CL2016002493A1 - Estabilización del factor viii sin calcio como un excipiente. - Google Patents
Estabilización del factor viii sin calcio como un excipiente.Info
- Publication number
- CL2016002493A1 CL2016002493A1 CL2016002493A CL2016002493A CL2016002493A1 CL 2016002493 A1 CL2016002493 A1 CL 2016002493A1 CL 2016002493 A CL2016002493 A CL 2016002493A CL 2016002493 A CL2016002493 A CL 2016002493A CL 2016002493 A1 CL2016002493 A1 CL 2016002493A1
- Authority
- CL
- Chile
- Prior art keywords
- excipient
- stabilization
- calcium
- factor viii
- viii
- Prior art date
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title 1
- 229910052791 calcium Inorganic materials 0.000 title 1
- 239000011575 calcium Substances 0.000 title 1
- 229960000301 factor viii Drugs 0.000 title 1
- 239000000546 pharmaceutical excipient Substances 0.000 title 1
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461973280P | 2014-04-01 | 2014-04-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2016002493A1 true CL2016002493A1 (es) | 2017-07-07 |
Family
ID=54241376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2016002493A CL2016002493A1 (es) | 2014-04-01 | 2016-09-30 | Estabilización del factor viii sin calcio como un excipiente. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9855319B2 (es) |
| EP (1) | EP3125925A4 (es) |
| JP (1) | JP2017509658A (es) |
| KR (1) | KR20160146763A (es) |
| CN (1) | CN106456720A (es) |
| AU (1) | AU2015240354A1 (es) |
| CA (1) | CA2944183A1 (es) |
| CL (1) | CL2016002493A1 (es) |
| MX (1) | MX2016012869A (es) |
| WO (1) | WO2015149144A2 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017509659A (ja) | 2014-04-01 | 2017-04-06 | アドヴァンテック・バイオサイエンス・ファルマスーティカ・リミターダ | 低糖−低グリシンの安定な第viii因子製剤 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994007510A1 (en) | 1992-10-02 | 1994-04-14 | Kabi Pharmacia Ab | Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer |
| US5763401A (en) * | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
| US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| CA2634663C (en) | 1999-02-22 | 2009-08-25 | University Of Connecticut | Novel albumin-free factor viii formulations |
| ATE310533T1 (de) | 1999-07-13 | 2005-12-15 | Zusammensetzungen mit stabilem faktor viii | |
| US20040185535A1 (en) | 2003-03-21 | 2004-09-23 | Giles Wilson | Industrial-scale serum-free production of recombinant FVII in mammalian cells |
| EP1233064A1 (en) | 2001-02-09 | 2002-08-21 | Aventis Behring Gesellschaft mit beschränkter Haftung | Modified factor VIII cDNA and its use for the production of factor VIII |
| US20040229335A1 (en) | 2003-05-15 | 2004-11-18 | Introgen Therapeutics, Inc. | Methods and compositions for the production of adenoviral vectors |
| KR100624013B1 (ko) | 2004-06-25 | 2006-09-19 | 주식회사 녹십자홀딩스 | 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제 |
| CA2656558A1 (en) | 2006-06-30 | 2008-01-10 | The Regents Of The University Of Michigan | Method of producing factor viii proteins by recombinant methods |
| US20090035807A1 (en) | 2007-07-31 | 2009-02-05 | Wyeth | Analysis of polypeptide production |
| US8580554B2 (en) | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
| DK2501822T3 (da) | 2009-11-17 | 2017-11-27 | Squibb & Sons Llc | Fremgangsmåder til forbedret proteinproduktion |
| US20140051832A1 (en) | 2011-03-11 | 2014-02-20 | Universidade De São Paulo - Usp | Method for the production of recombinant human factor viii |
| US8668886B2 (en) | 2011-04-24 | 2014-03-11 | Therapeutic Proteins International, LLC | Separative bioreactor |
| CA2850579A1 (en) * | 2011-10-18 | 2013-04-25 | Carsten Horn | Method for improving the stability of purified factor viii after reconstitution |
| JP2017506077A (ja) | 2014-02-17 | 2017-03-02 | アドヴァンテック・バイオサイエンス・ファルマスーティカ・リミターダ | 膜系細胞保持システムを利用する組換えタンパク質の発現向上 |
| CN106459180A (zh) | 2014-03-23 | 2017-02-22 | 爱德技术生物科学有限公司 | 在铜使用下重组蛋白表达的增强 |
| JP2017509659A (ja) | 2014-04-01 | 2017-04-06 | アドヴァンテック・バイオサイエンス・ファルマスーティカ・リミターダ | 低糖−低グリシンの安定な第viii因子製剤 |
-
2015
- 2015-03-30 KR KR1020167030252A patent/KR20160146763A/ko not_active Withdrawn
- 2015-03-30 MX MX2016012869A patent/MX2016012869A/es unknown
- 2015-03-30 JP JP2016559417A patent/JP2017509658A/ja not_active Withdrawn
- 2015-03-30 WO PCT/BR2015/000045 patent/WO2015149144A2/en not_active Ceased
- 2015-03-30 EP EP15772998.9A patent/EP3125925A4/en not_active Withdrawn
- 2015-03-30 AU AU2015240354A patent/AU2015240354A1/en not_active Abandoned
- 2015-03-30 CA CA2944183A patent/CA2944183A1/en not_active Abandoned
- 2015-03-30 US US15/120,274 patent/US9855319B2/en not_active Expired - Fee Related
- 2015-03-30 CN CN201580027428.8A patent/CN106456720A/zh active Pending
-
2016
- 2016-09-30 CL CL2016002493A patent/CL2016002493A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2016012869A (es) | 2017-05-12 |
| JP2017509658A (ja) | 2017-04-06 |
| EP3125925A4 (en) | 2017-12-06 |
| EP3125925A2 (en) | 2017-02-08 |
| KR20160146763A (ko) | 2016-12-21 |
| WO2015149144A3 (en) | 2016-03-10 |
| US20170080059A1 (en) | 2017-03-23 |
| CN106456720A (zh) | 2017-02-22 |
| US9855319B2 (en) | 2018-01-02 |
| CA2944183A1 (en) | 2015-10-08 |
| AU2015240354A1 (en) | 2016-11-17 |
| WO2015149144A2 (en) | 2015-10-08 |
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