CL2016003063A1 - Composición basada en una solución estabilizada de ingredientes activos - Google Patents
Composición basada en una solución estabilizada de ingredientes activosInfo
- Publication number
- CL2016003063A1 CL2016003063A1 CL2016003063A CL2016003063A CL2016003063A1 CL 2016003063 A1 CL2016003063 A1 CL 2016003063A1 CL 2016003063 A CL2016003063 A CL 2016003063A CL 2016003063 A CL2016003063 A CL 2016003063A CL 2016003063 A1 CL2016003063 A1 CL 2016003063A1
- Authority
- CL
- Chile
- Prior art keywords
- same
- pharmaceutically acceptable
- stabilized solution
- active ingredients
- water
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 239000003381 stabilizer Substances 0.000 abstract 2
- LRQIWRXCHWNNEA-UHFFFAOYSA-L 10-[dimethyl-[2-(5-methyl-2-propan-2-ylcyclohexyl)oxy-2-oxoethyl]azaniumyl]decyl-dimethyl-[2-(5-methyl-2-propan-2-ylcyclohexyl)oxy-2-oxoethyl]azanium;dichloride Chemical compound [Cl-].[Cl-].CC(C)C1CCC(C)CC1OC(=O)C[N+](C)(C)CCCCCCCCCC[N+](C)(C)CC(=O)OC1C(C(C)C)CCC(C)C1 LRQIWRXCHWNNEA-UHFFFAOYSA-L 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 229960003145 decamethoxine Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/305—Mercury compounds
- A61K31/31—Mercury compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
<p>LA INVENCIÓN SE RELACIONA CON COMPOSICIONES FARMACÉUTICAS (VARIANTES) EN BASE A UNA SOLUCIÓN ESTABILIZADA DE DOS INGREDIENTES ACTIVOS, EN DONDE DICHA SOLUCIÓN ESTABILIZADA DE DOS INGREDIENTES ACTIVOS COMPRENDE, COMO PRIMER INGREDIENTE ACTIVO, ÁCIDO HIALURÓNICO DE BAJO PESO MOLECULAR Y/O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO. EN DONDE LA MASA MOLECULAR DE DICHO ÁCIDO O SAL ES DE DESDE 100KDA A 400KDA O, EN UNA VARIANTE, DESDE 400 KDA A 2,5 MDA, Y, COMO SEGUNDO INGREDIENTE ACTIVO, DECAMETOXINA O UNA SAL DE LA MISMA SOLUBLE EN AGUA, Y UN ESTABILIZADOR EN LA FORMA DE UNA SAL FARMACÉUTICAMENTE ACEPTABLE QUE ES CAPAZ DE DISOLVERSE EN AGUA Y DE DISOCIARSE EN SOLUCIONES ACUOSAS EN CATIONES METÁLICOS Y ANIONES DE RESIDUO ÁCIDO, A UNA MEZCLA DE TALES SALES, SIENDO EL ESTABILIZADOR CAPAZ DE FORMAR COMPUESTOS SOLUBLES EN AGUA CON EL ÁCIDO HIALURÓNICO Y/O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO Y CON LA DECAMETOXINA O UNA SAL DE LA MISMA SOLUBLE EN AGUA, SIMULTÁNEAMENTE. LA SOLUCIÓN ESTABILIZADA CONTIENE ADEMÁS AL MENOS UN ADITIVO FARMACÉUTICAMENTE ACEPTABLE.</p>
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA201405946A UA113416C2 (xx) | 2014-05-30 | 2014-05-30 | Стабілізований розчин на основі декаметоксину та гіалуронової кислоти, що має терапевтичну активність, спосіб його одержання та фармацевтична композиція на його основі |
| UAU201406108U UA94395U (uk) | 2014-06-03 | 2014-06-03 | Спосіб одержання стабілізованого розчину на основі декаметоксину та гіалуронової кислоти, що має терапевтичну активність |
| UAA201505330A UA116892C2 (uk) | 2015-05-29 | 2015-05-29 | Фармацевтична композиція |
| UAA201505327 | 2015-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2016003063A1 true CL2016003063A1 (es) | 2017-08-04 |
Family
ID=68041370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2016003063A CL2016003063A1 (es) | 2014-05-30 | 2016-11-29 | Composición basada en una solución estabilizada de ingredientes activos |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP3153156A4 (es) |
| CN (1) | CN106794140A (es) |
| BR (1) | BR112016028176A2 (es) |
| CL (1) | CL2016003063A1 (es) |
| EA (1) | EA033306B1 (es) |
| MX (1) | MX2016015660A (es) |
| PL (1) | PL420378A1 (es) |
| RO (1) | RO131947A2 (es) |
| RU (1) | RU2016148820A (es) |
| WO (1) | WO2015183230A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2659175C1 (ru) * | 2017-04-12 | 2018-06-28 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва" | Композиция на основе бактериальной целлюлозы и гиалуроновой кислоты |
| UA116755C2 (uk) * | 2017-10-09 | 2018-04-25 | Товариство З Обмеженою Відповідальністю "Науково-Виробниче Об'Єднання "Фарматрон" | Фармацевтична композиція у формі супозиторіїв з ранозагоюючою, антиерозійною, протизапальною, антимікробною, протигрибковою, імуномодулюючою та антиоксидантною дією |
| CN110038027A (zh) * | 2018-01-16 | 2019-07-23 | 菲利达生技股份有限公司 | 用于抑制发炎的医药组合物 |
| GB2584074B (en) * | 2019-04-16 | 2021-08-11 | Alectrona Pte Ltd | Monoterpene phenol derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1116044C (zh) * | 1998-06-24 | 2003-07-30 | 凌沛学 | 含有透明质酸钠的防粘连颗粒剂和粉雾剂及其制作方法 |
| CN1302813C (zh) * | 2004-12-29 | 2007-03-07 | 中国海洋大学 | 含海藻糖和透明质酸的烧伤用药传递系统及其制备方法 |
| RU2280041C1 (ru) * | 2005-04-21 | 2006-07-20 | Общество с ограниченной ответственностью Научно-производственное предприятие "Тульская индустрия ЛТД" | Способ получения водорастворимых солевых комплексов гиалуроновой кислоты (варианты) |
| ITMI20072225A1 (it) * | 2007-11-23 | 2009-05-24 | Luso Farmaco Inst | "composizioni farmaceutiche a base di antagonisti della bradichinina ed acido ialuronico e loro uso" |
| US8119112B2 (en) * | 2008-01-31 | 2012-02-21 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and hyaluronic acid |
| WO2010125069A1 (en) * | 2009-04-28 | 2010-11-04 | Pharmasurgics In Sweden Ab | Hyaluronic acid for preventing post surgical adhesions |
-
2015
- 2015-06-02 PL PL420378A patent/PL420378A1/pl unknown
- 2015-06-02 CN CN201580022510.1A patent/CN106794140A/zh active Pending
- 2015-06-02 EP EP15799012.8A patent/EP3153156A4/en not_active Withdrawn
- 2015-06-02 RO ROA201600960A patent/RO131947A2/ro unknown
- 2015-06-02 WO PCT/UA2015/000047 patent/WO2015183230A1/ru not_active Ceased
- 2015-06-02 EA EA201691825A patent/EA033306B1/ru not_active IP Right Cessation
- 2015-06-02 BR BR112016028176A patent/BR112016028176A2/pt not_active Application Discontinuation
- 2015-06-02 MX MX2016015660A patent/MX2016015660A/es unknown
- 2015-06-02 RU RU2016148820A patent/RU2016148820A/ru not_active Application Discontinuation
-
2016
- 2016-11-29 CL CL2016003063A patent/CL2016003063A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3153156A1 (en) | 2017-04-12 |
| RU2016148820A (ru) | 2018-07-04 |
| EP3153156A4 (en) | 2018-02-14 |
| RO131947A2 (ro) | 2017-06-30 |
| EA033306B1 (ru) | 2019-09-30 |
| BR112016028176A2 (pt) | 2017-08-22 |
| CN106794140A (zh) | 2017-05-31 |
| MX2016015660A (es) | 2017-07-13 |
| WO2015183230A1 (ru) | 2015-12-03 |
| PL420378A1 (pl) | 2017-10-23 |
| EA201691825A1 (ru) | 2017-02-28 |
| WO2015183230A9 (ru) | 2015-12-23 |
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