CL2016002495A1 - Derivados de piridina macrocíclicos . - Google Patents
Derivados de piridina macrocíclicos .Info
- Publication number
- CL2016002495A1 CL2016002495A1 CL2016002495A CL2016002495A CL2016002495A1 CL 2016002495 A1 CL2016002495 A1 CL 2016002495A1 CL 2016002495 A CL2016002495 A CL 2016002495A CL 2016002495 A CL2016002495 A CL 2016002495A CL 2016002495 A1 CL2016002495 A1 CL 2016002495A1
- Authority
- CL
- Chile
- Prior art keywords
- pyridine derivatives
- macrocyclic
- macrocyclic pyridine
- macrociclycles
- ef2k
- Prior art date
Links
- 150000003222 pyridines Chemical class 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 101000605630 Homo sapiens Phosphatidylinositol 3-kinase catalytic subunit type 3 Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100038329 Phosphatidylinositol 3-kinase catalytic subunit type 3 Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
<p>COMPUESTOS DERIVADOS DE PIRIDINA MACROCICLICLAS, INHIBIDORES DE EF2K Y Vps34; COMPOSICION FARMACEUTICA; Y SU USO PARA EL TRATAMIENTO DE UNA ENFERMEDAD O UN ESTADO SELECCIONADO DE CANCER, DEPRESION Y TRATORNOS DEL APRENDIZAJE Y LA MEMORIA- </p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14163442 | 2014-04-03 | ||
| EP14183823 | 2014-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2016002495A1 true CL2016002495A1 (es) | 2017-02-24 |
Family
ID=52781118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2016002495A CL2016002495A1 (es) | 2014-04-03 | 2016-09-30 | Derivados de piridina macrocíclicos . |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20170022201A1 (es) |
| EP (1) | EP3126365B1 (es) |
| JP (1) | JP6420362B2 (es) |
| KR (1) | KR102390274B1 (es) |
| CN (1) | CN106132964B (es) |
| AU (1) | AU2015239100B2 (es) |
| BR (1) | BR112016022700B1 (es) |
| CA (1) | CA2942751C (es) |
| CL (1) | CL2016002495A1 (es) |
| EA (1) | EA029758B1 (es) |
| ES (1) | ES2665797T3 (es) |
| IL (1) | IL248001B (es) |
| MA (1) | MA39823A (es) |
| MX (1) | MX369799B (es) |
| MY (1) | MY185500A (es) |
| NZ (1) | NZ725406A (es) |
| PE (1) | PE20161365A1 (es) |
| PH (1) | PH12016501962A1 (es) |
| SG (1) | SG11201608241UA (es) |
| UA (1) | UA118120C2 (es) |
| WO (1) | WO2015150557A1 (es) |
| ZA (1) | ZA201606768B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6783311B2 (ja) | 2015-09-24 | 2020-11-11 | サイクレニウム ファーマ インコーポレーテッド | ヘテロアリール含有大環状化合物のライブラリならびにその製造方法および使用方法 |
| AU2017219846B2 (en) | 2016-02-19 | 2021-05-13 | Sprint Bioscience Ab | 6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes |
| DK3416957T3 (da) | 2016-02-19 | 2020-09-21 | Sprint Bioscience Ab | 6-heterocyclyl-4-morpholin-4-ylpyridin-2-on-forbindelser anvendelige ved behandlingen af cancer og diabetes |
| MA52117A (fr) | 2017-02-28 | 2022-04-06 | Morphic Therapeutic Inc | Inhibiteurs de l'intégrine (alpha-v) (bêta-6) |
| MA47697A (fr) | 2017-02-28 | 2020-01-08 | Morphic Therapeutic Inc | Inhibiteurs de l'(alpha-v)(bêta-6) intégrine |
| CA3057891A1 (en) | 2017-03-28 | 2018-10-04 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| EP3601253B1 (en) | 2017-03-28 | 2021-09-15 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| JP2020524701A (ja) * | 2017-06-22 | 2020-08-20 | サイクルニウム ファーマ インコーポレイテッド | ピリジン含有大環状化合物ライブラリーならびにその製造および使用方法 |
| US11560374B2 (en) | 2017-08-23 | 2023-01-24 | Sprint Bioscience Ab | Morpholinylpyridone compounds |
| WO2019038387A1 (en) | 2017-08-23 | 2019-02-28 | Sprint Bioscience Ab | PYRIDYLPYRIDONE COMPOUNDS |
| CN111094271B (zh) | 2017-08-23 | 2023-02-28 | 思普瑞特生物科学公司 | 吡啶胺-吡啶酮化合物和嘧啶胺-吡啶酮化合物 |
| JP7199738B2 (ja) | 2017-08-23 | 2023-01-06 | スプリント バイオサイエンス アクティエボラーグ | アザインドリルピリドンおよびジアザインドリルピリドン化合物 |
| FI3844162T3 (fi) | 2018-08-29 | 2025-03-27 | Morphic Therapeutic Inc | Alfa v beeta6 -integriinin estäjiä |
| EP4086254B1 (en) | 2018-08-29 | 2024-12-18 | Morphic Therapeutic, Inc. | Integrin inhibitors |
| WO2020047208A1 (en) | 2018-08-29 | 2020-03-05 | Morphic Therapeutic, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
| WO2021032588A1 (en) * | 2019-08-16 | 2021-02-25 | Inflazome Limited | Macrocyclic sulfonylamide derivatives useful as nlrp3 inhibitors |
| CN113845521B (zh) * | 2021-08-31 | 2024-06-18 | 中原工学院 | 水相中光催化一锅法合成咪唑并含氮杂环肼类衍生物的方法 |
| CN115260128B (zh) * | 2022-09-21 | 2022-12-09 | 苏州凯瑞医药科技有限公司 | 一种新型jak抑制剂关键中间体的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001227755A1 (en) * | 2000-01-12 | 2001-07-24 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
| WO2004078682A2 (en) * | 2003-03-05 | 2004-09-16 | Irm Llc | Cyclic compounds and compositions as protein kinase inhibitors |
| PA8603801A1 (es) * | 2003-05-27 | 2004-12-16 | Janssen Pharmaceutica Nv | Derivados de la quinazolina |
| UA83881C2 (en) | 2003-12-18 | 2008-08-26 | Янссен Фармацевтика Н.В. | Pyrido- and pyrimidopyrimidine derivatives as anti-proliferative agents |
| ATE446750T1 (de) | 2003-12-18 | 2009-11-15 | Janssen Pharmaceutica Nv | 3-cyano-chinolin-derivate mit antiproliferativer wirkung |
| JO3088B1 (ar) | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| MY169441A (en) | 2004-12-08 | 2019-04-11 | Janssen Pharmaceutica Nv | 2,4, (4,6) pyrimidine derivatives |
| WO2007003525A2 (en) | 2005-06-30 | 2007-01-11 | Janssen Pharmaceutica N.V. | Cyclic anilino-pyridinotriazines as gsk-3 inhibitors |
| NZ568325A (en) * | 2005-11-16 | 2011-05-27 | S Bio Pte Ltd | Macrocyclic oxygen linked pyrimidine derivatives |
| CA2687909C (en) | 2007-06-21 | 2015-09-15 | Janssen Pharmaceutica Nv | Indolin-2-ones and aza-indolin-2-ones |
| ES2562218T3 (es) | 2007-07-27 | 2016-03-03 | Janssen Pharmaceutica, N.V. | Pirrolopirimidinas útiles para el tratamiento de enfermedades proliferativas |
| EP2283024B1 (en) * | 2008-03-10 | 2013-05-15 | Janssen Pharmaceutica, N.V. | 4-aryl-2-anilino-pyrimidines as plk kinase inhibitors |
| AU2009256574A1 (en) | 2008-06-13 | 2009-12-17 | Novartis Ag | 2,4'-bipyridinyl compounds as protein kinase D inhibitors useful for the treatment of IA heart failure and cancer |
-
2015
- 2015-04-01 MA MA039823A patent/MA39823A/fr unknown
- 2015-04-02 ES ES15713523.7T patent/ES2665797T3/es active Active
- 2015-04-02 US US15/300,907 patent/US20170022201A1/en not_active Abandoned
- 2015-04-02 KR KR1020167028761A patent/KR102390274B1/ko not_active Expired - Fee Related
- 2015-04-02 CA CA2942751A patent/CA2942751C/en active Active
- 2015-04-02 EA EA201692000A patent/EA029758B1/ru not_active IP Right Cessation
- 2015-04-02 MX MX2016012994A patent/MX369799B/es active IP Right Grant
- 2015-04-02 MY MYPI2016001776A patent/MY185500A/en unknown
- 2015-04-02 PE PE2016001843A patent/PE20161365A1/es active IP Right Grant
- 2015-04-02 JP JP2016560816A patent/JP6420362B2/ja active Active
- 2015-04-02 WO PCT/EP2015/057401 patent/WO2015150557A1/en not_active Ceased
- 2015-04-02 SG SG11201608241UA patent/SG11201608241UA/en unknown
- 2015-04-02 CN CN201580018081.0A patent/CN106132964B/zh active Active
- 2015-04-02 UA UAA201611003A patent/UA118120C2/uk unknown
- 2015-04-02 BR BR112016022700-0A patent/BR112016022700B1/pt not_active IP Right Cessation
- 2015-04-02 AU AU2015239100A patent/AU2015239100B2/en not_active Ceased
- 2015-04-02 EP EP15713523.7A patent/EP3126365B1/en active Active
- 2015-04-02 NZ NZ725406A patent/NZ725406A/en not_active IP Right Cessation
-
2016
- 2016-09-25 IL IL248001A patent/IL248001B/en active IP Right Grant
- 2016-09-30 CL CL2016002495A patent/CL2016002495A1/es unknown
- 2016-09-30 ZA ZA2016/06768A patent/ZA201606768B/en unknown
- 2016-10-03 PH PH12016501962A patent/PH12016501962A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3126365A1 (en) | 2017-02-08 |
| SG11201608241UA (en) | 2016-10-28 |
| KR102390274B1 (ko) | 2022-04-22 |
| AU2015239100B2 (en) | 2019-06-27 |
| CA2942751C (en) | 2023-03-21 |
| ZA201606768B (en) | 2018-11-28 |
| EP3126365B1 (en) | 2018-01-10 |
| MX2016012994A (es) | 2016-12-07 |
| CN106132964A (zh) | 2016-11-16 |
| AU2015239100A1 (en) | 2016-09-29 |
| KR102390274B9 (ko) | 2023-03-03 |
| UA118120C2 (uk) | 2018-11-26 |
| MA39823A (fr) | 2018-01-09 |
| IL248001B (en) | 2018-11-29 |
| ES2665797T3 (es) | 2018-04-27 |
| MY185500A (en) | 2021-05-19 |
| EA029758B1 (ru) | 2018-05-31 |
| JP2017509685A (ja) | 2017-04-06 |
| PE20161365A1 (es) | 2016-12-17 |
| JP6420362B2 (ja) | 2018-11-07 |
| MX369799B (es) | 2019-11-21 |
| US20170022201A1 (en) | 2017-01-26 |
| EA201692000A1 (ru) | 2017-01-30 |
| KR20160140739A (ko) | 2016-12-07 |
| BR112016022700A2 (es) | 2017-08-15 |
| PH12016501962B1 (en) | 2017-01-09 |
| PH12016501962A1 (en) | 2017-01-09 |
| CN106132964B (zh) | 2019-07-19 |
| WO2015150557A1 (en) | 2015-10-08 |
| BR112016022700B1 (pt) | 2022-01-11 |
| CA2942751A1 (en) | 2015-10-08 |
| NZ725406A (en) | 2022-08-26 |
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