CL2016002689A1 - Anticuerpos humanizados contra la molécula de adhesión celular relacionada al antígeno carcinoembriónico 1 (ceacam1) - Google Patents

Anticuerpos humanizados contra la molécula de adhesión celular relacionada al antígeno carcinoembriónico 1 (ceacam1)

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Publication number
CL2016002689A1
CL2016002689A1 CL2016002689A CL2016002689A CL2016002689A1 CL 2016002689 A1 CL2016002689 A1 CL 2016002689A1 CL 2016002689 A CL2016002689 A CL 2016002689A CL 2016002689 A CL2016002689 A CL 2016002689A CL 2016002689 A1 CL2016002689 A1 CL 2016002689A1
Authority
CL
Chile
Prior art keywords
humanized antibodies
ceacam1
antibodies against
cell adhesion
adhesion molecule
Prior art date
Application number
CL2016002689A
Other languages
English (en)
Inventor
Moshe Tehila Ben
Yair Sapir
Ilana Mandel
Gal Markel
Jacob Schachter
Rona Ortenberg
Francis Joseph Carr
Robert George E Holgate
Timothy David Jones
Original Assignee
Ccam Biotherapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ccam Biotherapeutics Ltd filed Critical Ccam Biotherapeutics Ltd
Publication of CL2016002689A1 publication Critical patent/CL2016002689A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3007—Carcino-embryonic Antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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Abstract

<p>Se proporcionan anticuerpos humanizados, capaces de unión específica a moléculas de CEACAM1 humana que contienen mutaciones restauradoras de humano a murino en regiones variables distintas de CDR, y sus secuencias codificadoras de polinucleótidos; también se proporcionan composiciones farmacéuticas que comprenden estos anticuerpos, así como sus métodos de su uso para tratar y diagnosticar cáncer y otras condiciones.</p>
CL2016002689A 2014-04-27 2016-10-21 Anticuerpos humanizados contra la molécula de adhesión celular relacionada al antígeno carcinoembriónico 1 (ceacam1) CL2016002689A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461984786P 2014-04-27 2014-04-27
US201562099155P 2015-01-01 2015-01-01

Publications (1)

Publication Number Publication Date
CL2016002689A1 true CL2016002689A1 (es) 2017-11-03

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CL2016002689A CL2016002689A1 (es) 2014-04-27 2016-10-21 Anticuerpos humanizados contra la molécula de adhesión celular relacionada al antígeno carcinoembriónico 1 (ceacam1)

Country Status (24)

Country Link
US (2) US10550196B2 (es)
EP (2) EP3766902A1 (es)
JP (1) JP6805428B2 (es)
KR (1) KR102452349B1 (es)
CN (1) CN106573977B (es)
AP (2) AP2016009504A0 (es)
AU (1) AU2015254886A1 (es)
BR (1) BR112016024972B1 (es)
CA (1) CA2946262C (es)
CL (1) CL2016002689A1 (es)
CR (1) CR20160534A (es)
DO (1) DOP2016000282A (es)
EA (1) EA037613B1 (es)
ES (1) ES2825080T3 (es)
IL (1) IL248402B (es)
MD (1) MD20160130A2 (es)
MX (2) MX366359B (es)
NI (1) NI201600162A (es)
PE (1) PE20170764A1 (es)
PH (1) PH12016502151A1 (es)
PL (1) PL3137502T3 (es)
SG (1) SG11201608772UA (es)
SV (1) SV2016005307A (es)
WO (1) WO2015166484A1 (es)

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CA3013443C (en) * 2016-02-01 2021-06-15 Eli Lilly And Company Parathyroid hormone - anti-rankl antibody fusion compounds
JP6993812B2 (ja) * 2016-08-17 2022-01-14 治範 小田 細胞傷害活性を向上させたリンパ球の培養方法及び該方法で得られた細胞傷害活性を向上させたリンパ球を含む細胞免疫治療剤
KR102019913B1 (ko) * 2017-03-24 2019-09-09 재단법인 목암생명과학연구소 항-ceacam1 항체 및 이의 용도
EP3601361A4 (en) * 2017-03-24 2020-12-16 Mogam Institute For Biomedical Research ANTI-CEACAM1 ANTIBODIES AND ITS USE
CN109663130B (zh) * 2017-10-13 2021-06-29 江苏恒瑞医药股份有限公司 Pd-1抗体和mek抑制剂联合在制备治疗肿瘤的药物中的用途
GB201802201D0 (en) 2018-02-09 2018-03-28 Ultrahuman Five Ltd Binding agents
JP2022513729A (ja) * 2018-12-07 2022-02-09 ザ ブリガム アンド ウィメンズ ホスピタル，インコーポレイティド ヒト化及び親和性成熟抗ｃｅａｃａｍ１抗体
JP2022514615A (ja) * 2018-12-20 2022-02-14 アルバート アインシュタイン カレッジ オブ メディスン ヒト免疫チェックポイントＣＥＡＣＡＭ１（ＣＤ６６ａ）に対するアンタゴニスト抗体及びその製剤、キット並びに使用方法
CN111487411B (zh) * 2019-01-29 2023-05-09 瑞博奥(广州)生物科技股份有限公司 Ceacam1多肽的新应用
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