CL2016002875A1 - Un sistema de control del proceso que comprende unidades de procesamiento que operan un caudal de flujo con un tanque conectado además de un filtro conectado al tanque con una bomba de alimentación método de control y proceso de purificación - Google Patents

Un sistema de control del proceso que comprende unidades de procesamiento que operan un caudal de flujo con un tanque conectado además de un filtro conectado al tanque con una bomba de alimentación método de control y proceso de purificación

Info

Publication number
CL2016002875A1
CL2016002875A1 CL2016002875A CL2016002875A CL2016002875A1 CL 2016002875 A1 CL2016002875 A1 CL 2016002875A1 CL 2016002875 A CL2016002875 A CL 2016002875A CL 2016002875 A CL2016002875 A CL 2016002875A CL 2016002875 A1 CL2016002875 A1 CL 2016002875A1
Authority
CL
Chile
Prior art keywords
flow rate
feed pump
tank
processing units
control
Prior art date
Application number
CL2016002875A
Other languages
English (en)
Inventor
Eva Gefroh
Randolph W Schweickart
Krista Petty
Gregory Frank
Terpsma Christine Salstrom
Arthur C Hewig Iii
Joseph Edward Schultz
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53284536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016002875(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CL2016002875A1 publication Critical patent/CL2016002875A1/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/147—Microfiltration
    • B01D61/1471—Microfiltration comprising multiple microfiltration steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/149—Multistep processes comprising different kinds of membrane processes selected from ultrafiltration or microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/04—Specific process operations in the feed stream; Feed pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/06—Specific process operations in the permeate stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/16—Flow or flux control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2626—Absorption or adsorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2649—Filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/18—Specific valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/24—Specific pressurizing or depressurizing means
    • B01D2313/243—Pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/50—Specific extra tanks
    • B01D2313/501—Permeate storage tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/50—Specific extra tanks
    • B01D2313/502—Concentrate storage tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/60—Specific sensors or sensor arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration

Landscapes

  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Peptides Or Proteins (AREA)
  • General Factory Administration (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Abstract

Un sistema de control del proceso que comprende a una o más unidades de procesamiento corriente arriba, cada uno opera un caudal de flujo un tanque conectado a una o más unidades de procesamiento corriente arriba un filtro que tiene una entrada, una salida de permeado y una salida de la fracción retenida conectada al tanque una bomba de alimentación que tiene una entrada conectada al tanque y una salida conectada a la entrada del filtro un sensor dispuesto a la salida del permeado para determinar un caudal de flujo en la salida del permeado y un sistema de control, que es uno de los siguientes i a iv, i acoplado al sensor y a los procesos corriente arriba, y adaptado para controlar el caudal de flujo de una o más de una o más unidades de procesamiento corriente arriba de acuerdo con el caudal de flujo en la salida del permeado, ii acoplado al sensor y a la bomba de alimentación, y adaptado para controlar la bomba de alimentación de acuerdo con el caudal de flujo a la salida del permeado, iii acoplado al sensor y a la bomba de alimentación, adaptado para controlar la bomba de alimentación de acuerdo con el caudal de flujo a la salida del permeado hasta que se alcanza un caudal de flujo predeterminado para la bomba de alimentación, y controlar el caudal de flujo de una o más de una o más unidades de procesamiento corriente arriba de acuerdo con el caudal de flujo a la salida del permeado hasta que se alcanza el caudal de flujo predeterminado para la bomba de alimentación, o iv acoplado al sensor y a la bomba de alimentación, y adaptado para controlar la bomba de alimentación de acuerdo con el caudal de flujo a la salida del permeado hasta que se alcanza un caudal de flujo predeterminado para la bomba de alimentación, ya permitir un desajuste entre el caudal de flujo de una o más unidades de procesamiento corriente arriba y el caudal de flujo de la bomba de alimentación hasta que se alcanza el caudal de flujo predeterminado para la bomba de alimentación.
CL2016002875A 2014-05-13 2016-11-11 Un sistema de control del proceso que comprende unidades de procesamiento que operan un caudal de flujo con un tanque conectado además de un filtro conectado al tanque con una bomba de alimentación método de control y proceso de purificación CL2016002875A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461992595P 2014-05-13 2014-05-13

Publications (1)

Publication Number Publication Date
CL2016002875A1 true CL2016002875A1 (es) 2017-05-26

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Family Applications (1)

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CL2016002875A CL2016002875A1 (es) 2014-05-13 2016-11-11 Un sistema de control del proceso que comprende unidades de procesamiento que operan un caudal de flujo con un tanque conectado además de un filtro conectado al tanque con una bomba de alimentación método de control y proceso de purificación

Country Status (15)

Country Link
US (3) US10583397B2 (es)
EP (2) EP3142775A2 (es)
JP (3) JP6661547B2 (es)
KR (3) KR102707370B1 (es)
CN (2) CN106794424B (es)
AU (3) AU2015259228C1 (es)
BR (1) BR112016025854B1 (es)
CA (2) CA3140009C (es)
CL (1) CL2016002875A1 (es)
EA (2) EA037972B1 (es)
IL (3) IL296603B2 (es)
MX (2) MX383879B (es)
SG (2) SG10202008789QA (es)
WO (1) WO2015175679A2 (es)
ZA (1) ZA202001695B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6661547B2 (ja) 2014-05-13 2020-03-11 アムジエン・インコーポレーテツド フィルタ及び濾過プロセスで用いるためのプロセス制御システム及び方法
US10550148B2 (en) 2014-06-16 2020-02-04 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
WO2015195452A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Single-pass filtration systems and processes
CN115463546A (zh) 2014-06-25 2022-12-13 Emd 密理博公司 过滤器元件、切向流过滤系统、产生进料筛网的方法
CN105745009B (zh) 2014-08-29 2018-09-28 Emd 密理博公司 单程切向流过滤系统和具有渗余物的再循环的切向流过滤系统
ES2935333T3 (es) 2014-08-29 2023-03-06 Emd Millipore Corp Procesos para filtrar líquidos utilizando sistemas de filtración de flujo tangencial de paso único y sistemas de filtración de flujo tangencial con recirculación de retenido
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
CA3023486C (en) 2016-06-09 2022-03-29 Emd Millipore Corporation Radial-path filter elements, systems and methods of using same
EP3354330A1 (en) * 2017-01-25 2018-08-01 Sartorius Stedim Biotech GmbH Automated modular filtration system
US11547957B2 (en) 2017-05-11 2023-01-10 Emd Millipore Corporation Method of maintaining narrow residence time distributions in continuous flow systems
CN110891665B (zh) * 2017-05-11 2022-01-14 Emd密理博公司 在连续流动体系中保持窄停留时间分布的机械方法
WO2019107498A1 (ja) * 2017-11-30 2019-06-06 東レ株式会社 ろ過装置
TWI846694B (zh) 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
CN112236215A (zh) * 2018-06-21 2021-01-15 思拓凡瑞典有限公司 用于过滤的系统和相关联的方法
US20210355159A1 (en) * 2018-12-20 2021-11-18 Emd Millipore Corporation In-line product concentration to reduce volumetric load flow rate and increase productivity of a bind and elute chromatography purification
US11773365B2 (en) 2019-02-08 2023-10-03 Lonza Walkersville, Inc. Cell concentration methods and devices for use in automated bioreactors
EP3924458A1 (en) * 2019-02-15 2021-12-22 Just-Evotec Biologics, Inc. Automated biomanufacturing systems, facilities, and processes
BR112021019217A2 (pt) * 2019-04-03 2021-11-30 Genzyme Corp Produção contínua de proteínas recombinantes
CN113891656A (zh) * 2019-07-24 2022-01-04 利乐拉瓦尔集团及财务有限公司 浓缩乳制品中的物质的设备和方法
US20210047605A1 (en) * 2019-08-13 2021-02-18 Repligen Corporation Control systems and methods for automated clarification of cell culture with high solids content
GB2592573A (en) * 2019-12-19 2021-09-08 Leybold France S A S Lubricant-sealed vacuum pump, lubricant filter and method.
EP3895799B1 (en) * 2020-04-17 2024-08-07 Sartorius Stedim Biotech GmbH A fluid processing system
CN113559712B (zh) * 2020-04-29 2026-04-21 上海药明生物技术有限公司 切向流过滤系统与方法
CN117957050A (zh) * 2021-09-28 2024-04-30 默克专利股份有限公司 用于使用直列式恒压罐“icpt”进行处理强化的集成解决方案
CN118973592A (zh) * 2022-03-30 2024-11-15 富士胶片株式会社 生物制药的原料药的制造方法、生物制药的原料药的制造系统及生物制药的原料药
CN118984710A (zh) * 2022-03-30 2024-11-19 富士胶片株式会社 生物制药的原料药的制造方法、生物制药的原料药的制造系统及生物制药的原料药
KR102867966B1 (ko) * 2022-04-26 2025-10-13 (주)에코샤인 연속 생산이 가능한 한외여과 분리정제 장비
CN115430198A (zh) * 2022-09-21 2022-12-06 英脉生物医药(杭州)有限公司 一种蛋白纯化方法和蛋白纯化系统
CN119968454A (zh) * 2022-09-28 2025-05-09 建新公司 用于生产生物产品的系统和装置及其使用方法
CN115672037A (zh) * 2022-11-01 2023-02-03 上海药明生物技术有限公司 单向切向流过滤工艺开发装置和方法
CN115931676A (zh) * 2022-12-21 2023-04-07 华南农业大学 一种体外组织渗透装置
WO2024165043A1 (en) * 2023-02-08 2024-08-15 Beigene Switzerland Gmbh Preparation methods for a highly concentrated pd1 antibody solution by applying single-pass tangential flow filtration (sptff)
IL326755A (en) * 2023-09-08 2026-04-01 Genentech Inc Low concentration single pass tangential flow filtration for removing bottlenecks in high titer connected and/or fed-batch processes
WO2025087829A1 (en) * 2023-10-24 2025-05-01 Merck Patent Gmbh Continuous filtration by means of feed cycling
WO2025245073A1 (en) * 2024-05-20 2025-11-27 Sentinel Water Solutions, Llc Batch polyfluoroalkyl substances (pfas) pilot methods, mobile apparatus, and roughing filter system and methods

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63252505A (ja) 1987-04-07 1988-10-19 Shibuya Kogyo Co Ltd 精密限外濾過装置
CH673959A5 (es) * 1987-10-02 1990-04-30 Bucher Guyer Ag Masch
US4994188A (en) 1988-02-05 1991-02-19 Baxter International Inc. Adaptive filtrate flow control system using controlled reduction in filter efficiency
JPH074224B2 (ja) 1989-10-30 1995-01-25 三菱電機株式会社 膜分離型リアクタの制御装置
US5256294A (en) * 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
US5164092A (en) * 1991-02-20 1992-11-17 Eastman Kodak Company 2-stage ultrafiltration process for photographic emulsions
WO1995030468A1 (en) * 1994-05-10 1995-11-16 Womack International, Inc. Optimizing operation of a filter system
JP3579188B2 (ja) 1996-07-29 2004-10-20 旭化成ケミカルズ株式会社 濾過装置
US5843298A (en) * 1996-09-27 1998-12-01 Ucar Carbon Technology Corporation Method of production of solids-free coal tar pitch
AU4145897A (en) 1997-02-14 1998-09-08 Warner-Jenkinson Company, Inc. Method and apparatus for purifying water-insoluble compounds
GB2348155B (en) * 1997-02-14 2000-11-01 Warner Jenkinson Co Inc Apparatus for purifying water-insoluble compounds
US6096872A (en) * 1997-10-14 2000-08-01 Ortho Diagnostic Systems, Inc. Viral clearance process
JP4575592B2 (ja) * 1997-11-14 2010-11-04 パシラ ファーマシューティカルズ インコーポレーテッド 多小胞リポソームの製造
US6074551A (en) * 1998-04-30 2000-06-13 Culligan Water Conditioning Of Fairfield County Automatic cleaning system for a reverse osmosis unit in a high purity water treatment system
US6168714B1 (en) * 1999-05-17 2001-01-02 North Carolina A&T University Flux-enhanced cross-flow membrane filter
US6296770B1 (en) * 1999-12-09 2001-10-02 Eastman Kodak Company Constant concentration at the UF membrane wall UF process control and apparatus
US6607669B2 (en) * 2000-06-23 2003-08-19 Scilog, Inc. Method and apparatus for enhancing filtration yields in tangential flow filtration
AU784808B2 (en) * 2001-04-02 2006-06-29 Kedrion Melville Inc. Prion and viral clearance process
US6802342B2 (en) * 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
US7270744B2 (en) * 2001-10-09 2007-09-18 Millipore Corporation Automated low-volume tangential flow filtration process development device
US6764598B2 (en) * 2001-12-28 2004-07-20 Filtration Solutions, Inc. Method and apparatus for separating emulsified water from fuel
US6712963B2 (en) 2002-06-14 2004-03-30 Scilog, Llc Single-use manifold for automated, aseptic transfer of solutions in bioprocessing applications
CA2489123C (en) * 2002-06-14 2011-03-15 Centocor, Inc. Use of a clathrate modifier to promote passage of proteins during nanofiltration
WO2004004873A1 (en) 2002-07-10 2004-01-15 Pall Corporation Hollow fiber membrane systems
JP2006515227A (ja) 2003-02-24 2006-05-25 ジーティーシー バイオセラピューティックス インコーポレイテッド 十字流濾過の方法およびそのための装置
US20050067341A1 (en) * 2003-09-25 2005-03-31 Green Dennis H. Continuous production membrane water treatment plant and method for operating same
JP4439526B2 (ja) * 2004-02-18 2010-03-24 ブーハー−グイアー・アクチェンゲゼルシャフト 製品を完全濾過する方法とこの方法を実施する装置
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
US20050224412A1 (en) * 2004-04-09 2005-10-13 Best Graham J Water treatment system having upstream control of filtrate flowrate and method for operating same
US7410587B2 (en) * 2004-08-03 2008-08-12 Scilog, Inc. Liquid handling for filtration and preparative chromatography
US20060051347A1 (en) 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
DK1807101T3 (en) 2004-09-30 2016-05-23 Bayer Healthcare Llc Devices and methods for integrated continuous production of biological molecules
WO2006093746A2 (en) * 2005-02-25 2006-09-08 Biogen Idec Ma Inc. Process equipment monitoring
US8574595B2 (en) * 2005-04-11 2013-11-05 Crucell Holland B.V. Virus purification using ultrafiltration
WO2006138181A2 (en) * 2005-06-14 2006-12-28 Amgen Inc. Self-buffering protein formulations
US7510654B2 (en) * 2005-12-29 2009-03-31 Spf Innovations, Llc Method and apparatus for the filtration of biological samples
US20070246406A1 (en) * 2006-03-31 2007-10-25 Dibel Kevin R Tangential flow filtration apparatuses, systems, and processes for the separation of compounds
US9285354B2 (en) * 2007-04-02 2016-03-15 The United States Of America As Represented By The Administrator Of The U.S. Environmental Protection Agency Systems and methods for the detection of low-level harmful substances in a large volume of fluid
US8741600B2 (en) * 2007-06-19 2014-06-03 Asahi Kasei Kabushiki Kaisha Method for separation of immunoglobulin monomers
ES2437850T3 (es) * 2007-09-12 2014-01-14 Danisco Us Inc. Filtración con control de incrustación interno
US8231787B2 (en) 2008-05-06 2012-07-31 Spf Innovations, Llc Tangential flow filtration system
KR20110074563A (ko) * 2008-09-24 2011-06-30 메디뮨 엘엘씨 바이러스의 정제 방법
JP5431474B2 (ja) * 2009-06-26 2014-03-05 旭化成ケミカルズ株式会社 ろ過方法及び膜ろ過装置
ITVR20090155A1 (it) 2009-10-01 2011-04-02 Velo Spa Apparato di filtrazione tangenziale
US9216412B2 (en) * 2009-11-23 2015-12-22 Cyvek, Inc. Microfluidic devices and methods of manufacture and use
GB201014993D0 (en) * 2010-09-09 2010-10-20 Aquabio Ltd Separation system
WO2012037274A2 (en) * 2010-09-14 2012-03-22 The Regents Of The University Of California Apparatus, system and method for integrated filtration and reverse osmosis desalination
JP5860887B2 (ja) 2010-10-15 2016-02-16 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 大容量使い捨て限外濾過システム及び方法
DE102010052698A1 (de) * 2010-11-26 2012-05-31 Dürr Systems GmbH Reinigungsgerät und Reinigungsbürste für einen Zerstäuber und entsprechendes Reinigungsverfahren
JP5762041B2 (ja) * 2011-02-17 2015-08-12 株式会社日立製作所 複合淡水化システム
US8579620B2 (en) * 2011-03-02 2013-11-12 Andy Wu Single-action three-dimensional model printing methods
CN102276074B (zh) 2011-06-02 2012-11-14 郑州大学 一种超滤膜处理三聚氰胺废水的方法及设备
WO2012171026A2 (en) * 2011-06-10 2012-12-13 Biovest International, Inc. Methods for high yield virus production
CA2838737A1 (en) 2011-06-13 2012-12-20 Praxair Technology, Inc. Control system for wastewater treatment plants with membrane bioreactors
AU2012276702B2 (en) * 2011-06-29 2017-02-09 Toray Industries, Inc. Membrane filtration method and membrane filtration device
JP6280499B2 (ja) * 2011-07-08 2018-02-14 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｆｃ融合タンパク質の精製方法
EP2741836B1 (en) * 2011-08-12 2019-04-24 Pall Corporation Fluid treatment assemblies comprising manifold, and methods for treating fluids
US9345826B2 (en) * 2011-09-15 2016-05-24 Deka Products Limited Partnership Recirculating fluid filtration system
EP2682168A1 (en) * 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
KR20230142653A (ko) * 2013-09-16 2023-10-11 젠자임 코포레이션 세포 배양물을 가공하는 방법 및 시스템
JP6661547B2 (ja) 2014-05-13 2020-03-11 アムジエン・インコーポレーテツド フィルタ及び濾過プロセスで用いるためのプロセス制御システム及び方法
US20160176921A1 (en) * 2014-12-22 2016-06-23 Alexion Pharmaceuticals, Inc. Methods of purifying recombinant proteins
EP4010101A4 (en) * 2019-08-05 2022-11-16 Repligen Corporation DEVICES, SYSTEMS AND METHODS FOR CONTINUOUS TREATMENT WITH ALTERNATE TANGENTIAL FLOW

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