CL2016002836A1 - Compuestos derivados de pirido pirimidin con actividad moduladora del empalme genico de smn2; composicion farmaceutica y uso en el tratamiento de la atrofia muscular espinal (ame). - Google Patents

Compuestos derivados de pirido pirimidin con actividad moduladora del empalme genico de smn2; composicion farmaceutica y uso en el tratamiento de la atrofia muscular espinal (ame).

Info

Publication number
CL2016002836A1
CL2016002836A1 CL2016002836A CL2016002836A CL2016002836A1 CL 2016002836 A1 CL2016002836 A1 CL 2016002836A1 CL 2016002836 A CL2016002836 A CL 2016002836A CL 2016002836 A CL2016002836 A CL 2016002836A CL 2016002836 A1 CL2016002836 A1 CL 2016002836A1
Authority
CL
Chile
Prior art keywords
ame
pyrido
pyrimidin
treatment
muscular atrophy
Prior art date
Application number
CL2016002836A
Other languages
English (en)
Inventor
Hasane Ratni
Luke Green
Nikolai A Naryshkin
Marla L Weetall
Original Assignee
Hoffmann La Roche
Ptc Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53175048&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016002836(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche, Ptc Therapeutics Inc filed Critical Hoffmann La Roche
Publication of CL2016002836A1 publication Critical patent/CL2016002836A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos dericvados de 2-(imidazo[1,2-b]piridazin-6-il)-4h-pirido[1,2-a]pirimidin-4-ona; proceso de preparacion; composicion farmceutica; y su uso para el tratamiento o la prevencion de la atrofia muscular espinal (ame)
CL2016002836A 2014-05-15 2016-11-08 Compuestos derivados de pirido pirimidin con actividad moduladora del empalme genico de smn2; composicion farmaceutica y uso en el tratamiento de la atrofia muscular espinal (ame). CL2016002836A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461993839P 2014-05-15 2014-05-15

Publications (1)

Publication Number Publication Date
CL2016002836A1 true CL2016002836A1 (es) 2017-04-21

Family

ID=53175048

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002836A CL2016002836A1 (es) 2014-05-15 2016-11-08 Compuestos derivados de pirido pirimidin con actividad moduladora del empalme genico de smn2; composicion farmaceutica y uso en el tratamiento de la atrofia muscular espinal (ame).

Country Status (36)

Country Link
US (1) US9969754B2 (es)
EP (3) EP3143025B1 (es)
JP (1) JP6236173B2 (es)
KR (2) KR102256013B1 (es)
CN (1) CN106459092B (es)
AR (2) AR100442A1 (es)
AU (1) AU2015261046C1 (es)
BR (1) BR112016026205B1 (es)
CA (1) CA2948561C (es)
CL (1) CL2016002836A1 (es)
CR (1) CR20160518A (es)
DK (1) DK3143025T3 (es)
EA (2) EA202090486A3 (es)
ES (2) ES2761423T3 (es)
FR (1) FR21C1039I2 (es)
HR (2) HRP20192159T1 (es)
HU (2) HUE046491T2 (es)
IL (2) IL248653B (es)
LT (1) LTC3143025I2 (es)
MA (2) MA51988A (es)
MX (1) MX371050B (es)
MY (1) MY174284A (es)
NL (1) NL301128I2 (es)
NO (2) NO2021035I1 (es)
NZ (1) NZ725008A (es)
PE (1) PE20170128A1 (es)
PH (1) PH12016502081B1 (es)
PL (2) PL3143025T3 (es)
PT (1) PT3143025T (es)
RS (1) RS59718B1 (es)
SG (1) SG11201609497TA (es)
SI (2) SI3663296T1 (es)
TW (1) TWI667239B (es)
UA (1) UA119670C2 (es)
WO (1) WO2015173181A1 (es)
ZA (1) ZA201607026B (es)

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US10882868B2 (en) * 2014-05-15 2021-01-05 Hoffmann-La Roche Inc. Compounds for treating spinal muscular atrophy
EP3298017B1 (en) 2015-05-20 2019-08-14 H. Hoffnabb-La Roche Ag Compounds for treating spinal muscular atrophy
EP3310169B1 (en) 2015-05-30 2023-05-17 PTC Therapeutics, Inc. Methods for modulating rna splicing
AU2016353961B2 (en) 2015-11-12 2019-08-29 F. Hoffmann-La Roche Ag Compositions for treating spinal muscular atrophy
AR106652A1 (es) * 2015-11-12 2018-02-07 Hoffmann La Roche Compuestos para tratar la esclerosis lateral amiotrófica
CA3119019C (en) 2015-12-10 2024-06-11 Ptc Therapeutics, Inc. Compounds and methods for treating huntington's disease
EP3386978B1 (en) 2015-12-10 2021-01-27 H. Hoffnabb-La Roche Ag Bridged piperidine derivatives
JP2019535789A (ja) * 2016-11-28 2019-12-12 ピーティーシー セラピューティクス，インコーポレーテッド Ｒｎａスプライシングを調節する方法
EP4151627A1 (en) 2017-06-05 2023-03-22 PTC Therapeutics, Inc. Compounds for treating huntington's disease
CN111372611A (zh) 2017-06-14 2020-07-03 Ptc医疗公司 修饰rna剪接的方法
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
CN111163838B (zh) 2017-06-28 2023-03-28 Ptc医疗公司 用于治疗亨廷顿氏病的方法
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ES3072590T3 (en) * 2017-10-03 2026-07-02 Hoffmann La Roche New treatment of sma
BR112020019373A2 (pt) 2018-03-27 2020-12-29 Ptc Therapeutics, Inc. Compostos para o tratamento da doença de hutington
IL279688B2 (en) 2018-06-27 2025-01-01 Ptc Therapeutics Inc Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
KR20210038845A (ko) 2018-06-27 2021-04-08 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료를 위한 헤테로아릴 화합물
WO2020004594A1 (ja) 2018-06-27 2020-01-02 株式会社リボルナバイオサイエンス 脊髄性筋萎縮症の予防または治療剤
CN120554386A (zh) * 2018-10-19 2025-08-29 豪夫迈·罗氏有限公司 新型吡啶并[1,2-a]嘧啶-4-酮衍生物、其制剂及制备方法
CA3139821A1 (en) 2019-05-13 2020-11-19 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
WO2020249577A1 (en) 2019-06-12 2020-12-17 F. Hoffmann-La Roche Ag New treatment of sma
US12492214B2 (en) 2019-07-31 2025-12-09 Assia Chemical Industries Ltd. Solid state forms of Risdiplam and process for preparation thereof
MX2022012677A (es) * 2020-04-08 2023-01-11 Remix Therapeutics Inc Compuestos y metodos para modular el empalme.
WO2022048675A1 (zh) * 2020-09-07 2022-03-10 苏州科睿思制药有限公司 Risdiplam晶型及其制备方法和用途
WO2022162107A1 (en) 2021-02-01 2022-08-04 Sandoz Ag Crystalline form of risdiplam
EP4308577B1 (en) * 2021-03-17 2024-12-25 F. Hoffmann-La Roche AG New thiadiazolopyrimidone derivatives
EP4308572B1 (en) * 2021-03-17 2025-04-23 F. Hoffmann-La Roche AG New thienopyrimidinone derivatives
CR20230437A (es) 2021-03-17 2023-10-16 Hoffmann La Roche Nuevos derivados de tiazolopirimidinona
KR102973992B1 (ko) * 2021-03-18 2026-06-08 에프. 호프만-라 로슈 아게 리스디플람의 제조 방법
EP4426306A1 (en) 2021-10-06 2024-09-11 F. Hoffmann-La Roche AG Novel combined administration
CN118005654A (zh) * 2022-04-18 2024-05-10 深圳市塔吉瑞生物医药有限公司 取代的吡啶并嘧啶酮类化合物及包含该化合物的组合物及其用途
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US20260098048A1 (en) * 2022-09-26 2026-04-09 Natco Pharma Limited Improved process for the preparation of risdiplam and its intermediates
JP2025534681A (ja) 2022-10-14 2025-10-17 ジェネンテック， インコーポレイテッド 脊髄性筋萎縮症の治療方法
EP4669647A1 (en) * 2023-01-21 2025-12-31 Harman Finochem Limited METHOD FOR PREPARING RISDIPLATIN, NEW INTERMEDIARIES AND THEIR METHOD FOR PREPARATION
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Also Published As

Publication number Publication date
MA39995B1 (fr) 2019-11-29
EA035068B1 (ru) 2020-04-23
SI3663296T1 (sl) 2023-08-31
TW201609738A (zh) 2016-03-16
FR21C1039I1 (es) 2021-10-15
US20170197990A1 (en) 2017-07-13
IL270027B (en) 2020-08-31
EP3663296A1 (en) 2020-06-10
KR102213740B1 (ko) 2021-02-09
BR112016026205A8 (pt) 2021-07-20
PT3143025T (pt) 2019-12-03
ES2761423T3 (es) 2020-05-19
JP6236173B2 (ja) 2017-11-22
CA2948561C (en) 2019-10-22
MA51988A (fr) 2021-01-20
DK3143025T3 (da) 2019-12-09
NO2021035I1 (no) 2021-09-10
UA119670C2 (uk) 2019-07-25
HRP20230637T1 (hr) 2023-09-29
MX2016014547A (es) 2017-02-23
KR20210014219A (ko) 2021-02-08
IL248653B (en) 2019-11-28
FR21C1039I2 (fr) 2022-09-02
SG11201609497TA (en) 2016-12-29
AU2015261046B2 (en) 2019-04-18
EA202090486A2 (ru) 2020-06-30
HRP20192159T1 (hr) 2020-02-21
EP3663296B1 (en) 2023-05-17
JP2017515863A (ja) 2017-06-15
PL3663296T3 (pl) 2023-08-07
BR112016026205B1 (pt) 2021-12-07
CN106459092B (zh) 2019-10-15
IL248653A0 (en) 2017-01-31
EP4241772A3 (en) 2023-11-15
EA202090486A3 (ru) 2020-08-31
PH12016502081A1 (en) 2017-01-09
PE20170128A1 (es) 2017-03-16
AU2015261046A1 (en) 2016-10-27
RS59718B1 (sr) 2020-01-31
TWI667239B (zh) 2019-08-01
KR102256013B1 (ko) 2021-05-26
EP4241772A2 (en) 2023-09-13
NL301128I1 (es) 2021-09-22
NO2025038I1 (no) 2025-08-14
CR20160518A (es) 2017-02-21
AU2015261046C1 (en) 2019-07-25
US9969754B2 (en) 2018-05-15
KR20170003687A (ko) 2017-01-09
WO2015173181A1 (en) 2015-11-19
LTC3143025I2 (es) 2023-11-10
NL301128I2 (nl) 2021-10-25
PH12016502081B1 (en) 2022-11-23
MY174284A (en) 2020-04-01
EP3143025B1 (en) 2019-10-09
CA2948561A1 (en) 2015-11-19
BR112016026205A2 (pt) 2017-08-15
PL3143025T3 (pl) 2020-03-31
HUS2100037I1 (hu) 2021-10-28
AR131260A2 (es) 2025-03-05
ES2949660T3 (es) 2023-10-02
MX371050B (es) 2020-01-14
ZA201607026B (en) 2022-05-25
CN106459092A (zh) 2017-02-22
AR100442A1 (es) 2016-10-05
LTPA2021010I1 (es) 2021-10-11
SI3143025T1 (sl) 2020-01-31
NZ725008A (en) 2019-11-29
EA201692280A1 (ru) 2018-07-31
HUE046491T2 (hu) 2020-03-30
EP3143025A1 (en) 2017-03-22

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