SG11201604936TA (es) |
| SV (1) | SV2016005220A (es) |
| TN (1) | TN2016000239A1 (es) |
| TW (1) | TW201609713A (es) |
| WO (1) | WO2015091805A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201609713A (zh) | 2013-12-19 | 2016-03-16 | Ｈ 朗德貝克公司 | 作爲ｐｄｅ１抑制劑之喹唑啉－ｔｈｆ－胺 |
| EA032579B1 (ru) * | 2014-04-04 | 2019-06-28 | Х. Лундбекк А/С | Галогенированные хиназолин-тгф-амины в качестве ингибиторов pde1 |
| TWI729109B (zh) * | 2016-04-12 | 2021-06-01 | 丹麥商Ｈ 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
| EP3562828B1 (en) | 2016-12-28 | 2026-03-18 | Dart Neuroscience LLC | Substituted pyrazolopyrimidinone compounds as pde2 inhibitors |
| MX2020005447A (es) | 2017-11-27 | 2020-12-03 | Dart Neuroscience Llc | Compuestos de furanopirimidina sustituida como inhibidores de pde1. |
| JP7493460B2 (ja) | 2018-05-25 | 2024-05-31 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| US20220184240A1 (en) | 2019-04-12 | 2022-06-16 | Intra-Cellular Therapies, Inc. | Organic compounds |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1575916B1 (en) * | 2001-08-31 | 2013-05-22 | The Rockefeller University | Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain |
| CN1802177A (zh) * | 2003-04-01 | 2006-07-12 | 应用研究系统Ars股份公司 | 用于不育症中的磷酸二酯酶抑制剂 |
| CA2565037A1 (en) * | 2004-04-28 | 2005-11-10 | Cv Therapeutics, Inc. | Purine derivatives as a1 adenosine receptor antagonists |
| EP1940819A1 (en) * | 2005-08-16 | 2008-07-09 | Memory Pharmaceuticals Corporation | Phosphodiesterase 10 inhibitors |
| WO2007096743A1 (en) * | 2006-02-23 | 2007-08-30 | Pfizer Products Inc. | Substituted quinazolines as pde10 inhibitors |
| EP2279009A4 (en) * | 2008-05-05 | 2011-09-21 | Univ Rochester | METHOD AND COMPOSITIONS FOR TREATING OR PREVENTING PATHOLOGICAL CARDIAL REMODELING AND HEART FAILURE |
| EP2434895A4 (en) * | 2009-05-13 | 2013-08-07 | Intra Cellular Therapies Inc | ORGANIC CONNECTIONS |
| EP2480537A1 (en) * | 2009-09-24 | 2012-08-01 | Basf Se | Aminoquinazoline compounds for combating invertebrate pests |
| TW201609713A (zh) | 2013-12-19 | 2016-03-16 | Ｈ 朗德貝克公司 | 作爲ｐｄｅ１抑制劑之喹唑啉－ｔｈｆ－胺 |
-
2014
- 2014-12-01 TW TW103141539A patent/TW201609713A/zh unknown
- 2014-12-18 SG SG11201604936TA patent/SG11201604936TA/en unknown
- 2014-12-18 AU AU2014368601A patent/AU2014368601B2/en not_active Expired - Fee Related
- 2014-12-18 KR KR1020167016258A patent/KR20160098269A/ko not_active Withdrawn
- 2014-12-18 AP AP2016009293A patent/AP2016009293A0/en unknown
- 2014-12-18 PE PE2016000825A patent/PE20160855A1/es not_active Application Discontinuation
- 2014-12-18 CR CR20160282A patent/CR20160282A/es unknown
- 2014-12-18 CA CA2933299A patent/CA2933299A1/en not_active Abandoned
- 2014-12-18 CN CN201480068495.XA patent/CN105829300B/zh not_active Expired - Fee Related
- 2014-12-18 US US14/574,425 patent/US20150175584A1/en not_active Abandoned
- 2014-12-18 TN TN2016000239A patent/TN2016000239A1/en unknown
- 2014-12-18 EA EA201691108A patent/EA201691108A1/ru unknown
- 2014-12-18 BR BR112016013946A patent/BR112016013946A8/pt not_active IP Right Cessation
- 2014-12-18 JP JP2016541407A patent/JP6419832B2/ja not_active Expired - Fee Related
- 2014-12-18 WO PCT/EP2014/078475 patent/WO2015091805A1/en not_active Ceased
- 2014-12-18 GE GEAP201414180A patent/GEP201706764B/en unknown
- 2014-12-18 RU RU2016125315A patent/RU2016125315A/ru unknown
- 2014-12-18 ES ES14827431T patent/ES2728079T3/es active Active
- 2014-12-18 US US15/105,647 patent/US9701665B2/en not_active Expired - Fee Related
- 2014-12-18 EP EP14827431.9A patent/EP3083607B1/en active Active
- 2014-12-18 MX MX2016007945A patent/MX2016007945A/es unknown
-
2016
- 2016-06-14 CL CL2016001488A patent/CL2016001488A1/es unknown
- 2016-06-15 IL IL246230A patent/IL246230A0/en not_active IP Right Cessation
- 2016-06-15 SV SV2016005220A patent/SV2016005220A/es unknown
- 2016-06-16 PH PH12016501173A patent/PH12016501173A1/en unknown
- 2016-06-17 DO DO2016000152A patent/DOP2016000152A/es unknown
- 2016-07-18 EC ECIEPI201661208A patent/ECSP16061208A/es unknown
-
2017
- 2017-06-05 US US15/614,104 patent/US10030007B2/en active Active
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