CL2016002144A1 - Inhibidores de la jak1 para el tratamiento de síndromes mielodisplásicos. - Google Patents

Inhibidores de la jak1 para el tratamiento de síndromes mielodisplásicos.

Info

Publication number
CL2016002144A1
CL2016002144A1 CL2016002144A CL2016002144A CL2016002144A1 CL 2016002144 A1 CL2016002144 A1 CL 2016002144A1 CL 2016002144 A CL2016002144 A CL 2016002144A CL 2016002144 A CL2016002144 A CL 2016002144A CL 2016002144 A1 CL2016002144 A1 CL 2016002144A1
Authority
CL
Chile
Prior art keywords
treatment
myelodysplastic syndromes
jak1 inhibitors
pirrolo
patient
Prior art date
Application number
CL2016002144A
Other languages
English (en)
Inventor
Krishna Vaddi
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of CL2016002144A1 publication Critical patent/CL2016002144A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

UN METODO PARA TRATAR UN SINDROME MIELODISPLASICO EN UN PACIENTE, QUE COMPRENDE ADMINISTRAR AL PACIENTE UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE UN COMPUESTO DERIVADO DE PIRROLO[2,3-D]PIRIMIDINA O PIRROLO[2,3-B]PIRIDINA, INHIBIDOR SELECTIVO DE LA JAK1.
CL2016002144A 2014-02-28 2016-08-24 Inhibidores de la jak1 para el tratamiento de síndromes mielodisplásicos. CL2016002144A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461946124P 2014-02-28 2014-02-28

Publications (1)

Publication Number Publication Date
CL2016002144A1 true CL2016002144A1 (es) 2016-12-16

Family

ID=52693052

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002144A CL2016002144A1 (es) 2014-02-28 2016-08-24 Inhibidores de la jak1 para el tratamiento de síndromes mielodisplásicos.

Country Status (29)

Country Link
US (4) US20150246046A1 (es)
EP (1) EP3110409B1 (es)
JP (1) JP6576941B2 (es)
KR (1) KR20160136323A (es)
CN (2) CN112494652A (es)
AU (1) AU2015222913B2 (es)
CA (1) CA2940659C (es)
CL (1) CL2016002144A1 (es)
CR (1) CR20160449A (es)
CY (1) CY1120857T1 (es)
DK (1) DK3110409T3 (es)
EA (1) EA201691745A1 (es)
ES (1) ES2688553T3 (es)
HR (1) HRP20181661T1 (es)
HU (1) HUE041456T2 (es)
IL (1) IL247475B (es)
LT (1) LT3110409T (es)
MX (1) MX372939B (es)
MY (1) MY185392A (es)
PE (1) PE20161388A1 (es)
PL (1) PL3110409T3 (es)
PT (1) PT3110409T (es)
RS (1) RS57723B1 (es)
SG (2) SG10201807952PA (es)
SI (1) SI3110409T1 (es)
SM (1) SMT201800551T1 (es)
UA (1) UA121857C2 (es)
WO (1) WO2015131031A1 (es)
ZA (1) ZA201606610B (es)

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JP6576941B2 (ja) 2019-09-18
BR112016019511A8 (pt) 2023-01-24
MX372939B (es) 2020-04-03
ZA201606610B (en) 2020-08-26
CN112494652A (zh) 2021-03-16
KR20160136323A (ko) 2016-11-29
AU2015222913A1 (en) 2016-09-29
IL247475A0 (en) 2016-11-30
SMT201800551T1 (it) 2019-01-11
SI3110409T1 (sl) 2018-11-30
US20190111058A1 (en) 2019-04-18
US20210069193A1 (en) 2021-03-11
AU2015222913B2 (en) 2019-12-12
HRP20181661T1 (hr) 2018-12-14
DK3110409T3 (en) 2018-10-22
SG11201607083VA (en) 2016-09-29
IL247475B (en) 2020-05-31
MY185392A (en) 2021-05-17
ES2688553T3 (es) 2018-11-05
CR20160449A (es) 2016-12-20
EP3110409B1 (en) 2018-08-15
UA121857C2 (uk) 2020-08-10
EA201691745A1 (ru) 2016-12-30
PE20161388A1 (es) 2016-12-28
PL3110409T3 (pl) 2018-12-31
MX2016011103A (es) 2017-02-28
BR112016019511A2 (es) 2017-08-15
LT3110409T (lt) 2019-01-25
SG10201807952PA (en) 2018-10-30
PT3110409T (pt) 2018-11-07
NZ724464A (en) 2021-01-29
HUE041456T2 (hu) 2019-05-28
JP2017506659A (ja) 2017-03-09
US20220378791A1 (en) 2022-12-01
US20150246046A1 (en) 2015-09-03
WO2015131031A1 (en) 2015-09-03
CA2940659C (en) 2023-01-03
CN106456773A (zh) 2017-02-22
RS57723B1 (sr) 2018-12-31
CY1120857T1 (el) 2019-12-11
EP3110409A1 (en) 2017-01-04
CA2940659A1 (en) 2015-09-03

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