CL2016002835A1 - “compuestos derivados de pladienolida con un resto piridinico; composición farmacéutica que los comprende; y su uso en el tratamiento del cáncer”. pct - Google Patents

“compuestos derivados de pladienolida con un resto piridinico; composición farmacéutica que los comprende; y su uso en el tratamiento del cáncer”. pct

Info

Publication number
CL2016002835A1
CL2016002835A1 CL2016002835A CL2016002835A CL2016002835A1 CL 2016002835 A1 CL2016002835 A1 CL 2016002835A1 CL 2016002835 A CL2016002835 A CL 2016002835A CL 2016002835 A CL2016002835 A CL 2016002835A CL 2016002835 A1 CL2016002835 A1 CL 2016002835A1
Authority
CL
Chile
Prior art keywords
pladienolide
pyridinic
pharmaceutical composition
moiety
pct
Prior art date
Application number
CL2016002835A
Other languages
English (en)
Inventor
Gregg F Keaney
John Wang
Baudouin Gerard
Kenzo Arai
Xiang Liu
Guo Zhu Zheng
Kazunobu Kira
Parcharee Tivitmahaisoon
Sudeep Prajapati
Nicholas C Gearhart
Yoshihiko Kotake
Satoshi Nagao
Sonobe Regina Kanada
Masayuki Miyano
Norio Murai
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53284528&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016002835(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of CL2016002835A1 publication Critical patent/CL2016002835A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA SOLICITUD SE REFIERE A COMPUESTOS DERIVADOS DE PLADIENOLIDA CON UN RESTO PIRIDINICO, A UNA COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE Y A SU USO EN EL TRATAMIENTO DEL CÁNCER.
CL2016002835A 2014-05-15 2016-11-08 “compuestos derivados de pladienolida con un resto piridinico; composición farmacéutica que los comprende; y su uso en el tratamiento del cáncer”. pct CL2016002835A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461993423P 2014-05-15 2014-05-15

Publications (1)

Publication Number Publication Date
CL2016002835A1 true CL2016002835A1 (es) 2017-04-17

Family

ID=53284528

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002835A CL2016002835A1 (es) 2014-05-15 2016-11-08 “compuestos derivados de pladienolida con un resto piridinico; composición farmacéutica que los comprende; y su uso en el tratamiento del cáncer”. pct

Country Status (36)

Country Link
US (1) US9481669B2 (es)
EP (2) EP3143016B1 (es)
JP (1) JP6067943B1 (es)
KR (2) KR101710318B1 (es)
CN (1) CN107074827B (es)
AR (1) AR100431A1 (es)
AU (1) AU2015259237B2 (es)
BR (1) BR112016026638B1 (es)
CA (1) CA2947754C (es)
CL (1) CL2016002835A1 (es)
CY (1) CY1121550T1 (es)
DK (1) DK3143016T3 (es)
ES (1) ES2712401T3 (es)
HR (1) HRP20190432T1 (es)
HU (1) HUE041838T2 (es)
IL (1) IL248529B (es)
JO (1) JO3668B1 (es)
LT (1) LT3143016T (es)
MA (1) MA39915B1 (es)
ME (1) ME03417B (es)
MX (2) MX373324B (es)
MY (1) MY195081A (es)
PE (1) PE20170384A1 (es)
PH (1) PH12016502249B1 (es)
PL (1) PL3143016T3 (es)
PT (1) PT3143016T (es)
RS (1) RS58400B1 (es)
RU (1) RU2707730C2 (es)
SG (1) SG11201609693XA (es)
SI (1) SI3143016T1 (es)
SM (1) SMT201900158T1 (es)
TR (1) TR201902328T4 (es)
TW (1) TWI634115B (es)
UA (1) UA119458C2 (es)
WO (1) WO2015175594A1 (es)
ZA (1) ZA201607354B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3344780B1 (en) 2015-09-01 2021-06-23 Eisai R&D Management Co., Ltd. Splice variants associated with neomorphic sf3b1 mutants
IL259198B2 (en) * 2015-11-18 2023-04-01 Eisai R&D Man Co Ltd A solid form of paladinolide pyridine compound and methods of its use
JP2020514348A (ja) * 2017-03-15 2020-05-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 スプライセオソーム変異及びその使用
CN111727059A (zh) 2017-10-31 2020-09-29 卫材研究发展管理有限公司 包含至少一种剪接体调控剂和至少一种选自BCL2抑制剂、BCL2/BCLxL抑制剂和BCLxL抑制剂的抑制剂的组合及其使用方法
CA3096400A1 (en) * 2018-04-09 2019-10-17 Eisai R&D Management Co., Ltd. Certain pladienolide compounds and methods of use
CA3096424A1 (en) * 2018-04-12 2019-10-17 Eisai R&D Management Co., Ltd. Pladienolide derivatives as spliceosome targeting agents for treating cancer
IL278740B2 (en) * 2018-06-01 2024-01-01 Eisai R&D Man Co Ltd Methods for using splicing modulators
CN119405833A (zh) 2018-06-01 2025-02-11 卫材R&D管理有限公司 剪接调节抗体-药物缀合物及其使用方法
IL262658A (en) * 2018-10-28 2020-04-30 Memorial Sloan Kettering Cancer Center Prevention of age related clonal hematopoiesis and diseases associated therewith
EP4161966A1 (en) * 2020-06-05 2023-04-12 Eisai R&D Management Co., Ltd. Anti-bcma antibody-drug conjugates and methods of use
US20240043928A1 (en) 2020-11-04 2024-02-08 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same
EP4361136A4 (en) * 2021-06-18 2025-08-13 Univ Cordoba Compound for the treatment of glioblastoma
CN113876771B (zh) * 2021-11-12 2022-09-23 中国医学科学院基础医学研究所 一种靶向pabpc1的小分子药物及其在慢性髓系白血病中的应用
WO2023131866A1 (en) 2022-01-05 2023-07-13 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same
MA71743A (fr) 2022-11-07 2025-05-30 Eisai R&D Management Co., Ltd. Procédé de production d'un composé macrolide

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI312681B (en) * 2001-02-01 2009-08-01 Novel physiologically active substance
TWI334866B (en) 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
RU2338741C2 (ru) 2002-07-31 2008-11-20 Мершан Корпорейшн Новые физиологически активные вещества
US7576204B2 (en) 2002-07-31 2009-08-18 Mercian Corporation Heterocyclic macrolide pharmaceutical agent, a method of producing the same and use of the same
AU2003285012A1 (en) 2002-10-24 2004-05-13 Sepracor, Inc. Compositions comprising zopiclone derivatives and methods of making and using the same
RU2330069C2 (ru) 2002-11-29 2008-07-27 Мершан Корпорейшн Способ получения макролидного соединения и штаммы streptomyces sp., mortierella sp. и micromonosporaceae
CN1886505A (zh) 2003-11-27 2006-12-27 美露香株式会社 参与大环内酯类化合物的羟化作用的dna
CA2552553C (en) 2003-11-28 2015-01-06 Kanagawa Academy Of Science And Technology Method of detecting liver cancer, diagnostic for liver cancer and remedy for cancer
JPWO2006003706A1 (ja) 2004-07-02 2008-04-17 株式会社プラスワンテクノ 組み合わせ計量技術
CN1977046A (zh) 2004-07-20 2007-06-06 卫材R&D管理有限公司 编码参与普拉地内酯生物合成的多肽的dna
TW200716744A (en) * 2005-05-26 2007-05-01 Eisai R&D Man Co Ltd Genetically modified microorganism and process for production of macrolide compound using the microorganism
CN101282967B (zh) 2005-10-13 2011-01-26 卫材R&D管理有限公司 普拉二烯内酯b和普拉二烯内酯d的全合成
WO2008111464A1 (ja) * 2007-03-05 2008-09-18 Eisai R & D Management Co., Ltd. スプライシング異常を指標とする抗ガン剤の作用検定方法
US20080312317A1 (en) 2007-04-12 2008-12-18 Eisai R&D Management Co., Ltd. 12 membered-ring macrolactam derivatives

Also Published As

Publication number Publication date
IL248529A0 (en) 2016-12-29
RU2019124012A (ru) 2019-08-12
RU2016148887A (ru) 2018-06-18
US9481669B2 (en) 2016-11-01
KR20160082256A (ko) 2016-07-08
US20150329528A1 (en) 2015-11-19
EP3143016B1 (en) 2018-12-12
WO2015175594A1 (en) 2015-11-19
PH12016502249B1 (en) 2023-12-13
KR101710318B9 (ko) 2026-02-06
CY1121550T1 (el) 2020-05-29
LT3143016T (lt) 2019-06-10
AU2015259237A1 (en) 2016-11-10
MX388580B (es) 2025-03-20
ME03417B (me) 2020-01-20
KR20170021899A (ko) 2017-02-28
TW201625596A (zh) 2016-07-16
PH12016502249A1 (en) 2017-02-06
ZA201607354B (en) 2018-05-30
CA2947754A1 (en) 2015-11-19
UA119458C2 (uk) 2019-06-25
CA2947754C (en) 2024-01-02
HUE041838T2 (hu) 2019-05-28
BR112016026638B1 (pt) 2022-08-02
SI3143016T1 (sl) 2019-04-30
PE20170384A1 (es) 2017-05-11
RS58400B1 (sr) 2019-04-30
IL248529B (en) 2019-11-28
HRP20190432T1 (hr) 2019-04-19
EP3514154A1 (en) 2019-07-24
PL3143016T3 (pl) 2019-04-30
JP6067943B1 (ja) 2017-01-25
JO3668B1 (ar) 2020-08-27
PT3143016T (pt) 2019-02-27
MX2020004476A (es) 2021-12-08
MA39915A (fr) 2017-03-22
ES2712401T3 (es) 2019-05-13
NZ725603A (en) 2023-11-24
CN107074827B (zh) 2020-12-18
BR112016026638A2 (es) 2017-08-15
SG11201609693XA (en) 2016-12-29
MX373324B (es) 2020-05-04
NZ764190A (en) 2023-11-24
JP2017505282A (ja) 2017-02-16
AR100431A1 (es) 2016-10-05
KR102146726B1 (ko) 2020-08-21
MX2016014997A (es) 2017-06-29
KR102146726B9 (ko) 2026-02-05
EP3143016A1 (en) 2017-03-22
MY195081A (en) 2023-01-09
MA39915B1 (fr) 2019-05-31
SMT201900158T1 (it) 2019-05-10
RU2707730C2 (ru) 2019-11-29
RU2016148887A3 (es) 2018-12-11
KR101710318B1 (ko) 2017-02-24
DK3143016T3 (en) 2019-04-08
TWI634115B (zh) 2018-09-01
AU2015259237B2 (en) 2019-08-15
CN107074827A (zh) 2017-08-18
EP3514154B1 (en) 2022-08-03
TR201902328T4 (tr) 2019-03-21

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